Quadratic Matrix Factorization With Applications to Manifold Learning.

Matrix factorization is a popular framework for modeling low-rank data matrices. Motivated by manifold learning problems, this paper proposes a quadratic matrix factorization (QMF) framework to learn the curved manifold on which the dataset lies. Unlike local linear methods such as the local principal component analysis, QMF can better exploit the curved structure of the underlying manifold.

Discovery of novel PRMT5 inhibitors bearing a methylpiperazinyl moiety.

PRMT5 is an epigenetics-related enzyme, which plays a critical role in cancer development. Hence PRMT5 inhibition has been validated as a promising therapeutic strategy. We synthesized a series of methylpiperazinyl derivatives as novel PRMT5 inhibitors that were achieved by scaffold-hopping from by virtual screening followed by rational drug design.

Erythrocyte-mimicking paclitaxel nanoparticles for improving biodistributions of hydrophobic drugs to enhance antitumor efficacy.

Recent decades have witnessed several nanocrystal-based hydrophobic drug formulations because of their excellent performance in improving drug loading and controlling drug release as mediate drug forms in tablets or capsules. However, the intravenous administration of drug nanocrystals was usually hampered by their hydrophobic surface properties, causing short half-life time in circulation and low drug distribution in tumor. Here, we proposed to enclose nanocrystals (NC) of hydrophobic drug, such as paclitaxel (PTX) into erythrocyte membrane (EM).

π-Expanded Coumarins: One-Pot Photo Synthesis of 5-Benzo[12,1]tetrapheno[7,6,5-]chromen-5-ones and Photophysical Properties.

The synthesis of a unique type of π-expanded coumarin derivatives, bearing six fused phenyl rings, was achieved via one-pot Suzuki reaction and visible light-driven electrocyclization. The large π-expanded 5-benzo[12,1]tetrapheno[7,6,5-]chromen-5-ones were obtained in good to high yields from 1-bromo-2-phenaleno[1,2,3-]chromen-2-ones, and the intriguing optical properties were explored by altering the attached functional groups. 2-Arylaminosubstituted-5-benzo[12,1]tetrapheno[7,6,5-]chromen-5-ones showed a large Stokes shift (4005 cm) or excellent fluorescence quantum yield (Φ = 0.

Glutathione-Priming Nanoreactors Enable Fluorophore Core/Shell Transition for Precision Cancer Imaging.

In an attempt to develop an imaging probe with ultra-high sensitivity for a broad range of tumors in vivo and inspired by the concept of chemical synthetic nanoreactors, we designed a type of glutathione-priming fluorescent nanoreactor (GPN) with an albumin-coating shell and hydrophobic polymer core containing disulfide bonds, protonatable blocks, and indocyanine green (ICG), a near-infrared fluorophore. The albumin played multiple roles including biocompatible carriers, hydrophilic stabilizer, "receptor" of the fluorophores, and even targeting molecules. The protonation of the hydrophobic core triggered the outside-to-core transport of acidic glutathione (GSH), as well as the core-to-shell transference of ICGs after the disulfide bond cleavage by GSH, which induced strong binding of fluorophores with albumins on the GPN shell, initiating intensive fluorescence signals.

Design, synthesis and biological evaluation of novel dithiocarbamate-substituted diphenylaminopyrimidine derivatives as BTK inhibitors.

Bruton's tyrosine kinase (BTK) has emerged as an attractive target related to B-lymphocytes dysfunctions, especially hematologic malignancies and autoimmune diseases. In our study, a series of diphenylaminopyrimidine derivatives bearing dithiocarbamate moieties were designed and synthesized as novel BTK inhibitors for treatment of B-cell lymphoma. Among all these compounds, 30ab (IC = 1.

Uniform Projection for Multi-View Learning.

Multi-view learning aims to integrate multiple data information from different views to improve the learning performance. The key problem is to handle the unconformities or distortions among view-specific samples or measurements of similarity or dissimilarity. This paper models the view-specific samples as a nonlinear mapping of uniform but latent intact samples for all the views, and the view-specific dissimilarity matrices or similarity matrices are estimated in terms of the uniform latent one.

[The Effect of Hydrogen Bonding on the Spectrum of HPAM in Various Systems].

IR and UV-Vis was employed to analyzed the spectrum effect of hydrogen bonding on the partially hydrolyzed polyacrylamide polymer(HPAM). The study reveals that, the characteristic absorption peak of free amino group moves to the low frequency due to the formation of intramolecular hydrogen bonding between amide group and carboxyl group. In the water solution, intramolecular hydrogen bonding is the main factor that shifted maximal absorption towards long wavelength.

Band-gap energy as a descriptor of catalytic activity for propene oxidation over mixed metal oxide catalysts.

The development of a descriptor or descriptors that can relate the activity of catalysts to their physical properties is a major objective of catalysis research. In this study, we have found that the apparent activation energy for propene oxidation to acrolein over scheelite-structured, multicomponent, mixed metal oxides (Bi3FeMo2O12, Bi2Mo2.5W0.

Submicrometer-sized hierarchical hollow spheres of heavy lanthanide orthovanadates: sacrificial template synthesis, formation mechanism, and luminescent properties.

Hollow spheres of heavy lanthanide orthovanadates (LnVO4, Ln = Tb, Dy, Er, Tm, Yb, Lu) and yolk-shell structures of Ho(OH)CO3@HoVO4 have been successfully prepared by employing Ln(OH)CO3 colloidal spheres as a sacrificial template and NH4VO3 as a vanadium source. In particular, the as-obtained LuVO4 hollow spheres are assembled from numerous hollow-structured elliptic nanoparticles, and their textural parameters such as the inner and outer diameters, shell thicknesses, and number of shells could be finely tuned through introducing different amounts of NH4VO3 and employing Lu(OH)CO3 templates with different sizes. The possible mechanisms for the formation of hollow spheres and yolk-shell structures, and also the hollow-structured elliptic nanoparticles of LuVO4, i.

Sulfur and iron co-doped titanoniobate nanosheets: a novel efficient solid acid catalyst for alcoholysis of styrene epoxide at room temperature.

Sulfur and iron co-doped titanoniobate nanosheets were prepared and evaluated in alcoholysis of styrene epoxide. The resultant co-doped catalyst exhibited excellent catalytic performance (yield of 99% with methanol as the nucleophile in only 1 h at room temperature) and may act as a promising candidate in many acid-catalyzed reactions.

Surfactant-free sacrificial template synthesis of submicrometer-sized YVO4:Eu3+ hierarchical hollow spheres with tunable textual parameters and luminescent properties.

For the first time, well-dispersed submicrometer-sized YVO(4):Eu(3+) hollow spheres were successfully synthesized though a surfactant-free method by employing Y(OH)CO(3):Eu(3+) colloidal spheres as a sacrificial template and NH(4)VO(3) as a vanadium source. The synthetic process mainly consists of two steps, i.e.

Novel mesoporous NiO/HTiNbO5 nanohybrids with high visible-light photocatalytic activity and good biocompatibility.

Mesoporous nanohybrids of NiO nanoparticles and HTiNbO(5) nanosheets have been successfully synthesized by first exfoliating layered HTiNbO(5) in tetrabutylammonium hydroxide (TBAOH) to obtain HTiNbO(5) nanosheets, then reassembling with a nickel precursor and finally heating with urea. The resulting samples were characterized by X-ray diffraction (XRD), high resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), UV-vis spectroscopy, photoluminescence spectroscopy (PL) and N(2) adsorption-desorption measurements. It was found that the as-prepared nanohybrids had a relatively large interlayer spacing of 1.

Chiral separation performance of micrometer-sized monodispersed silica spheres with high protein loading.

Micrometer-sized monodispersed silica spheres (approximately 360 microm) with high loading of bovine serum albumin (BSA) (approximately 450 mg/g) were prepared as an adsorbent for large-scale chiral separation. The new adsorbent was characterized with scanning electron microscopy (SEM), nitrogen adsorption-desorption isotherms, the mercury intrusion method, infrared spectroscopic analysis, and elementary analysis. The extent of chiral separation was tested with rac-tryptophan (rac-Trp) and rac-phenylalanine (rac-Phe) as solutes.

Fast adsorption and separation of bovine serum albumin and lysozyme using micrometer-sized macromesoporous silica spheres.

Micrometer-sized silica spheres with bimodal macromesoporous structures are synthesized continuously by a modified gelation technology, and a novel coaxial microfluidic device is applied to control the size of the silica spheres. These spheres are used as a new protein adsorbent to realize fast adsorption and separation of protein mixture. BSA and lysozyme (LYS) are as model proteins with different sizes and pIs.