Multimodal assessment predicts cognitive impairment after aneurysmal subarachnoid hemorrhage: a prospective cohort study.

Background: Risk factors and mechanisms of cognitive impairment (CI) after aneurysmal subarachnoid hemorrhage (aSAH) are unclear. This study used a neuropsychological battery, MRI, ERP and CSF and plasma biomarkers to predict long-term cognitive impairment after aSAH.

Materials And Methods: 214 patients hospitalized with aSAH (n = 125) or unruptured intracranial aneurysms (UIA) (n = 89) were included in this prospective cohort study.

AURKB affects the proliferation of clear cell renal cell carcinoma by regulating fatty acid metabolism.

Background: Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer with a high metastatic rate and high mortality rate. The molecular mechanism of ccRCC development, however, needs further study. Aurora kinase B (AURKB) functions as an important oncogene in various tumors; therefore, in the present study, we aimed to explore the mechanism by which AURKB affects ccRCC development.

Efficacy of the nutritional support team model in the management of patients undergoing total gastrectomy combined with Roux-en-Y anastomosis.

Objective: To explore the efficacy of the nutritional support team (NST) management model in patients undergoing total gastrectomy combined with Roux-en-Y anastomosis.

Methods: Clinical data of 102 patients who underwent total gastrectomy combined with Roux-en-Y anastomosis in Xingtai Central Hospital from January 2020 to October 2023 were retrospectively collected. Of 102 patients, 53 received the NST model of management (NST group), while 49 were managed by the conventional nutritional support (TN group).

Efficacy, Safety, Pharmacokinetics, and Immunogenicity of ABBV-154 in Adults With Glucocorticoid-Dependent Polymyalgia Rheumatica: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial.

Objective: An unmet need exists for glucocorticoid-sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody-drug conjugate ABBV-154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV-154 versus placebo in patients with glucocorticoid-dependent PMR.

Anchoring Ag(I) into MOF-253 for Effectively Catalyzing Cycloaddition of CO with Alkynyl Alcohols/Amine under Ambient Conditions.

In the era of global warming, the conversion of carbon dioxide into high-value products has become a widely scrutinized emerging mitigation strategy. Metalation of bpy-containing MOF-253 led to the synthesis of MOF-253-0.5Ag, which acts as an efficient catalyst for the carbonylative cyclization of CO with alkyne molecules (such as propynyl alcohols and propynyl amines) at room temperature and ambient CO pressure, yielding the corresponding α-alkyl cyclic carbonates and oxazolidinones, thus endowing the catalytic system with bifunctional characteristics.

Divergent responses of plant multi-element coupling to nitrogen and phosphorus addition in a meadow steppe.

The intricate biogeochemical cycling of multiple elements plays a pivotal role in upholding a myriad of ecosystem functions. However, our understanding of elemental stoichiometry and coupling in response to global changes remains primarily limited to plant carbon: nitrogen: phosphorus (C: N: P). Here, we assessed the responses of 11 elements in plants from different functional groups to global changes.

Finding a needle in a haystack: functional screening for novel targets in cancer immunology and immunotherapies.

Genome-wide functional genetic screening has been widely used in the biomedicine field, which makes it possible to find a needle in a haystack at the genetic level. In cancer research, gene mutations are closely related to tumor development, metastasis, and recurrence, and the use of state-of-the-art powerful screening technologies, such as clustered regularly interspaced short palindromic repeat (CRISPR), to search for the most critical genes or coding products provides us with a new possibility to further refine the cancer mapping and provide new possibilities for the treatment of cancer patients. The use of CRISPR screening for the most critical genes or coding products has further refined the cancer atlas and provided new possibilities for the treatment of cancer patients.

Effects of different water and fertilizer treatments on the matrix properties and plant growth of tailings waste.

Vegetation ecological restoration technology is widely regarded as an environmentally sustainable and green technology for the remediation of mineral waste. The appropriate ratio of amendments can improve the substrate environment for plant growth and increase the efficiency of ecological restoration. Herbs and shrubs are preferred for vegetation restoration in abandoned mines because of their rapid establishment and easy management.

The combination of hyperspectral imaging, untargeted metabolomics and lipidomics highlights a coordinated stress-related biochemical reprogramming triggered by polyethylene nanoparticles in lettuce.

Polyethylene nanoplastics (NPs) are widely diffused in terrestrial environments, including soil ecosystems, but the stress mechanisms in plants are not well understood. This study aimed to investigate the effects of two increasing concentrations of NPs (20 and 200 mg kg of soil) in lettuce. To this aim, high-throughput hyperspectral imaging was combined with metabolomics, covering both primary (using NMR) and secondary metabolism (using LC-HRMS), along with lipidomics profiling (using ion-mobility-LC-HRMS) and plant performance.

Melatonin protects aged oocytes from depalmitoylation-mediated quality reduction by promoting PPT1 degradation and antioxidation.

Oocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes in protein posttranslational modifications. However, the role of protein palmitoylation in oocyte aging has not been investigated. In the present study, a new association between redox and palmitoylation in aging oocytes was found.

An Investigation of the Influence of Paste's Rheological Characteristics on the Tensile Creep of HVFAC at Early Ages.

The rheological properties of concrete paste significantly influence its tensile creep behavior. In this study, the tensile creep behavior of high-volume fly ash concrete (HVFAC) employing the same cementitious pastes was experimentally investigated, and the rheological properties of the paste containing a high volume of fly ash using the (NI) technique was investigated in order to explore the influence of the paste's rheological properties (such as micro-mechanical properties and microscopic creep) on the early-age tensile creep of HVFAC. The results demonstrated that the micro-strain of paste containing a high volume of fly ash (HVFA) showed a larger value than that without fly ash.

Extracellular electron shuttles induced transformation and mobilization of Fe/As with the occurrence of biogenic vivianite.

Microorganisms that utilize organic matter to reduce Fe oxides/hydroxides constitute the primary geochemical processes controlling the formation of high-arsenic (As) groundwater. Biogenic secondary iron minerals play a significant role in As migration. However, the influence of quinone electron shuttles and competitive anionic phosphate on this process has not been thoroughly studied.

Assessing the efficacy of psychological interventions in enhancing the quality of life of patients diagnosed with cancer and psychiatric disorders: An umbrella analysis.

Background: Psychosocial interventions encompass psychotherapy and psychological education that explicitly target psychosocial adaptation. These interventions have been shown to have a substantial positive effect on reducing anxiety and depression, as well as improving overall quality of life (QoL). Nevertheless, there is still no consensus concerning the therapeutic effectiveness of these interventions.

BioGSF: a graph-driven semantic feature integration framework for biomedical relation extraction.

The automatic and accurate extraction of diverse biomedical relations from literature constitutes the core elements of medical knowledge graphs, which are indispensable for healthcare artificial intelligence. Currently, fine-tuning through stacking various neural networks on pre-trained language models (PLMs) represents a common framework for end-to-end resolution of the biomedical relation extraction (RE) problem. Nevertheless, sequence-based PLMs, to a certain extent, fail to fully exploit the connections between semantics and the topological features formed by these connections.

A Chromosome-Scale Genome of and Transcriptome-Based Screening for Light-Induced Genes That Promote Triterpene Biosynthesis.

is an important fungus with medicinal properties and a significant role in lignocellulose degradation. In this study, we constructed a high-quality chromosome-level genome of using Illumina, PacBio HiFi, and Hi-C sequencing technologies. The assembled genome is 47.

p54-Fc-Labeled Gold Nanoparticle-Based Lateral Flow Strip-Assisted Portable Devices for Rapid and Quantitative Point-of-Care Detection of ASFV Antibodies.

In this study, a novel rapid immunochromatographic (IC) test for African swine fever virus (ASFV) antibodies is presented. An immunochromatographic test (IC) is a detection technique that combines membrane chromatography with immunolabeling. This approach saves time for antibody preparation, resulting in a shorter production cycle.

Improved Entropy-Based Condition Monitoring for Pressure Pipeline Through Acoustic Denoising.

During long-term operation in complex environments, the pressure pipeline systems are prone to damage and faults, and serious safety accidents may occur without real-time condition monitoring. Moreover, in traditional non-contact monitoring approaches, acoustic signals are widely employed for condition monitoring for pressure pipelines, which are easily contaminated by background noise and provide unsatisfactory accuracy. As a tool for quantifying uncertainty and complexity, signal entropy is applied to detect abnormal conditions.

Neuromodulation technologies improve functional recovery after brain injury: from bench to bedside.

Spontaneous recovery frequently proves maladaptive or insufficient because the plasticity of the injured adult mammalian central nervous system is limited. This limited plasticity serves as a primary barrier to functional recovery after brain injury. Neuromodulation technologies represent one of the fastest-growing fields in medicine.

The relationship between psychological capital and athlete burnout: the mediating relationship of coping strategies and the moderating relationship of perceived stress.

Background: Athlete burnout represents a critical concern in sports psychology, significantly affecting athletes' well-being and performance. This study examined the relationships among psychological capital, coping strategies, perceived stress, and athlete burnout.

Methods: A cross-sectional survey was conducted among 344 athletes, and data were analyzed using SPSS Statistics 25.

Directed Evolution and Unusual Protonation Mechanism of Pyridoxal Radical C-C Coupling Enzymes for the Enantiodivergent Photobiocatalytic Synthesis of Noncanonical Amino Acids.

Visible light-driven pyridoxal radical biocatalysis has emerged as a new strategy for the stereoselective synthesis of valuable noncanonical amino acids in a protecting-group-free fashion. In our previously developed dehydroxylative C-C coupling using engineered PLP-dependent tryptophan synthases, an enzyme-controlled unusual α-stereochemistry reversal and pH-controlled enantiopreference were observed. Herein, through high-throughput photobiocatalysis, we evolved a set of stereochemically complementary PLP radical enzymes, allowing the synthesis of both l- and d-amino acids with enhanced enantiocontrol across a broad pH window.

Global burden of heart failure in children and adolescents from 1990 to 2019: an analysis from the Global Burden of Disease Study 2019.

Background: Heart failure (HF) significantly impacts the cardiovascular health of children and adolescents. This study aims to assess epidemiologic trends in HF across sex, age, region, and time period.

Methods: The number and age-standardized rate (ASR) of prevalence and years lived with disability (YLDs) were derived from the Global Burden of Disease Study 2019.

MGST1 overexpression ameliorates mitochondrial dysfunction and ferroptosis during myocardial ischemia/reperfusion injury after heart transplantation.

Mitochondrial dysfunction and ferroptosis play crucial roles in myocardial ischemia/reperfusion (I/R) following heart transplantation. Microsomal glutathione s transferase 1 (MGST1) is widely distributed in mitochondria and has a protective effect against ferroptosis, and its involvement in myocardial I/R injury has not yet been elucidated. In this study, donor hearts from C57BL/6 male mice were subjected to 12 h of ex-vivo cold ischemia treatment and transplanted into the abdomen of recipient mice for 24 h of reperfusion.

Key Performance Indicators for College American Football Starters: An Exploratory Study.

Objectives: The purpose of this study was twofold: (a) to profile body composition and physical fitness characteristics of collegiate American football starters and (b) to examine differences in key performance indicators across position groups. These indicators included select measures of body composition, joint kinematics, as well as muscular strength and power.

Methods: Sixteen National Collegiate Athletic Association (NCAA) Division-II American football athletes (age: 22.

DNA Origami Framework-Based Spatial Nanochip for Circular ssDNA Assembly and Data Storage.

A 3D DNA spatial chip (DSC) based on an icosahedral DNA origami framework is introduced to construct customized circular single-stranded DNA (c-ssDNA) for data storage. Within the confined space of the DSC, thirty addressable location sequences extending from the framework edges are available for designing circular paths and directing the assembly of a series of information oligonucleotides for efficient ligation. This strategy is verified by constructing c-ssDNAs from up to 15 fragments to encode two poems (800 and 860 nucleotides).

Bioactive Polysaccharides from Cremastra Appendiculata Attenuate Lipid Accumulation In Vitro Model of Non-Alcoholic Fatty Liver Disease.

Non-alcoholic fatty liver disease (NAFLD) is a most common chronic disease with a rapid growing incidence worldwide, presenting as an ever-increasing burden to the healthcare system. In this study, we explored that Cremastraappendiculata, a valuable traditional medicine in China, could alleviate lipid accumulation in HepG2 cells. Polysaccharide (CAP) was extracted from the pseudobulbs of C.