Tumour necrosis factor-like weak inducer of apoptosis participates in the development of cutaneous fibrosis in an experimental systemic sclerosis model.

Objectives: Systemic sclerosis (SSc), a chronic autoimmune disorder, characterised by local inflammation and progressive fibrosis. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) has been established as a key mediator in fibrotic processes across multiple organs, primarily through binding to its receptor, fibroblast growth factor-inducible 14 (Fn14). However, the precise role of the TWEAK/Fn14 signalling in SSc pathogenesis remains unclear.

infection is associated with the risk and phenotypes of cholelithiasis: A multi-center study and meta-analysis.

Background: () is a prevalent pathogen associated with various diseases. Cholelithiasis is also a common condition. infection has been identified in the biliary system, suggesting its potential involvement in biliary diseases.

Removal, conversion and utilization technologies of alkali components in bayer red mud.

Bayer red mud is a highly alkaline industrial solid waste generated during alumina production, and its massive discharge and stockpiling poses significant environmental risks. The strong alkalinity of red mud is a primary challenge limiting its effective utilization. This study systematically analyzes the composition and characteristics of alkaline components in red mud, emphasizing the roles of soluble free alkali and chemically bound alkali in regulating its alkalinity.

Ultra-Broadband Perfect Absorbers Based on Biomimetic Metamaterials with Dual Coupling Gradient Resonators.

Ultra-broadband metamaterial absorbers can achieve near-perfect absorption of omnidirectional electromagnetic waves, crucial for light utilization and manipulation. Traditional ultra-broadband metamaterials rely on the superposition of different resonator units either in the plane or in perpendicular directions to broaden absorption peaks. However, this approach is subject to quantity restrictions and complicates the fabrication process.

Hydrogeochemical mechanism of Li-Cs-rich thermal springs in the Karakoram Fault, Qinghai-Xizang Plateau: New insights from multiple stable isotopes.

High lithium (Li) and cesium (Cs) concentrations in the Qinghai-Xizang Plateau thermal springs pose environmental and health challenges, but their origins and enrichment mechanisms remain unclear. This study focuses on the Sogdoi geothermal field, located along the southern Karakoram Fault, to investigate these processes. Multi-isotope analyses (H, O, Li, Sr) reveal that Li and Cs predominantly originate from the host rocks, especially granitoids and meta-sedimentary rocks, rather than from magmatic fluids.

Antibiotics versus Non-Antibiotic in the treatment of Aspiration Pneumonia: analysis of the MIMIC-IV database.

Background: Aspiration pneumonia (AP) is a common complication in the intensive care unit (ICU), which is associated with significantly increased morbidity and mortality and has a significant impact on patient prognosis. Antibiotics are commonly used in the clinical treatment of AP. However, the prognostic impact of antibiotics on patients with AP has not been adequately characterized.

subsp. relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation.

species are known for their efficacy in alleviating constipation. This study aimed to compare the constipation-relieving effects of different species ( subsp. , , , , subsp.

Multiparametric Chemical Exchange Saturation Transfer MRI Detects Metabolic Changes in Mild Cognitive Impairment Cases at 3.0 Tesla.

This study aimed to assess the potential of multiparametric chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) for MCI detection. Twenty-eight patients with MCI and 31 age- and gender-matched normal controls (NCs) were enrolled. CEST MRI was performed with a gradient and spin-echo sequence on a 3T scanner.

Identification of Contactin-1 as a Potential Biomarker and Therapeutic Target in Neuroblastoma.

Background: Neuroblastoma is a common pediatric solid tumor with poor outcomes in high-risk patients. The identification of new therapeutic biomarkers is critical for the treatment of disease.

Methods: An analysis of large publicly available datasets of tumor gene expression was performed.

Fully Conjugated Microporous Polymers as Metal-Free Heterogeneous Photocatalysts for Organic Transformations.

Photoactive conjugated microporous polymers (CMPs) have recently received huge attention in photocatalytic organic transformations owing to their adjustable structure and functionality. However, commonly reported CMPs are synthesized through metal catalyzed coupling reactions, which require complicated product separation and result in increased costs. In this study, two sp carbon-linked CMPs are constructed by organic base induced Knoevenagel reaction using 2,6-dimethylbenzo[1,2-d:4,5-d']bisoxazole and aromatic polyaldehydes as co-monomers.

Multi-functional active frequency reconfigurable polarization converter using a simple DC bias circuit.

A multi-functional active converter with frequency reconfiguration is proposed and experimentally verified. The unit cell is composed of two T-shaped metal patches connected with a PIN diode. Two metal vias are designed to connect the T-shaped metal to the ground.

Preparation of nutrient hydrogels with core-shell structure for seed germination and seedling growth in high temperature saline environment.

Drought and soil degradation are the key factors in desertification control. How to improve the utilization efficiency of water and fertilizer has always been the focus of research in desert areas. The conventional hydrogel-loaded fertilizer is not suitable because of the high salinity and large temperature difference in sandy land.

Adeno-Associated Virus-Mediated Gene Transduction Reduces Silica-Induced Oxidative Stress and Silicosis in Mouse Lung.

Silicosis is a lung disease caused by inhalation of silica particles. Both silica-induced oxidative stress and aberrant activation of the Wnt/β-catenin signaling pathway are potential targets in the treatment of pulmonary fibrosis. Dickkopf-1 (Dkk1), an inhibitor of the Wnt/β-catenin signaling pathway, plays regulatory roles in cell fate determination and immune responses.

Lithium isotope evidence for a plumeworld ocean in the aftermath of the Marinoan snowball Earth.

The snowball Earth hypothesis predicts that continental chemical weathering diminished substantially during, but rebounded strongly after, the Marinoan ice age some 635 Mya. Defrosting the planet would result in a plume of fresh glacial meltwater with a different chemical composition from underlying hypersaline seawater, generating both vertical and lateral salinity gradients. Here, we test the plumeworld hypothesis using lithium isotope compositions in the Ediacaran Doushantuo cap dolostone that accumulated in the aftermath of the Marinoan snowball Earth along a proximal-distal (nearshore-offshore) transect in South China.

Predictive factors for the development of depression in children and adolescents: a clinical study.

Background: The prevalence of depression among adolescents has been gradually increasing with the COVID-19 pandemic, and the purpose of this study was to develop and validate logistic regression models to predict the likelihood of depression among 6-17 year olds.

Methods: We screened participants from the National Center for Health Statistics (NCHS) in 2022. Independent risk factors were identified via univariate logistic regression analyses and least absolute shrinkage and selection operator (LASSO) for feature screening.

A large-scale retrospective study in China explores risk factors for disease severity in plaque psoriasis.

Severe psoriasis has a long course and poor outcome, and it has long been a problem for patients. Understanding the independent risk factors that contribute to patients with severe psoriasis is critical for the development of effective treatment strategies. This large, multicenter study recruited 2,109 plaque psoriasis patients from 12 hospitals across China (October 31, 2019 - May 31, 2022).

Isosilybin A exhibits anti-inflammatory properties in rosacea by inhibiting MAPK pathway and M1 macrophage polarization.

Rosacea is a chronic inflammatory skin disease, which is prone to flares and requires continuous management and treatment. However, long-term use of drugs can lead to additional adverse drug reactions. Based on the comorbid relationship between rosacea and Parkinson's disease, bioinformatics and network pharmacology analysis were used to identify a safer drug for rosacea.

Cold atmospheric plasma (CAP): a revolutionary approach in dermatology and skincare.

Cold atmospheric plasma (CAP) technology has emerged as a revolutionary therapeutic technology in dermatology, recognized for its safety, effectiveness, and minimal side effects. CAP demonstrates substantial antimicrobial properties against bacteria, viruses, and fungi, promotes tissue proliferation and wound healing, and inhibits the growth and migration of tumor cells. This paper explores the versatile applications of CAP in dermatology, skin health, and skincare.

Spherical harmonics-based deep learning achieves generalized and accurate diffusion tensor imaging.

Diffusion tensor imaging (DTI) is a prevalent magnetic resonance imaging (MRI) technique, widely used in clinical and neuroscience research. However, the reliability of DTI is affected by the low signal-to-noise ratio inherent in diffusion-weighted (DW) images. Deep learning (DL) has shown promise in improving the quality of DTI, but its limited generalization to variable acquisition schemes hinders practical applications.