Assessing the global dengue burden: Incidence, mortality, and disability trends over three decades.

Background: Dengue, the fastest-spreading vector-borne disease (VBD), significantly burdens global health systems. This study analyzed the trends in the global burden of dengue from 1990 to 2021, utilizing data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021).

Methodology/principal Findings: We retrieved data from GBD 2021 regarding dengue, including the number of incidences and age-standardized incidence rate (ASIR), the number of deaths and age-standardized death rate (ASDR), disability-adjusted life-years (DALYs) and age-standardized DALYs.

Predictive Value of Serum sIL-2R Levels and Th17/Treg Immune Balance for Disease Progression in Patients With Rheumatoid Arthritis-Associated Interstitial Lung Disease.

Background: This article analyzed the relationship between serum sIL-2R levels and Th17/Treg immune balance in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and their prognostic value.

Methods: RA patients (n = 311) were retrospectively selected for research and then allocated to the RA and RA-ILD groups. Baseline data and 3-year follow-up records of all patients were attained to assess disease progression.

Phenotypic plasticity of bread wheat contributes to yield reliability under heat and drought stress.

Yield reliability under diverse environments is important to address climate stress consequences in wheat production systems. Breeding for reliability under a changing climate remains a challenge in wheat. We assessed the performance of 18 hexaploid (Triticum aestivum L.

Osimertinib long-term tolerability in patients with EGFRm NSCLC enrolled in the AURA program or FLAURA study.

Introduction: This post-hoc analysis of the registrational FLAURA study and AURA program reports long-term safety data in epidermal growth factor receptor-mutated (EGFRm), advanced non-small cell lung cancer (NSCLC) treated with osimertinib for ≥ 36 months.

Methods: Patients from FLAURA who received first-line osimertinib and from the AURA program (AURA, AURA2, AURA3) who received ≥ second-line osimertinib were included. Patients received osimertinib 80 mg once daily.

Dental service for United Nations peacekeepers coping with COVID-19 in Bukavu: preparation, implementation and recommendation.

Background: The Chinese level 2 hospital (CHH L2) deployed in Bukavu provides medical supports to peacekeepers in MONUSCO. This study aimed to statistically analyze the types of oral and maxillofacial problems and corresponding treatments provided from October 2018 to September 2022, and to describe the trends of dental service pre and post COVID-19 outbreak.

Methods: The medical records of all patients visited to the CHN L2 during the 48 months were collected and were accessed for the research purposes between October 2018 and September 2022.

Printability in Multi-material Projection-Based 3-Dimensional Bioprinting.

Accurately reconstructing the intricate structure of natural organisms is the long-standing goal of 3-dimensional (3D) bioprinting. Projection-based 3D printing boasts the highest resolution-to-manufacturing time ratio among all 3D-printing technologies, rendering it a highly promising technique in this field. However, achieving standardized, high-fidelity, and high-resolution printing of composite structures using bioinks with diverse mechanical properties remains a marked challenge.

Intelligent tetrahydrothiophene gas detection based on electrochemical sensor array.

With extensive use of natural gas energy, various gas accidents occur frequently. Reasonable odorization of natural gas is an effective way to detect gas leakage in time and avoid gas explosions. Therefore, it is necessary to realize the identification and concentration detection of natural gas odorants to ensure early warning without degrading the gas quality.

Robust Time-Varying Formation Control of One-Sided Lipschitz Nonlinear Multiagent System With Delays via Optimization Algorithm.

This article develops a novel robust control methodology for nonlinear multiagent systems (MASs) to address the time-varying formation (TVF) problem. The methodology offers a concise yet efficacious technique based on the Lyapunov functional for more general one-sided Lipschitz (OSL) nonlinear MASs with external disturbances and time-varying delays. Note that most existing TVF controllers can only achieve formation targets under small delays, which significantly limits their performance.

Membership-Functions-Dependent Resilient Hybrid-Triggered Passivity Control for Networked Fuzzy Systems Against Deception Attacks.

In this work, membership-functions-dependent resilient hybrid-triggered (HT) passivity control is considered for networked fuzzy systems against deception attacks. To mitigate the transmission burden and enhance resilience to attacks, a resilient membership-functions-dependent HT mechanism is proposed that considers the properties of a Takagi-Sugeno fuzzy model. The presented HT strategy incorporates membership functions to generalize the HT threshold and weighting matrices.

Hyaluronic acid-liposomes hybridized with HucMSC exosomes for enhanced exosomes transdermal delivery and acute skin photodamage repair.

Long-term exposure to ultraviolet (UV) radiation can damage human skin, resulting in photodamage. Repairing photodamaged skin has been a major focus of research in recent years. Extensive research has shown that human umbilical cord mesenchymal stem cell-derived exosomes (Exo) possess anti-inflammatory, pro-angiogenic, and wound healing properties, holding great potential for treating skin damage.

Developing Single-Ion Conductor Polymer Electrolytes for Rechargeable Magnesium Batteries: A Concept.

Single-ion conductor polymer electrolytes (SICPEs), which exhibit a transference number (t) approaching unity, offer significant advantages for rechargeable magnesium batteries (RMBs). These advantages include reducing parasitic side reactions from salt anions, promoting the uniform deposition of Mg during cycling, and enhancing the overall performance and stability of full cells. Despite these promising benefits, research on SICPEs for RMBs is still in its early stages, with many challenges remaining to be addressed.

Hepatic microRNA-320 restrains ferroptosis to mitigate acute-on-chronic alcohol-induced liver injury.

Alcohol-associated Liver Disease (ALD) is one of the major chronic liver diseases worldwide and has high mortality and high incidence rate. microRNA-320 (miR-320), a highly conserved and widely expressed miRNA, has been reported to be involved in lipid metabolism; however, whether miR-320 affects the progression of ALD remains unclear. In this study, we demonstrated that hepatic miR-320 was significantly downregulated in chronic-plus-binge alcohol-fed mice.

Construction of the Red Swamp Crayfish () Family Selection Population and Whole Genome Sequencing to Screen Candidate Genes Related to Growth.

is an important freshwater aquaculture species in China which has the characteristics of rich nutrition and delicious taste. However, the expansion of aquaculture scale, germplasm degradation, and other problems that have become increasingly prominent seriously restrict the sustainable development of the crayfish industry. Genetic improvement is an urgent need for the crayfish aquaculture industry, and selective breeding is an important way to improve the crayfish varieties.

Study on Mechanical Properties and Impact Energy Release Characteristics of Skeleton-Structured Al/Ni Reactive Materials.

Reactive materials can be employed to realize the integration of damage element kinetic energy and chemical energy damage, as well as strengthen the destruction ability of warheads. Among them, Al/Ni material has become a research hotspot because of its simple structure, easy process, and high reaction heat. In this paper, a skeleton-structured Al/Ni reactive material was successfully prepared.

Biological Reinforced Concrete for Cartilage Repair With 3D Printing.

The development of biomimetic cartilage constructs (BCCs) with natural extracellular matrix (ECM) microenvironments and topological cues to accelerate the reconstruction of natural articular cartilage (NAC) after injury is challenging due to its complex structure, low cellular content, and less vascularity. Inspired by concrete rebar structure, a biomimetic cartilage named "biological reinforced concrete" is fabricated, with collagen fiber orientation transitioning from parallel to perpendicular, replicating the ECM microenvironments and complex construct of NAC. 3D-printed ultrafine fiber networks (UFNs) served as a degradable "biorebars", while a hybrid biohydrogel acted as "biocement".

Cirsiliol suppresses the proliferation of human oral cancer cells by targeting topoisomerase I.

Oral cancer poses a significant global health challenge, with increasing incidence rates and substantial morbidity and mortality. This study aimed to investigate the antiproliferative effects of cirsiliol in human oral cancer cells. Results from the MTT cell viability assay showed that cirsiliol significantly ( < 0.

Mesenchymal Stromal Cell-Based Therapy: A Promising Approach for Autoimmune Diseases.

Autoimmune diseases are characterized by immune dysregulation, resulting in aberrant reactivity of T cells and antibodies to self-antigens, leading to various patterns of inflammation and organ dysfunction. However, current therapeutic agents exhibit broad-spectrum activity and lack disease-specific selectivity, leading to enduring adverse effects, notably severe infections, and malignancies, and patients often fail to achieve the intended clinical goals. Mesenchymal stromal cells (MSCs) are multipotent stromal cells that can be easily derived from various tissues, such as adipose tissue, umbilical cords, Wharton's jelly, placenta, and dental tissues.

SIRT1 Alleviates Oxidative Stress-Induced Mitochondrial Dysfunction and Mitochondria-Associated Membrane Dysregulation in Stress Urinary Incontinence.

The pathogenesis of stress urinary incontinence (SUI), a condition common in women, remains to be fully elucidated. This study revealed that the incidence of SUI is associated with mitochondrial homeostasis dysregulation following oxidative stress in the fibrous connective tissue of the pelvic floor. SIRT1 is an essential factor for maintaining mitochondrial homeostasis; however, its potential role and mechanism of action in SUI pathogenesis remain unclear.

Hemodynamics are associated with subsequent lumen remodeling and clinical maturation of hemodialysis arteriovenous fistula.

The pathogenesis of arteriovenous fistula (AVF) maturation failure is unclear. We evaluated the associations of wall shear stress (WSS) with subsequent AVF remodeling and clinical maturation using regression models in this prospective cohort study. Participants underwent duplex ultrasound at postoperative Day 1, Week 2, and Week 6 to measure AVF blood flow rate and diameter of the draining vein and proximal artery.

Multieffect Specific Nanovesicles for Homing Resistant Tumors and Overcoming Osimertinib-Acquired Resistance in NSCLC.

Acquired resistance to osimertinib (Osi) remains a major obstacle in the treatment of patients with EGFR-mutant non-small cell lung cancer (NSCLC). AXL elevation is a known key mechanism of Osi-resistance, and therapeutic strategies remain scarce. Emerging evidence reveals that an increased intracellular glutathione (GSH) level induces Osi resistance.

Short-term effects of air pollution on the infectious disease spectrum in Shanghai, China: a time-series analysis from 2013 to 2019.

Background: Epidemiological evidence on the effects of air pollution on infectious diseases remains inconsistent, highlighting the need for further research and analysis. We aimed to investigate the relationship between exposure to fine particulate matter (PM) and ozone (O) and the risk of national notifiable infectious diseases in Shanghai, a megacity in China.

Methods: A double-pollutant model was used for each air pollutant, utilizing time-series analysis to separately apply single and distributed lag models (DLMs) to assess the exposure-lag-response relationship for 43 national notifiable infectious diseases (NNIDs) from 2013 to 2019.

West-East Hydrogen Transmission: Mode selection and key factor analysis of green hydrogen supply chain.

Promoting the transformation of the energy structure and establishing a diversified clean energy system are essential for achieving China's goal of "dual carbon". It is worth noting that hydrogen energy plays a significant role in this energy structure transformation. This study aims to select the optimum green hydrogen supply chain mode and analyze the impact of key factors, considering the entire green hydrogen supply chain, including production, compression and storage, transportation, and refueling.

CircFUNDC1 interacts with CDK9 to promote mitophagy in nucleus pulposus cells under oxidative stress and ameliorates intervertebral disc degeneration.

Intervertebral disc degeneration (IVDD) is a leading cause of low back pain, with limited effective treatments due to an incomplete understanding of disease mechanisms. In this study, we report that circFUNDC1, a nuclear circular RNA, is markedly downregulated in nucleus pulposus cells (NPCs) from patients with end-stage IVDD. CircFUNDC1 is derived from the gene encoding the FUN14 domain-containing 1 (FUNDC1) protein, which is essential for mitophagy and cell survival.