Lotus-inspired cellulose-based aerogel with Janus wettability and vertically aligned vessels for salt-rejecting solar seawater purification.

High-performance solar interface evaporators provide a promising, sustainable, and cost-effective solution to the global freshwater crisis through seawater purification. However, achieving a delicate balance between maximizing the evaporation rate and ensuring continuous, stable, and durable operation presents a critical challenge. Herein, we present a biomimetic cellulose/polypyrrole-coated silica/graphene evaporator with self-assembled nanofiber networks and vertically aligned vessels for enhanced salt resistance.

Iridium(III) Blue Phosphors with Heteroleptic Carbene Cyclometalates: Isomerization, Emission Tuning, and OLED Fabrications.

Ir(III) complexes are particularly noted for their excellent photophysical properties in giving blue OLED phosphors. In this study, two distinctive carbene pro-chelates LAH2+ and LBH2+ (or LCH2+) were employed in preparation of heteroleptic Ir(III) complexes, to which LAH2+ bears a cyano substituted benzoimidazolium along with N-mesityl appendage, while LBH2+ (or LCH2+) carries the symmetrical benzoimidazolium entity. Notably, the reversible equilibration at high temperature was observed for m, f-ct14 and m, f-ct15 with a single LA chelate.

Skin inflammation and lipid disorder induced by topical application of Mal f 1.

Objected: Mal f 1, the first allergen cloned from Malassezia furfur, has been found to have positive IgE reactivity in sera from patients with skin inflammation. In vitro, it has also been shown to induce maturation of dendritic cells and release inflammatory factors. However, its role in skin lipid homeostasis remains largely unexplored.

Genome-wide characterization of the TRP gene family and transcriptional expression profiles under different temperatures in gecko Hemiphyllodactylus yunnanensis.

Temperature is closely linked to the life history of organisms, and thus thermoception is an important sensory mechanism. Transient receptor potential (TRP) ion channels are the key mediators of thermal sensation. In this study, we analyzed the sequence characteristics of TRPs in gecko Hemiphyllodactylus yunnanensis and compared the phylogenetic relationships of TRP family members among different Squamata species.

Strong, ductile, and hierarchical hetero-lamellar-structured alloys through microstructural inheritance and refinement.

The strength-ductility trade-off exists ubiquitously, especially in brittle intermetallic-containing multiple principal element alloys (MPEAs), where the intermetallic phases often induce premature failure leading to severe ductility reduction. Hierarchical heterogeneities represent a promising microstructural solution to achieve simultaneous strength-ductility enhancement. However, it remains fundamentally challenging to tailor hierarchical heterostructures using conventional methods, which often rely on costly and time-consuming processing.

Polyphenol-mediated assembly of toll-like receptor 7/8 agonist nanoparticles for effective tumor immunotherapy.

Toll-like receptor (TLR) 7/8 agonists have shown significant potential in tumor immunotherapy. However, the limited pharmacokinetic properties and systemic toxicity resulting from off-target effects limits their biomedical applications. We here report the polyphenol-mediated assembly of resiquimod (R848, a TLR7/8 agonist) nanoparticles (RTP NPs) to achieve tumor-selective immunotherapy while avoiding systemic adverse effects.

The prevalence and profiles of adverse childhood experiences and their associations with adult mental health outcomes in China: a cross-sectional study.

Background: Adverse childhood experiences (ACEs) are common and associated with mental disorders. However, the prevalence and co-occurrence of ACEs and their association with mental health outcomes among Chinese adults have not been well demonstrated.

Methods: China Mental Health Survey, a cross-sectional nationally representative survey consisting of 28,140 adults, was conducted from July 2013 to March 2015.

Revealing Local Structure of Angiotensin Receptor-Neprilysin Inhibitor (S086) Drug Cocrystal by Linear and Nonlinear Infrared Spectroscopies.

Structurally knowing the active sites of a drug is important for understanding its therapeutic functions. S086 is a novel angiotensin receptor-neprilysin inhibitor that consists of the molecular moieties of EXP3174 (the active metabolite of the angiotensin receptor blocker losartan) and sacubitril (a neprilysin inhibitor prodrug) in a 1:1 molar ratio. There are two forms of cocrystals of S086, namely, ξ-crystal and α-crystal, which were formed both via intermolecular coordination bonding to calcium ions, with the aid of internal water.

Mycorrhizal fungi mitigate cadmium leaching losses by decreasing the inorganic cadmium proportion in soil solutions.

Arbuscular mycorrhizal fungi (AMF) are common in cadmium (Cd)-contaminated soil. However, the effects of AMF on Cd migration in contaminated soil are still poorly understood. A pot experiment involving a control without AMF inoculation (CK), inoculation with AMF (AMF), and bacterial filtrate of the AMF inoculant (LY) was conducted in the present study.

The β-Chain Mutation p.Arg17Stop Impairs Fibrinogen Synthesis and Secretion: A Nonsense Mutation Associated With Hypofibrinogenemia.

Background: Congenital hypofibrinogenemia, a quantitative fibrinogen disorder, is characterized by abnormally low levels of both functional and antigen fibrinogen. We identified a heterozygous nonsense mutation, p.Arg17Stop, in the fibrinogen Bβ chain of a three-month-old female infant.

Risk factors of allergic rhinitis and its prevention strategies.

Allergic rhinitis (AR) is a global disease with high prevalence. It reduces the patient's quality of life seriously. The health care and management of AR was also a heavy social burden.

Genome-wide screen and multi-omics analysis reveal participate in the biosynthesis of safflower flavonoid glycosides.

Safflower, an economic crop, is renowned for its flowers, which are widely used in medicines for treating cardiovascular and cerebrovascular diseases and in dyes for food and industry. The utility of safflower depends on its flavonoid glycosides. Therefore, the biosynthesis of safflower flavonoid glycosides has been a focus of attention, but the present mechanisms remain poorly understood.

Multifactorial influences on childhood insomnia: Genetic, socioeconomic, brain development and psychopathology insights.

Insomnia is the most prevalent sleep disturbance during childhood and can result in extensively detrimental effects. Children's insomnia involves a complex interplay of biological, neurodevelopmental, social-environmental, and behavioral variables, yet remains insufficiently addressed. This study aimed to investigate the multifactorial etiology of childhood insomnia from its genetic architecture and social-environmental variables to its neural instantiation and the relationship to mental health.

Development of a nomogram for high antibody titre of COVID-19 convalescent plasma.

This study aimed to develop a predictive tool for identifying individuals with high antibody titers crucial for recruiting COVID-19 convalescent plasma (CCP) donors and to assess the quality and storage changes of CCP. A convenience sample of 110 plasma donors was recruited, of which 75 met the study criteria. Using univariate logistic regression and random forest, 6 significant factors were identified, leading to the development of a nomogram.

Life-history traits trade-off in gecko (Gekko japonicus) under the influence of climate warming and spirotetramat: Different adaptations to stressors in female and male.

Global warming and rising surface temperatures are adversely affecting organisms. As the use of pesticides increases, concerns about their impacts on non-target organisms are growing. However, climate warming and pesticides may interact to produce combined effects on organisms.

A Highly Active Molybdenum Carbide Catalyst with Dynamic Carbon Flux for Reverse Water-Gas Shift Reaction.

Molybdenum carbide has been reported as an efficient and stable catalyst for reverse water-gas shift (RWGS) reaction. The conventional understanding of the mechanism suggests domination of the surface phenomena, with only surface or subsurface layers partaking in the catalytic cycle. In this study, we presented a highly active MoC catalyst from carburization process, which showed a mass-specific reaction rate over 260 μm with dynamic carbon flux in the bulk phase of the catalyst.

Association of tea consumption with life expectancy in US adults.

Objective: The association of tea consumption with life expectancy in US adults remains unclear. This study aimed to evaluate the correlation between tea consumption and life expectancy among US adults.

Methods: Tea consumption records and available mortality data from National Health and Nutrition Examination Survey 2001 to 2018 for adults ≥ 20 years of age were used (n = 43,276).

A multicenter study on the sex difference of dysfunctions among rehabilitation outpatients in China.

Dysfunction is a common clinical symptom among rehabilitation patients; however, whether there are sex differences in dysfunctions remains unclear. Therefore, this study aimed to explore this issue by examining a large sample of the population with dysfunctional problems. A multi-stage sampling scheme was used to select the rehabilitation outpatients as study participants.

Epigenetic effects of exercise on improving the adverse placental environment associated with maternal overweight and obesity.

Objective: We aimed to explore whether maternal exercise has epigenetic effects on improving the adverse placental environment associated with maternal overweight/obesity.

Methods: Based on samples collected from an RCT cohort, differentially methylated genes and expressed protein-coding RNA were identified in the placentas of 16 women with overweight and obesity who did or did not participate in an exercise intervention using the Infinium HumanMethylation850 BeadChip array and RNA Sequencing-Based lncRNA Profiling. Potential target genes were further identified by integrating this information.