Objective: Both blood loss and lower extremity swelling after total knee arthroplasty (TKA) can affect a patient's postoperative recovery. The aim of this trial was to investigate whether different doses of intra-articular tranexamic acid (TXA) can reduce blood loss and postoperative lower limb swelling.
Methods: In a prospective, randomized-controlled trial, a total of 225 patients were randomly assigned to three groups from September 2020 through January 2021: intra-articular injections of 3 g, 1 g of TXA, or placebo (saline solution).
To investigate the protective effects and underlying mechanisms of Qin-Zhu-Liang-Xue decoction (QZLX) in atopic dermatitis (AD) and glucocorticoid resistance, we conducted a single-blinded, randomized controlled clinical trial to evaluate the efficacy and safety of this concoction. Network pharmacology analysis was performed and validated through clinical studies. The efficacy, safety, and mechanism of action of QZLX and glucocorticoid receptor (GR) α recombinant protein were assessed in AD mice induced by 2,4-dinitrofluorobenzene (DNFB).
View Article and Find Full Text PDFBackground: Given the increasing commitment of numerous nations to achieving future carbon neutrality, urban development planning that integrating carbon storage considerations plays a crucial role in enhancing urban carbon efficiency and promoting regional sustainable development. Previous studies have indicated that optimizing land use structure and quality is essential for regional carbon storage management. Taking the core area of Taihu Bay as study area, this study innovatively combined high-precision urban 3D data to account for the whole urban carbon pools of buildings, vegetation, soils, water.
View Article and Find Full Text PDFObjectives: People living with HIV are aging. This study aimed to assess the factors influencing the requirements for geriatric nursing of older adults living with HIV (OALHIV).
Methods: Convenience sampling was used to conduct a survey on the 295 OALHIV aged over 50 in Luzhou, China.
Different Zn/Al ratios of Cl intercalated ZnAl-layered double hydroxide (ZnAl-LDH) were prepared using the coprecipitation method, and their adsorption performance for Cu in aqueous solution was evaluated. The factors affecting adsorption properties, such as dosage, reaction time, and pH, were determined by adsorption experiments. Then, the adsorption kinetics and isotherm models were fitted to evaluate the adsorption mechanism.
View Article and Find Full Text PDFWith medical technology development, endovascular intervention has been widely used in clinical practice, and the establishment of surgical access through the femoral artery, where most vascular interventions are performed, is a common method. Postoperative hemostasis at the femoral artery puncture site is a key part of interventional procedures and is particularly important to ensure the safety and effectiveness of hemostasis. Some patients undergoing interventional therapy also use anticoagulant and antiplatelet drugs preoperatively and undergo systemic heparin session intraoperatively, which leads to abnormal coagulation, thus increasing the difficulty of hemostasis at the puncture point postoperatively.
View Article and Find Full Text PDFBackground: In recent years, the widespread use of computed tomography (CT) in early lung cancer screening has led to an increase in the detection rate of lung ground glass nodules (GGNs). The persistence of GGNs, which may indicate early lung adenocarcinoma, has been a focus of attention for scholars in the field of lung cancer prevention and treatment in recent years. Despite the rapid development of research into GGNs, there is a lack of intuitive content and trend analyses in this field, as well as a lack of detailed elaboration on possible research hotspots.
View Article and Find Full Text PDFType 1 Diabetes (T1D) is an autoimmune disease characterized by the attack and destruction of Pancreatic islet beta cells by T cells. Understanding the role of T-cell receptor (TCR) in the development of T1D is of paramount importance. This study employs single-cell RNA sequencing (scRNA-seq) to delve into the mechanistic actions and potential therapeutic applications of autoreactive stem cell-like CD8 TCR in T1D.
View Article and Find Full Text PDFThe pandemic has reinforced older adults' reliance on their homes and the concept of "aging in place". Changes like reduced physical strength and cognitive deficit, however, have heightened the challenge of simple tasks like obstacle crossing among older adults, let alone when older adults cannot perceive the surroundings well during the nighttime. The study is, therefore, to evaluate the impact of lighting on older adults' obstacle-crossing behavior during the nighttime.
View Article and Find Full Text PDFIn this study, we redefine the diagnostic landscape of diabetic ulcers (DUs), a major diabetes complication. Our research uncovers new biomarkers linked to immunogenic cell death (ICD) in DUs by utilizing RNA-sequencing data of Gene Expression Omnibus (GEO) analysis combined with a comprehensive database interrogation. Employing a random forest algorithm, we have developed a diagnostic model that demonstrates improved accuracy in distinguishing DUs from normal tissue, with satisfactory results from ROC analysis.
View Article and Find Full Text PDFGastric cancer is a common malignant tumor, and its incidence rate ranks first among malignant tumors of the digestive tract, seriously endangering human physical and mental health. Changes in the physiological state of gastric cancer patients can bring about many physical and psychological symptoms and have a serious impact on their quality of life. Symptom clusters are 2 or more concurrently occurring and interrelated symptoms, with the core symptoms within the cluster remaining stable over time and the symptoms in the cluster being independent of each other.
View Article and Find Full Text PDFThe brain atlas is essential for exploring the anatomical structure and function of the brain. Non-human primates, such as cynomolgus macaque, have received increasing attention due to their genetic similarity to humans. However, current macaque brain atlases only offer coarse sections with intervals along the coronal direction, failing to meet the needs of single-cell resolution studies in functional and multi-omics research of the macaque brain.
View Article and Find Full Text PDFBackground: Psoriasis (PSO) poses a global health threat. The current research challenge in PSO is relapse. Liquiritin (LIQ), a major active compound from Glycyrrhiza inflata Batalin, has multiple pharmacological properties, including anti-inflammatory and anti-proliferative.
View Article and Find Full Text PDFMicroplastics (MPs) affect the carbon cycle in coastal salt marsh soils. However, studies on their effects on CHCl and CHBr, which are volatile halohydrocarbons that can damage the ozone layer, are lacking. In this study, indoor simulation experiments were conducted to explore the effects of MPs invasion on the source and sink characteristics of soil CHCl and CHBr.
View Article and Find Full Text PDFPsoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis will relapse after remission.
View Article and Find Full Text PDFBackground: Intrapancreatic fat deposition (IPFD) exerts a significant negative impact on patients with type 2 diabetes mellitus (T2DM), accelerates disease deterioration, and may lead to impaired β-cell quality and function.
Aim: To investigate the correlation between T2DM remission and IPFD.
Methods: We enrolled 80 abdominally obese patients with T2DM admitted to our institution from January 2019 to October 2023, including 40 patients with weight loss-induced T2DM remission (research group) and 40 patients with short-term intensive insulin therapy-induced T2DM remission (control group).
This study examines the impact of Human-Drone Interaction (HDI) modalities on construction workers' safety and balance control within virtual environments. Utilising virtual reality (VR) simulations, the study explored how gesture and speech-based communications influence workers' physical postures and balance, contrasting these modalities with a non-interactive control group. One hundred participants were recruited, and their movements and balance control were tracked using motion sensors while they interacted with virtual drones through either gesture, speech, or without communication.
View Article and Find Full Text PDF