Boron's Role in Diminishing Cadmium Concentrations in Rice ( ): Insights into Absorption Inhibition and Ripening Promotion.

Boron, a crucial element for plant growth, has been demonstrated to mitigate cadmium (Cd) absorption in rice seedlings. However, its impact on Cd accumulation in rice grains and the underlying regulatory mechanisms remain poorly understood. The current study explored the roles of boron in reducing Cd accumulation and promoting ripening in rice through pot and hydroponic experiments.

NEDD4-Mediated GSNOR Degradation Aggravates Cardiac Hypertrophy and Dysfunction.

Background: The decrease in S-nitrosoglutathione reductase (GSNOR) leads to an elevation of S-nitrosylation, thereby exacerbating the progression of cardiomyopathy in response to hemodynamic stress. However, the mechanisms under GSNOR decrease remain unclear. Here, we identify NEDD4 (neuronal precursor cell expressed developmentally downregulated 4) as a novel molecule that plays a crucial role in the pathogenesis of pressure overload-induced cardiac hypertrophy, by modulating GSNOR levels, thereby demonstrating significant therapeutic potential.

Molybdenum and Sulfur Doping To Create Active Sites and Regulate d-Band Centers of Ni-Mo-S Electrocatalysts for the Hydrogen Evolution Reaction.

Defining the active sites and further optimizing their activity are of great significance for enhancing the hydrogen evolution reaction (HER) performances, especially for inexpensive Ni-based catalysts doped with metals and nonmetal elements. This work reports the role of the incorporated molybdenum and sulfur in enhancing the HER activity of nickel. The prepared molybdenum and sulfur coincorporated Ni (NMS) electrocatalysts exhibit excellent HER performance, with an overpotential and Tafel slope of 77.

The Superior Glenoid Humeral Ligament's Role in Superior Labrum Anterior-Posterior Lesions and Subtype Classification Based on Arthroscopic Views: A Multicenter, Retrospective Study.

Background: Superior labrum anterior-posterior (SLAP) lesions are common shoulder injuries. The 10-type classification system has been widely used to diagnose SLAP lesions since it was proposed. However, growing evidence from arthroscopic studies indicates the existence of many SLAP lesions, especially those associated with superior glenoid humeral ligament (SGHL) injuries, that were not included in the initial classification.

Assessing Glenoid Defects in Anterior Shoulder Instability: Comparison of a Simple Linear Formula Method With Traditional Methods Using 3-Dimensional Computed Tomography.

Background: Anterior glenoid bone defects significantly influence surgical outcomes in shoulder instability cases. Various measurement methods based on 3-dimensional computed tomography (3D-CT) have been developed. Recently, the simple linear formula method, which establishes a correlation between glenoid height and width, has emerged as a promising technique.

CircZmMED16 delays plant flowering by negatively regulating starch content through its binding to ZmAPS1.

Circular RNAs (circRNAs), a type of head-to-tail closed RNA molecules, have been implicated in various aspects of plant development and stress responses through transcriptome sequencing; however, the precise functional roles of circRNAs in plants remain poorly understood. In this study, we identified a highly expressed circular RNA, circZmMED16, derived from exon 8 of the mediator complex subunit 16 (ZmMED16) across different maize (Zea mays L.) inbred lines using circRNA-seq analysis.

Femoral neck system (FNS) versus 4 cannulated compression screws (CCSs) in the treatment of young patients with Pauwels type III femoral neck fracture: a retrospective comparative study.

Objective: This study aimed to evaluate the clinical effectiveness of the femoral neck system (FNS) compared to four cannulated compression screws (CCSs) for managing Pauwels type III femoral neck fractures in young patients.

Methods: A retrospective analysis was conducted on young patients with Pauwels type III femoral neck fractures treated at our hospital from January 2021 to December 2022. Patients were categorized into two groups based on their respective internal fixation methods: the FNS group (32 cases) and the CCSs group (41 cases).

An alternative choice for overweight pediatric patient with femoral shaft fracture when rigid nail is contraindicated due to narrow intramedullary canal: Elastic stable intramedullary nail plus temporary external fixator.

Background: Length unstable femoral shaft fractures in school-aged children usually demand surgical treatment, but the optimal choice remains controversial, especially in overweight adolescents. This study aimed to compare the clinical results of locking compression plates (LCP) and elastic stable intramedullary nails (ESIN) combined with temporary external fixator (TEF) in school-aged children weighing over 50 kg.

Methods: Between January 2010 and January 2018, children over 50 kg with length unstable femoral shaft fracture treated with ESIN & EF in the authors' institute were included in this study.

GlSIRT1 deacetylates and activates pyruvate kinase to improve pyruvate content and enhance heat stress resistance in Ganoderma lucidum.

Heat stress is a prevalent environmental stressor. Previous studies have shown that heat stress drives many cellular changes in Ganoderma lucidum. Interestingly, glycolysis is activated during heat stress, which could contribute to increased heat resistance.

Classification Prediction of Hydrocephalus After Intercerebral Haemorrhage Based on Machine Learning Approach.

In order to construct a clinical classification prediction model for hydrocephalus after intercerebral haemorrhage(ICH) to guide clinical treatment decisions, this paper retrospectively analyses the clinical data of 844 cases of ICH and hydrocephalus inpatients admitted to Yueyang People's Hospital from May 2019 to October 2022, of which 95 cases of hydrocephalus occurred after ICH and no hydrocephalus in 749 cases. The following indicators were compared between the two groups of patients: gender, age, Glasgow Coma Scale(GCS)score, whether the amount of bleeding was greater than 30 ml, whether it broke into the ventricle or not, modified Graeb score(MGS), modified Rankin Scale (MRS) score, whether surgery was performed or not, red blood cells, white blood cells, and platelets. After variable screening, the following six variables were selected: GCS score, MGS, MRS score, whether the bleeding volume was greater than 30 ml, whether it broke into the ventricle or not, and whether surgery was performed or not were modelled and analysed using logistic regression model and support vector machine model in machine learning.

Reversible light-responsive protein hydrogel for on-demand cell encapsulation and release.

The design of biomaterials that can reconfigure on-demand in response to external stimuli is an emerging area in materials research. However, achieving reversible assembly of protein-based biomaterials by light input remains a major challenge. Here, we present the engineering of a new protein material that is capable of switching between liquid and solid state reversibly, controlled by lights of different wavelengths.

A hybrid unsupervised machine learning model with spectral clustering and semi-supervised support vector machine for credit risk assessment.

In credit risk assessment, unsupervised classification techniques can be introduced to reduce human resource expenses and expedite decision-making. Despite the efficacy of unsupervised learning methods in handling unlabeled datasets, their performance remains limited owing to challenges such as imbalanced data, local optima, and parameter adjustment complexities. Thus, this paper introduces a novel hybrid unsupervised classification method, named the two-stage hybrid system with spectral clustering and semi-supervised support vector machine (TSC-SVM), which effectively addresses the unsupervised imbalance problem in credit risk assessment by targeting global optimal solutions.

Long-term Outcomes of Endoscopic Radiofrequency Ablation versus Endoscopic Submucosal Dissection for Widespread Superficial Esophageal Squamous Cell Neoplasia.

Background/aims: Endoscopic radiofrequency ablation (ERFA) is a treatment option for superficial esophageal squamous cell neoplasia (ESCN), with a relatively low risk of stenosis; however, the long-term outcomes remain unclear. We aimed to compare the long-term outcomes of patients with widespread superficial ESCN who underwent endoscopic submucosal dissection (ESD) or ERFA.

Methods: We retrospectively analyzed the clinical data of patients with superficial ESCN who underwent ESD or ERFA between January 2015 and December 2021.

MGFusion: a multimodal large language model-guided information perception for infrared and visible image fusion.

Existing image fusion methods primarily focus on complex network structure designs while neglecting the limitations of simple fusion strategies in complex scenarios. To address this issue, this study proposes a new method for infrared and visible image fusion based on a multimodal large language model. The method proposed in this paper fully considers the high demand for semantic information in enhancing image quality as well as the fusion strategies in complex scenes.

Two types of cannulated screw fixation based on Letenneur classification for the treatment of Hoffa fracture: A finite element analysis.

Purpose: A finite element analysis was performed to simulate the biomechanical differences between anterior-posterior (AP) direction and posterior-anterior (PA) direction placement of two cannulated screws in Hoffa fractures.

Methods: Computed tomography images of an healthy male volunteer were used to simulate Letenneur Ⅰ, Ⅱa, Ⅱb, Ⅱc, Ⅲ Hoffa fractures, and two groups of screw internal fixation models were constructed. Two 6.

Prediction and analysis of toxic and side effects of tigecycline based on deep learning.

Background: In recent years, with the increase of antibiotic resistance, tigecycline has attracted much attention as a new broad-spectrum glycylcycline antibiotic. It is widely used in the treatment of complex skin and soft tissue infections, complex abdominal infections and hospital-acquired pneumonia by inhibiting bacterial protein synthesis. Tigecycline can exhibit significant time-dependent bactericidal activity, and its efficacy is closely related to pharmacokinetics.

Research on muck conditioning for EPB shield tunnelling in composite formation.

Compared with simple formations, EPB (earth pressure balance) shield tunnelling in composite formations encounters severe problems with muck conditioning and require improved muck conditioning technology to fulfil expectations for continuous and efficient excavation. In the Nanchang Metro Line 4 Project, a water-rich sand-argillaceous siltstone composite formation is encountered. With a high moisture content and complex composite formation ratio, it is quite difficult to determine the optimum muck conditioning scheme, and thus, muck spewing accidents frequently occur during the tunnelling process.

[Influence analysis of glenohumeral bone structure on anterior shoulder instability].

Objective: To investigate the effect of glenohumeral bone structure on anterior shoulder instability by three-dimensional CT reconstruction.

Methods: The clinical data of 48 patients with unilateral anterior shoulder dislocation (instability group) and 46 patients without shoulder joint disease (control group) admitted between February 2012 and January 2024 were retrospectively analyzed. There was no significant difference in gender and side between the two groups ( >0.

Growth Hormone-Releasing Peptide 2 May Be Associated With Decreased M1 Macrophage Production and Increased Histologic and Biomechanical Tendon-Bone Healing Properties in a Rat Rotator Cuff Tear Model.

Purpose: To explore the potential of growth hormone-releasing peptide 2 (GHRP-2) for tendon-bone healing in a rat rotator cuff tear (RCT) model.

Methods: The impact of GHRP-2 on M1 macrophage polarization in vitro was determined using real-time polymerase chain reaction, Western blot, and immunofluorescence staining. GHRP-2 was then applied in a rat RCT model, and the healing of the tendon-bone interface was systemically evaluated by histologic staining, radiologic assessments, gait analysis, and biomechanical tests.

Effect of Acupoint Catgut Embedding on Subjective Appetite in Overweight and Obese Adults with Strong and Moderate Appetite: A Secondary Analysis of a Randomized Clinical Trial.

Background: Appetite plays a crucial role in obesity and weight loss outcomes. while conventional therapies reduce appetite, They often have limitations. Acupoint Catgut Embedding (ACE) is widely used for weight loss, but its impact on subjective appetite, especially across different appetite status, remains underexplored.

Total parietal peritonectomy and multivisceral resection for extensive cytoreductive surgery in pseudomyxoma peritonei: En bloc "Rolled-up carpet" technique and perioperative and oncologic outcomes.

Background: Patients diagnosed with pseudomyxoma peritonei (PMP) of appendiceal origin typically present with high tumor burden and require extensive cytoreductive surgery (CRS) to achieve optimal cytoreduction. This study describes an en bloc "rolled-up carpet" surgical technique for total parietal peritonectomy and multivisceral resection while also analyzing the perioperative and tumor outcomes of this technique.

Methods: The study reviewed the data of 7 patients underwent en bloc "rolled-up carpet" extensive CRS between August 2020 and April 2023.

Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing.

Astrocytes, which are increasingly recognized as pivotal constituents of brain circuits governing a wide range of functions, express GABA transporter 3 (Gat3), an astrocyte-specific GABA transporter responsible for maintenance of extra-synaptic GABA levels. Here, we examined the functional role of Gat3 in astrocyte-mediated modulation of neuronal activity and information encoding. First, we developed a multiplexed CRISPR construct applicable for effective genetic ablation of Gat3 in the visual cortex of adult mice.

Sources, metabolism, health benefits and future development of saponins from plants.

Saponins are a class of glycoside compounds whose aglycones are triterpenoids or spirostanes, widely exist in a variety of Chinese herbs. Saponins are one of the important active components of medicinal plants and have a wide range of bioactivities. In order to promote the better development and utilization of saponins, the process of digestion, absorption and metabolism of saponins in vivo was reviewed in this paper.

Arthroscopic Suture Anchor Repair and Debridement for Refractory Lateral Epicondylitis Show Significant Clinical Improvement.

Purpose: To retrospectively compare the clinical outcomes of arthroscopic suture anchor repair of the common extensor tendon (CET) and arthroscopic debridement of CET for the treatment of refractory lateral epicondylitis.

Methods: Patients with refractory lateral epicondylitis who underwent arthroscopic surgery between August 2018 and September 2022 with a minimum 1-year follow-up were included. All patients were divided into 2 groups based on whether they underwent suture anchor repair.