Design of Interface ASIC with Power-Saving Switches for Capacitive Accelerometers.

High-precision, low-power MEMS accelerometers are extensively utilized across civilian applications. Closed-loop accelerometers employing switched-capacitor (SC) circuit topologies offer notable advantages, including low power consumption, high signal-to-noise ratio (SNR), and excellent linearity. Addressing the critical demand for high-precision, low-power MEMS accelerometers in modern geophones, this work focuses on the design and implementation of closed-loop interface ASICs (Application-Specific Integrated Circuits).

A pair of LysM receptors mediates symbiosis and immunity discrimination in Marchantia.

Most land plants form symbioses with microbes to acquire nutrients but also must restrict infection by pathogens. Here, we show that a single pair of lysin-motif-containing receptor-like kinases, MpaLYR and MpaCERK1, mediates both immunity and symbiosis in the liverwort Marchantia paleacea. MpaLYR has a higher affinity for long-chain (CO7) versus short-chain chitin oligomers (CO4).

Comprehensive genomic analysis and selection signature detection in endangered Beigang pigs using whole-genome sequencing data.

The Beigang pig was recently identified as one of the endangered breeds during a Chinese indigenous pig genetic resource survey. The Beigang breed is notable for its remarkable roughage tolerance and high reproductive capacity according to historical records. Morphologically, the Beigang pig resembles many indigenous pigs in eastern China, especially in its large ears.

Retinal vascular geometry and its association to silent brain infarction.

Objective: To examine the relationship between retinal vascular geometry and silent brain infarction (SBI) in the Chinese population.

Methods: We conducted a cross-sectional study that retrospectively analyzed the fundus photographs, MRI and other clinical data of 227 SBIs and 227 controls who visited Shanghai Health And Medical Center for physical examination. The retinal vessel fractal dimension (FD), retinal artery fractal dimension (FDa), retinal vein fractal dimension (FDv), central retinal artery diameter in the region from 0.

Mechanistic investigation of impact of malic acid, ultrasound and dual treatment on starch digestibility of cooked whole rice grains.

Physical, chemical, and dual modifications can all significantly affect the digestibility of isolated rice granules, while their effects on the starch digestibility of whole cooked rice grains remain elusive. Therefore, the impact of malic acid, ultrasound, and ultrasound + malic acid dual treatment on the starch digestibility of cooked rice grains with different starch molecular structures was investigated in this study. Ultrasound mainly caused cavitation on the surface of rice grains, promoting the leaching of materials (> 11 %) and amylose during cooking.

Highly efficient green phosphor CaLa(PO)O:Eu,Tb for white LEDs.

Although the green light emission of Tb ions can be effectively improved by utilizing energy transfer from Eu to Tb ions, obtaining phosphors with high quantum efficiency remains a major problem. Here, we have achieved a novel apatite-type structure CaLa(PO)O (CLPO) containing Eu and Tb ions. The CLPO:Eu is capable of being effectively excited by near-ultraviolet light and emits blue light at about 460 nm.

Highly sensitive temperature sensors based on the fluorescence intensity ratio of dual-emissive lead-free metal halides.

Given that optical thermometers are widely used due to their unique advantages, this study aims to address critical challenges in existing technologies, such as insufficient sensitivity, limited temperature measurement ranges, and poor signal recognition capabilities. Herein, we develop a thermometer based on the fluorescence intensity ratio (FIR) of Sb-doped CsNaInCl (CsNaInCl:Sb). As the temperature increases from 203 to 323 K, the thermally induced transition from triplet to singlet self-trapped excitons (STEs) leads to enhanced 455 nm photoluminescence (PL) from singlet STE recombination.

Programmed cell death in nasopharyngeal carcinoma: Mechanisms and therapeutic targets.

Programmed cell death is a type of autonomic and orderly cell death mode controlled by genes that maintain homeostasis and growth. Tumor is a typical manifestation of an imbalance in environmental homeostasis in the human body. Currently, several tumor treatments are designed to trigger the death of tumor cells.

Effects of hawthorn pectin and its oligomers on gut microbiota and metabolites in high-fat diet mice.

Pectin is an acidic heteropolysaccharide with natural, green, and inexpensive characteristics. Compared to polysaccharides, oligosaccharides are more easily utilized by the body, and the physiological function of hawthorn pectin oligosaccharides (POS) may vary depending on their degree of polymerization (DP). Therefore, we mainly studied the effects of hawthorn pectin (HP) and POS with different DP on gut microbiota disorders induced by high-fat diet (HFD).

Oncolytic Virus Targeted Therapy for Glioma via Intravenous Delivery.

Glioma, the deadly primary intracranial tumor, poses challenges in clinical treatment due to its infiltrative growth and resistance to radiation. Oncolytic virus therapy holds potential for the treatment of malignant gliomas, but its application is impeded by the requirement for intracranial injections due to the presence of blood-brain barrier (BBB). In this study, to overcome this limitation, the study develops a nanocapsule encapsulating the recombinant oncolytic virus EV-A71-miR124T, enabling the treatment of glioma through intravenous administration.

The overview of lactylation in the placenta of preeclampsia.

Background: Preeclampsia is a major challenge for obstetricians due to its severe impacts on maternal and fetal health. Lysine lactylation (Kla) derived from lactate is a novel type of post-translational modification which has been confirmed to affect the malignant progression of diseases as an epigenetic modifier. However, the systemic lactylome profiling of preeclampsia is still unclear.

Critical Structures of Bisphenol Analogues on Embryonic Toxicity Identified by a Computational Approach.

Safer chemical alternatives to bisphenol (BP) have been a major pursuit of modern green chemistry and toxicology. Using a chemical similarity-based approach, it is difficult to identify minor structural differences that contribute to the significant changes of toxicity. Here, we used omics and computational toxicology to identify chemical features associated with BP analogue-induced embryonic toxicity, offering valuable insights to inform the design of safer chemical alternatives.

Shenghui decoction inhibits neuronal cell apoptosis to improve Alzheimer's disease through the PDE4B/cAMP/CREB signaling pathway.

Background: Shenghui Decoction (SHD) is a frequently utilized traditional Chinese medicine formula in clinical settings for addressing cognitive impairment in elderly individuals. Nevertheless, the precise mechanism by which SHD exerts its effects on the most prevalent form of dementia, Alzheimer's disease (AD), remains to be elucidated.

Methods: Temperature-induced transgenic C.

Immune-related adverse events with renal colic as the main manifestation: a case report of sintilimab-induced ureteritis/cystitis treated by ureteral stent and review of the literature.

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of systemic cancer therapy. During disinhibiting the antitumor responses of immune system, ICIs may also cause unique immune-related adverse events (irAEs) which could affect any organ. Here, we report a rare case of sintilimab-induced ureteritis/cystitis in a 55-year-old male undergoing neoadjuvant chemo-immunotherapy for gastric cancer.

Apple MIEL1/ABI5-MAX2 regulatory module links strigolactone and abscisic acid signals.

In apple (Malus domestica), the abscisic acid (ABA)-responsive factor ABA INSENSITIVE5 directly activates MORE AXILLARY GROWTH2 (MdMAX2), an important strigolactone signaling component; an abscisic acid-restricted E3 ubiquitin ligase modulates MdMAX2 turnover, thus linking strigolactone and abscisic acid signaling.

Comparison of Robot-assisted Laparoscopic Extravesical Ureteral Reimplantation for Primary Vesicoureteral Reflux in Infants Under One Year of Age and Older Children.

Purpose: To assess the surgical outcomes of Robot-Assisted Laparoscopic Extravesical Ureteral Reimplantation (RALUR-EV) in infants under one year of age with primary vesicoureteral reflux (VUR) as compared to older children.

Materials And Methods: A retrospective analysis was conducted on 48 children with VUR who underwent unilateral or bilateral RALUR-EV between June 2018 and December 2022. Patients were divided into two groups: Group A (25 infants under one year) and Group B (23 children over one year).

Optimization design and experiment of cam-elliptical gear combined vegetables curved surface labeling mechanism.

To address the problems of the labeling curved surfaces vegetable with long label, such as the label wrinkled and the easy detachment, a cam-elliptical gear combined labeling mechanism with an improved hypocycloid trajectory is proposed. Provide the process of the mechanism, and establish a kinematic model of the mechanism. In order to improve the motion performances of the cam-elliptical gear combined labeling mechanism and avoid labels damage, the NSGA-II algorithm is used to optimize the parameters of the mechanism, resulting in 80 sets of Pareto solutions.

Case report: Multiphenotypic cervical cancer resembling human papillomavirus-related multiphenotypic sinonasal carcinoma.

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a biphasic epithelial tumor associated with HPV infection. This rare tumor primarily affects the nasal cavity and paranasal sinuses, with only two cases reported outside these locations to date-one in the breast and one in the vulva. This report presents a case of a tumor resembling an HMSC arising in the cervix.

[Glycoside compounds from Chrysanthemum indicum and their antioxidant activity].

Thirteen glycoside compounds were isolated and purified from 95% ethanol extract of Chrysanthemum indicum by normal and reversed phase silica gels, glucan gel, and high performance liquid chromatography, and their chemical structures were identified by spectroscopic data and physicochemical properties. These compounds were(2S,3R)-2,3-dihydro-3-hydroxymethyl-7-methoxy-2-benzodioxole-5-benzofuranpropanol-10-O-β-D-glucopyranoside(1), 4,6,8-decatriynyl-β-D-glucopyranoside(2), 5-(β-D-glucopyranosyloxy)-2-hydroxy benzoic acid methyl ester(3), citrusin C(4), cuminyl β-D-glucopyranoside(5), benzyl-6-[(2E)-2-butenoate]-β-D-glucopyranoside(6), benzyl β-D-glucoside(7), viridoside(8), phenylethyl β-D-glucopyranoside(9), syringaresinol-4'-O-β-D-glucoside(10), pinoresinol-4'-O-β-D-glucoside(11), isoeucommin A(12), and eucommin A(13). Among them, compound 1 was a new compound.

Prognostic importance of an indicator related to systemic inflammation and insulin resistance in patients with gastrointestinal cancer: a prospective study.

Background: Systemic inflammation (SI) and insulin resistance (IR) are correlated to the progression of gastrointestinal (GI) cancer. Therefore, this study aimed to analyze the potential clinical value of the C-reactive protein-triglyceride-glucose index (CTI) in relation to SI and IR in patients with GI cancer.

Methods: This prospective cohort study included patients with GI cancer.

Role of Neutrophil Extracellular Traps in Hypertension and Their Impact on Target Organs.

Hypertension is the predominant cause of cardiovascular diseases (CVDs) globally, and essential hypertension (EH) represents a significant public health challenge due to its multifactorial etiology involving complex interactions between genetic and environmental factors. However, the pathogenesis of EH is still unclear. Hypertension is a dysregulation in the renin-angiotensin-aldosterone system and sympathetic nervous system, both regulating saline homeostasis and cardiovascular function.

Case report: Granulomatosis with polyangiitis patient presented with a mass in the aortic root.

Granulomatosis with polyangiitis (GPA) is an autoimmune inflammatory disease that affects small- and medium-sized blood vessels in the body, representing a rare entity. Cardiac involvement was identified as an independent risk factor for death in GPA patients, yet it has not been systematically elucidated in previous literature. Cardiac lesions in patients with GPA can manifest in various ways, such as pericarditis, myocarditis, coronary vasculitis, valvular abnormalities, conduction system abnormalities, and heart failure.

Prognostic significance of elevated expression levels of protein phosphatase 1 regulatory subunit 3G in thyroid carcinoma.

The prognosis of the poorly differentiated subtype of thyroid carcinoma (THCA) is less favorable due to its aggressive nature, which also increases the likelihood of metastasis to distant organs. The present study aimed to assess the potential application of protein phosphatase 1 regulatory subunit 3G (PPP1R3G) as a molecular biomarker for early identification and prognosis prediction in THCA. The Cancer Genome Atlas (TCGA) database was used to identify genes associated with prognosis and differentially expressed genes in THCA.