Bone-Induced Her2 Promotes Secondary Metastasis in HR+/Her2- Breast Cancer.

Bone metastases can disseminate to secondary sites and promote breast cancer progression creating additional clinical challenges. The mechanisms contributing to secondary metastasis are barely understood. Here, we evaluate the prediction power of Her2-expressing (Her2E) circulating tumor cells (CTCs) after analyzing over 13,000 CTCs from a cohort of 137 metastatic breast cancer (MBC) patients with initial HR+/Her2- status and employ preclinical models of bone metastasis (BM) to validate the role of Her2E CTCs in multi-organ metastases.

Impact of hospital readmission site on outcomes in acute ischemic stroke patients undergoing mechanical thrombectomy: a nationwide analysis.

Background: Mechanical thrombectomy (MT) significantly improves outcomes in patients with acute ischemic stroke due to large vessel occlusion. There is limited understanding of how the site of hospital readmission after MT influences patient outcomes. Addressing this gap may be important for optimizing post-MT care and improving long-term outcomes for stroke patients.

Biomagnetic monitoring of urban atmospheric pollution: A review of magnetic signatures from different types of plants.

Biomagnetic monitoring has rapidly emerged as a valuable tool in urban atmospheric pollution (UAP) assessment due to its high spatial resolution, complementing traditional monitoring systems. This review systematically elucidates the principles of plant dust retention and the factors influencing it, while also reviewing the advancements in global research on UAP monitoring through the magnetic properties of various plant species. We provide a comprehensive analysis of the current applications of biomagnetic monitoring in UAP and identify critical challenges, including species-specific monitoring discrepancies, complex pollution sources, and non-standardized sample preparation methods.

Atomically Dispersed Fe-Mo Catalysts Mediate Fenton-Like Reaction to Efficiently Degrade Chlorophenol Pollutants Through Synergistic Oxidation and Dechlorination Reactions.

Chlorophenols are difficult to degrade and mineralize by traditional advanced oxidation processes due to the strong electronegativity of chlorine. Here, a dual-site atomically dispersed catalyst (FeMoNC) is reported, which Fe/Mo supported on mesoporous nitrogen-doped carbon is prepared through high-temperature migration. The FeMoNC exhibits a high dechlorination rate of 93.

Twisted Cucurbit[14]uril-Based Supramolecular Self-Assembly Induces Fluorescence Emission of Dye Molecules for Multi-Channel Cell Imaging.

In this study, a supramolecular fluorescent material was constructed by using double-cavity twisted cucurbit[14]uril (tQ[14]) and positively charged Astrazon Pink FG (APFG) based on the non-covalent host-guest interaction for the first time. The thermodynamic parameters of the APFG@tQ[14] in aqueous solution were determined by isothermal titration calorimetry (ITC), the results indicated that the spontaneous assembly of APFG@tQ[14] is mainly driven by enthalpy. The intramolecular charge transfer (ICT) effect induced the APFG@tQ[14] probe to emit a strong orange-red fluorescence.

TSC complex decrease the expression of mTOR by regulated miR-199b-3p.

The TSC complex formed by TSC1 and TSC2 is the most important upstream negative regulator of mTORC1. Genetic variations in either TSC1 or TSC2 cause tuberous sclerosis complex (TSC) disease which is a rare autosomal dominant disorder resulting in impairment of multiple organ systems. In this study, besides a reported variation, c.

Study on Few-Shot Fault Diagnosis Method for Marine Fuel Systems Based on DT-SViT-KNN.

The fuel system serves as the core component of marine diesel engines, and timely and effective fault diagnosis is the prerequisite for the safe navigation of ships. To address the challenge of current data-driven fault-diagnosis-based methods, which have difficulty in feature extraction and low accuracy under small samples, this paper proposes a fault diagnosis method based on digital twin (DT), Siamese Vision Transformer (SViT), and K-Nearest Neighbor (KNN). Firstly, a diesel engine DT model is constructed by integrating the mathematical, mechanism, and three-dimensional physical models of the Medium-speed diesel engines of 6L21/31 Marine, completing the mapping from physical entity to virtual entity.

Antifouling Hydrogel Based on Zwitterionic Poly(carboxybetaine diacrylate) Cross-Linkers.

Antifouling zwitterionic materials have extensive applications in the biomedical field. This study designed and successfully synthesized a novel poly(carboxybetaine) diacrylate (PCBDA) via cationic ring-opening polymerization of 2-methyl-2-oxazine, chain modification by the Michael reaction, and chain end transformation to acrylate. The cross-linker was obtained with a tunable molecular weight.

Microwave-assisted synthesis of carbonized polymer dots/CdS quantum dots/BiWO Z-scheme heterojunctions: Enhancing photocatalytic environmental remediation via dual-quantum dot heterostructures.

The fabrication of dual-quantum dot heterostructures offers a promising strategy to enhance the environmental remediation performance of photocatalysts. Herein, a BiWO-based Z-scheme heterojunction was constructed by incorporating carbonized polymer dots (CPDs) and CdS quantum dots (QDs) via a microwave-assisted solvothermal method. The 1 wt% CPDs/CdS QDs/BiWO (CCBW-1) composite achieved optimal Cr(VI) removal, reaching 97.

[Cardiac β-adrenergic receptor regulation of mitochondrial function in heart failure].

Heart failure is characterized by abnormal β-adrenergic receptor (β-AR) activation and mitochondrial dysfunction. In heart failure, overactivation of β-AR mediates key pathological processes in cardiomyocytes, including oxidative stress, calcium overload and metabolic abnormalities, which subsequently lead to inflammation, myocardial apoptosis and necrosis. Mitochondria are the core organelles for energy metabolism, and also play a vital role in calcium homeostasis, redox balance and signaling transduction.

Association between gut microbiota and short-chain fatty acids in children with obesity.

The gut microbiome and its metabolites may be important role in regulating the pathogenesis of obesity. This study aimed to characterize the gut microbiome and short-chain fatty acid (SCFA) metabolome in obese children. This case-control study recruited children aged 7‒14 years and divided them into a normal group (NG) and an obese group (OG) based on their body mass index.

Multi-stain deep learning prediction model of treatment response in lupus nephritis based on renal histopathology.

The response of the kidney after induction treatment is one of the determinants of prognosis in lupus nephritis, but effective predictive tools are lacking. Here, we sought to apply deep learning approaches on kidney biopsies for treatment response prediction in lupus nephritis. Patients who received cyclophosphamide or mycophenolate mofetil as induction treatment were included, and the primary outcome was 12-month treatment response, complete response defined as 24-h urinary protein under 0.

Global research on nanomaterials for liver cancer from 2004 to 2023: a bibliometric and visual analysis.

Background: Primary liver cancer, particularly hepatocellular carcinoma, is one of the most common gastrointestinal cancers. An increasing number of studies indicate that nanomaterials play a significant role in the diagnosis and treatment of liver cancer. However, despite the extensive and diverse research on nanomaterials and liver cancer, bibliometric studies in this field have not yet been reported.

Strategically Designed Ternary Nanohybrids of Titanate Nanosheet and Polydopamine-Coated Carbon Nanotubes for Highly Efficient Enrichment of Uranium(VI).

A strategically designed ternary nanohybrid (TNS-PDA/CNT), consisting of titanate nanosheet (TNS) and polydopamine-modified multiwalled carbon nanotube (PDA/CNT composite), was synthesized by the facile hydrothermal method and wet impregnation method for removal of U(VI) from aqueous solution and were characterized by transmission electron microscopy (TEM), scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDS), X-ray diffraction (XRD), Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), Raman spectroscopy, Brunauer-Emmett-Teller (BET), and X-ray photoelectron spectroscopy (XPS). TNSs were introduced into the PDA/CNT composite, which effectively averted the agglomeration of the CNT and further exposed more adsorption sites. PDA thin layer exposing more active sites was conducive to enhance adsorption capacity and kinetic.

Time-Frequency functional connectivity alterations in Alzheimer's disease and frontotemporal dementia: An EEG analysis using machine learning.

Objective: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are prevalent neurodegenerative diseases characterized by altered brain functional connectivity (FC), affecting over 100 million people worldwide. This study aims to identify distinct FC patterns as potential biomarkers for differential diagnosis.

Methods: Resting-state EEG data from 36 AD patients, 23 FTD patients, and 29 healthy controls were analyzed using time-frequency and bandpass filtering FC metrics.

Prediction Model and Decision Analysis for Early Recognition of SDNS/FRNS in Children.

Purpose: This study identified factors that identification of progression-predicting utility from steroid-sensitive nephrotic syndrome(SSNS) to steroid-dependent or frequently relapsing nephrotic syndrome (SDNS/FRNS) in patients and developed a corresponding predictive model.

Patients And Methods: This retrospective study analyzed clinical data from 756 patients aged 1 to 18 years, diagnosed with SSNS, who received treatment at the Department of Nephrology, Children's Hospital of Chongqing Medical University, between November 2007 and May 2023. We developed a shrinkage and selection operator (LASSO) - logistic regression model, which was visualized using a nomogram.

Highly efficient Ni/Ac-AlO catalysts in the dry reforming of methane: influence of acetic acid treatment and Ni loading.

The presence of abundant hydroxyl groups on the surface of AlO can promote the dispersion of Ni species but produce an inactive NiAlO phase at high temperatures. Moreover, the catalysts prepared by the conventional incipient wetness impregnation method lack the sites for the activation of CO, which leads to coke deposition and thus affects the catalyst activity. The above restricts the utilization of Ni in conventional Ni/AlO catalysts.

The effect of integrated medical care on the daily life of patients with coronary heart disease.

This study aims to explore the impact of comprehensive medical care on the daily life of patients with coronary heart disease (CHD) and to evaluate its effectiveness in improving quality of life, alleviating symptoms, and reducing the risk of cardiac events. A new comprehensive medical care scheme combining Traditional Chinese Medicine nursing differentiation, collaborative nursing interventions, and specialized community care was proposed. Patients with CHD were recruited as study subjects.

JAK2/ULK1 axis promotes cervical cancer progression by autophagy induction and SRPK1 phosphorylation.

Cervical cancer is the most common gynecologic cancer. Autophagy is involved in the progression of CCa. ULK1 is a crucial kinase in autophagy initiation.

A histopathology-based artificial intelligence system assisting the screening of genetic alteration in intrahepatic cholangiocarcinoma.

Background: Targeted therapy for intrahepatic cholangiocarcinoma (ICC) shows superior survival outcomes but patients with certain targetable alterations are no more than 20%. Genetic alteration screening for all ICC patients is of high cost and not routinely performed. This study intends to develop a histopathology-based artificial intelligence (AI)-assisted system for predicting genetic alteration of ICC.

An attention mechanism-based lightweight UNet for musculoskeletal ultrasound image segmentation.

Background: Accurate musculoseletal ultrasound (MSKUS) image segmentation is crucial for diagnosis and treatment planning. Compared with traditional segmentation methods, deploying deep learning segmentation methods that balance segmentation efficiency, accuracy, and model size on edge devices has greater advantages.

Purpose: This paper aims to design a MSKUS image segmentation method that has fewer parameters, lower computation complexity and higher segmentation accuracy.

Screening and validation of key genes associated with osteoarthritis.

Background: Osteoarthritis is recognized as a common geriatric condition characterized by irregular chronic pain. Its prevalence is steadily increasing, posing significant challenges to global public health, while some studies indicate a trend towards younger individuals being affected. This condition severely impacts patients' quality of life.

Cardiomyocyte-derived small extracellular vesicle-transported let-7b-5p modulates cardiac remodeling via TLR7 signaling pathway.

Cardiac remodeling is the major pathological change of heart failure. And let-7 family has been implicated in the development and pathogenesis of cardiovascular diseases. However, the mechanisms underlying let-7b-5p-mediated cellular pathogenesis of cardiac remodeling are not well understood.

Electronic relaxation pathways in thio-acridone and thio-coumarin: two heavy-atom-free photosensitizers absorbing visible light.

Heavy-atom-free photosensitizers (HAF-PSs) have emerged as a new class of photosensitizers aiming to broaden their applicability and versatility across various fields of the photodynamic therapy of cancers. The strategy involves replacing the exocyclic oxygen atoms of the carbonyl groups of established biocompatible organic fluorophores with sulfur, thereby bathochromically shifting their absorption spectra and enhancing their intersystem crossing efficiencies. Despite these advancements, the photophysical attributes and electronic relaxation mechanisms of many of these HAF-PSs remain inadequately elucidated.