TRPV4 Channel Modulators as Potential Drug Candidates for Cystic Fibrosis.

Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator () gene, resulting in defective chloride ion channels. This leads to thick, dehydrated mucus that severely disrupts mucociliary clearance in the respiratory system and triggers infection that eventually is the cause of death of CF patients. Current therapeutic strategies primarily focus on restoring CFTR function, blocking epithelial sodium channels to prevent mucus dehydration, or directly targeting mucus to reduce its viscosity.

A Multi-center Cross-Sectional Assessment of Healthcare Professionals' Knowledge, Attitudes, and Practices Toward Thromboprophylaxis.

Background Venous thromboembolism (VTE) is a potentially avoidable condition that affects hospitalized patients. Risk stratification and preventative strategies have substantial evidence supporting their use, but reasons hinder widespread adoption, compliance, and success, explaining the continuation of VTE. Thromboprophylaxis consists of several measures that are frequently adopted to avoid the complications of VTE.

Endoscopic Removal of Intrauterine Contraceptive Device From the Descending Colon: A Case Report.

Intrauterine contraceptive device (IUCD) is a popular method of contraception used worldwide. Although successful, it can get dislodged from its primary position and perforate the uterine wall. Migration to the colon is an uncommon complication.

K2 and K3.1 Channels in the Airways: A New Therapeutic Target.

K channels are involved in many critical functions in lung physiology. Recently, the family of Ca-activated K channels (K) has received more attention, and a massive amount of effort has been devoted to developing selective medications targeting these channels. Within the family of K channels, three small-conductance Ca-activated K (K2) channel subtypes, together with the intermediate-conductance K3.