Preliminary comparison of net gain in final adult height of girls with early menarche treated with or without gonadotropin-releasing hormone agonist.

Background: Early menarche is associated with both physical and psychosocial problems. Based on psychological and physical health considerations, for girls with early menarche, some parents and physicians may elect to use gonadotropin-releasing hormone agonists (GnRHa) to delay menstruation. This study aimed to explore the effects of GnRHa treatment on the final height of girls with early menarche and build the models to predict the final adult height (FAH).

Nucleic Acid Aptamer-Based Sensors for Bacteria Detection: A Review.

Bacteria have a significant impact on human production and life, endangering human life and health, so rapid detection of infectious agents is essential to improve human health. Aptamers, which are pieces of oligonucleotides (DNA or RNA) have been applied to biosensors for bacteria detection due to their high affinity, selectivity, robust chemical stability, and their compatibility with various signal amplification and signal transduction mechanisms. In this review, we summarize the different bacterial aptamers selected in recent years using SELEX technology and discuss the differences in optical and electrochemical bacterial aptamer sensors.

Te-Regulated Black Arsenic Phosphorus Monocrystalline Film with Excellent Uniformity for High Performance Photodetection.

Two-dimensional (2D) black arsenic phosphorus (b-AsP) material has been attracting considerable attention for its extraordinary properties. However, its application in large-scale device fabrication remains challenging due to the limited scale and irregular shape. Here, we found the special effect of Te upon growth of b-AsP and developed a novel Te-regulated steady growth (Te-SG) strategy to obtain high-quality b-AsP single crystal.

Optimizing the NGS-based discrimination of multiple lung cancers from the perspective of evolution.

Next-generation sequencing (NGS) offers a promising approach for differentiating multiple primary lung cancers (MPLC) from intrapulmonary metastasis (IPM), though panel selection and clonal interpretation remain challenging. Whole-exome sequencing (WES) data from 80 lung cancer samples were utilized to simulate MPLC and IPM, with various sequenced panels constructed through gene subsampling. Two clonal interpretation approaches primarily applied in clinical practice, MoleA (based on shared mutation comparison) and MoleB (based on probability calculation), were subsequently evaluated.

Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood.

Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk of Alzheimer disease, solid tumors, and other age-related diseases. We sought to gain a better understanding of genetic drivers and associated phenotypes of mLOY through analyses of whole-genome sequencing (WGS) of a large set of genetically diverse males from the Trans-Omics for Precision Medicine (TOPMed) program.

Nlnemo suppresses of BMP signaling in wing development of the brown planthopper, Nilaparvata lugens.

Nemo-like kinases (NLKs) integrate multiple signaling pathways and exhibit functional diversity in developmental processes, including the bone morphogenetic protein (BMP) pathway. However, their roles in insect wing development, particularly in hemimetabolous insects like the brown planthopper (Nilaparvata lugens), remain poorly understood. Here, we investigated the role of Nlnemo (Nlnmo), an NLK, in the wing development of N.

Fe diaspora titanium dioxide and graphene: A study of conductive powder materials and coating applications.

Developing new conductive primers to ensure electrostatic spraying is crucial in response to the call for lightweight production of new energy vehicles. We report a stabilized material, Fe-T/G, of Fe-doped TiO composite graphene synthesized by a simple hydrothermal and electrostatic self-assembly method. The resistivity decreases from 0.

The bHLH transcription factor DlbHLH68 positively regulates DlSPS1 expression to promote sucrose biosynthesis in longan.

Sucrose is an important factor affecting plant growth and fruit quality, but the molecular regulatory mechanism of sucrose biosynthesis in longan is not yet understood. Here, we characterized a transcription factor, DlbHLH68, positively regulates sucrose accumulation in longan. Subcellular localization and transcriptional activity analysis indicated that DlbHLH68 is a nuclear transcriptional activator.

Characterization changes of volatile organic compounds in Aconitum sinomontanum Nakai (Gao Wu Tou) with different proportions of yellow wine steamed by GC-IMS, E-nose.

Gas chromatography-ion mobility spectrometry (GC-IMS) combined with multiple analytical methods and E-nose were used to study the differences in volatile organic compounds (VOCs) in 0 %, 10 %, 15 %, 20 %, 25 % yellow wine steamed A. sinomontanum and its raw products. The results indicated that the VOCs in different proportions of yellow wine steamed A.

Knowledge Distillation-Enhanced Behavior Transformer for Decision-Making of Autonomous Driving.

Autonomous driving has demonstrated impressive driving capabilities, with behavior decision-making playing a crucial role as a bridge between perception and control. Imitation Learning (IL) and Reinforcement Learning (RL) have introduced innovative approaches to behavior decision-making in autonomous driving, but challenges remain. On one hand, RL's policy networks often lack sufficient reasoning ability to make optimal decisions in highly complex and stochastic environments.

Cockpit-Llama: Driver Intent Prediction in Intelligent Cockpit via Large Language Model.

The cockpit is evolving from passive, reactive interaction toward proactive, cognitive interaction, making precise predictions of driver intent a key factor in enhancing proactive interaction experiences. This paper introduces Cockpit-Llama, a novel language model specifically designed for predicting driver behavior intent. Cockpit-Llama predicts driver intent based on the relationship between current driver actions, historical interactions, and the states of the driver and cockpit environment, thereby supporting further proactive interaction decisions.

Combination ATR-FTIR with Multiple Classification Algorithms for Authentication of the Four Medicinal Plants from L. in Rhizomes and Tuberous Roots.

Curcumae Longae Rhizoma (CLRh), Curcumae Radix (CRa), and Curcumae Rhizoma (CRh), derived from the different medicinal parts of the species, are blood-activating analgesics commonly used for promoting blood circulation and relieving pain. Due to their certain similarities in chemical composition and pharmacological effects, these three herbs exhibit a high risk associated with mixing and indiscriminate use. The diverse methods used for distinguishing the medicinal origins are complex, time-consuming, and limited to intraspecific differentiation, which are not suitable for rapid and systematic identification.

Electromagnetic Interference Shielding Effectiveness of Pure SiC-TiSiC Composites Fabricated by Reactive Melt Infiltration.

Silicon carbide-based titanium silicon carbide (SiC-TiSiC) composites with low free alloy content and varying TiSiC contents are fabricated by two-step reactive melt infiltration (RMI) thorough complete reactions between carbon and TiSi alloy in SiC-C preforms obtained. The densities of SiC-C preform are tailored by the carbon morphology and volumetric shrinkage of slurry during the gel-casting process, and pure composites with variable TiSiC volume contents are successfully fabricated with different carbon contents of the preforms. Due to the increased TiSiC content in the obtained composites, both electrical conductivity and electromagnetic interference (EMI) shielding effectiveness improved progressively, while skin depth exhibited decreased consistently.

Large Polarization Change Induced by Spin Crossover-Driven Fe(II) Ion Shuttling within a Tripodal Ligand.

The integration of spin crossover (SCO) magnetic switching and electric polarization properties can engender intriguing correlated magnetic and electric phenomena. However, achieving substantial SCO-induced polarization change through rational molecular design remains a formidable challenge. Herein, we present a polar Fe(II) compound that exhibits substantial polarization change in response to a thermally regulated low-spin ↔ high-spin transition.

Genetic Basis and Identification of Candidate Genes for Alkalinity Tolerance Trait in Spotted Sea Bass (Lateolabrax maculatus) by Genome-Wide Association Study (GWAS).

Given the challenges of overcrowded coastal aquaculture spaces and insufficient production, utilizing saline-alkaline water areas represents a vital strategy to alleviate these bottlenecks. Spotted sea bass (Lateolabrax maculatus), with its formidable osmoregulatory capabilities, is an ideal candidate to develop a saline-alkaline tolerant strain. In our study, genotypic and phenotypic data from 287 L.

PbSO reaction mechanism in oxygen and reduction atmospheres during co-smelting process with primary lead material.

At present, lead-containing wastes have increasingly become the raw materials together with primary lead concentrate for lead production to meet the ever-increasing lead demand market. PbSO is the dominant component in the lead-containing wastes, nevertheless, its reaction behavior during lead smelting is not sufficiently investigated. This study investigated PbSO decomposition behaviors and phase transformation mechanisms at oxidizing and reductive atmospheres and various gas flow rates.

Sex and Age Differences in Glucocorticoid Signaling After an Aversive Experience in Mice.

Background: glucocorticoids may play an important role in the formation of fear memory, which is relevant to the neurobiology of post-traumatic stress disorder (PTSD). In our previous study, we showed the glucocorticoid receptor (GR) forms a protein complex with FKBP51, which prevents translocation of GR into the nucleus to affect gene expression; this complex is elevated in PTSD patients and by fear-conditioned learning in mice, and disrupting this complex blocks the storage and retrieval of fear-conditioned memories. The timing of release of glucocorticoid relative to the formation of a traumatic memory could be important in this process, and remains poorly understood.

Application value of CT three-dimensional reconstruction technology in the identification of benign and malignant lung nodules and the characteristics of nodule distribution.

Objective: The study aimed to evaluate the application value of computed tomography (CT) three-dimensional (3D) reconstruction technology in identifying benign and malignant lung nodules and characterizing the distribution of the nodules.

Methods: CT 3D reconstruction was performed for lung nodules. Pathological results were used as the gold standard to compare the detection rates of various lung nodule signs between conventional chest CT scanning and CT 3D reconstruction techniques.

Performance of Chest CT-Based Artificial Intelligence Models in Distinguishing Pulmonary Mucormycosis, Invasive Pulmonary Aspergillosis, and Pulmonary Tuberculosis.

In clinical practice, differentiating among pulmonary mucormycosis (PM), invasive pulmonary aspergillosis (IPA), and pulmonary tuberculosis (PTB) can be challenging. This study aimed to evaluate the performance of chest CT-based artificial intelligence (AI) models in distinguishing among these three diseases. Patients with confirmed PM, IPA, or PTB were retrospectively recruited from three tertiary hospitals.

Severe liver injury induced by minocycline in hepatitis B patient: a Case Report.

Physical liver injury is an acute and potentially serious adverse event that may result in acute liver failure or even death. Diagnosis is often challenging. Minocycline, a semi-synthetic second-generation tetracycline, has high fat solubility and good tissue permeability.

The combination of RL-QN15 and OH-CATH30 promotes the repair of acne via the TLR2/NF-κB pathway.

Acne is a prevalent and chronic inflammatory skin disease, and its treatment remains a huge clinical challenge. In the present study, we evaluated the therapeutic potential of combining the peptides RL-QN15 and OH-CATH30 for the treatment of acne in mice. Results indicated that the topical application of RL-QN15 and OH-CATH30 significantly inhibited the proliferation of Propionibacterium acnes (P.

Comprehensive analysis reveals the prognostic and immunological role of PSMD13 in hepatocellular carcinoma.

Immune cell infiltration in liver hepatocellular carcinoma (LIHC) is promising for immunotherapy. However, effective predictive markers to accurately predict a tumour's immune status are lacking. PSMD13, a native component of the 26 S proteasome subunit involved in intracellular metabolism, has an unclear association with cancer and immunity.

Chromosome-level genome assembly of the northern snakehead (Channa argus) using PacBio and Hi-C technologies.

The evolutionary origins of specialized organs pose significant challenges for empirical studies, as most such organs evolved millions of years ago. The Northern snakehead (Channa argus), an air-breathing fish, possesses a suprabranchial organ, a common feature of the Anabantoidei, offering a unique opportunity to investigate the function and evolutionary origins of specialized organs. In this study, a high-quality chromosome-level reference genome of C.

Worldview, psychological flexibility, and depression-anxiety-stress in Chinese youth.

Background: The psychological problems among the youth population have received widespread attention in the information age. However, little research has been conducted on the effects and mechanisms of worldview on depression, anxiety, and stress (DAS) among youth. In this study, we aim to investigate the relationship between worldview and DAS among youth.

Multi-label speech feature selection for Parkinson's Disease subtype recognition using graph model.

Parkinson's Disease (PD) is the second-most common neurodegenerative disorder. There is a certain pathological connection between PD and dysphonia. Speech signals have been successfully used to identify PD and predict its severity.