Publications by authors named "Xiao Wei"

Deuterated compounds have broad applications across various fields, with dehalogenative deuteration serving as an efficient method to obtain these molecules. However, the diverse electronic structures of active sites in the heterogeneous system and the limited recyclability in the homogeneous system significantly hinder the advancement of dehalogenative deuteration. In this study, we present a catalyst composed of copper single-atom sites anchored within an ordered mesoporous nitrogen-doped carbon matrix, synthesized via a mesopore confinement method.

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This paper develops a finite element analysis model to investigate the seepage characteristics of cement sheaths, considering the flow properties of their porous medium. The model's applicability under various conditions was evaluated through grid sensitivity tests and model validation, indicating that it effectively captures the seepage behavior of cement sheaths with a reasonable degree of reliability. Key parameters, including cement sheath length, permeability, gap structure, pressure differential, and fluid properties, were analyzed using finite element methods to determine their impact on seepage flow.

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Optically-pumped magnetometer (OPM) has been of increasing interest for biomagnetic measurements due to its low cost and portability compared with superconducting quantum interference devices (SQUID). Miniaturized spin-exchange-relaxation-free (SERF) OPMs typically have limited bandwidth (less than a few hundred Hertz), making it difficult to measure high-frequency biomagnetic signals such as the magnetocardiography (MCG) signal of the mouse. Existing experiments mainly use SQUID systems to measure the signal.

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As the antibiotic resistance of pathogens becomes increasingly severe, it is becoming more feasible to use methods that suppress the virulence of pathogens rather than exerting selective pressure on their growth. , a dangerous opportunistic pathogen, infects hosts by producing multiple virulence factors, which are regulated by quorum-sensing (QS) systems, including the systems, systems, and systems. This study used the chromosome transcription fusion reporter model to screen the traditional Chinese medicine monomer library and found that bakuchiol can effectively inhibit the system and related virulence phenotypes of , including the production of virulence factors (pyocyanin, hydrogen cyanide, elastase, and lectin) and motility (swarming, swimming, and twitching motility) without affecting its growth.

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In uncertain situations, individuals seek to maximize rewards while managing risks. Yet, the effects of acute stress and anxiety on decision-making in ambiguous and risky contexts are unclear. This study aims to contribute to the exploration of how acute stress influences sensitivity to immediate vs.

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Purpose: The purpose of this study was to use the advanced technique of Network Intervention Analysis (NIA) to investigate the trajectory of symptom change associated with the effects of self-control training on youth university students' chronic ego depletion aftereffects.

Methods: The nine nodes of chronic ego depletion aftereffects and integrated self-control training were taken as nodes in the network and analyzed using NIA. Networks were computed at the baseline, at the end of treatment, at 1-, 3-, 6-, 9- and 12-month follow up.

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In the business context, effectively responding to negative reviews is critical for a hotel to maintain reputation and customer relations. To explore the linguistic devices employed in addressing guest complaints, a corpus-based study is conducted on the use of interactional metadiscourse and identity construction in responses to negative online reviews of Chinese and British Hotels. Drawing upon the statistical results of the usage of interactional metadiscourse and the analysis of discourse examples, this study delves into the frequency and similarities/differences in the employment of five subcategories of interactional metadiscourse across the respective corpora of 100 responses to negative reviews from hotels in Beijing and hotels in London.

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Background: Retinal microvascular abnormalities (RMA) reflect cumulative microvascular damage from systemic diseases and aging. However, little is known about the association between RMA and long-term survival outcomes. This study aimed to examine the relationships between RMA and the risk of all-cause and specific-cause mortality among U.

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The research and development of new traditional Chinese medicine drugs has gradually formed a new system based on the combination of traditional Chinese medicine theory, human experience, and clinical trials(referred to as the "three combinations"). However, given the characteristics of traditional Chinese medicine's "syndrome differentiation and treatment" and "diverse components and complex mechanisms", there are still problems in the current research and development of new traditional Chinese medicine drugs, such as insufficient research on the material basis and overall mechanism of action, and incomplete evidence chain system. At the same time, there are still many challenges in collecting human experience, evaluating clinical efficacy, and controlling the quality of active ingredients, which restrict the innovation process of research and development of new traditional Chinese medicine drugs.

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Chimeric antigen receptor T (CAR-T) cells are genetically engineered T cells expressing transmembrane chimeric antigen receptors with specific targeting abilities. As an emerging immunotherapy, the use of CAR-T cells has made significant breakthroughs in cancer treatment, particularly for hematological malignancies. The success of CAR-T cell therapy in blood cancers highlights its potential for other conditions in which the clearance of pathological cells is therapeutic, such as liver diseases, infectious diseases, heart failure, and diabetes.

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Background: To compare the efficacy of intramedullary nailing via the lateral parapatellar approach versus the infrapatellar approach in treating fractures at the tibial metaphyseal-diaphyseal junction.

Methods: A retrospective analysis was conducted on the clinical data of 45 patients with proximal or distal tibial fractures treated with intramedullary nailing via lateral parapatellar approach (n = 23) or infrapatellar approach (n = 22) between January 2019 and March 2023. We recorded and compared the operative time, intraoperative blood loss/fluoroscopies, success rate of closed reduction, anteroposterior and lateral entry point accuracy, postoperative infection, fracture healing time, as well as NRS pain scores, Lysholm knee function scores, and knee range of motion.

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The rare and endangered wild plant, , has been listed as a second-level key protected plant in China. Currently, its habitat is severely damaged, and the population has dramatically declined, necessitating urgent intervention for protection. In this study, the aim was to explore the correlations and differences from the perspectives of photosynthetic characteristics and leaf structure, providing scientific references for conservation and cultivation.

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Background: The association between serum uric acid (UA) and all-cause and cardiovascular-related mortality in hemodialysis (HD) patients is conflicting. We investigated this association and explored the effect modification of underlying nutritional status, as reflected in the lean tissue index (LTI) and the Geriatric Nutritional Risk Index (GNRI), which serve as markers of muscle mass and nutritional risk in HD patients.

Methods: A retrospective cohort study was conducted from January 2019 to December 2023.

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The 7085 aluminum alloy with a low Cu content is an important lightweight structural material in the aerospace field due to its advantages of low density, high specific strength, and high hardenability. However, like other high-strength Al-Zn-Mg-Cu alloys, this alloy is susceptible to stress corrosion cracking (SCC). Additionally, the lower Cu content may increase its tendency toward SCC, potentially impacting the safe use of this alloy.

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Plants subjected to cold stress have been observed to accumulate proline, but the underlying regulatory mechanism remains to be elucidated. In this study, we identified a pyrroline-5-carboxylate synthetase (P5CS)-encoding gene (CtrP5CS1) from trifoliate orange (Citrus trifoliata L.), a cold-hardy citrus species, as a critical gene for cold-induced proline accumulation.

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Dazhu Hongjingtian (DZ) is renowned for its diverse pharmacological activities, yet its metabolic pathways remain to be fully elucidated. In this study, the metabolic profile after oral administration of DZ extract (DZE) in rats was systematically identified by the UPLC/Q-TOF-MS/MS method for the first time. A total of 94 components, including 32 prototypes and 62 metabolites, were tentatively characterized in rat plasma and various tissues samples.

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Article Synopsis
  • - Breast cancer is a major global health issue for women, often complicated by current treatments like chemotherapy and radiotherapy that can lead to drug resistance and poor outcomes due to mechanisms like anti-apoptosis.
  • - Ferroptosis is a new form of cell death linked to factors such as iron overload and oxidative stress, which has been shown to hinder cancer cell growth and increase sensitivity to standard treatments.
  • - The paper reviews the mechanisms and signaling pathways involved in ferroptosis related to breast cancer, highlighting the need for more research to better understand its regulatory factors and improve treatment strategies.
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Patients with advanced metastatic castration-resistant prostate cancer (mCRPC) are refractory to immune checkpoint inhibitors (ICIs), partly because there are immunosuppressive myeloid cells in tumours. However, the heterogeneity of myeloid cells has made them difficult to target, making blockade of the colony stimulating factor-1 receptor (CSF1R) clinically ineffective. Here we use single-cell profiling on patient biopsies across the disease continuum and find that a distinct population of tumour-associated macrophages with elevated levels of SPP1 transcripts (SPP1-TAMs) becomes enriched with the progression of prostate cancer to mCRPC.

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Article Synopsis
  • - Triple-negative breast cancer has a "cold" microenvironment that resists current immunotherapy, but activating the STING pathway shows potential for improving treatment effectiveness.
  • - The study combines photothermal therapy (PTT) using a semiconductor nano-agent (DPTT-Mn Lipo NPs) with innate immune responses to reprogram the immune-suppressive environment and enhance anti-tumor immunity.
  • - This approach not only triggers cell death and activates immune cells but also works well with anti-PD-1 therapy to create lasting immune memory, helping to prevent tumor recurrence.
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Article Synopsis
  • The study focuses on enhancing the oxygen evolution reaction (OER) in perovskites by inducing surface reconstruction through trace Ce-doped LaCeNiFeO nanofibers (LCNF-NFs), which improves their catalytic activity.* -
  • High oxygen vacancies in the LCNF-NFs lower the reconstruction potential and increase electrolyte access, leading to significant generation of self-reconstructed electroactive Ni/FeO(OH) species on the surface.* -
  • The restructured LCNF-NFs demonstrated superior performance with a lower Tafel slope of 50.12 mV dec and a reduced overpotential of 342.3 mV, making them highly efficient compared to conventional electrocatalysts.*
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Background: While immunotherapy has revolutionized oncological management, its efficacy in lung cancer patients with liver metastases remains limited, potentially due to the unique immunosuppressive microenvironment of the liver. Local liver treatment has been shown to enhance the immunotherapy response, and high-intensity focused ultrasound (HIFU), a minimally invasive local treatment, has demonstrated promising results in combination with immunotherapy. However, clinical data regarding HIFU in lung cancer with liver metastases are limited.

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Article Synopsis
  • Hybrid organic-inorganic molecular ferroelectrics are being developed into flexible, dual-responsive composites for better application in piezoelectric devices, overcoming issues like brittleness.
  • The new SEBS/TMCM-MnCl composite shows impressive mechanical properties, with over 1300% tensile strain, and capabilities like piezoelectricity and photoluminescence, suitable for advanced anticounterfeiting and encryption applications.
  • This research paves the way for innovative designs in optoelectronic materials, leading to more secure password systems and potential advancements in human-machine interaction and robotics.
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The study was to evaluate the physical condition and mental health of Chinese college student COVID-19 survivors, and to perform severity clustering of physical symptoms. The study finally included 1912 Chinese college students. A total of 33 symptoms including general physical symptoms, cardiopulmonary system, digestive system, neurological system, mental health and other symptoms were investigated three months after recovery from COVID-19, and these symptoms are identified using latent class analysis.

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Liver disease involves a complex interplay of pathological processes, including inflammation, hepatocyte necrosis, and fibrosis. End-stage liver disease (ESLD), such as liver failure and decompensated cirrhosis, has a high mortality rate, and liver transplantation is the only effective treatment. However, to overcome problems such as the shortage of donor livers and complications related to immunosuppression, there is an urgent need for new treatment strategies that need to be developed for patients with ESLD.

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