Smartphone-assisted hydrogel sensing platform based on double emission carbon dots for portable on-site tetracycline detection.

Innovative double-emission carbon dots (DE-CDs) were synthesized via a one-step hydrothermal method using fennel and m-phenylenediamine (m-PD) as precursors. These DE-CDs exhibited dual emission wavelengths at 432 and 515 nm under different excitations, making them highly versatile for fluorescence-based applications. The fluorescence of the DE-CDs was efficiently quenched by tetracycline (TC) through the inner filter effect (IFE), allowing for the construction of a sensitive dual-response fluorescent sensor.

End-of-Life Inpatient Palliative Care for Glioblastoma Multiforme: Lessons Learned from One Case.

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor with a poor prognosis and limited survival. Patients with GBM have a high demand for palliative care. In our present case, a 21-year-old female GBM patient received inpatient palliative care services including symptom management, mental and psychological support for the patient, psychosocial and clinical decision support for her family members, and pre- and post-death bereavement management for the family.

Research Hotspots and Trends in the Antioxidant Effects of Acupuncture: A Bibliometric analysis from 2003 to 2024.

Objective: Oxidative stress is an important factor mediating the pathologic progression of many diseases. In recent years, the antioxidant effects of acupuncture have been gradually confirmed. However, bibliometric analysis in this field, which is still lacking.

Spatial metabolomics and feature-based molecular networking to unveiling in-situ quality markers landscape and reflecting geographic origins of pomegranate seeds.

Pomegranate seeds, a by-product of pomegranate processing, are gaining attention in food industries due to their high antioxidant activity. However, the lack of quality markers reflecting activity and spatial characteristics limits their utilization and product stability. In this research, a selective and sensitive method integrating ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry with feature-based molecular networking, and desorption electrospray ionization-mass spectrometry imaging developed to identify components and locate in-situ images of quality markers via spatial metabolomics analysis.

AIScholar: An OpenFaaS-enhanced cloud platform for intelligent medical data analytics.

This paper presents AIScholar, an intelligent research cloud platform developed based on artificial intelligence analysis methods and the OpenFaaS serverless framework, designed for intelligent analysis of clinical medical data with high scalability. AIScholar simplifies the complex analysis process by encapsulating a wide range of medical data analytics methods into a series of customizable cloud tools that emphasize ease of use and expandability, within OpenFaaS's serverless computing framework. As a multifaceted auxiliary tool in medical scientific exploration, AIScholar accelerates the deployment of computational resources, enabling clinicians and scientific personnel to derive new insights from clinical medical data with unprecedented efficiency.

Biomarkers.

Background: The pathophysiological evolutions involved in early-stage Alzheimer's disease (AD) are not well understood.

Methods: We used data of 2,923 plasma proteins from 51,296 non-demented middle-aged adults in the UK Biobank with 15 years of follow-up. We first identified AD-associated proteins using Cox proportional hazard models and then delineated their temporal sequences to characterize the pathophysiological evolution.

Drug Development.

Background: Pivotal Alzheimer's Disease (AD) trials typically require thousands of participants, resulting in long enrollment timelines and substantial costs. We leverage deep learning predictive models to create prognostic scores (forecasted control outcome) of trial participants and in combination with a linear statistical model to increase statistical power in randomized clinical trials (RCT). This is a straightforward extension of the traditional RCT analysis, allowing for ease of use in any clinical program.

HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY.

The current research revealed a strong link between lipid reprogramming and dysregulated lipid metabolism to the genesis and development of clear cell renal cell carcinoma (ccRCC). Pathologically, ccRCC exhibits a high concentration of lipid droplets within the cytoplasm. HIF-2α expression has previously been demonstrated to be elevated in ccRCC caused by mutations in the von Hippel-Lindau (VHL) gene, which plays a vital role in the development of renal cell carcinoma.

"Modified arthroscopic disc repositioning and suturing technique for the treatment of TMJ anterior disc displacement without reduction: A technical note".

Anterior disc displacement without reduction (ADDwoR) is one of the most common types temporomandibular disorders (TMD), which is often characterized by joint pain, abnormal joint sounds, and limited mouth opening. Disc repositioning has been described as an effective method to reduce joint pain and improve range of motion. Yang's arthroscopic disc repositioning and suturing surgery has been reported to be the most stable technique with 95%-98% of success rate.

Structural characterization of polysaccharide from an edible fungus Dictyophora indusiata and the remodel function of gut microbiota in inflammatory mice.

Dictyophora indusiata is an edible fungus, which is known as bamboo fungus. D. indusiata polysaccharide is considered as the most important bioactive component.

Exploring the impact of environmental factors on male reproductive health through epigenetics.

Male infertility has become an increasingly severe global health issue, with its incidence significantly rising over the past few decades. This paper delves into the crucial role of epigenetics in male reproductive health, focusing particularly on the effects of DNA methylation, histone modifications, chromatin remodeling and non-coding RNAs regulation on spermatogenesis. Exposure to various environmental factors can cause sperm DNA damage, leading to epigenetic abnormalities.

Formation Dynamics of Thermally Stable 1D/3D Perovskite Interfaces for High-Performance Photovoltaics.

Direct understanding of the formation and crystallization of low-dimensional (LD) perovskites with varying dimensionalities employing the same bulky cations can offer insights into LD perovskites and their heterostructures with 3D perovskites. In this study, the secondary amine cation of N-methyl-1-(naphthalen-1-yl)methylammonium (M-NMA) and the formation dynamics of its corresponding LD perovskite are investigated. The intermolecular π-π stacking of M-NMA and their connection with inorganic PbI octahedrons within the product structures control the formation of LD perovskite.

BTK inhibition in primary central nervous system lymphoma: mechanisms, clinical efficacy, and future perspectives.

The prognosis of primary central nervous system lymphoma (PCNSL) patients is relatively poor, and there is currently no standard treatment plan. Most patients choose high-dose chemotherapy based on methotrexate. While traditional chemotherapy combined with biological therapy has achieved limited results, some patients still do not respond to treatment or cannot tolerate its toxicity and side effects.

Bibliometric analysis of nurses' moral distress research.

Objective: To identify the research status of nurses' moral distress and predict emerging research hotspots and development trends.

Methods: Articles on nurses' moral distress were retrieved from the Web of Science Core Collection database from the inception of the database to 2024. A bibliometric analysis was conducted using VOSviewer and CiteSpace software to analyze publication distributions by country, institution, journal, author contributions, keyword trends, and reference co-citations.

Characterization of children's prospective prescription review and exploration of factors influencing the success of interventions.

Background: Medication safety is crucial in clinical care. Although many hospitals have implemented prospective prescription review systems to manage medication use, the impact of these systems on pediatric patients is not yet fully understood.

Objectives: We explore the characteristics and economic impacts of pediatric prospective prescription review and identify factors influencing intervention success rates.

Variables associated with cognitive function: an exposome-wide and mendelian randomization analysis.

Background: Evidence indicates that cognitive function is influenced by potential environmental factors. We aimed to determine the variables influencing cognitive function.

Methods: Our study included 164,463 non-demented adults (89,644 [54.

Development of a Synthetic VP1 Protein Peptide-Based ELISA to Detect Antibodies Against Porcine Bocavirus Group 3.

Porcine bocavirus (PBoV), classified within the genus Bocaparvovirus, has been reported worldwide. PBoV has been divided into group 1, group 2, and group 3. PBoV group 3 (G3) viruses are the most prevalent in China.

Association of TyG Index and TG/HDL-C Ratio with Trajectories of Depressive Symptoms: Evidence from China Health and Retirement Longitudinal Study.

Objectives: To explore whether the triglyceride-glucose (TyG) index and the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio are associated with the trajectories of depressive symptoms.

Methods: In this longitudinal study, 4215 participants aged 45 years and older were recruited from the China Health and Retirement Longitudinal Study from 2011 to 2018. The trajectories of depressive symptoms, measured by the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10), were identified using group-based trajectory modeling.

First Detection of a Novel Posavirus 2 Strain Identified from Pigs in China.

Porcine stool-associated RNA virus (Posavirus) is an unclassified virus with sequence similarity to viruses in the order of Picornaviridae. In China, lineage 1 Posavirus (Posavirus 1) has been circulating in the field since its initial emergence in 2014 however no other lineages have been reported. To investigate the genetic diversity of Posavirus in China, 1200 diarrheic samples were collected from pigs in China.

Association Between Long Term Exposure to PM and Its Components on Severe Obesity in Chinese Children and Adolescents: A National Study in China.

Background: The aim of this study was to explore the association between long-term exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM) and its components and severe obesity in children and adolescents.

Methods: Data for children and adolescents aged 9-18 in this cross-sectional study were obtained from the 2019 Chinese National Survey on Students' Constitution and Health (CNSSCH).

Machine learning analysis of factors affecting college students' academic performance.

This study aims to explore various key factors influencing the academic performance of college students, including metacognitive awareness, learning motivation, participation in learning, environmental factors, time management, and mental health. By employing the chi-square test to identify features closely related to academic performance, this paper discussed the main influencing factors and utilized machine learning models (such as LOG, SVC, RFC, XGBoost) for prediction. Experimental results indicate that the XGBoost model performs the best in terms of recall and accuracy, providing a robust prediction for academic performance.

Accurate DNA Sequence Prediction for Sorting Target-Chirality Carbon Nanotubes and Manipulating Their Functionalities.

Synthetic single-wall carbon nanotubes (SWCNTs) contain various chiralities, which can be sorted by DNA. However, finding DNA sequences for this purpose mainly relies on trial-and-error methods. Predicting the right DNA sequences to sort SWCNTs remains a substantial challenge.

Turning the band alignment of carbon dots for visible-light-driven enzymatic asymmetric reduction of aromatic ketone.

Keto reductases are crucial NAD(P)H-dependent enzymes used for the enantioselective synthesis of alcohols from prochiral ketones. Typically, the NADPH cofactor is regenerated through a second enzyme and/or substrate. However, photocatalytic cofactor regeneration using water as a sacrificial electron and hydrogen donor presents a promising alternative, albeit a challenging one.

Sex-Stratified Bidirectional Mendelian Randomization Analysis of Eating Habits and Female Pelvic Peritoneal Adhesions.

Background: Female pelvic peritoneal adhesions (FPPA) represent a significant global health burden. Dietary habits play a crucial role in health outcomes, yet their influence on FPPA remains unclear. This study aims to explore the bidirectional causal relationships between 72 eating habits and FPPA using sex-stratified Mendelian randomization (MR).