Purpose: Multiple sclerosis (MS) is a neurological disorder affecting almost 2.8 million people globally, approximately 80-85% of whom have the relapsing-remitting form of the disease (RRMS). There are several autoinjectors available for the administration of injectable disease-modifying therapies for the treatment of MS.
View Article and Find Full Text PDFThe premise of extreme value theory focuses on the stochastic behaviour and occurrence of extreme observations in an event that is random. Traditionally for univariate case, the behaviour of the maxima is described either by the types-I, types-II or types-III extreme value distributions, primarily known as the Gumbel, Fréchet or reversed Weibull models. These are all particular cases of the generalized extreme value ( ) model.
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