Water triggered injectable polylactic acid hydrogel based on zwitterionic sulfobetaine modification for incompressible bleeding and tissue anti-adhesion.

Massive blood loss is the main cause of prehospital trauma-related death, the development of rapid and effective hemostatic materials is imminent. Injectable hydrogels have the advantages of covering irregular bleeding sites and quickly closing the wound. However, its inherent viscosity can easily precipitate tissue adhesion and other complications.

Fabrication of Self-Standing Inorganic-Organic Composite Films at a Miscible Interface by "Soft Spray" Technique.

Membranes have extensive applications in catalysis, separation, antimicrobial activities, and sensing. However, developing a simple and environmentally friendly method for preparing membranes remains challenging. Here, we report a novel strategy for fabricating self-standing inorganic-organic composite films at the miscible liquid/liquid interface using a soft spray technique.

Preparation of Carbon Dots with High Fluorescence Quantum Yields and its Detection of Hg in Simulated Wastewater.

Fluorescent carbon quantum dots (CDs) have received widespread attention for their potential applications in optical sensing. Meanwhile, as the importance of mercury ion (Hg) detection in the environment, the exploration of Hg fluorescent nanosensor based on CDs with high quantum yield is particularly intriguing. Herein, nitrogen-doped carbon quantum dots (N-CDs) were prepared by microwave method using citric acid as carbon source and urea as nitrogen source, and glycerol as microwave solvent.

Constructing Three-Dimensional Porous SnS/RGO as Superior-Rate and Long-Life Anodes for Lithium-Ion Batteries.

Tin-based sulfides, possessing a unique layered structure and a high theoretical capacity, stand as highly prospective contenders for anode materials in lithium-ion batteries (LIBs). Nevertheless, the pronounced volume expansion that occurs during lithium storage and poor capacity retention have limited its progress toward commercialization. Herein, we designed and prepared a SnS/RGO composite with a three-dimensional porous structure by sulfurizing the SnO(OH)/GO precursor.

Recent advances targeting chemokines for breast cancer.

Breast cancer (BC) is a complex and heterogeneous disease, and its onset and progression involve the interplay of multiple molecular mechanisms. Chemokines and their receptors are key regulators of cell migration and immune responses and contribute significantly to the pathophysiology of BC. This article reviews the classification, functions, and mechanisms of chemokines and their receptors in the proliferation, migration, invasion, and angiogenesis of BC cells.

Development of anti-cancer drugs for tumor-associated macrophages: a comprehensive review and mechanistic insights.

This review provides an in-depth summary of the development of anti-cancer drugs for tumor-associated macrophages (TAMs), with a particular focus on the development and tissue specialization of macrophages, and factors influencing the polarization of M1 and M2 macrophages, and mechanistic insights underlying the targeting therapeutic approaches. TAMs, pivotal in the tumor microenvironment, exhibit notable plasticity and diverse functional roles. Influenced by the complex milieu, TAMs polarize into M1-type, which suppresses tumors, and M2-type, which promotes metastasis.

Integrative multi-omics analysis reveals a novel subtype of hepatocellular carcinoma with biological and clinical relevance.

Background: Hepatocellular carcinoma (HCC) is a highly heterogeneous tumor, and the development of accurate predictive models for prognosis and drug sensitivity remains challenging.

Methods: We integrated laboratory data and public cohorts to conduct a multi-omics analysis of HCC, which included bulk RNA sequencing, proteomic analysis, single-cell RNA sequencing (scRNA-seq), spatial transcriptomics sequencing (ST-seq), and genome sequencing. We constructed a tumor purity (TP) and tumor microenvironment (TME) prognostic risk model.

Evaluation of the safety, biodistribution, dosimetry of [F]AlF-NYM005 and initial experience in clear cell renal cell carcinoma: an interim analysis of a prospective trial.

Purpose: This first-in-human study aimed to evaluate the radiation dosimetry and whole-body biodistribution of [F]AlF-NYM005, a novel small-molecule carbonic anhydrase IX (CAIX) targeting agent, and to investigate its ability to detect CAIX-positive tumors using PET scans in a cohort of clear cell renal cell carcinoma (ccRCC) patients.

Methods: [F]AlF-NYM005 was synthesized using a fully automatic cassette module Mortenon M1 (Nuoyu, China). Thirty-five patients with a suspicious lesion considered primary renal malignancy or a history of ccRCC were prospectively recruited and studied.

Summary of the best evidence for risk stratification of exercise rehabilitation in patients with a cardiac implantable electronic device.

Background: Hierarchical management of sports risk is highly critical to ensure the safety of sports rehabilitation. Early identification, timely prevention and control of sports-related risk factors, and enhanced supervision and guidance can provide a basis for the formulation of sports programmes and the setting of sports monitoring levels.

Objective: This study aimed to retrieve, evaluate, and integrate evidence for the stratified management of motor risk in patients with a cardiac implantable electronic device (CIED).

Up-regulated ITGB4 promotes hepatocellular carcinoma metastasis by activating hypoxia-mediated glycolysis and cancer-associated fibroblasts.

The pre-metastatic niche constructed by cancer-associated fibroblasts (CAFs) plays a key role in the hypoxic tumor microenvironment (TME), promoting hepatocellular carcinoma (HCC) metastasis. Integrin, which is involved in cell-to-cell or cell-to-matrix interactions and TME regulation, affects tumor metastasis. However, the complex interactions between integrin-mediated HCC cells and CAFs remain unclear.

Research progress on biomass-based materials for oil/water separation: Designing strategy and efficiency mechanism.

The treatment of water contaminated with oil or organic solvents has always been a thorny challenge, considering the complexity of water pollution, the susceptibility to secondary pollution and the consequent depletion of resources. Biomass is a versatile, green and self-circulating natural material that shows important potential in designing high-performance oil/water separation materials. This review highlights the recent research progress on biomass-based materials (BBMs) in the field of oil-water separation.

Nitrogen-Doped Graphene-Supported Tungsten Oxynitride Nanoparticles as an Efficient Bidirectional Polysulfide Convertor for Advanced Lithium-Sulfur Batteries.

Catalytic materials are considered pivotal in addressing the sluggish kinetics and shuttle effect in lithium-sulfur batteries (LSBs). However, effectively harnessing the utilization rate of active sites within catalytic materials remains a pivotal challenge. In this study, a novel conductive nitrogen-doped graphene-loaded tungsten oxynitride nanoparticle (WNO/NG) with abundant active sites is prepared through a polymer-assisted templating method for serving as a sulfur host.

Single cell-spatial transcriptomics and bulk multi-omics analysis of heterogeneity and ecosystems in hepatocellular carcinoma.

This study profiled global single cell-spatial-bulk transcriptome landscapes of hepatocellular carcinoma (HCC) ecosystem from six HCC cases and a non-carcinoma liver control donor. We discovered that intratumoral heterogeneity mainly derived from HCC cells diversity and pervaded the genome-transcriptome-proteome-metabolome network. HCC cells are the core driving force of taming tumor-associated macrophages (TAMs) with pro-tumorigenic phenotypes for favor its dominant growth.

Water-Stable Magnetic Lipiodol Micro-Droplets as a Miniaturized Robotic Tool for Drug Delivery.

Magnetic microrobots, designed to navigate the complex environments of the human body, show promise for minimally invasive diagnosis and treatment. However, their clinical adoption faces hurdles such as biocompatibility, precise control, and intelligent tracking. Here a novel formulation (referred to water-stable magnetic lipiodol micro-droplets, MLMD), integrating clinically approved lipiodol, gelatin, and superparamagnetic iron oxide nanoparticles (SPION) with a fundamental understanding of the structure-property relationships is presented.

Analysis method of point defects evolution in fused silica under multi-pulse nanosecond laser irradiation.

Although no optically visible damage is produced in the fused silica under laser irradiation below its laser-induced damage threshold (LIDT), defect proliferation may occur due to the evolution of its internal atomic structure. The escalation in defect content leads to heightened absorption, and resulting in the degradation of the optical performance of the optics. In recent decades, there have been a lot of experimental studies on laser-induced damage and laser conditioning, but there is still a great lack of in-depth understanding and theoretical analysis of the evolution process of point defects in fused silica.

Revealing the intrinsic mechanism of the influence of different rings and oxidized structures on the room temperature phosphorescence.

In this work, we used density functional theory (DFT) and time-dependent density functional theory (TD-DFT) methods to study the mechanism of pure organic room temperature phosphorescence emission. The effects on the electronic structure and photochemical properties of thiophene and diketone derivatives with different cyclic and oxidized structures. The result suggests that varying ring configurations and oxidation products significantly influence the photochemical characteristics of thiophene and diketone derivatives.

Natural Silkworm Cocoon-Derived Separator with Na-Ion De-Solvated Function for Sodium Metal Batteries.

The commercialization of sodium batteries faces many challenges, one of which is the lack of suitable high-quality separators. Herein, we presented a novel natural silkworm cocoon-derived separator (SCS) obtained from the cocoon inner membrane after a simple degumming process. A Na||Na symmetric cell assembled with this separator can be stably cycled for over 400 h under test conditions of 0.

Can we skip invasive biopsy of sentinel lymph nodes? A preliminary investigation to predict sentinel lymph node status using PET/CT-based radiomics.

Background: Sentinel lymph node (SLN) biopsy (SLNB) is considered the gold standard for detecting SLN metastases in patients with invasive ductal breast cancer (IDC). However, SLNB is invasive and associated with several complications. Thus, this study aimed to evaluate the diagnostic performance of a non-invasive radiomics analysis utilizing 2-deoxy-2-[F]fluoro-d-glucose positron emission tomography/computed tomography (F-FDG-PET/CT) for assessing SLN metastasis in IDC patients.

Relationships between organizational support, emotional intelligence and work engagement among Chinese nurses: A correlation study.

Aim: To investigate and analyse the current situation of clinical nurses' sense of organisational support, emotional intelligence and work engagement in different departments and their correlation, in order to provide guidance for enhancing the sense of organisational support, improving nurses' emotional intelligence and mobilising nurses' work engagement and to promote the development of nursing teams.

Methods: Clinical nurses from three hospitals in eastern and western China were selected by convenience sampling method from September to October 2023 and were surveyed using a general information questionnaire, organisational support questionnaire, emotional intelligence scale and work engagement scale. We investigated the correlation between nurses' sense of organisational support, emotional intelligence and work engagement in clinical units.