Multi-modal feature fusion with multi-head self-attention for epileptic EEG signals.

It is important to classify electroencephalography (EEG) signals automatically for the diagnosis and treatment of epilepsy. Currently, the dominant single-modal feature extraction methods cannot cover the information of different modalities, resulting in poor classification performance of existing methods, especially the multi-classification problem. We proposed a multi-modal feature fusion (MMFF) method for epileptic EEG signals.

Thrombopoietin improves the functions of bone marrow endothelial progenitor cells via METTL16/Akt signalling of haematological patients with chemotherapy-induced thrombocytopenia.

Bone marrow endothelial progenitor cells (BM EPCs) are crucial in supporting haematopoietic regeneration, while the BM EPCs of haematological patients with chemotherapy-induced thrombocytopenia (CIT) are unavoidably damaged. Therefore, the present study aimed to examine the effect of thrombopoietin (TPO) on the recovery of BM EPCs of CIT patients and to identify the underlying mechanisms. The cell functions were determined by 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (Dil)-acetylated low-density lipoprotein (Dil-Ac-LDL) uptake and fluorescein isothiocyanate (FITC)-labeled Ulex europaeus agglutinin-I (FITC-UEA-I) binding assay, as well as proliferation, migration and tube formation experiments.

[Analysis of food carbon footprint and its socio-demographic disparities in China in 2018].

Objective: To analyze food carbon footprint and its socio-demographic disparities among adults in China.

Methods: A total of 12 777 adults aged 18 years and above from the China Health and Nutrition Survey in 2018 who have completed dietary and socio-demographic data were analyzed. The information of food intake were collected by 24 h recalls combined with the weighing of household seasonings.

Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson's disease through Mfn2-cGAS signaling.

Background: Senescent astrocytes play crucial roles in age-associated neurodegenerative diseases, including Parkinson's disease (PD). Metformin, a drug widely used for treating diabetes, exerts longevity effects and neuroprotective activities. However, its effect on astrocyte senescence in PD remains to be defined.

Avatrombopag for the salvage treatment of platelet transfusion refractoriness.

Background: Platelet transfusion refractoriness (PTR) is a life-threatening and intractable condition in hematological patients. Thrombopoietin receptor agonists such as avatrombopag promote platelet production and modulate immune intolerance. However, its application in PTR has not been extensively studied.

[Epidemiological characteristics of cardio-metabolic risk factors in women aged 15-49 years in 4 provinces of China in 2018].

Objective: To analyze the prevalence of cardio-metabolic(CM) risk in women aged 15-49 years in 4 provinces of China and the influence of socioeconomic factors on them.

Methods: A total of 2851 women aged 15-49 years from Community-based Cohort Study on Nervous System Disease in 2018 were selected. Obesity, central obesity, elevated triglyceride(TG), elevated total cholesterol(TC), decreased high-density lipoprotein cholesterol(HDL-C), elevated low-density lipoprotein cholesterol(LDL-C), elevated blood pressure, elevated blood glucose and risk factor aggregation were analyzed.

A strategy to reduce the byproduct glucose by simultaneously producing levan and single cell oil using an engineered Yarrowia lipolytica strain displaying levansucrase on the surface.

Currently, levan is attracting attention due to its promising applications in the food and biomedical fields. Levansucrase synthesizes levan by polymerizing the fructosyl unit in sucrose. However, a large amount of the byproduct glucose is produced during this process.

Detecting slow eye movements using multi-scale one-dimensional convolutional neural network for driver sleepiness detection.

Background: Slow eye movements (SEMs), which occurs during eye-closed periods with high time coverage rate during simulated driving process, indicate drivers' sleep onset.

New Method: For the multi-scale characteristics of slow eye movement waveforms, we propose a multi-scale one-dimensional convolutional neural network (MS-1D-CNN) for classification. The MS-1D-CNN performs multiple down-sampling processing branches on the original signal and uses the local convolutional layer to extract the features for each branch.

Trajectories of Meat Intake and Risk of Type 2 Diabetes: Findings from the China Health and Nutrition Survey (1997-2018).

Few articles have investigated the impact of long-term meat intake trends and their changes during follow-up on the risk of type 2 diabetes (T2D). We aimed to explore the long-term trajectories of meat intake and determine its association with T2D risk in Chinese adults. This study used seven rounds of data from the China Health and Nutrition Survey (1997, 2000, 2004, 2006, 2009, 2015, and 2018), and 4464 adults aged 18 years or older were analyzed.

[Cardiovascular health status and related factors among adults aged 20-59 in 15 provinces of China in 2018].

Objective: To evaluate the cardiovascular health status of Chinese adults and explore the related influencing factors.

Methods: Adults aged 20-59 from the China Health and Nutrition Survey covering 15 provinces and cities in 2018 were selected as the study subjects. The average score of 8 health factors was calculated using the definition of the "Life's Essential 8" for cardiovascular health released by the American Heart Association in 2022.

[Analysis of differentiated regional dietary patterns of adults aged 18-64 years in 15 provinces( autonomous regions, municipalities) in 2018].

Objective: To analyze the dietary patterns of Chinese adults in 15 provinces and cities in China.

Methods: A total of 9208 adults aged 18-64 from the "China Health and Nutrition Survey" in 2018 were selected as subjects. Food consumption data were collected through 3 d-24 h dietary recalls and weighing household cooking oil and condiments, and the average daily dietary nutrient intake was calculated by the food composition table.

Association between regional dietary patterns and cardiovascular health status among elderly in China.

Objectives: To evaluate the cardiovascular health (CVH) status of the elderly and analyze the effects of dietary patterns and demographic characteristics on CVH.

Methods: A total of 4299 individuals aged 60 years and above from the China Health and Nutrition Survey in 2018 were selected as the research objects. Cluster analysis was used to analyze the dietary patterns.

Association of egg intake with risks of cardiometabolic factors among adults in China.

Objective: To explore the association between egg intake and cardiometabolic factors (CMFs) in Chinese adults.

Method: The subjects were 6,182 adults aged 18-64 who had complete survey data and had no CMFs at baseline. Egg intake was assessed with 3 days-24 h dietary recalls in all waves of the China Health and Nutrition Survey (CHNS).

Identification of Potential miRNA-mRNA Regulatory Network Associated with Pig Growth Performance in the Pituitaries of Bama Minipigs and Landrace Pigs.

Pig growth performance is one of the criteria for judging pork production and is influenced by genotype and external environmental factors such as feeding conditions. The growth performance of miniature pigs, such as Bama minipigs, differs considerably from that of the larger body size pigs, such as Landrace pigs, and can be regarded as good models in pig growth studies. In this research, we identified differentially expressed genes in the pituitary gland of Bama minipigs and Landrace pigs.

Peptides Isolated from Amphibian Skin Secretions with Emphasis on Antimicrobial Peptides.

The skin of amphibians is a tissue with biological functions, such as defense, respiration, and excretion. In recent years, researchers have discovered a large number of peptides in the skin secretions of amphibians, including antimicrobial peptides, antioxidant peptides, bradykinins, insulin-releasing peptides, and other peptides. This review focuses on the origin, primary structure, secondary structure, length, and functions of peptides secreted from amphibians' skin.

Health Effects of Peptides Extracted from Deer Antler.

Deer antler is widely used as a nutraceutical in Asian countries. In the past decades, deer antler peptides (DAPs) have received considerable attention because of their various biological properties such as antioxidant, anti-inflammatory, anti-bone damage, anti-neurological disease, anti-tumor and immunomodulatory properties. This review describes the production methods of DAPs and the recent progress of research on DAPs, focusing on the physiological functions and their regulatory mechanisms.

Edge electron-rich carbon nitride via π-acceptor frame with high-efficient charge separation for photocatalytic hydrogen evolution and environmental remediation.

Carbon nitride (g-CN) has broad application prospects in photocatalytic hydrogen production, but its photocatalytic efficiency is not ideal because of the rapid recombination of photogenerated electrons and holes. Herein, we developed a green strategy to fabricate hydroxyls and carbon-bridging co-modified g-CN (CCN-OH) through a one-pot copolymerization and hydrothermal treatment. Experiments and density functional theory (DFT) calculations illustrated that carbon substitution of partial bridge nitrogen can improve the degree of electron delocalization to enhance the electron supply capacity of g-CN, and the exsitence of the electron-withdrawing OH group induces electron migration from carbon nitride to hydroxyl group, which further improves the efficiency of photogenerated charge separation.

Relationship between Dietary Magnesium Intake and Metabolic Syndrome.

Metabolic syndrome (MetS) is increasingly prevalent, and the relationship between dietary magnesium and MetS remains controversial. Therefore, we aimed to explore the association and dose-response relationship between dietary magnesium intake and MetS and its single component. The sample was adults aged 18 years and above who participated in at least two follow-up surveys in 2009, 2015 and 2018.

Association of Serum Magnesium with Insulin Resistance and Type 2 Diabetes among Adults in China.

Magnesium is an essential mineral for the human body and a cofactor or activator for more than 300 enzymatic reactions, including blood glucose control and insulin release. Diabetes is a well-known global burden of disease with increasing global prevalence. In China, the prevalence of diabetes in adults is higher than the global average.

A Novel miRNA Y-56 Targeting IGF-1R Mediates the Proliferation of Porcine Skeletal Muscle Satellite Cells Through AKT and ERK Pathways.

As a key regulator of gene transcription and post-transcriptional modification, miRNAs play a wide range of roles in skeletal muscle development. Skeletal muscle satellite cells contribute to postnatal growing muscle fibers. Thus, the goal of this study was to explore the effects of novel miRNA Y-56 on porcine skeletal muscle satellite cells (PSCs).

Key pituitary miRNAs mediate the expression of pig GHRHR splice variants by regulating splice factors.

The growth hormone releasing hormone receptor (GHRHR) is well documented in organism growth and its alternative splicing may generate multiple functional GHRHR splice variants (SVs). Our previous study has demonstrated the key pituitary miRNAs (let-7e and miR-328-5p) in pig regulated the expression of GHRHR SVs by directly targeting to them. And according to recent reports, the interplay between miRNA-based silencing of mRNAs and alternative splicing of pre-mRNAs is a crucial post-transcriptional mechanism.

Nitrobenzene inarched carbon nitride nanotube drives efficient directional carriers separation for superior photocatalytic hydrogen production.

Carbon nitride (g-CN) is aussichtsreich for photocatalytic hydrogen evolution, but its photocatalytic activity is not ideal due to the existence of photogenerated electrons and holes in the form of excitons. Herein, a novel nitrobenzene inarched g-CN nanotube photocatalyst (CN-DNP) was firstly fabricated via a facial copolymerization method. The aromatic ring in nitrobenzene could enhance the conjugation of carbon nitride to promote electron delocalization.

Sulfur/phosphorus doping-mediated morphology transformation of carbon nitride from rods to porous microtubes with superior photocatalytic activity.

Hetero-atoms doping or morphology controlling of carbon nitride (g-CN) can availably regulate its electronic band structure and optimize photocatalytic performance under visible light. Herein, sulful (S), phosphorus (P) co-doped porous carbon nitride microtubes (SPCN) was synthesized by using ammonium dihydrogen phosphate and melamine as precursors, in which ammonium dihydrogen phosphate can not only control the morphology of carbon nitride from nanorods to porous microtubes, but also provide a potential P source for P-doped CN. The prepared SPCN0.

Silencing of lncRNA SNHG12 inhibits proliferation and migration of vascular smooth muscle cells via targeting miR-766-5p/EIF5A axis.

Background: Although long non-coding RNAs (lncRNAs) have been reported to serve as potential biomarkers of atherosclerosis (AS), the role of lncRNA small nucleolar RNA host gene 12 (SNHG12) in AS still remains to be elucidated.

Objectives: The present study aimed to investigate the regulatory effects and potential mechanisms of SNHG12 in human vascular smooth muscle cells (hVSMCs).

Material And Methods: Reverse-transcription quantitative polymerase chain reaction (RT-qPCR) was employed to determine the expression of SNHG12, miR-766-5p and eukaryotic translation initiation factor 5A (EIF5A) in oxidized low-density lipoprotein (ox-LDL)-induced hVSMCs.