[Perioperative nitric oxide inhalation therapy for open heart surgery patients with pulmonary hypertension].

Objective: To investigate effectiveness and safety of perioperative nitric oxide (NO) inhalation therapy for open heart surgery patients with pulmonary hypertension.

Methods: Servo 300A and Pulmonox Aeronox were used for NO delivery and monitoring. NO was used perioperatively in 27 adult and 1 pediatric open heart surgery patients with pulmonary hypertension which were not effectively relieved by conventional treatment.

[The analysis of 252 episodes of recruitment maneuver during mechanical ventilation in surgery intensive care unit].

Objective: To analyze the clinical effects of recruitment maneuver and the impacts on blood pressure and oxygen saturation in patients with mechanical ventilation.

Methods: To analyze all related data from 252 episodes of recruitment maneuver of 46 patients admitted from July 2005 to February 2007. Recruitment maneuver method: the drive pressure constant was kept at 15 cm H(2)O (1 cm H(2)O=0.

[PET study of effects of combination of different points on glucose metabolism in the patient of cerebral infarction].

Objective: To observe effects of combination of different points on glucose metabolism in the patient of cerebral infarction.

Methods: Neiguan (PC 6), Shuigou (GV 26), Fengchi (GB 20), Sanyinjiao (SP 6), Yinlingquan (SP 9), Taichong (LR 3) were selected for the Xingnao Kaiqiao group (n =7), and Hegu (LI 4), Quchi (LI 11), Zusanli (ST 36), Yanglingquan (GB 34) and Xuanzhong (GB 39) for the routine acupuncture group (n = 5). PET-CT was used to observe the local cerebral glucose metabolism.

Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines.

Insig-1 and Insig-2 are closely related proteins of the endoplasmic reticulum that play crucial roles in cholesterol homeostasis by inhibiting excessive cholesterol synthesis and uptake. In sterol-depleted cells Insig-1 is degraded at least 15 times more rapidly than Insig-2, owing to ubiquitination of Lys-156 and Lys-158 in Insig-1. In this study, we use domain-swapping methods to localize amino acid residues responsible for this differential degradation.