NNMT promotes the progression of intrahepatic cholangiocarcinoma by regulating aerobic glycolysis via the EGFR-STAT3 axis.

Nicotinamide N-methyltransferase (NNMT), a member of the N-methyltransferase family, plays an important role in tumorigenesis. However, its expression and biological functions in intrahepatic cholangiocarcinoma (iCCA) remain to be established. In our study, we identified NNMT as an oncogene in iCCA and provided mechanistic insights into the roles of NNMT in iCCA progression.

Alleviates Obesity by Altering the Composition of the Gut Microbiota in High-Fat Diet-Fed Mice.

Metabolic disorders and intestinal flora imbalance usually accompany obesity. Due to its diverse biological activities, is widely used to alleviate various diseases as a probiotic. Here, we show that can reduce the body weight of mice fed high-fat diets, reduce fat accumulation, and enhance mice glucose tolerance.

Fabrication of one-dimensional M (Co, Ni)@polyaniline nanochains with adjustable thickness for excellent microwave absorption properties.

The development of microwave absorbing materials with strong absorption capacity, wide bandwidth and light weight has always been a topic of concern. Herein, one-dimensional (1D) M (Co, Ni)@polyaniline (PANI) nanochains (NCs) with adjustable thickness have been successfully synthesized by reducing the mental ions under a parallel magnetic field, pretreating metal nanochains with KH550 and pre-oxidization of aniline monomer. It is found that Co has a more favorable absorption width for electromagnetic waves (EMW) and Ni aims at the absorption intensity.

Identification of CFHR4 as a Potential Prognosis Biomarker Associated With lmmune Infiltrates in Hepatocellular Carcinoma.

Background: Complement factor H-related 4 (CFHR4) is a protein-coding gene that plays an essential role in multiple diseases. However, the prognostic value of CFHR4 in hepatocellular carcinoma (HCC) is unknown.

Methods: Using multiple databases, we investigated CFHR4 expression levels in HCC and multiple cancers.

Study on the expression level of NF-κB and clinical evaluations in spinal tuberculosis patients.

Spinal tuberculosis or tuberculous spondylitis is one of the most common types of skeletal tuberculosis. Complications of the spine and spinal cord tuberculosis include destruction of the vertebrae, deformity, and paraplegia. Since in some patients, the clinical manifestations of tuberculosis are unusual and timely diagnosis and treatment of this disease can prevent its serious consequences, so in the present study, some cases of rare manifestations of tuberculosis were investigated.

Study on the expression level of NF-κB and clinical evaluations in spinal tuberculosis patients.

Spinal tuberculosis or tuberculous spondylitis is one of the most common types of skeletal tuberculosis. Complications of the spine and spinal cord tuberculosis include destruction of the vertebrae, deformity, and paraplegia. Since in some patients, the clinical manifestations of tuberculosis are unusual and timely diagnosis and treatment of this disease can prevent its serious consequences, so in the present study, some cases of rare manifestations of tuberculosis were investigated.

Constructing 3D magnetic flower-like FeO@SiO@CoO@BiOCl heterojunction photocatalyst for degrading rhodamine B.

In this work, the 3D magnetic flower-like FeO@SiO@CoO@BiOCl heterojunction photocatalyst was successfully prepared. The combination of BiOCl with CoO favored to increase specific surface area and separate photo-generated carriers of the resulting composite, resulting in the improvement of catalytic efficiency. The photocatalytic activities of FeO@SiO@CoO@BiOCl were researched in details.

Seasonal variations of geofluids from mud volcano systems in the Southern Junggar Basin, NW China.

Variations in the chemical composition of geofluids and of gas fluxes are significant parameters for understanding mud volcanism and correctly estimate their emissions in carbon species, particularly greenhouse gas, methane. In this study, muddy water and gas samples were collected from the Anjihai, Dushanzi, Aiqigou, and Baiyanggou mud volcanoes in the southern Junggar Basin during the four seasons, around a year. This region hosts the most active mud volcanism throughout China.

Removal of collagen three-dimensional scaffold bubbles utilizing a vacuum suction technique.

The process of generating type I/II collagen scaffolds is fraught with bubble formation, which can interfere with the three-dimensional structure of the scaffold. Herein, we applied low-temperature vacuum freeze-drying to remove mixed air bubbles under negative pressure. Type I and II rubber sponges were acid-solubilized via acid lysis and enzymolysis.

Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.

Acute kidney injury (AKI) induced by cisplatin (CP), a first-line anticancer drug for chemotherapy, is common. To date, there is an urgent need to find effective treatments to reduce the nephrotoxicity caused by CP. Meanwhile, the restoration of mitochondrial dysfunction shows potential to be used as an adjunct to conventional therapeutic strategies.

Synthesis of multi-branched Au nanocomposites with distinct plasmon resonance in NIR-II window and controlled CRISPR-Cas9 delivery for synergistic gene-photothermal therapy.

Clinical implementation of photothermal therapy (PTT) is mainly hampered by limited tissue penetration, undesirable thermal damage to normal tissues, and thermotolerence induced by heat shock proteins (HSPs). To overcome these obstacles, we constructed a novel gene-photothermal synergistic therapeutic nanoplatform composed of a multi-branched Au nanooctopus (AuNO) core and mesoporous polydopamine (mPDA) shell, followed by CRISPR-Cas9 ribonucleoprotein (RNP) loading and then polyethylene glycol-folic acid (PEG-FA) coating. AuNO was simply synthesized by adjusting the ratio of cetyltrimethylammonium chloride (CTAC) and cetyltrimethylammonium bromide (CTAB), which showed significant localized surface plasmon resonances in the NIR-II window, and exhibited an excellent tissue penetration capability and high photothermal conversion efficiency (PCE, 47.

Mortality Among Parkinson's Disease Patients Treated With Pimavanserin or Atypical Antipsychotics: An Observational Study in Medicare Beneficiaries.

Objective: Pimavanserin, a serotonin 5-HT antagonist, is indicated for treatment of hallucinations and delusions associated with Parkinson's disease psychosis. In premarketing trials in patients with Parkinson's disease psychosis, 11% of patients died during open-label pimavanserin treatment. Antipsychotics, which are used off-label in Parkinson's disease psychosis, increase mortality in dementia patients.

[Clinical Characteristics and Prognosis of Patients with Hematological Malignancies Superimposed with Solid Tumors].

Objective: To investigate the clinical characteristics and prognosis of hematological malignancies superimposed patients with solid tumors.

Methods: The clinical data of 30 patients with more than two kinds of malignancy (the second is hematological malignancy) from October 2011 to October 2020 in Department of Hematology, Jiangning Hospital Affiliated to Nanjing Medical University were collected and analyzed retrospectively. The overall survival time was used as the prognostic evaluation standard, and the survival of patients were analyzed by KaplanMeier method.

A Three-Dimensional Cement Quantification Method for Decision Prediction of Vertebral Recompression after Vertebroplasty.

Objective: Proposing parameters to quantify cement distribution and increasing accuracy for decision prediction of vertebroplasty postoperative complication.

Methods: Finite element analysis was used to biomechanically assess vertebral mechanics ( = 51) after percutaneous vertebroplasty (PVP) or kyphoplasty (PKP). The vertebral space was divided into 27 portions.

ORF8 protein of SARS-CoV-2 reduces male fertility in mice.

As one of the most rapidly evolving proteins of the genus Betacoronavirus, open reading frames (ORF8's) function and potential pathological consequence in vivo are still obscure. In this study, we show that the secretion of ORF8 is dependent on its N-terminal signal peptide sequence and can be inhibited by reactive oxygen species scavenger and endoplasmic reticulum-Golgi transportation inhibitor in cultured cells. To trace the effect of its possible in vivo secretion, we examined the plasma samples of coronavirus disease 2019 (COVID-19) convalescent patients and found that the patients aged from 40 to 60 had higher antibody titers than those under 40.

Aurora kinase a inhibitor MLN8237 suppresses pancreatic cancer growth.

Pancreatic ductal adenocarcinoma (PDAC) is notorious for high mortality due to limited options of appropriate chemotherapy drugs. Here we report that Aurora kinase-A expression is elevated in both human and mouse PDAC samples. MLN8237, an inhibitor of Aurora kinase-A, efficiently reduced the proliferation and motility of PDAC cells in vitro as well as tumor growth in orthotropic xenograft model and genetic pancreatic cancer animal models (p53/LSL/Pdx-Cre mice) in vivo.

Quercetin Attenuates Osteoporosis in Orchiectomy Mice by Regulating Glucose and Lipid Metabolism the GPRC6A/AMPK/mTOR Signaling Pathway.

Quercetin, a flavonoid found in natural medicines, has shown a role in disease prevention and health promotion. Moreover, because of its recently identified contribution in regulating bone homeostasis, quercetin may be considered a promising agent for improving bone health.This study aimed to elucidate the role of quercetin in androgen deprivation therapy-induced osteoporosis in mice.

Differences in medical costs among urban lung cancer patients with different health insurance schemes: a retrospective study.

Background: Health insurance plays a significant role in reducing the financial burden for lung cancer patients. However, limited research exists regarding the differences in medical costs for lung cancer patients with different insurance schemes across different cities. We aimed to assess disparities in lung cancer patients' costs by insurance type and city-specific insurance type.

The Effect of Anlotinib Combined with anti-PD-1 in the Treatment of Gastric Cancer.

Background: Protein tyrosine kinase (PTK) signaling pathway has been confirmed to be involved in the proliferation, differentiation and migration of tumor cells. Anlotinib, as a multi-target tyrosine kinase inhibitor, which can inhibit the expression of vascular endothelial growth factor receptor (VEGFR), has been confirmed to have significant therapeutic effects on non-small cell lung cancer, medullary thyroid carcinoma, and soft tissue sarcoma, but the therapeutic effect on gastric cancer (GC) is still unclear.

Methods: Anlotinib was screened out of 880 drugs through Cell Counting Kit 8 (CCK-8) technology.

Recent progress of MOF-derived porous carbon materials for microwave absorption.

Microwave absorbing materials (MAM) have attracted considerable attention over the years in stealth and information technologies. Metal-organic framework (MOF) with a unique microstructure and electronic state has become an attractive focus as self-sacrificing precursors of microwave absorbers. The MOF-derived porous carbon (PC) materials exhibit a high absorbing performance due to the stable three-dimensional structure and homogeneous distribution of metal particles.

One-dimensional recoverable ZnFeO/C/MnO/BiOI magnetic composite with enhanced photocatalytic performance for organic dyes degradation.

Excessive discharge of toxic dyes is detrimental to ecological system and human health. Therefore, an effective photocatalyst must be designed and developed to degrade dyes from wastewater. Herein, a novel one-dimensional (1D) flower-like recoverable ZnFeO/C/MnO/BiOI magnetic composite photocatalyst was synthesized via electrospinning technique combined with hydrothermal method.

Homogenizing LiCO Nucleation and Growth through High-Density Single-Atomic Ru Loading toward Reversible Li-CO Reaction.

The high activation barrier and sluggish kinetics of LiCO decomposition impose a severe challenge on the development of a Li-CO battery with high Coulombic efficiency. To tackle this issue, herein we devise a novel synthetic tactic by combining electrostatic assembly with polycondensation to obtain a single-atomic Ru catalyst of high density up to ∼5 wt %. When deployed to the CO cathode, the catalyst delivered an extraordinary capacity of 44.

A PEGylated water-soluble fluorescent and colorimetric probe for carbon monoxide detection.

A CO probe with PEGylation is synthesized, achieving the detection of CO in pure water solution with high intensity color change and fluorescence enhancement. Importantly, this probe with high affinity to paper strips and low toxicity to living cells is successfully used for sensing CO in air and in living cells.