[The effect of reaferon and alpha-tocopherol on lipid peroxidation in experimental influenza].

Reaferon administered to outbred young mice with experimental influenza had a positive effect on morphologic changes in pulmonary tissues and on lipid peroxidation in the blood plasma and pulmonary tissues. Combined use of reaferon and alpha-tocopherol in mice infected with influenza A virus reduced the mortality rate, boosted the antiviral effect of reaferon proper, and led to virtually complete normalization of lipid peroxidation processes in the blood plasma and pulmonary tissues.

[The systemic disorder of connective tissue metabolism and hypoplasia of the nephron elements in hereditary nephritis in children].

Clinical biochemistry and morphological methods were employed to examine 25 children aged 3 to 15 years with hereditary nephritis. Measurements were made of morphological alterations in renal biopsy specimens, excretion with urine of connective tissue metabolites (hydroxyproline, hydroxylysine glycosides, glycosaminoglycans), the level of the same metabolites and characteristic features of the cellular growth of skin fibroblasts in culture. The early stages of nephritis development were marked by hypoplasia of nephron elements, followed by dystrophy and destruction of its ultrastructural elements including collagen of the glomerular basal membranes.

[State of lipid peroxidation system and antioxidant defense in acute respiratory viral infection in children and the principles of pathogenetic therapy].

Summary. Altogether 187 young children presenting with acute respiratory viral infection were examined for lipid peroxidation and antioxidant defense. The principles of the pathogenetically validated antioxidant treatment are discussed.

[Characteristics of higher nervous activity in young children, cholesterol metabolism and state of the adrenal cortex].

The relationship was established between cholesterol metabolism, adrenocortical function and the typological features of the higher nervous activity in children. Cholesterol metabolism was found to correlate with the type of the higher nervous activity. The children with deficient force and mobility of the nervous processes showed a decrease of glucocorticoid function of the adrenal cortex, proneness to an elevation of the cholesterol level in blood serum and delay of its excretion with feces.