Artificial intelligence and food flavor: How AI models are shaping the future and revolutionary technologies for flavor food development.

The food flavor science, traditionally reliant on experimental methods, is now entering a promising era with the help of artificial intelligence (AI). By integrating existing technologies with AI, researchers can explore and develop new flavor substances in a digital environment, saving time and resources. More and more research will use AI and big data to enhance product flavor, improve product quality, meet consumer needs, and drive the industry toward a smarter and more sustainable future.

-GlcNAcylation of Focal Adhesion Kinase Regulates Cell Adhesion, Migration, and Proliferation via the FAK/AKT Pathway.

Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase pivotal in cellular signal transduction, regulating cell adhesion, migration, growth, and survival. However, the regulatory mechanisms of FAK during tumorigenesis and progression still need to be fully understood. Our previous study demonstrated that -GlcNAcylation regulates integrin-mediated cell adhesion.

The relationship between thigh circumference and sarcopenia in Chinese community-dwelling elderly aged ≥60 years.

Background: There has been a growing body of research demonstrating that thigh circumference is closely associated with the development of various chronic disease. However, limited evidence has been obtained regarding the relationship between thigh circumference and sarcopenia.

Objective: The aim of this study was to investigate the relationship between thigh circumference and sarcopenia, and explore the potential role of thigh circumference for sarcopenia screening among community-dwelling older adults.

Arthroscopic treatment of calcific tendinitis of the popliteal tendon: A case report.

Introduction And Importance: Calcific tendinitis occurring in the popliteal tendon is extremely rare and has rarely been reported in the past. This case describes a patient who underwent arthroscopic surgery to remove the calcification of the popliteal tendon and achieved satisfactory results after surgery, providing valuable evidence for the feasibility of arthroscopic treatment of calcific tendinitis of the popliteal tendon.

Case Presentation: The patient was a 55-year-old female who was admitted to the hospital due to right knee pain and limited mobility.

The South China Sea Mooring Array and its applications in exploring oceanic multiscale dynamics.

The South China Sea (SCS) is abundant with complex multiscale dynamic processes but their spatiotemporal variations, generation and evolution mechanisms, and mutual interactions remain inadequately understood due to the lack of long-term in situ observations. To explore oceanic multiscale dynamics in the SCS, the SCS Mooring Array (SCSMA) was began to be constructed since 2009. The SCSMA consists of ∼40 moorings and is the largest in situ ocean observing system in marginal seas worldwide.

Alpha-lipoic acid targets expression to inhibit cervical cancer progression.

It is unclear what part KLF7 plays in cervical cancer. In this study, immunohistochemical and bioinformatics analyses reveal that KLF7 expression is lower in normal cervical tissues than in cervical cancer tissues ( ≤0.05), and the high level of transcripts in cervical cancer tissues is negatively correlated with patients' overall and disease-free survival ( <0.

Integrative multi-omics analysis reveals the contribution of neoVTX genes to venom diversity of Synanceia verrucosa.

Background: Animal venom systems are considered as valuable model for investigating the molecular mechanisms underlying phenotypic evolution. Stonefish are the most venomous and dangerous fish because of severe human envenomation and occasionally fatalities, whereas the genomic background of their venom has not been fully explored compared with that in other venomous animals.

Results: In this study, we followed modern venomic pipelines to decode the Synanceia verrucosa venom components.

A Likelihood Perspective on Dose-Finding Study Designs in Oncology.

Dose-finding studies in oncology often include an up-and-down dose transition rule that assigns a dose to each cohort of patients based on accumulating data on dose-limiting toxicity (DLT) events. In making a dose transition decision, a key scientific question is whether the true DLT rate of the current dose exceeds the target DLT rate, and the statistical question is how to evaluate the statistical evidence in the available DLT data with respect to that scientific question. This article introduces generalized likelihood ratios (GLRs) that can be used to measure statistical evidence and support dose transition decisions.

Bidirectional two-sample Mendelian randomization study of atrial fibrillation and breast cancer.

Background: Observational studies have shown an association between Breast Cancer (BC) and Atrial Fibrillation (AF). However, due to confounding factors and reverse causality, the causal role between BC and AF remains unclear. In this study, bidirectional two-sample Mendelian randomization (MR) combined with meta-analysis was used to evaluate the causal association between BC and AF.

LncRNA 93358 Aggravates the Apoptosis of Myocardial Cells After Ischemia-Reperfusion by Mediating the PI3K/AKT/mTOR Pathway.

To investigate the impact of LncRNA 93358 on ischemia-reperfusion induced myocardial cell apoptosis and the underlying mechanism. After being subjected to hypoxia for 4 h, three models of hypoxia-reoxygenation (H/R) with reoxygenation times of 8, 16, and 24 h were established. The expression of LncRNA 93358 was detected by qPCR, and the most suitable conditions were selected for subsequent experiments.

Construction of a circularly polarized luminescence sensor based on self-assembly of carbon dots and G-quartet chiral nanofibers.

Circularly polarized luminescence (CPL) is a fascinating luminescence phenomenon that has garnered significant research attention for chiroptical applications. In this study, we developed a highly sensitive chiroptical sensor by co-assembling G-quartet nanofibers and nonchiral nitrogen sulfur-doped carbon dots (N-S-CDs) for dual ion detection. The N-S-CDs were synthesized using the one-step microwave method, and a helical G-quartet-based nanofiber structure (g-fiber) was simultaneously formed from guanosine 5'-monophosphate (GMP) in the presence of Sr.

α,β-Epoxy Ketone Rearrangements for the Practical Synthesis of Cephalotaxine and the Stereodivergent Synthesis of Azaspiro Allylic Alcohols.

We report herein that three facile rearrangements of epoxy ketones can be employed for the efficient and practical synthesis of cephalotaxine, the parent member of the family of alkaloids. The Meinwald rearrangement of epoxy ketone (90%) was used for the preparation of the dense functional groups in the cyclopentane ring of cephalotaxine. A novel acid-catalyzed umpolung S2' rearrangement and the Wharton transposition reaction of epoxy ketones were also developed to synthesize the Mori intermediate via the key azaspiro allylic alcohols in a stereodivergent manner.

Peli1 Deficiency in Macrophages Attenuates Pulmonary Hypertension by Enhancing Foxp1-Mediated Transcriptional Inhibition of IL-6.

Background: The infiltration of macrophages into the lungs is a common characteristic of perivascular inflammation, contributing to vascular remodeling in pulmonary hypertension (PH). Peli1 (pellino E3 ubiquitin-protein ligase 1) plays a critical role in regulating the production of proinflammatory cytokines and the polarization of macrophages in various diseases. However, the role of Peli1 in PH remains to be investigated.

KanCell: dissecting cellular heterogeneity in biological tissues through integrated single-cell and spatial transcriptomics.

KanCell is a deep learning model based on Kolmogorov-Arnold networks (KAN) designed to enhance cellular heterogeneity analysis by integrating single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) data. ST technologies provide insights into gene expression within tissue context, revealing cellular interactions and microenvironments. To fully leverage this potential, effective computational models are crucial.

Preparation of hydrophobic and lipophilic carboxymethyl cellulose composite aerogel using ferrous ion/ persulfate and its directed oxidation for oil-water emulsion separation.

In particular, efficient oxidative demulsification is an effective method for oil-water separation. However, the inactivation of free radicals owing to the rapid release of transition metals is the main factor that reduces the effectiveness. In this study, a hydrophobic and lipophilic CP/SiO@Fe composite aerogel was prepared using carboxymethyl cellulose as substrate, polyvinyl alcohol as reinforcement, and SiO nanoparticles as hydrophobic modifier.

Fast and high-fidelity EUV curvilinear mask optimization by distance-versus-angle signature.

Curvilinear mask has received much attention in recent years due to its ability to obtain better image quality in advanced nodes. A common method for optimizing curvilinear mask in optical proximity correction (OPC) flow is moving control points on the edge directly (MCED-based OPC), but it requires storing mass data. This paper uses distance-versus-angle signature (DVAS), a one-dimensional function, to represent a two-dimensional boundary of mask.

Nonaqueous Contact-Electro-Chemistry via Triboelectric Charge.

Mechanochemistry revolutionizes traditional reactions through mechanical stimulation, but its reaction efficiency is limited. Recent advancements in utilizing triboelectric charge from liquid-solid contact electrification (CE) have demonstrated significant potential in improving the reaction efficiency. However, its efficacy remains constrained by interfacial electrical double-layer screening in aqueous solutions.

Knowledge, attitude, and practice toward advanced precision radiotherapy among patients with head and neck cancer.

Background: Advancements in radiotherapy (RT) technology have led to the prominence of precision RT in head and neck cancer (HNC) treatment. The new progress in precision RT offers more efficient therapy, potentially improving outcomes for HNC patients.

Objective: The present cross-sectional study aimed to assess the knowledge, attitude, and practice (KAP) of patients in advanced precision RT for HNC treatment.