Impact of Gas Diffusion Layer Compression on Electrochemical Performance in Proton Exchange Membrane Fuel Cells: A Three-Dimensional Lattice Boltzmann Pore-Scale Analysis.

Proton exchange membrane fuel cells (PEMFCs) are being pursued for applications in the maritime industry to meet stringent ship emissions regulations. Further basic research is needed to improve the performance of PEMFCs in marine environments. Assembly stress compresses the gas diffusion layer (GDL) beneath the ribs, significantly altering its pore structure and internal transport properties.

Toxic effects of chlorantraniliprole on zebrafish (Danio rerio) at different developmental stages under antibiotic pressure.

Pesticides and antibiotics have been frequently reported in the environment, but it remains unclear whether antibiotics affect the toxicity of pesticides to aquatic organisms. In this study, the acute, developmental and reproductive toxicity effects of the pesticide chlorantraniliprole on zebrafish at different developmental stages under pressure of ciprofloxacin and erythromycin at environmental concentration were explored. Chlorantraniliprole, ciprofloxacin, and erythromycin are all low toxic to zebrafish (LC > 100 mg/L), and environmental concentrations of antibiotics have no effect on the acute toxicity of chlorantraniliprole to zebrafish.

Probing the interaction mechanism of tigecycline with γ-globulin and hemoglobin in the absence and presence of amikacin.

The interaction mechanism of tigecycline with γ-globulin and hemoglobin in the absence and presence of amikacin was investigated through multipectral, molecular docking and molecular dynamics simulation. The results show that tigecycline and γ-globulin/hemoglobin forms a ground state complex without or with amikacin. The presence of amikacin slightly increases the binding constant of tigecycline to γ-globulin/hemoglobin, but all are of moderate binding affinity, at 10 L mol.

Study on the effect of occupational exposure on hypertension of steelworkers based on Lasso-Logistic regression model.

Objectives: This study aimed to use a stable and predictive method: Lasso regression model to analyze hypertension's influencing factors and explore the interactions between occupational exposures.

Study Design: This has been a nested case-control study.

Methods: The case group consisted of 959 patients with high blood pressure found during the study.

Influence of remnant lipoprotein particle cholesterol on non-target lesions progression in patients undergoing percutaneous coronary intervention.

Background: Low-Density Lipoprotein Cholesterol (LDL-C) is the primary lipid therapy target for coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI). However, progression of coronary atherosclerosis occurs even LDL-C controlled well, some potentially important factors have been overlooked.

Objective: This study aims to elucidate the relationship between remnant lipoprotein particle cholesterol (RLP-C) and the progression of non-target lesions (NTLs) in patients with well-controlled lipid levels after PCI.

Performance expectation fallout, knowledge search, and corporate dual innovation.

How do firms determine their approach to dual innovation about performance expectations? This paper analyzes the decision-making process known as "assessment-search-innovation" that businesses use in response to performance feedback. Furthermore, the research investigates the function of knowledge search in the relationship between the gap in performance expectations and dual innovation. The study sample consists of 827 A-share high-tech firms from 2010 to 2022.

Comparison of conventional diffusion-weighted imaging and multiplexed sensitivity-encoding combined with deep learning-based reconstruction in breast magnetic resonance imaging.

Purpose: To evaluate the feasibility of multiplexed sensitivity-encoding (MUSE) with deep learning-based reconstruction (DLR) for breast imaging in comparison with conventional diffusion-weighted imaging (DWI) and MUSE alone.

Methods: This study was conducted using conventional single-shot DWI and MUSE data of female participants who underwent breast magnetic resonance imaging (MRI) from June to December 2023. The k-space data in MUSE were reconstructed using both conventional reconstruction and DLR.

Enantioseparation, bioactivity, environmental fate and toxicity of chiral triazole fungicide ipconazole in soil and earthworm.

Ipconazole (IPC) is a chiral triazole fungicide and commonly used for disease control in seeds. This study investigated the bioactivity and potential mechanism of ipconazole against pathogenic microorganisms at the chiral perspective. It explored the accumulation behavior of ipconazole enantiomers within the soil-earthworm system and evaluated its toxic effects on earthworms.

Interfacial engineering-based colonization of biofilms on polyethylene terephthalate (PET) surfaces: Implications for whole-cell biodegradation of microplastics.

Microplastic pollution has become a significant environmental issue. One of the most important sources and components of microplastics is polyester fabric - polyethylene terephthalate (PET). Because the catalytic depolymerization of PET typically requires specific conditions such as alkaline environments, specific solvents, or high temperatures, there is an urgent need for a simpler, eco-friendly solution with high degradation efficiency for managing the vast amounts of PET textile waste.

The criticality of exports sophistication and CO emissions: A new path towards sustainable environmental management.

This study investigates the relation between exports sophistication and CO emissions, with particular attention paid to how foreign direct investment moderates them in Asian economies from 1995 to 2020. This study investigates the influence of exports sophistication, which measures productivity and income associated with an export basket, on environmental quality. Utilizing a two-step Generalized Method of Moments (GMM), we found that exports sophistication has an inverted U-shaped relationship with CO emissions.

Clinical effectiveness of unilateral single-armed vasoepididymostomy in obstructive azoospermia: a single-center experience.

Background: Vasoepididymostomy (VE) is an important surgical treatment to achieve natural conception for patients with obstructive azoospermia (OA), and only unilateral VE can be performed under certain conditions, such as OA patients with congenital unilateral absence of the vas deferens (CUAVD) and some acquired OA. There is a lack of relevant reports assessing the clinical outcomes of unilateral VE in OA patients with different causes. This study is aimed to describe the clinical features and evaluate treatments and outcomes of unilateral single-armed VE in OA patients.

Cardiomyocyte proliferation and heart regeneration in adult Xenopus tropicalis evidenced by a transgenic reporter line.

Cardiomyocyte proliferation in adult Xenopus tropicalis during heart regeneration has remained largely contentious due to the absence of genetic evidence. Here, we generated a transgenic reporter line Tg(mlc2:H2C) expressing mCherry specifically in cardiomyocyte nuclei driven by the promoter of myosin light chain 2 (mlc2). Using the reporter line, we found that traditional whole-cell staining is not a rigorous way to identify cardiomyocytes in adult Xenopus tropicalis when using a cryosection with common thickness (5 μm) which leading to a high error, but this deviation could be reduced by increasing section thickness.

The lived experience of living liver donors: A meta-synthesis of qualitative studies.

Background: Living liver donors are frequently used for liver transplantation, but they experience many physical changes and psychological challenges. A better understanding of the experiences of liver donors can provide them with comprehensive and individualized patient-centred support and health care. Thus, this study sought to identify and synthesize existing qualitative studies to develop an in-depth understanding of the lived experiences of living liver donors.

The calcium-dependent protein kinase CmaCPK4 regulates sex determination in pumpkin (Cucurbita maxima D.).

Pumpkin (Cucurbita maxima D.) is typically monoecious with individual male and female flowers, and its yield is associated with the degree of femaleness, i.e.

Why the adventitious roots of poplar are so colorful: RNAseq and metabolomic analysis reveal anthocyanin accumulation in canker pathogens-induced adventitious roots in poplar.

This study revealed a substrate-level synthesis of pigment cyanidin-3-O-glucoside and the redirection of metabolomic flux in the flavonoid/anthocyanin biosynthesis pathway in poplar adventitious roots (ARs) induced by stem canker pathogens. Recently, we observed a novel allometry on poplar stems, with copious colorful adventitious roots (ARs) induced by fungal canker pathogens. Here, we reveal chemical, physiological, and molecular mechanisms of AR coloration in poplar-pathogens (Valsa sordida/Botrosphaeria dothidea) interaction system using our phloem girdling-inoculation system.

One-Step Construction of 2-Methylquinazolin-4(3)-ones Using Solid Calcium Carbide as an Alternative to Gaseous Acetylene.

2-Methylquinazolin-4(3)-ones were efficiently constructed using solid calcium carbide as an alkyne source, 2-aminobenzamides or 2-aminobenzohydrazides as substrates, and -tolylsulfonyl azide as a mediator through simultaneous formation of two C-N bonds in one step. The salient features of this protocol are the use of an inexpensive, abundant and easy-to-use alkyne source as a substitute for flammable and explosive gaseous acetylene, low-cost catalyst, wide substrate scope, satisfactory yield, and simple manipulation. This method can also be extended to gram scale.

Development of the Curcumin Analog CA7 Liposome and Its Evaluation for Efficacy Against Cervical Cancer in vitro and in vivo.

Objective: The objective of this study was to develop liposomes (LP) containing a curcumin (CU) analog CA7 to enhance its pharmacokinetic profile and anti-cervical cancer (CC) effects.

Methods: Single-factor and Box-Behnken experiments were conducted to optimize the formulation of CA7-loaded liposomes (CA7-LP). The in vitro release, stability, biocompatibility, and pharmacokinetic of CA7-LP were evaluated.

Engineering Mild-Photothermal Responsive and NO Donor Prussian Blue Nanozymes Using Mild Synthesis for Inflammation Regulation and Bacterial Eradication in Periodontal Disease.

Periodontitis, an infectious disease of periodontal tissues caused by oral bacterial biofilms, is characterized by reactive oxygen species (ROS) accumulation and immune microenvironment imbalance. Multifunctional nanozymes, leveraging their physiochemical properties and enzymatic activities, offer promising antibacterial and anti-inflammatory strategies for managing periodontitis. In particular, Prussian blue nanozymes (PBzymes) exhibit exceptional ROS control due to their robust catalytic activity, diverse antioxidant functions, and high biocompatibility.

The Correlation Analysis Between m6A Methylation Modification and Ferroptosis Induced by Cigarette Smoke in Human Bronchial Epithelium.

Background: Chronic obstructive pulmonary disease (COPD), a prevalent respiratory condition, is characterized by long-term airway inflammation, which can lead to airway remodeling and persistent airflow restriction. Exposure to cigarette smoke is known as a major contributor to COPD development. Research has confirmed that ferroptosis and m6A modification are closely related to various inflammatory-related diseases.

Research on occupational health and safety management in the context of big data.

At present, with the rapid development of China's economy and industrial transformation, the situation of China's occupational health and safety is grim, and at this stage, there are still problems such as unsound laws and regulations and standard system, weak awareness of the primary responsibility of the enterprise, weak supervisory, technical capacity, and backward application of information technology. Based on the current situation of occupational health and safety management at home and abroad and relevant theories, this study adopts the method of systematic review and takes the evaluation of China's occupational health and safety management system as the theme and conducts a valuable exploration of the evaluation research of China's occupational health and safety management system, analyzes the current situation of occupational health and safety from the aspects of prevention and control of occupational diseases, prevention and control of safety accidents, and monitoring of the psychology of insecurity, and researches the two aspects of governmental regulation and social responsibility It analyzes the current situation of occupational health and safety from the aspects of prevention and control of occupational diseases, prevention and control of safety accidents and monitoring of unsafe psychology, and studies the current situation of post-performance evaluation of the development of OHS management system from the aspects of government supervision and social responsibility, aiming at providing countermeasure suggestions for the sustainable development of OHS management system in China. The research indicates that in the context of the new economic normal, effectively safeguarding workers' occupational health rights and interests, promoting sustainable and robust economic and social development, as well as enhancing the sustainability of China's occupational health and safety management system have emerged as challenging yet pivotal areas for comprehensive exploration.

Determination of Strength Parameters of Composite Reinforcement Consisting of Steel Member, Adhesive, and Carbon Fiber Textile.

The main aim of the study was the determination of the strength parameters of composite bonded joints consisting of galvanised steel elements, an adhesive layer, and Carbon-Fiber-Reinforced Plastic (CFRP) fabric. For this purpose, shear laboratory tests were carried out on 60 lapped specimens composed of 2 mm thick hot-dip galvanised steel plates of S350 GD. The specimens were overlapped on one side with SikaWrap 230 C carbon fibre textile (CFT) using SikaDur 330 adhesive.

Determination of Lactoferrin Using High-Frequency Piezoelectric Quartz Aptamer Biosensor Based on Molecular Bond Rupture.

In this study, an aptamer biosensor for detecting lactoferrin (LF) was developed using piezoelectric quartz-induced bond rupture sensing technology. The thiol-modified aptamer I was immobilized on the gold electrode surface of the quartz crystal microbalance (QCM) through an Au-S bond to specifically bind LF. It was then combined with aptamer-magnetic beads to amplify the mass signal.

Study on the Mechanisms of Flavor Compound Changes During the Lactic Fermentation Process of Peach and Apricot Mixed Juice.

This study employed headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS) and liquid chromatography-mass spectrometry (LC-MS) for non-targeted metabolomics analyses to examine the impact of mixed fermentation with various lactic acid bacteria (LAB) on the flavor compounds and metabolites of peach and apricot mixed juice (PAMJ), specifically focusing on the alterations of volatile compounds and non-volatile metabolites, as well as their metabolic pathways during the fermentation process. A total of 185 volatiles were identified using HS-SPME-GC-MS analysis, revealing significant differential metabolites, including eugenol, benzaldehyde, and γ-decalactone etc. The results indicated that lactic fermentation significantly enhanced the overall flavor of the juice toward the end of the fermentation process.

Motor Cortex Stimulation for Refractory Facial Neuralgia and Paresthesia in Ramsay Hunt Syndrome.

This study explores motor cortex stimulation (MCS) as a treatment for Ramsay Hunt syndrome (RHS)-related neuralgia, which often persists despite traditional therapies. A 68-year-old patient with RHS experienced significant pain and sensory relief after MCS, after ineffective conventional treatments. MCS enhances neural plasticity, offering a promising alternative for managing intractable neuralgia and sensory disturbances in RHS patients.

Medicine Usage for Hypertension Management in Type 2 Diabetes Patients in the Rural-Urban Fringe Zone, Suzhou City, Jiangsu Province, China.

Objective: Medicine is critical for blood-pressure control in patients with type 2 diabetes mellitus (T2DM), for evaluation of treatment patterns and effects would offer baselines for future health services.

Methods: A cross-sectional study was conducted from August 2018 to January 2021 in the urban-rural fringe zone of Suzhou City, Jiangsu Province, China. Blood pressure and antihypertensive medication use were collected from T2DM patients combined with hypertension (HTN).