Publications by authors named "- Gasim Dobie"
Article Synopsis
- The CRISPR/Cas system is a powerful genome-editing tool used in biomedical research to manipulate genes associated with both normal and disease functions, known for its efficiency and specificity.
- Key challenges in its therapeutic applications include safe delivery to target cells and minimizing off-target effects, which can be addressed by understanding anti-CRISPR proteins (Acrs) that can inhibit the CRISPR/Cas system.
- Acrs operate through various mechanisms, and recent research on their action can enhance the safe use of CRISPR/Cas technologies, potentially leading to advancements in gene therapy, diagnostics, and antimicrobial treatments.
Anemia, particularly iron deficiency anemia (IDA), is a prevalent health issue globally and in Saudi Arabia, especially among young adult females. This study investigates the association between anemia and academic achievement among female students at the Female Health Campus of Jazan University, Jazan, Saudi Arabia. This cross-sectional study included 118 randomly selected participants aged 18-22.
View Article and Find Full Text PDFBackground: More than 90,000 children and adults in the United States are hospitalized with an asthma exacerbation annually, and between 5% and 34% of these hospitalizations include admission to an ICU. It is unclear how adolescent and young adults with severe asthma exacerbations are triaged in the inpatient setting between PICUs and adult ICUs. Using a large multicenter US cohort, we characterized how hospitals triage adolescents and young adults with asthma exacerbations between PICUs and adult ICUs.
View Article and Find Full Text PDFAims: This study aimed to review the survivorship, indication for revision and patient reported outcomes for 257 consecutive Oxford cementless unicompartmental knee arthroplasties (OUKA's) in 238 patients at 12-14 years post-operatively.
Methods: Patients underwent surgery between April 2008 and October 2010 by two non-design surgeons including their learning curve. The 5-year clinical and radiological outcomes have already been reported.
Guidelines recommend systemic corticosteroids and inhaled β-agonists for patients with severe asthma exacerbation who are admitted to intensive care units. The benefits and utilization of adjunct treatments after guideline-recommended first-line treatments have been initiated are unclear. Examine practice patterns of adjunct interventions in US intensive care units (ICUs) and their associations with outcomes for adults with severe asthma exacerbations.
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