Osteoclastogenesis markers in craniofacial bone defects after demineralized dentin material membrane implantation as guided bone regeneration.

Unlabelled: Guided bone regeneration (GBR) is an alternative treatment for craniofacial bone defects reconstruction through membrane barrier adaptation, such as demineralized dentin material membrane (DDMM). DDMM is used as a substitute for GBR material, which aligns with Green Economy principles, it has a good biological osteoinductive and osteoconductive effects, and its structure resembles bones. The balance of bone remodeling when experiencing craniofacial defects will be altered and allow changes to resorption activity, so the mechanisms of osteoclastogenesis and bone resorption are vital.

Anti-Inflammatory Effects of Calcium Hydroxide Combined with Ellagic Acid as Pulp Capping Material: In Vivo Study.

Objectives:  Pulp capping is a pivotal treatment in dentistry aimed at preserving pulp vitality. While calcium hydroxide has long been considered the gold standard in pulp capping materials, its long-term use can induce chronic inflammation, ultimately leading to pulp necrosis and affecting human health. In this context, ellagic acid, a natural compound with potent anti-inflammatory properties, emerged as a promising adjunct to mitigate inflammation associated with calcium hydroxide application, thereby sustaining pulp vitality.

Minipterional craniotomy for resection of epileptogenic cavernous malformation.

Epilepsy is a common symptom of pediatric cavernous malformations. In medically refractory patients, surgery can achieve high seizure freedom rates with low morbidity. This video depicts the use of a minipterional craniotomy and transsulcal resection of a frontal opercular cavernous malformation in a 13-year-old female with medically intractable epilepsy.

Strategy development to increase consumer intention of purchasing prescription drugs through e-pharmacy in Indonesia.

Background: The global COVID-19 pandemic has forced people to obtain health products and services from home. Similar to other e-commerce, medicines are bought online and delivered using a courier service.

Objective: By being fully concerned to patient safety, this study aims to determine development strategies to increase intention in purchasing prescription drugs through e-pharmacy.

The challenging journey of cervical cancer diagnosis and treatment at the second largest hospital in Indonesia.

Objectives: Cervical cancer is a major health concern in developing countries. Access to preventive measures is limited in low- and middle-income countries, and cervical cancer is often identified at an advanced stage of the disease. In this study, we aimed to investigate when patients were first diagnosed and received treatment at a large hospital in Indonesia.

Computational fluid dynamics dataset of secondary air modification in a circulating fluidized bed boiler.

Computer simulation has been proven to provide a good understanding of engineering phenomenon. This work presents numerical simulation results on secondary air jet penetration into a dense phase of a three-dimensional fluidized bed at a commercial scale. Initial model as a reference and four modified models which are called as case A, B, C, and D were created by modifying the angle of secondary air.

Perception study of perceived value and social influence of digital health services in Indonesia.

Background: Healthtech has become a nascent sector of the internet economy since the emergence of the COVID-19 pandemic in 2020. Telemedicine features are facilitated, such as teleconsultation, e-diagnosis, e-prescribing, and e-pharmacy. However, the intention to use digital health services in Indonesia is still underdeveloped though the sales of other risk-free e-commerce products are high enough.

Recent advances in synthesis of polymers based on palm oil and its fatty acids.

Palm oil is a versatile bio-renewable resource for consumer products, oleochemicals, and biofuels. The utilization of palm oil in polymer production as a bio-based polymer is considered a promising alternative to conventional petrochemical-based polymers due to its non-toxicity, biodegradability, and vast obtainability. Triglycerides and fatty acids in palm oil and their derivatives can be utilized as bio-based monomers for synthesizing polymers.

The Impact of Phenobarbital on the Ability of Electroencephalogram to Predict Adverse Outcome in Asphyxiated Neonates during Therapeutic Hypothermia.

Objective: Classification of electroencephalogram (EEG) background has been established to predict outcome in neonates with hypoxic ischemic encephalopathy (HIE). However, the impact of phenobarbital therapy on the predictability of EEG background has not been studied. Our objective is to determine if EEG background after treatment with phenobarbital during therapeutic hypothermia (TH) remains a good predictor for brain injury in neonates with HIE.

The EGCG and α-Mangosteen Stimulate SHED-IL10 and SHED-LL37 Metabolite Concentration.

Objective:  Stem cells of human exfoliated deciduous teeth (SHED) metabolites are secreted molecules from SHED, namely cytokines, chemokines, and growth factors. The metabolite can be used in various regenerative therapy based on cell-free immunomodulatory potential effects, like interleukin 10 (IL-10) and LL37. This molecule can stimulate with epigallocatechin gallate (EGCG) and α-mangosteen and has been proven to have anti-inflammatory and antibacterial effects.

Osteoinductive and Osteogenic Capacity of Freeze-Dried Bovine Bone Compared to Deproteinized Bovine Bone Mineral Scaffold in Human Umbilical Cord Mesenchymal Stem Cell Culture: An In Vitro Study.

Objective:  Freeze-dried bovine bone scaffold (FDBB) or decellularized FDBB (dc-FDBB) was developed as an ideal scaffold with osteoinductive properties. This research aims to compare the osteoinductive properties marked by the expression of runt-related transcription factor-2 (RUNX2) and Osterix (OSX) and the osteogenic capacity of these scaffolds imbued with human umbilical cord mesenchymal stem cells (hUCMSCs).

Materials And Methods:  This study was performed in five experimental groups: a negative control group (C-) of hUCMSCs with a normal growth medium, a positive control group (C + ) of hUCMSCs with an osteogenic medium, experimental group 1 (E1) with an FDBB conditioned medium (CM), and experimental group 2 (E2) with a dc-FDBB-CM, and a third experimental group (E3) consisting of a DBBM-CM.

IMMUNE RESPONSE UPON THE ADMINISTRATION OF RECOMBINANT PROTEIN ANTIBODIES Ag-38 KDa AND RIFAMPICIN .

Background: Development a granuloma model resembling latent tuberculosis is needed with a fast and efficient time to be used as an effective therapy. This study aimed to form efficient granulomas, increase cellular immunity and humoral immunity, and evaluate growth on media using recombinant protein antibody Ag38kDa, Rifampicin, and a combination of both. Peripheral Blood Mononuclear Cell (PBMC) is derived from a healthy individual separated from monocytes and lymphocytes.

The effect of secretory leukocyte protease inhibitor amnion membrane on incisional wound healing.

In human body, biomaterials can be used to accelerate the wound healing process. Amniotic membrane-derived secretory leukocyte protease inhibitor (SLPI) is one of the biomaterials which able to accelerate the wound healing process by its several functions such as protease inhibition, leukocytes activity control, growth factor regulation such as transforming growth factor β (TGF-β), and its anti inflammatory, anti bacterial also anti retroviral properties. Objectives: To analyzed the SLPI effect on the TNF-α expression and the quantity of new blood vessel in the incisional wound healing.

The Characteristics of Demineralized Dentin Material Sponge as Guided Bone Regeneration Based on the FTIR and SEM-EDX Tests.

Objective:  The objective of this study was to determine the characteristics of demineralized dentin material sponge (DDMS).

Material And Methods:  An observational study was conducted on DDMS and BPCM. Fourier transform infrared (FTIR) test was performed to determine the characterizations of the materials.

The efficacy of okra fruit extract on the expression of transforming growth factor beta 1 in the tooth socket of diabetic Wistar rats.

Background: Patients with diabetes mellitus suffer from an additional macrophage dysfunction in the secretion of growth factor, which later decreases transforming growth factor beta 1 (TGF-β1). This condition disrupts proliferation and angiogenesis. Extract of okra fruit () contains flavonoid, an active substance which acts as antioxidant, anti-inflammation, and antidiabetes.

A study of the mucoadhesive patches loaded with mangosteen peel extract in periodontitis.

Objective: The treatment of periodontitis with scaling and root planing has a good prognosis. However, periodontitis may also exacerbate. The mucoadhesive patch is one of the distribution systems of topical drugs, which is not irritable to the mucosa and eventually increases permeability.

Ellagic acid and hydroxyapatite promote angiogenesis marker in bone defect.

The combination of hydroxyapatite and the herbal extract ellagic acid is expected to accelerate the bone healing process (osteogenesis) due to the extract's anti-inflammatory and antioxidant properties. The osteogenesis process is closely associated with angiogenesis markers, such as fibroblast growth factor 2 (FGF-2), vascular endothelial growth factor (VEGF) and alkali phosphatase (ALP). The objective of this study is to analyse the combination of ellagic acid and hydroxyapatite to promote FGF-2, VEGF and ALP expression as angiogenesis markers in a bone defect model.

A decade of systematic literature review on Airbnb: the sharing economy from a multiple stakeholder perspective.

Airbnb, which launched its business in 2009, has experienced explosive growth by creating value through the sharing economy business model. The Airbnb business model helps property owners exploit underutilized assets. However, along with its rapid growth, controversies have arisen among many stakeholders, especially the traditional hotel industry, communities, and policymakers.

Effect of Message Approach and Image Size on Pictorial Health Warning Effectiveness on Cigarette Pack in Indonesia: A Mixed Factorial Experiment.

Background: Cigarette consumption remains high and increasing in Indonesia. The government implemented a pictorial health warnings requirement of 40% cover of the pack (front and back) using fear appeal messages.

Objective: Our study aims to assess the effectiveness of cigarette pictorial health warnings by message and size.

Successful Cesarean Myomectomies of Large Uterine Fibroids: Two Cases and a Literature Review.

BACKGROUND No standard guidelines have been specified for a cesarean myomectomy, and several centers remain divided on the justification to perform this procedure, especially for large fibroids. Only a few case reports have been published of cesarean myomectomy for large fibroids. Here, we report 2 cases of successful cesarean myomectomies for large fibroids (>15 cm) during the 38th week of pregnancy.

Novel luminescent Schiff's base derivative with an azo moiety for ultraselective and sensitive chemosensor of Fe ions.

Chemosensors with ultrasensing capabilities for detection of metal ions have received particular attention when using luminescent organic compounds. Even though hundreds of chemosensor agents have been reported for Fe ion sensing, the designs of those molecules have been complicated and time consuming, in addition to having limited application for aquatic samples due to their poor hydrophilicity. Here, we synthesized a novel azo-imine derivative (L2) that showed ultrasensitive and selective sensing for Fe ions.

Towards Thermally Reversible Networks Based on Furan-Functionalization of Jatropha Oil.

A novel biobased monomer for the preparation of thermally reversible networks based on the Diels-Alder reaction was synthesized from jatropha oil. The oil was epoxidized and subsequently reacted with furfurylamine to attach furan groups via an epoxide ring opening reaction. However, furfurylamine also reacted with the ester groups of the triglycerides via aminolysis, thus resulting in short-chain molecules that ultimately yielded brittle thermally reversible polymers upon cross-linking via a Diels-Alder reaction.

Thermally Reversible Polymeric Networks from Vegetable Oils.

Low cross-link density thermally reversible networks were successfully synthesized from jatropha and sunflower oils. The oils were epoxidized and subsequently reacted with furfurylamine to attach furan groups onto the triglycerides, preferably at the epoxide sites rather than at the ester ones. Under the same reaction conditions, the modified jatropha oil retained the triglyceride structure more efficiently than its sunflower-based counterpart, i.

Prevalence of Seizures and Risk Factors for Mortality in a Continuous Cohort of Pediatric Extracorporeal Membrane Oxygenation Patients.

Objectives: To evaluate the risk factors for mortality in pediatric extracorporeal membrane oxygenation patients.

Design: Retrospective, single-center study.

Setting: PICU and Pediatric cardiothoracic ICU in an urban, quaternary care center.

Proliferation and osteogenic differentiation of bone marrow-derived mesenchymal stem cell after exposure to red flesh dragon fruit extract.

Background: Induction of the proliferation and differentiation of stem cells could represent a viable alternative therapeutic method for treating bone diseases. Stem cells are essential to bone tissue regeneration; although, their availability is limited. One possible method of increasing the number of stem cells and promote osteogenic differentiation is the application of red flesh dragon fruit extract supplement.