Publications by authors named "A A Agnihotri"
Purpose: To compare the assessment of clinically relevant retinal and choroidal lesions as well as optic nerve pathologies using a novel three-wavelength ultra-widefield (UWF) scanning laser ophthalmoscope with established retinal imaging techniques for ophthalmoscopic imaging.
Methods: Eighty eyes with a variety of retinal and choroidal lesions were assessed on the same time point using Topcon color fundus photography (CFP) montage, Optos red/green (RG), Heidelberg SPECTRALIS MultiColor 55-color montage (MCI), and novel Optos red/green/blue (RGB). Paired images of the optic nerve, retinal, or choroidal lesions were initially diagnosed based on CFP imaging.
We give for the first time theoretical estimates of unknown rare electron-capture (EC) decay branchings of ^{44}Ti, ^{57}Co, and ^{139}Ce, relevant for searches of (exotic) dark-matter particles. The nuclear-structure calculations have been done exploiting the nuclear shell model with well-established Hamiltonians and an advanced theory of β decay. In the absence of experimental measurements of these rare branches, these estimates are of utmost importance for terrestrial searches of dark-matter particles, such as axionic dark matter in the form of axionlike particles, anapole dark matter, and dark photons in nuclear transitions.
View Article and Find Full Text PDFThis study investigates the efficacy of predicting age-related macular degeneration (AMD) activity through deep neural networks (DNN) using a cross-instrument training dataset composed of Optical coherence tomography-angiography (OCTA) images from two different manufacturers. A retrospective cross-sectional study analyzed 2D vascular en-face OCTA images from Heidelberg Spectralis (1478 samples: 1102 training, 276 validation, 100 testing) and Optovue Solix (1003 samples: 754 training, 189 validation, 60 testing). OCTA scans were labeled based on clinical diagnoses and adjacent B-scan OCT fluid information, categorizing activity into normal, dry AMD, active wet AMD, and wet AMD in remission.
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- Rhynchosia minima plants from the Indian Institute of Pulses Research exhibited yellow mosaic symptoms, suspected to be caused by begomoviruses, primarily identified as mungbean yellow mosaic India virus in four samples tested via PCR.
- One plant sample (Rhm2) tested negative for this virus but later analyses revealed it contained two DNA molecules associated with the rhynchosia yellow mosaic virus (RhYMV), which were closely related to known isolates with significant nucleotide similarities.
- Phylogenetic analysis indicated RhYMV-IN-Knp's lineage and highlighted two recombination events, suggesting a risk of infection to cultivated legumes, emphasizing the need for ongoing monitoring, particularly in pigeonpea
Article Synopsis
- The study focuses on a specific chromosomal translocation (t(1;19)) that creates the TCF3::PBX1 fusion protein, which is linked to childhood pre-B-cell acute lymphoblastic leukemia (ALL).
- Researchers used gene expression data and advanced analytical techniques to identify genes that are dysregulated due to this fusion protein.
- They discovered a group of genes related to metal ion stress, particularly from the metallothionein family, that are influenced by TCF3::PBX1, suggesting a potential new mechanism in the development of this form of leukemia.