Tanshinone IIA, a component of Salvia miltiorrhiza Bunge, attenuated sepsis-induced liver injury via the SIRT1/Sestrin2/HO-1 signaling pathway.

Ethnopharmacological Relevance: As a traditional Chinese medicine, Salvia miltiorrhiza Bunge has been widely used to treat ischemic and inflammation-related diseases for more than 2000 years. S. miltiorrhiza Bunge has hepatoprotective effects, but the underlying mechanism is not fully understood.

Erratum: The role of β-catenin in the initiation and metastasis of TA2 mice spontaneous breast cancer: Erratum.

[This corrects the article DOI: 10.7150/jca.19723.

Battery-Free and Multifunctional Microfluidic Janus Wound Dressing with Biofluid Management, Multi-Indicator Monitoring, and Antibacterial Properties.

The sophisticated environment of chronic wounds, characterized by prolonged exudation and recurrent bacterial infections, poses significant challenges to wound recovery. Recent advancements in multifunctional wound dressings fall short of providing comprehensive, accurate, and comfortable treatment. To address these issues, a battery-free and multifunctional microfluidic Janus wound dressing (MM-JWD) capable of three functions, including exudate management, antibacterial properties, and multiple indications of wound infection detection, has been developed.

[Effectiveness of vertical compression of locking plate combined with hollow screws in treatment of Sanders type and calcaneal fractures].

Objective: To probe into the effectiveness of vertical compression of locking plate combined with hollow screws in the treatment of Sanders type Ⅱ and Ⅲ calcaneal fractures.

Methods: The clinical data of 128 patients with Sanders type Ⅱ and Ⅲ calcaneal fractures who were admitted between March 2019 and April 2022 and met the selection criteria were retrospectively analyzed. Among them, 65 patients were treated with locking plate combined with hollow screw vertical compression (study group), and 63 patients were treated with simple locking plate (control group).

Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1/NLRP3 Pathway.

Doxorubicin (DOX) is a powerful anthracycline antineoplastic drug used to treat a wide spectrum of tumors. However, its clinical application is limited due to cardiotoxic side effects. Astragaloside IV (AS IV), one of the major compounds present in aqueous extracts of , possesses potent cardiovascular protective properties, but the underlying molecular mechanisms are unclear.

Variability of BMP-2 content in DBM products derived from different long bone.

Demineralized bone matrix (DBM) has been regarded as an ideal bone substitute as a native carrier of bone morphogenetic proteins (BMPs) and other growth factors. However, the osteoinductive properties diverse in different DBM products. We speculate that the harvest origin further contributing to variability of BMPs contents in DBM products besides the process technology.

Modular intercalary prosthetic reconstruction for malignant and metastatic tumours of the proximal femur.

To illustrate the surgical technique and explore clinical outcomes of the reconstruction for the malignant and metastatic bone tumour of proximal femur with metallic modular intercalary prosthesis. Sixteen patients who underwent modular intercalary prosthetic reconstruction after tumour resection were included from April 2012 and October 2020. Prosthesis and screws parameters, resected bone length and residual bone length, clinical outcomes and survivorship were analyzed.

Establishment and validation of a nomogram to predict postoperative anemia after total hip arthroplasty.

Background: Anemia is a common complication of total hip arthroplasty (THA). In this study, we evaluated the preoperative risk factors for postoperative anemia after THA and developed a nomogram model based on related preoperative and intraoperative factors.

Methods: From January 2020 to May 2023, 927 THA patients at the same medical center were randomly assigned to either the training or validation cohort.

Piezoelectric Interlayer Enabling a Rechargeable Quasisolid-State Sodium Battery at 0 °C.

Solid-state sodium (Na) batteries (SSNBs) hold great promise but suffer from several major issues, such as high interfacial resistance at the solid electrolyte/electrode interface and Na metal dendrite growth. To address these issues, a piezoelectric interlayer design for an NaZrSiPO (NZSP) solid electrolyte is proposed herein. Two typical piezoelectric films, AlN and ZnO, coated onto NZSP function as interlayers designed to generate a local stress-induced field for alleviating interfacial charge aggregation coupling stress concentration and promoting uniform Na plating.

Associations of serum DNA methylation levels of chemokine signaling pathway genes with mild cognitive impairment (MCI) and Alzheimer's disease (AD).

Objective: To investigate the associations of serum DNA methylation levels of chemokine signaling pathway genes with Alzheimer's disease (AD) and mild cognitive impairment (MCI) in elderly people in Xinjiang, China, and to screen out genes whose DNA methylation could distinguish AD and MCI.

Materials And Methods: 37 AD, 40 MCI and 80 controls were included in the present study. DNA methylation assay was done using quantitative methylation-specific polymerase chain reaction (qMSP).

Early clinical efficacy analysis of enhanced recovery following surgery combined with interscalene brachial plexus block for arthroscopic rotator cuff repair.

To explore the early clinical value of enhanced recovery after surgery (ERAS) with interscalene brachial plexus block (ISB) for arthroscopic rotator cuff repair (ARCR). We enrolled 240 patients who underwent arthroscopic rotator cuff repair, randomly divided into 3 groups (n = 80 each). Groups A, B, and C underwent only surgery, surgery + ERAS, and ISB + surgery + ERAS, respectively.

NaBr-Assisted Sintering of NaZrSiPO Ceramic Electrolyte Stabilizes a Rechargeable Solid-state Sodium Metal Battery.

Solid-state metal batteries with nonflammable solid-state electrolytes are regarded as the next generation of energy storage technology on account of their high safety and energy density. However, as for most solid electrolytes, low room temperature ionic conductivity and interfacial issues hinder their practical application. In this work, Na super ionic conductor (NASICON)-type NaZrSiPO (NZSP) electrolytes with improved ionic conductivity are synthesized by the NaBr-assisted sintering method.

[TightRope elastic fixation combined with functional total repair of inferior tibiofibular ligament in treatment of distal tibiofibular syndesmosis injury].

Objective: To study the effectiveness of TightRope elastic fixation combined with functional total repair of the inferior tibiofibular ligament in the treatment of distal tibiofibular syndesmosis injury.

Methods: The clinical data of 34 patients with distal tibiofibular syndesmosis injury who met the selection criteria between January 2020 and January 2022 were retrospectively analyzed, and they were divided into improved group (TightRope elastic fixation combined with functional total repair of inferior tibiofibular ligament) and control group (distal tibiofibular screw fixation) according to the surgical methods, with 17 cases in each group. There was no significant difference in age, gender, body mass index, fracture type, and other baseline data between the two groups (0.

[Content of bone morphogenetic protein 2 in demineralized bone matrix prepared from different long bones and study of the osteogenic properties ].

Objective: To measure the concentration of bone morphogenetic protein 2 (BMP-2) in demineralized bone matrix (DBM) prepared from different long bones and to evaluate the osteoinductivity of different DBM on MC3T3-E1 cells.

Methods: Different bones from the same cadaver donor were used as the initial materials for making DBM, which were divided into ulna group (uDBM), humerus group (hDBM), tibia group (tDBM), and femur group (fDBM) according to the origins, and boiled DBM (cDBM) was taken as the control group. The proteins of DBM were extracted by guanidine hydrochloride, and the concentrations of BMP-2 were determined by ELISA assay.

Composition and sequence-controlled conductance of crystalline unimolecular monolayers.

Understanding how the charge travels through sequence-controlled molecules has been a formidable challenge because of simultaneous requirements in well-controlled synthesis and well-manipulated orientation. Here, we report electrically driven simultaneous synthesis and crystallization as a general strategy to study the conductance of composition and sequence-controlled unioligomer and unipolymer monolayers. The structural disorder of molecules and conductance variations on random positions can be extremely minimized, by uniform synthesis of monolayers unidirectionally sandwiched between electrodes, as an important prerequisite for the reproducible measurement on the micrometer scale.

Screening of Sintering Aids for Oxide Ceramics: A Case of NASICON Electrolyte.

In this work, an efficient screening method to select appropriate sintering aids for a wide range of oxide material systems is developed. Consequently, Na B O , NaF, and CuO are selected as sintering aids for sodium super ionic conductor (NASICON)-type Na Zr Si PO ceramic to verify the feasibility of the as-proposed method. As evidenced by the results, the sinterability and densification of ceramic matrix are apparently improved.

Crystalline Unipolymer Monolayer with High Modulus and Conductivity.

The synthesis of crystalline polymer with a well-defined orientated state and a two-dimensional crystalline size beyond a micrometer will be essential to achieve the highest physical feature of polymer material but remain challenging. Herein, we show the synthesis of the crystalline unipolymer monolayer with an unusual ultrahigh modulus that is higher than the ITO substrate and high conductance by simultaneous electrosynthesis and manipulation. We find that the polymer monolayer has fully extended in the vertical and unidirectional orientation, which is proposed to approach their theoretically highest density, modulus, and conductivity among all aggregation formations of the current polymer.

Heparin purification by expanded bed anion exchange in a countercurrent chromatography column.

In this study, an expanded bed anion exchange in a countercurrent chromatography column (EB-CCC) technique for separation and purification of heparin, an anticoagulant and antithrombotic glycosaminoglycan, is reported for the first time. A comparative evaluation of the EB-CCC technique with the conventional fixed bed column chromatography (FBCC) revealed its effectiveness in improving adsorption at high flow rates and reducing separation time. A significantly higher maximum adsorption (91.

Coupling Dual-phased nickel selenides with N-doped carbon enables efficient urea electrocatalytic oxidation.

Electrochemical urea oxidation reaction (UOR) is urgently in demand for diverse energy conversion and storage device coupled with pollution treatment because of its favorable thermodynamic potential (0.37 V vs RHE) and wide distribution nature of urea, but simultaneously gravely limited by the sluggish reaction dynamics and poisoning of catalyst. Herein, dual-phased NiSe/NiSe coupling with N doped carbon (NiSe/NiSe@NC-2) in situ is prepared by a solvothermal-selenization pathway.

Sulforaphane kills Mycobacterium tuberculosis H37Ra and Mycobacterium smegmatis mc155 through a reactive oxygen species dependent mechanism.

Mycobacterium tuberculosis (M. tuberculosis) is a highly pathogenic intracellular pathogen that causes tuberculosis (TB), the leading cause of mortality from single infections. Redox homeostasis plays a very important role in the resistance of M.

Active Control of Interface Dynamics in NASICON-Based Rechargeable Solid-State Sodium Batteries.

Severe challenges are restraining the practical application of solid-state batteries, such as the dendrite growth and unsatisfactory compatibility between solid electrolyte and electrode. Here, we propose an interface dynamic control (IDC) strategy to ensure the stable operation of NASICON-based solid-state sodium batteries. First, we introduce intergranular phase (CuO) to effectively promote the densification of NaZrSiPO with an optimized ionic conductivity of 1.

Effects of demineralization mode and particle size of allogeneic bone powder on its physical and chemical properties.

At present, the commonly used allogeneic bone powder in the clinic can be divided into nondemineralized bone matrix and demineralized bone matrix (DBM). Commonly used demineralizers include acids and ethylene diamine tetraacetic acid (EDTA). There may be some diversities between them.