An empirical study of LLaMA3 quantization: from LLMs to MLLMs.

The LLaMA family, a collection of foundation language models ranging from 7B to 65B parameters, has become one of the most powerful open-source large language models (LLMs) and the popular LLM backbone of multi-modal large language models (MLLMs), widely used in computer vision and natural language understanding tasks. In particular, LLaMA3 models have recently been released and have achieved impressive performance in various domains with super-large scale pre-training on over 15T tokens of data. Given the wide application of low-bit quantization for LLMs in resource-constrained scenarios, we explore LLaMA3's capabilities when quantized to low bit-width.

Extraction, purification, structural characteristics, biological activities, modifications, and applications from Hericium erinaceus polysaccharides: A review.

Hericium erinaceus (Bull.) Pers. is a respected medicinal and edible fungus known for its outstanding nutritional profile.

No need for hip precautions after total hip arthroplasty with posterior approach: A systematic review and meta-analysis.

Background: Nowadays, total hip arthroplasty (THA) is one of the most successful procedures in the field of orthopedics and trauma. The posterior approach has historically been associated with a higher rate of hip dislocation. To reduce the rate of hip dislocation in the posterior approach, most orthopedic surgeons would recommend hip precautions (HP) for their patients postoperatively based on previous theories.

Nucleus-Targeting Photosensitizers Enhance Neutrophil Extracellular Traps for Efficient Eradication of Multidrug-Resistant Bacterial Infections.

Neutrophil extracellular traps (NETs) are web-like complexes of DNA and proteins that are extruded by activated neutrophils and play critical roles as major components of the innate immune response against pathogen invasion. However, some microbes have developed strategies to evade NET attacks, leading to impaired immune defenses and persistent infections. In this study, an engineered neutrophil strategy for enhancing the antibacterial activity of NETs is developed.

Imaging of permeability defect distribution by electromagnetic tomography with hybrid L1 norm and nuclear norm penalty terms.

Electromagnetic tomography (EMT), with the advantages of being non-contact, non-invasiveness, low cost, simple structure, and fast imaging speed, is a multi-functional tomography technique based on boundary measurement voltages to image the conductivity distribution within the sensing field. EMT is widely used in industrial and biomedical fields. Currently, there are few studies on the application of EMT in magnetic permeability materials, which makes it difficult to obtain high-quality reconstructed images due to its own properties that lead to obvious attenuation of electromagnetic waves during propagation, as well as the ill-posed and ill-conditioned characteristics of EMT.

Combating Fungal Infections and Resistance with a Dual-Mechanism Luminogen to Disrupt Membrane Integrity and Induce DNA Damage.

Antifungal drug resistance is a critical concern, demanding innovative therapeutic solutions. The dual-targeting mechanism of action (MoA), as an effective strategy to reduce drug resistance, has been validated in the design of antibacterial agents. However, the structural similarities between mammalian and fungal cells complicate the development of such a strategy for antifungal agents as the selectivity can be compromised.

Thiolate-mediated photoreduction and aerobic oxidation cycles in a bismuth-bismuth oxide nanosystem towards thiol-to-disulfide photocatalytic transformation.

Bismuth(III) alkanethiolates [Bi(SR)] formed by reacting BiO with alkanethiols (RSH) undergo a UV-blue light driven ligand-to-metal charge transfer photoreduction to disulfides and Bi colloids, which are then oxidised to BiO by dissolved oxygen and reconverted to Bi(SR) by RSH to prepare for the next Bi-BiO photoredox cycle, forming a basis for Bi(III)-catalysed thiol-to-disulfide conversion.

The destruction of cytoplasmic skeleton leads to the change of nuclear structure and the looseness of lamin A submicroscopic network.

The interaction between lamin A and the cytoplasmic skeleton plays a key role in maintaining nuclear mechanical properties. However, the effect of destruction of the cytoplasmic skeleton on the 3D submicroscopic structure of lamin A has not been elucidated. In this study, we developed an image quantization algorithm to quantify changes in the submicroscopic structure of the intact lamin A 3D network within the nucleus.

Long-Chain Molecular Crystals Antimony(III) Alkanethiolates Sb(SCH) ( ≥ 12): Synthesis, Crystal and Electronic Structures, and Supramolecular Self-Assembly via Secondary Interactions.

Currently, there is not much success in solving the molecular and crystal structures of long-chain metal alkanethiolate complexes [M(SCH)] at the atomic level. Taking Sb(SCH) () as an example, we herein disclose the structural characteristics of long-chain trivalent antimony(III) alkanethiolates Sb(SCH) ( ≥ 12) by single-crystal X-ray crystallography. Specifically, the Sb atom is three-coordinated by alkanethiolate ligands and a slightly distorted triangular pyramid SbS core is formed owing to the unique intramolecular stereochemistry of three alkyl chains, namely, two of them almost parallel aligning and the third chain extending alone around the SbS core.

Study on the mechanism of macrophages activated by phosphoesterified rehmanniae polysaccharide on human gastric cancer cells.

Gastric cancer(GC)is one of the most common gastrointestinal malignant tumors in the world, requiring the development of novel therapeutic agents with reduced toxicity. Rehmannia polysaccharide (RPS) possesses immunomodulatory and anti-tumor properties, yet its efficacy is suboptimal. To enhance its biological activity, we subjected RPS to molecular modifications, resulting in phosphorylated Rehmannia polysaccharides (P-RPS).

Identification of the health education targeted susceptible population of tuberculosis in Ningxia, Northwest China.

Knowledge, Attitude, and Practice (KAP) survey, as an effective measure tool, is of practical significance for identifying the susceptible population in high-incidence regions of tuberculosis (TB). We aim to identify the health education targeted susceptible population of TB and discuss the acting pathway of KAP in Ningxia. A multistage random sampling method was used to conduct a face-to-face questionnaire survey for residents.

Image reconstruction of electrostatic tomography based on the improved residual network.

The core of electrostatic tomography (EST) is to solve the inverse problem, but the EST independent measurement data are much smaller than the value that needs to be reconstructed, resulting in a more serious inverse problem. This paper presents an improved ResNet-34 network (P-ResNet), which consists of an input layer, a residual feature extraction layer, and an output layer. The number of residual blocks is 3, 4, 4, and 3.

Hierarchical Perceptual Noise Injection for Social Media Fingerprint Privacy Protection.

Billions of people share images from their daily lives on social media every day. However, their biometric information (e.g.

Surface-Enriched Single-Bi-Atoms Tailoring of Pt Nanorings for Direct Methanol Fuel Cells with Ultralow-Pt-Loading.

Single-atom decorating of Pt emerges as a highly effective strategy to boost catalytic properties, which can trigger the most Pt active sites while blocking the smallest number of Pt atoms. However, the rational design and creation of high-density single-atoms on Pt surface remain as a huge challenge. Herein, a customized synthesis of surface-enriched single-Bi-atoms tailored Pt nanorings (SE-Bi/Pt NRs) toward methanol oxidation is reported, which is guided by the density functional theory (DFT) calculations suggesting that a relatively higher density of Bi species on Pt surface can ensure a CO-free pathway and accelerate the kinetics of *HCOOH formation.

Association between ambient temperature, PM and tuberculosis in Northwest China.

   Existing evidence suggested that the risk of tuberculosis (TB) infection was associated to the variations in temperature and PM. A total of 9,111 cases of TB were reported in Ningxia Hui Autonomous Region, China from 2013 to 2015 on a daily basis, and 57.2% of them were male.

Capsule Shedding and Membrane Binding Enhanced Photodynamic Killing of Gram-Negative Bacteria by a Unimolecular Conjugated Polyelectrolyte.

The development of new antimicrobial agents to treat infections caused by Gram-negative bacteria is of paramount importance due to increased antibiotic resistance worldwide. Herein, we show that a water-soluble porphyrin-cored hyperbranched conjugated polyelectrolyte () exhibits high photodynamic bactericidal activity against the Gram-negative bacteria tested, including a multidrug-resistant (MDR) pathogen, while demonstrating low cytotoxicity toward mammalian cells. Comprehensive analyses reveal that the antimicrobial activity of proceeds via a multimodal mechanism by effective bacterial capsule shedding, strong bacterial outer membrane binding, and singlet oxygen generation.

Targeted Depletion of Individual Pathogen by Bacteria-Templated Polymer.

Selective and targeted removal of individual species or strains of bacteria from complex communities can be desirable over traditional and broadly acting antibiotics in several conditions. However, strategies that can detect and ablate bacteria with high specificity are emerging in recent years. Herein, a platform is reported that uses bacteria as a template to synthesize polymers containing guanidinium groups for self-selective depletion of specific pathogenic bacteria without disturbing microbial communities.

Associations Between Gender Gaps in Life Expectancy, Air Pollution, and Urbanization: A Global Assessment With Bayesian Spatiotemporal Modeling.

It's evident that women have a longer life expectancy than men. This study investigates the spatiotemporal trends of gender gaps in life expectancy (GGLE). It demonstrates the spatiotemporal difference of the influence factors of population-weighted air pollution (pwPM) and urbanization on GGLE.

Diverse Sample Generation: Pushing the Limit of Generative Data-Free Quantization.

Generative data-free quantization emerges as a practical compression approach that quantizes deep neural networks to low bit-width without accessing the real data. This approach generates data utilizing batch normalization (BN) statistics of the full-precision networks to quantize the networks. However, it always faces the serious challenges of accuracy degradation in practice.

BiFSMNv2: Pushing Binary Neural Networks for Keyword Spotting to Real-Network Performance.

Deep neural networks, such as the deep-FSMN, have been widely studied for keyword spotting (KWS) applications while suffering expensive computation and storage. Therefore, network compression technologies such as binarization are studied to deploy KWS models on edge. In this article, we present a strong yet efficient binary neural network for KWS, namely, BiFSMNv2, pushing it to the real-network accuracy performance.

Imaging system design based on electromagnetic tomography for high conductivity medium reconstruction.

Electromagnetic tomography (EMT) is used to create tomographic images of the electrical properties of conducting material based on electromagnetic measurements from coils evenly distributed around the imaging region. EMT is widely used in industrial and biomedical fields for which it offers the advantages of being non-contact, fast, and non-radiative. Most EMT measurement systems are implemented with commercial instruments, such as impedance analyzers and lock-in amplifiers, which are bulky and inconvenient for portable detection devices.

Spatiotemporal trends in neonatal, infant, and child mortality (1990-2019) based on Bayesian spatiotemporal modeling.

Background: Neonatal mortality rate (NMR), infant mortality rate (IMR), and child mortality rate (CMR) show a huge difference across countries, which has been posing challenges for public health policies and medical resource allocation.

Methods: Bayesian spatiotemporal model is applied to assess the detailed spatiotemporal evolution of NMR, IMR, and CMR from a global perspective. Panel data from 185 countries from 1990 to 2019 are collected.

Identification of copper metabolism and cuproptosis-related subtypes for predicting prognosis tumor microenvironment and drug candidates in hepatocellular carcinoma.

Copper (Cu) is an essential element of organisms, which can affect the survival of cells. However, the role of copper metabolism and cuproptosis on hepatic carcinoma is still unclear. In this study, the TCGA database was used as the test set, and the ICGC database and self-built database were used as the validation set.