Factors predisposing to limited flexion after total hip arthroplasty for the treatment of axial spondyloarthritis.

Hip involvement is a common condition in about one-third of patients with axial spondyloarthritis (axSpA). We assessed the incidence of possible factors that predispose patients to limited flexion after total hip arthroplasty (THA) for the treatment of axSpA. We retrospectively reviewed 516 patients with axSpA (759 hips) who underwent THA.

EIF4A3-induced circ_0022382 promotes breast cancer cell progression through the let-7a-5p/PI3K/AKT/mTOR signaling pathway and SLC7A11 axis.

Introduction: Breast cancer is one of the most common cancers in women and poses a serious threat to women's health. Circular RNAs (circRNAs) have been found to be specifically expressed in cancers and regulate the growth and death of tumor cells. The role of circRNAs in breast cancer remain unknown.

The Utilization of Ultrasound-Guided Regional Nerve Blocks in Anesthetic Management for Fracture Surgery.

Fracture surgeries are frequently accompanied by severe pain, necessitating efficacious pain management strategies to enhance postoperative recovery. Nerve block techniques, which are critical in mitigating pain, involve the targeted administration of local anesthetics to disrupt nerve signal transmission, thereby achieving significant analgesia. Traditionally, these techniques rely on anatomical landmarks and the clinician's expertise, which can introduce variability and potential risks.

Energy Dynamics Powered by Traction and Stress Control Formation and Motion of +1/2 Topological Defects in Epithelial Cell Monolayers.

In confluent cell monolayers, patterns of cell forces and motion are systematically altered near topological defects in cell shape. In turn, defects have been proposed to alter cell density, extrusion, and invasion, but it remains unclear how the defects form and how they affect cell forces and motion. Here, we studied +1/2 defects, and, in contrast to prior studies, we observed both tail-to-head and head-to-tail defect motion occurring at the same time in the same cell monolayer.

Evolutionary dynamics of SARS-CoV-2 variants under strict non-pharmaceutical interventions - a population-based study.

Introduction: China implemented a dynamic zero-COVID strategy to curb viral transmission in response to the coronavirus disease 2019 (COVID-19) pandemic. This strategy was designed to inhibit mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19. This study explores the dynamics of viral evolution under stringent non-pharmaceutical interventions (NPIs) through real-world observations.

Highly printable, strong, and ductile ordered intermetallic alloy.

Ordered intermetallic alloys are renowned for their impressive mechanical, chemical, and physical properties, making them appealing for various fields. However, practical applications of them have long been severely hindered due to their severe brittleness and poor fabricability. It is difficult to fabricate such materials into components with complex geometries through traditional subtractive manufacturing methods.

CRISPR-Cas12a-Mediated Growth of Gold Nanoparticles for DNA Detection in Agarose Gel.

The rapid, simple, and sensitive detection of nucleic acid biomarkers plays a significant role in clinical diagnosis. Herein, we develop a label-free and point-of-care approach for isothermal DNA detection through the trans-cleavage activity of CRISPR-Cas12 and the growth of gold nanomaterials in agarose gel. The presence of the target can activate CRISPR-Cas12a to cleave single-stranded DNA, thus modulating the length and number of DNA sequences that mediate the growth of gold nanoparticles (AuNPs) or gold nanorods (AuNRs).

NcSWP8, a New Spore Wall Protein, Interacts with Polar Tube Proteins in the Parasitic Microsporidia .

is a pathogen that affects and Fabricius, capable of spreading within and between honeybee colonies. The spore wall of microsporidia is the initial structure to contact the host cell directly, which may play a crucial role in the infection process. Currently, several spore wall proteins have been identified in microsporidia, but only two spore wall proteins from have been characterized.

Comparative study of Baduanjin and brisk walking on balance and stability in older adults.

Objective: To investigate the impact of practicing the health Qigong-Baduanjin exercise on lower limb balance among elderly individuals.

Methods: Two intervention methods, Baduanjin and brisk walking, were applied to study the effect of exercise on senior balancing. Sixty elderly individuals aged 65 to 79 were selected and randomly divided into the Baduanjin group, the brisk walking group, and the control group that did not engage in exercise.

Tumor Microenvironment-Driven Structural Transformation of Vanadium-Based MXenzymes to Amplify Oxidative Stress for Multimodal Tumor Therapy.

MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal catalytic efficiency and kinetics in the tumor microenvironment (TME). Herein, this study draws inspiration from the electronic structure of transition metal vanadium, proposing the leverage of TME specific-features to induce structural transformations in sheet-like vanadium carbide MXenzymes (TVMz). These transformations trigger cascading catalytic reactions that amplify oxidative stress, thereby significantly enhancing multimodal tumor therapy.

Novel role of FTO in regulation of gut-brain communication via -produced hydrogen sulfide under arsenic exposure.

Fat mass and obesity-associated protein (FTO) is the key demethylase that reverses the abnormally altered N6-methyladenosine (m6A) modification in eukaryotic cells under environmental pollutants exposure. Arsenic is an environmental metalloid and can cause severe symptoms in human mainly through drinking water. However, there is no specific treatment for its toxic effects due to the uncovered mechanisms.

Indirect Multicultural Experiences: A Multidimensional Journey to Inspire Self-Change.

Self-change is crucial for driving both individual growth and societal progress. Based on schema theory, this study proposes that indirect multicultural experiences may be an effective pathway to promote self-change, with positive emotions and meaning seeking serving as mediators, and social class as a moderator. To test this hypothesis, an online survey was conducted with 1627 participants aged 18-55 years, using scales to assess indirect multicultural experiences, self-change, positive emotions, meaning seeking, and both subjective and objective social classes.

Ethical leadership and nurses' job performance: the mediating role of self-compassion.

Background: Ethical leadership is crucial in nursing management, and self-compassion is increasingly recognized as a significant factor influencing nurses' job performance. Although the link between ethical leadership and nurse job performance has been established, the specific mechanisms that underlie this relationship remain unclear. Additionally, there is a paucity of research examining the potential role of self-compassion in this context.

Association between genetic variation rs57095329 of microRNA-146a and development of cognitive impairment after anesthesia: a case-control study in a Chinese Han population.

The latest studies have demonstrated that aberrant expression of microRNA-146a is related to cognitive decline. The rs57095329 polymorphism occurring in the miR-146a promoter modulates its expression and causes downstream pathogenicity. A case-control study in a Chinese Han population was established to investigate the genetic association between the miR-146a rs57095329 polymorphism and postoperative cognitive dysfunction (POCD).

[Simultaneous determination of 51 indazole-type synthetic cannabinoids in urine and blood by online solid-phase extraction-liquid chromatography-linear ion trap mass spectrometry].

To evade legal controls, new psychoactive substances (NPS), which have been designed as substitutes for traditional and synthetic drugs, are gradually dominating the drug market. Synthetic cannabinoids (SCs), which account for the majority of NPS, are rapidly being derivatized; consequently, controlling increasing abuse by merely listing individual compounds is difficult. Therefore, China has included the entire SC category of SCs listed as legal controlled substances since July 1, 2021.

Effects of key physiological parameters on cardiovascular disease and osteoporosis risk in perimenopausal and postmenopausal women.

The essential cause of menopause is ovarian failure, which can cause decline in sex hormones (especially estrogen) that can increase the risk of metabolic diseases, such as cardiovascular disease and osteoporosis. This study screened 1511 eligible patients from 2148 perimenopausal and postmenopausal women, measuring various physiological and biochemical indicators to analyze differences among age groups (40-44, 45-49, and 50-54 years) with laboratory techniques. The study found no significant difference in the incidence of cardiovascular disease betweenperimenopausal and postmenopausal women.

The regional ventilation distribution monitored by electrical impedance tomography during anesthesia induction with head-rotated mask ventilation.

Abstract Objective: Abnormal regional lung ventilation can lead to undesirable outcomes during the induction of anesthesia. Head rotated ventilation has proven to change the airflow of upper airway tract and be effective in increasing the tidal volume. This study aimed to investigate the influence of head rotated mask ventilation on regional ventilation distribution during the induction phase of anesthesia.

Comparison of outcomes following prepectoral and subpectoral implants for breast reconstruction in patients with breast cancer.

Background: In recent years, different approaches to implant-based breast reconstruction have increasingly become an important option to meet both the treatment and postoperative aesthetic needs of breast cancer patients. This study selected two commonly used techniques for the prepectoral approach: single-incision, gas-inflated endoscopic prepectoral breast reconstruction (SIE-BR) and open prepectoral implant-based breast reconstruction (C-BR), as well as a commonly used technique for the subpectoral approach: open subpectoral implant-based breast reconstruction (SI-BR). By comparing the clinical efficacy and aesthetic outcomes of these three techniques in the treatment of breast cancer patients, this study aims to summarize the advantages of the prepectoral approach.

Prognostic value of nighttime blood pressure in patients with chronic kidney disease.

The optimal blood pressure (BP) in patients with chronic kidney disease (CKD) remains uncertain. Therefore, this cohort study aimed to investigate the prognostic value of ambulatory blood pressure (ABP) in patients with CKD and to determine the optimal range for ABP. In total, 1051 hospitalized patients with CKD were enrolled.

A single residue switch mediates the broad neutralization of Rotaviruses.

Broadly neutralizing antibodies (bNAbs) could offer escape-tolerant and lasting protection against viral infections and therefore guide development of broad-spectrum vaccines. The increasing challenge posed by viral evolution and immune evasion intensifies the importance of the discovery of bNAbs and their underlying neutralization mechanism. Here, focusing on the pivotal viral protein VP4 of rotavirus (RV), we identify a potent bNAb, 7H13, exhibiting broad-spectrum neutralization across diverse RV genotypes and demonstrating strong prevention of virus infection in female mice.

Transauricular vagus nerve stimulation in preventing post-traumatic stress disorder in emergency trauma surgery patients in China: a study protocol for a multicenter, double-blind, randomised, controlled trial.

Introduction: The incidence of post-traumatic stress disorder (PTSD) in emergency trauma surgery patients is 24%, emphasising the urgent need for effective early interventions and treatments. Transauricular vagus nerve stimulation (ta-VNS) modulates the autonomic nervous system by stimulating the nucleus tractus solitarius while affecting PTSD-related neural networks, including the prefrontal cortex, hippocampus and amygdala, potentially offering new options for PTSD prevention and treatment. This study aims to evaluate the efficacy and safety of ta-VNS in preventing PTSD in emergency trauma surgery patients.

Predictive Model for Histological Chorioamnionitis Risk in Parturients with Intrapartum Fever.

This study aimed to analyze the causative factors of histological chorioamnionitis (HCA) in parturients with intrapartum fever, assess the implications for maternal and neonatal outcomes, and develop a predictive model to enhance clinical decision-making. A retrospective analysis was performed on 408 parturients with intrapartum fever at Fujian Provincial Maternal and Child Health Hospital from January 2022 to June 2023. Based on post-delivery placental pathology, the data were categorized into HCA (249 cases) and non-HCA groups (159 cases).

Online Measurements during Simulated Atmospheric Aging Track the Strongly Increasing Oxidative Potential of Complex Combustion Aerosols Relative to Their Primary Emissions.

Oxidative potential (OP) is increasingly recognized as a more health-relevant metric than particulate matter (PM) mass concentration because of its response to varying chemical compositions. Given the limited research on the OP of complex combustion aerosols, the effects of aging processes on their OP remain underexplored. We used online instruments to track the evolution of OP [via dithiothreitol (DTT) assays] during the aging of wood burning and coal combustion emissions by hydroxyl-radical-driven photooxidation and dark ozonolysis.

Relationship Between Sleep Time and Depressive Symptoms in Middle-Aged and Elderly Chinese: Mediating Role of Body Pain.

Objective: Existing research has yet to adequately examine the correlation between sleep time, body pain, and depressive symptoms. This study seeks to elucidate the interconnections between these three elements.

Methods: The study used 2020 CHARLS data for analysis.