Self-assembled water soluble and bone-targeting phosphorylated quercetin ameliorates postmenopausal osteoporosis in ovariectomy mice.

Natural compounds have shown promising application prospects in preventing or treating various diseases, including osteoporosis on account of their abundant sources, low price, multi-targeting and multiple biological effects. As a bioactive natural product, quercetin (Que) has previously demonstrated to ameliorate osteoporosis (OP), however, its poor bioavailability resulting from low water solubility, poor stability and lack of bone-targeting largely restricted its efficacy and clinical applications. Inspired by the bone-targeting capability of phosphate compounds, we reported a one-step procedure for synthesis of phosphorylated Que (p-Que) by direct phosphorylating phenol groups of Que for the first time.

Wavelet-Driven Multi-Band Feature Fusion for RGB-T Salient Object Detection.

RGB-T salient object detection (SOD) has received considerable attention in the field of computer vision. Although existing methods have achieved notable detection performance in certain scenarios, challenges remain. Many methods fail to fully utilize high-frequency and low-frequency features during information interaction among different scale features, limiting detection performance.

Encourage or Reject Employee Involvement: Value Creation in Human Resource Management in the AI Era-An Evolutionary Game Analysis of Enterprises and Employees.

In the context of globalization and rapid technological advancement, the introduction of Artificial Intelligence (AI) has brought new opportunities and challenges to Human Resource Management (HRM). This study constructs an evolutionary game model to explore the strategy choices and evolutionary paths of enterprises and employees in HRM value co-creation with AI involvement. We numerically simulated the dynamic evolution of strategies under different scenarios, revealing the equilibrium characteristics of strategic interactions between enterprises and employees in the AI context.

[Advances in epigenetic regulation of the dioxygenase TET1].

Ten-eleven translocation 1 (TET1) protein is an alpha-ketoglutaric acid (α-KG) and Fe-dependent dioxygenase. It plays a role in the active demethylation of DNA by hydroxylation of 5-methyl-cytosine (5-mC) to 5-hydroxymethyl-cytosine (5-hmC). Ten-eleven translocation 1 (TET1) protein is involved in maintaining genome methylation homeostasis and epigenetic regulation.

ANGPTL4 promotes choroidal neovascularization and subretinal fibrosis through the endothelial‒mesenchymal transition.

Purpose: This study aimed to investigate the possible mechanisms by which ANGPTL4 is involved in the pathogenesis of choroidal neovascularization (CNV) and subretinal fibrosis.

Methods: Differentially expressed genes in retinal pigmented epithelium (RPE)-choroid-sclera complex tissues from nAMD patients and control individuals were identified via the GEO database, followed by GO and KEGG analyses. A Venn diagram was used to identify EndMT-related DEGs.

[Advancements in the regulatory effects and mechanisms of the immune metabolite itaconate in diseases].

Itaconate is a pivotal intermediate metabolite in the tricarboxylic acid (TCA) cycle of immune cells. It is produced by decarboxylation of -aconitic acid under the catalysis of aconitate decarboxylase 1 (ACOD1), which is encoded by the immune response gene 1 (IRG1). Itaconate has become a focal point of research on immunometabolism.

Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction.

Purpose: Fibroblast growth factor receptor 2 (Fgfr2) is crucial for the homeostasis of meibomian gland (MG). However, the role of Fgfr2 in MG ductal epithelial progenitors remains to be delineated. Herein, we created a new transgenic mouse model with conditional deletion of Fgfr2 from MG ductal progenitors and investigated the cell-specific role in the pathogenesis of obstructive meibomian gland dysfunction.

The perspective of ceRNA regulation of circadian rhythm on choroidal neovascularization.

Abnormal growth of blood vessels (choroidal neovascularization) can lead to age-related macular degeneration (AMD) and eventually cause vision loss due to detachment of the retinal pigmented epithelium. This indicates that choroidal neovascularization is important for the treatment of AMD. The circadian clock in the mammalian retina is responsible for controlling various functions of the retina, enabling it to adjust to changes in light and darkness.

A porous network of boron-doped IrO nanoneedles with enhanced mass activity for acidic oxygen evolution reactions.

While proton exchange membrane water electrolyzers (PEMWEs) are essential for realizing practical hydrogen production, the trade-off among activity, stability, and cost of state-of-the-art iridium (Ir)-based oxygen evolution reaction (OER) electrocatalysts for PEMWE implementation is still prohibitively challenging. Ir minimization coupled with mass activity improvement of Ir-based catalysts is a promising strategy to address this challenge. Here, we present a discovery demonstrating that boron doping facilitates the one-dimensional (1D) anisotropic growth of IrO crystals, as supported by both experimental and theoretical evidence.

Excessive Erythrophagocytosis Accounts for Systemic Inflammation in Chronic Kidney Disease.

Purpose: Chronic kidney disease (CKD) is associated with persistent systemic inflammation. Reduced red blood cell (RBC) survival in patients with CKD has been identified for several decades. The purpose of this study is to explore whether excessive erythrophagocytosis exists and contributes to systemic inflammation in CKD.

TLR4/TRIF/Caspase-8/Caspase-1 Pathway in Choroidal Endothelial Cells Promotes Choroidal Neovascularization.

Purpose: The purpose of this study was to investigate the role and mechanism of caspase-8 in the development of choroidal neovascularization induced by age-related macular degeneration, with the aim of identifying a potential therapeutic target for neovascular age-related macular degeneration.

Methods: Mouse models of laser photocoagulation-induced choroidal neovascularization and hypoxic human choroidal endothelial cells were utilized to examine the involvement of caspase-8 in choroidal neovascularization development. The toll-like receptor 4/TIR domain-containing adaptor molecule 1/caspase-8 pathway was explored in hypoxic human choroidal endothelial cells to elucidate its contribution to pathological angiogenesis.

Geniposide attenuates influenza virus-induced pneumonia by regulating inflammatory cytokines production. Evidences to elucidate the followed pathway.

Background: Influenza virus-induced pneumonia (IVP) is an infectious pulmonary disease characterized by exacerbated pulmonary inflammation caused by invasion of the influenza virus. IVP continues to threaten public health due to its high morbidity and mortality rates. Geniposide is one of the major bioactive constituents of G.

Defect Engineering: Can it Mitigate Strong Coulomb Effect of Mg in Cathode Materials for Rechargeable Magnesium Batteries?

Rechargeable magnesium batteries (RMBs) have been considered a promising "post lithium-ion battery" system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage market. However, the sluggish diffusion kinetics of bivalent Mg in the host material, related to the strong Coulomb effect between Mg and host anion lattices, hinders their further development toward practical applications. Defect engineering, regarded as an effective strategy to break through the slow migration puzzle, has been validated in various cathode materials for RMBs.

The Effects of STRA6 Regulation of the Circadian Rhythm on Choroidal Neovascularization.

Purpose: This study aims to investigate the relationship among STRA6, circadian rhythm, and choroidal neovascularization (CNV) formation, as well as the regulatory mechanism of STRA6 in CNV under circadian rhythm disturbances.

Methods: C57BL/6J male mice (aged 6 weeks) were randomly divided into control and jet lag groups (using a time shift method every 4 days to disrupt the molecular clock's capacity to synchronize with a stable rhythm). A laser-induced CNV model was established in both the control and the jet lag group after 2 weeks of jet lag.

Impact of Microparticle Transarterial Chemoembolization (mTACE) on myeloid-derived suppressor cell subtypes in hepatocellular carcinoma: Clinical correlations and therapeutic implications.

Background: Myeloid-derived suppressor cells (MDSCs) play a pivotal role in immunosuppression and tumor progression in hepatocellular carcinoma (HCC). While various treatments like surgical resection, ablation, and radiotherapy have been studied for their effects on circulating MDSC frequencies in HCC patients, the findings remain inconclusive. Transarterial Chemoembolization (TACE) stands as the standard care for unresectable HCC, with Microparticle TACE (mTACE) gaining prominence for its capacity to induce significant tumor necrosis.

Nanocrystalline transition metal tetraborides as efficient electrocatalysts for hydrogen evolution reaction at the large current density.

While great efforts have been made to improve the electrocatalytic activity of existing materials toward hydrogen evolution reaction (HER), it is also importance for searching new type of nonprecious HER catalysts to realize the practical hydrogen evolution. Herein, we firstly report nanocrystalline transition metal tetraborides (TMB, TM=W and Mo) as an efficient HER electrocatalyst has been synthesized by a single-step solid-state reaction. The optimized nanocrystalline WB exhibits an overpotential as low as 172 mV at 10 mA/cm and small Tafel slope of 63 mV/dec in 0.

School Bullying Victimization and Depression Symptoms in Adolescents: The Mediating Role of Internet Addiction and Moderating Role of Living Areas.

School bullying and depression are both serious social and public health problems among adolescents. Prior studies indicated a correlation between bullying and depression. However, the potential moderators remain largely unexplored.

Group-based pelvic floor muscle training for pregnant women: A randomized controlled feasibility study.

Aim: This study aims to test the feasibility and acceptability of a group-based pelvic floor muscle training for pregnant women in China and facilitate women's adherence to the pelvic floor muscle training programme.

Background: Urinary incontinence is a prevalent health problem in women worldwide, especially in pregnant women. Supervised pelvic floor muscle training is recommended as the first-line conservative treatment for urinary incontinence.

Integrating Multi-omics to Identify Age-Related Macular Degeneration Subtypes and Biomarkers.

Age-related macular degeneration (AMD) is one of the most common causes of irreversible vision loss in the elderly. Its pathogenesis is likely multifactorial, involving a complex interaction of metabolic and environmental factors, and remains poorly understood. Previous studies have shown that mitochondrial dysfunction and oxidative stress play a crucial role in the development of AMD.