Publications by authors named "A'Doriann Bradley"
Article Synopsis
- * The study introduces the SHINE method, a CRISPR-based RNA detection system, which features four validated assays able to identify and differentiate between key influenza species and subtypes with high accuracy.
- * The research also develops advanced assays capable of simultaneously detecting multiple targets, demonstrating potential for improved diagnosis and surveillance of influenza outside traditional clinical settings.
The widespread transmission and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) call for rapid nucleic acid diagnostics that are easy to use outside of centralized clinical laboratories. Here we report the development and performance benchmarking of Cas13-based nucleic acid assays leveraging lyophilised reagents and fast sample inactivation at ambient temperature. The assays, which we named SHINEv.
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- The COVID-19 pandemic highlighted the urgent need for widespread and decentralized nucleic acid testing, especially for SARS-CoV-2 Variants of Concern (VOCs).
- SHINEv2 is a new diagnostic tool that uses Cas13 technology, allowing for quick testing at room temperature with easy-to-use, lyophilized reagents.
- In tests, SHINEv2 showed 50 times more sensitivity and 100% specificity compared to leading antigen tests, and can identify multiple VOCs in under 90 minutes without any special equipment.