Publications by authors named "A A Askarova"

Article Synopsis
  • Researchers used advanced computational models to explore how different histone marks affect gene expression but found previous approaches missed important factors like cell state and histone function.
  • The study examined seven histone marks in eleven cell types and discovered that no single histone mark consistently predicts gene expression, emphasizing the importance of considering histone function, genomic distance, and cellular context together.
  • The research also included simulations that revealed potential disease-related genetic loci and suggested new ways to leverage deep learning models for further biological discoveries.
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Hemorrhagic stroke (HS) in childhood accounts for almost 50% of childhood strokes, is among the top ten causes of deaths, or determines lifelong disability. These facts form significant socio-economic and demographic problems. The purpose of this review is to analyze current knowledge about HS in children.

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Microglia cells, the immune cells residing in the brain, express immune regulatory molecules that have a central role in the manifestation of age-related brain characteristics. Our hypothesis suggests that galectin-1, an anti-inflammatory member of the beta-galactoside-binding lectin family, regulates microglia and neuroinflammation in the aging brain. Through our in-silico analysis, we discovered a subcluster of microglia in the aged mouse brain that exhibited increased expression of galectin-1 mRNA.

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Unlabelled: Migraine is a primary form of headache characterized by throbbing unilateral attacks, increased sensitivity to light and sound, accompanied by nausea and/or vomiting, lasting from 4 hours to 3 days. Developing and implementing new methods of pain relief is an urgent task of modern medicine. One of the safest and most commonly recommended methods is transcranial magnet therapy (TMT).

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Pediatric hemorrhagic stroke (HS) has become a problem, determining both a high frequency of fatal outcomes and early disability. The priority objective determining the effectiveness of diagnosis, treatment, and prevention of hemorrhagic stroke is to identify the etiology of the disease. We report a case of hemorrhagic stroke in a 2-month old child with cytomegalovirus infection, which led to a negative outcome of the disease.

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