Tumor-Selective Nano-Dispatcher Enforced Cancer Immunotherapeutic Effects via Regulating Lactate Metabolism and Activating Toll-Like Receptors.

The development of tumors relies on lactate metabolic reprogramming to facilitate their unchecked growth and evade immune surveillance. This poses a significant challenge to the efficacy of antitumor immunity. To address this, a tumor-selective nano-dispatcher, PIMDQ/Syro-RNP, to enforce the immunotherapeutic effect through regulation of lactate metabolism and activation of toll-like receptors is developed.

Molecular networking-assisted systematical profiling and the in vivo neuroprotective effect of ellagitannins from the Melastoma dodecandrum Lour.

Background: Ellagitannins (ETs) are a major classification of natural tannins, with relatively large and complex structures. ETs from medicinal plants are focused increasingly due to urolithins, a kind of intestinal metabolite of ETs, which showed promising anti-Alzheimer's disease (AD) effects. Melastoma dodecandrum (MD), a widely used traditional Chinese medicine is rich in ETs, but their chemistry and potential neuroprotective effects have not been investigated.

Identification of ellagic acid and urolithins as natural inhibitors of Aβ-induced neurotoxicity and the mechanism predication using network pharmacology analysis and molecular docking.

Ellagic acid (EA) is a dietary polyphenol that widely exists in grapes, strawberries, and walnuts. It usually exerts multiple biological activities together with its metabolites called urolithins. EA and urolithins had been proposed as natural agents for applying on the early intervention of Alzheimer's disease (AD).

Stress-strain and acoustic emission characteristics of cement-based materials used to simulate soft rock with fractures.

Instability failure in rock mass engineering is closely related to expansion of joint fissures. In this study, uniaxial compression tests and acoustic emission (AE) measurements were carried out simultaneously on specimens of soft rock-like material with different fracture angles and connectivity values to better understand their influence on the deformation and failure of the material. The stress-strain curve and AE signal of fractured soft rock-like material are similar to those of intact soft rock-like; specifically, they exhibit a compaction, elastic deformation, stable fracture development, and unstable fracture development.

Phosphorylated and Phosphonated Low-Complexity Protein Segments for Biomimetic Mineralization and Repair of Tooth Enamel.

Biomimetic mineralization based on self-assembly has made great progress, providing bottom-up strategies for the construction of new organic-inorganic hybrid materials applied in the treatment of hard tissue defects. Herein, inspired by the cooperative effects of key components in biomineralization microenvironments, a new type of biocompatible peptide scaffold based on flexibly self-assembling low-complexity protein segments (LCPSs) containing phosphate or phosphonate groups is developed. These LCPSs can retard the transformation of amorphous calcium phosphate into hydroxyapatite (HAP), leading to merged mineralization structures.

[Investigation of Dominant Plants and Analysis of Ecological Restoration Potential in Lailishan Tin Tailings].

To investigate the dominant plants in ecological restoration of tin mining areas, field investigations were conducted in a tin tailings area in Lailishan, Yunnan Provence, and 15 dominant plants and corresponding rhizosphere soils were collected. The plant root mycorrhizal infection rate; the copper (Cu), cadmium (Cd), arsenic (As), nickel (Ni), lead (Pb), and tin (Sn) contents; and the chemical properties of the rhizosphere tailings were determined. The transfer and enrichment coefficients of six heavy metals were calculated for each of the 15 plants to comprehensively evaluate the application potential of native plants.

Exploring the Mechanism of Zhibai Dihuang Decoction in the Treatment of Ureaplasma Urealyticum-Induced Orchitis Based on Integrated Pharmacology.

Ureaplasma urealyticum (UU) infection is the most common cause of male infertility. Zhibai Dihuang Decoction (ZBDHD) can improve the rate of forwarding motility sperm, sperm deformity rate, seminal plasma zinc and refined berry sugar levels. The potential targets of ZBDHD are obtained from The Encyclopedia of Traditional Chinese Medicine (ETCM).

Use of a Systematic Pharmacological Methodology to Explore the Mechanism of Shengmai Powder in Treating Diabetic Cardiomyopathy.

BACKGROUND Cardiovascular complications, such as diabetic cardiomyopathy (DCM), are the leading cause of death in diabetic patients. Shengmai Powder (SMP) was found to have cardioprotective effects. MATERIAL AND METHODS Based on the systematic pharmacological methodology, this research determined the genes of DCM and the known targets of SMP, predicted potential compounds and targets of SMP, constructed networks for DCM and SMP, and performed network analysis.

The correlation of ESCO1 expression with a prognosis of prostate cancer and anti-tumor effect of ESCO1 silencing.

Background: Recently, it has been reported that establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1) is involved in tumorigenesis. However, its role in prostate cancer remains unclear. In the present study, the association between ESCO1 expression and the prognosis of prostate cancer was investigated, and the potential molecular mechanisms underlying its actions in tumor progression were also examined.

Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

Objective: To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM).

Methods: Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study's registration number is CRD42018088474.

[Quick Start-up and Sustaining of Shortcut Nitrification in Continuous Flow Reactor].

How to achieve fast and stable startup of shortcut nitrification has a very important practical value for treatment of low C/N ratio wastewater. Thus, the quick start-up and sustaining of shortcut nitrification were investigated in continuous flow reactor targeting at the current situation of urban wastewater treatment plant using a continuous flow process. The results showed that quick start-up of shortcut nitrification could be successfully achieved in a continuous flow reactor after 60 days' operation with intermittent aeration and controlling of three stages of stop/aeration time (15 min/45 min, 45 min/45 min and 30 min/30 min).

[Nitrogen Removal of Municipal Wastewater by ANAMMOX Coupled Shortcut Nitrification in Anaerobic Baffled Reactor].

If the technology of anaerobic ammonium oxidation(ANAMMOX) can substitute the mainstream technology of municipal wastewater treatment plant, the energy of municipal wastewater treatment will be decreased significantly. Thus, anaerobic baffled reactor(ABR) was used to build carbon system, shortcut nitrification system and anaerobic ammonia oxidation system. And the three systems were coupled to shortcut nitrification-anaerobic ammonia oxidation reactor to treat municipal wastewater.

[Nitrogen Removal Using ANAMMOX and Denitrification for Treatment of Municipal Sewage].

In this study, an Anaerobic Baffled Reactor ( ABR) was constructed. The ANAMMOX process was successfully started up using this reactor within 45 days under the following condition: 27 degrees C, pH of 8, HRT of 10 h, and the influent NO2(-) -N/NH4(+) -N was 1.32.

A novel Halomonas ventosae-specific virulent halovirus isolated from the Qiaohou salt mine in Yunnan, Southwest China.

Although Halomonas phages belonging to the families Myoviridae and Siphoviridae have been reported, no virulent Halomonas siphoviruses are known. In this study, a virulent bacteriophage, QHHSV-1, of the family Siphoviridae that specifically infects H. ventosae QH52-2 was isolated from the Qiaohou salt mine.

Effect of Calcium Ions on Dewaterability of Enzymatic-Enhanced Anaerobic Digestion Sludge.

Waste-activated sludge (WAS) solubilized remarkably after enzymatic-enhanced anaerobic digestion, but its dewaterability was deteriorated. In this study, a novel method was performed to improve the dewaterability of enzymatic-enhanced anaerobic digestion sludge by adding CaCl2 (0.01~1.

Arenimonas taoyuanensis sp. nov., a novel bacterium isolated from rice-field soil in China.

A Gram-stain negative, aerobic, rod-shaped bacterial strain, YN2-31A(T), was isolated from rice-field soil, Taoyuan Village, Yunnan province of China. The bacterium was observed to grow at 20-45 °C (optimum 28 °C), at pH 5.0-10.

[Expressions of CMTM8 and E-cadherin in primary and metastatic clear cell renal cell carcinoma].

Objective: To investigate the expression and clinical pathological significance of CMTM8 and E-cadherin in primary and metastatic clear-cell renal cell carcinoma.

Methods: The immunohistochemistry was used to detect the expressions of CMTM8 and E-cadherin in 17 cases of primary clear-cell renal cell carcinoma, 8 cases of normal renal tissue, 9 cases of metastatic renal cell carcinoma in lungs and 10 cases of metastatic renal cell carcinoma in bones.

Results: The membranous staining intensities of CMTM8 and E-cadherin in normal renal tissue were strong, but reduced in low-grade clear-cell renal cell carcinoma.

Comparative molecular analysis of the prokaryotic diversity of two salt mine soils in southwest China.

While much is known about the microbial diversity in some hypersaline environments, little is known about those of salt mine tunnel soils. The objective of this study was to conduct a comprehensive phylogenetic comparison of the archaeal and bacterial communities present in Yipinglang salt mine (YPL) and Qiaohou salt mine (QH) tunnels differing in salinity and salt composition using 16S rRNA gene clone libraries. Two hundred twenty-eight sequences for QH and 182 sequences for YPL were analyzed by amplified ribosomal DNA-restriction analysis.

Efficacy and safety of bipolar plasma vaporization of the prostate with "button-type" electrode compared with transurethral resection of prostate for benign prostatic hyperplasia.

Background: Transurethral resection of prostate (TURP) has been considered as the standard treatment for benign prostatic hyperplasia (BPH). However, issues that have not yet been overcome for TURP include bleeding and absorption of irrigation fluid. Thus, novel improvement of the surgery is necessary.

Susceptibility to AcMNPV and expression of recombinant proteins by a novel cell clone derived from a Trichoplusia ni QAU-BTI-Tn9-4s cell line.

It is well known that Tn5B1-4 (commercially known as the High Five) cell line is highly susceptible to baculovirus and provides superior production of recombinant proteins when compared to other insect cell lines. But the characteristics of the cell line do not always remain stable and may change upon continuous passage. Recently an alphanodavirus, named Tn5 Cell Line Virus (or TNCL Virus), was identified in High Five cells in particular.

[A survey of Japanese encephalitis antibody migrant workers in Shenzhen 2009].

Objective: To understand the immunological status of Japanese encephalitis (JE) antibodies amongst migrant workers and to provide epidemiological basis for public health strategies on JE prevention and control in Shenzhen.

Methods: A multi-stage random sampling method was used, and 1003 migrant workers aged 18 to 60 from 44 factories were investigated and their serum specimens were collected. The enzyme-linked immunosorbent assay (ELISA) was used to detect JE antibodies qualitatively.

[Study on the epidemiological characteristics of hemorrhagic fever with renal syndrome in Inner Mongolia].

Objective: In order to better understand the epidemiological features of Hantviruses in Inner Mongolia.

Methods: Epidemiological surveillance data during the period of the past 52 years were analyzed. An epidemiological survey was carried out in the main epidemic areas in 2005.

[Study on luminescence property of nanocrystalline Y2O3:Eu3+ red phosphor].

The nanocrystalline of Y2O3:Eu3+ red phosphor has been studied. The result shows that the maximum excitation spectrum of Y2O3:Eu3+ peaks at lambdaex = 252.6 nm, while the maximum emission spectrum peaks at lambdaem = 613.