A Phase I Clinical Trial to Evaluate the Bioequivalence of an Adalimumab Biosimilar Adalimumab-WIBP and Humira.

Background And Objectives: The high costs associated with biological agents often limit accessibility for many patients, whereas biosimilars allow the wider application of biological treatment. The objectives of this phase I clinical trial were to compare the pharmacokinetics, immunogenicity, and safety profiles of the biosimilar adalimumab-WIBP and the reference product Humira and to assess the precision of the bioequivalence evaluation.

Methods: In this randomized, double-blind, parallel-group bioequivalence study, 164 healthy male Chinese participants were selected and randomly divided into two groups on a 1:1 ratio.

Ralstonia solanacearum Infection Drives the Assembly and Functional Adaptation of Potato Rhizosphere Microbial Communities.

Bacterial wilt caused by Ralstonia solanacearum is a destructive disease that affects potato production, leading to severe yield losses. Currently, little is known about the changes in the assembly and functional adaptation of potato rhizosphere microbial communities during different stages of R. solanacearum infection.

Simultaneous utilization of copper and non-metals from waste integrated circuits for precious metal melting capture and organics thermal detoxification.

Waste integrated circuits, with underlying resource attributes and environmental risks, are complex in composition. Current processes suffer from high resource inputs, excessive pollutant emissions and incomplete treatment of varied species. Therefore, a comprehensive resource recycling and safe disposal process integrated with precious metal enrichment, non-metal resource utilization, and organic detoxification was proposed.

Impact of resistance exercise on patients with chronic kidney disease.

Background: Chronic kidney disease (CKD) has become an increasingly important public health disease with a high incidence rate and mortality. Although several studies have explored the effectiveness of resistance exercise in improving the prognosis of CKD patients, the number of studies is still limited and the results are still controversial.

Objectives: We conducted this meta-analysis of randomized controlled trials (RCT) studies to evaluate the effectiveness of resistance exercise on CKD patients.

Melatonin alleviates cisplatin-induced mice spermatogenesis defects.

Cisplatin (CDDP) is a chemotherapeutic drug that is used to treat many different types of tumors. However, it also has significant adverse effects on male reproduction, which are partially mediated oxidative damage. Melatonin (MLT) is a promising antioxidant that can be used for reproductive protection.

Exploration of cultural norms and behavioural beliefs about zoo animal behaviour, welfare, ethics and husbandry practices in a sample of the international zoo community.

Beliefs influence the intentions of people to behave in certain ways towards animals. This study presents survey responses from 237 people working in zoos in China and Europe and describes their demographic characteristics. It explores their beliefs about zoo animal behaviour, welfare and ethical issues, and zoo practices, using a survey methodology.

Recovering metals from flue dust produced in secondary copper smelting through a novel process combining low temperature roasting, water leaching and mechanochemical reduction.

Flue dust from secondary copper smelting (FDSC) is a hazardous waste as well as a secondary resource due to the high content of Cl, Br, and valuable metals (Pb, Cu, Zn, Cd). Herein, a novel process, combined low-temperature roasting, water leaching, and mechanochemical reduction, was developed for recovering metals from the FDSC. The phase conversion and behavior of the main elements in the whole process were explored based on thermodynamic analysis, experimental research, and various characterization.

Insights into the effect of cations on cathodic behavior and microstructure in cadmium electrochemical recovery process.

Secondary resources provide an essential source for cadmium recovery, but also bring severe environmental problems. Due to the short process and high product purity, electrodeposition is suitable for realizing the reduction, reuse, and recycling of cadmium, while the complex composition of the resources contributes to a complicated electrochemical system. In this work, the effect of common cations (Cu, Ni, Fe, and Zn) on cadmium electrochemical recovery was investigated from the perspective of electrochemical behavior and microstructure.

Co-treatment of copper smelting flue dust and arsenic sulfide residue by a pyrometallurgical approach for simultaneous removal and recovery of arsenic.

As the typical hazardous arsenic pollutants, copper smelting flue dust (CSFD) and arsenic sulfide residue (ASR) are produced extensively during copper smelting process, which pose significant pressure on environmental protection and green development of the copper industry. This work proposed an economic, efficient, and applicable approach to treat waste with waste, in which the simultaneous removal and recovery of As from CSFD and ASR were realized by a roasting process, with adding sulfuric acid, at a relatively low temperature (300-350 ℃). The thermodynamic analysis and experiments confirmed that the main phases of AsS and S in the ASR were used as a reductant for reducing As(Ⅴ) in the CSFD, and the introduction of sulfuric acid favorably enhanced the thermodynamic driving force and greatly lowered the reaction temperature.

Efficient removal and recovery of arsenic from copper smelting flue dust by a roasting method: Process optimization, phase transformation and mechanism investigation.

The efficient removal and recovery of arsenic from copper smelting flue dust have received widespread attention due to its extremely high toxicity and carcinogenicity. In this research, a roasting method used for treating the dust at a relatively low temperature (300-400 ℃), with adding sulfuric acid and bitumite, was proposed, in which the reduction of As(Ⅴ) and oxidation of arsenic sulfides were achieved simultaneously. It was proved by thermodynamic analysis and experiments that adding sulfuric acid was favorable for the removal of arsenic, through enhancing the thermodynamic driving force and promoting the transformation of arsenate and arsenic sulfides to AsO.

3D Cascaded Convolutional Networks for Multi-vertebrae Segmentation.

Background: Automatic approach to vertebrae segmentation from computed tomography (CT) images is very important in clinical applications. As the intricate appearance and variable architecture of vertebrae across the population, cognate constructions in close vicinity, pathology, and the interconnection between vertebrae and ribs, it is a challenge to propose a 3D automatic vertebrae CT image segmentation method.

Objective: The purpose of this study was to propose an automatic multi-vertebrae segmentation method for spinal CT images.

Association between resting-state brain functional connectivity and cortisol levels in unmedicated major depressive disorder.

Disturbed hypothalamus-pituitary-adrenal axis function, which leads to excessive and prolonged hypercortisolemia, is a core feature of major depressive disorder (MDD). However, the relationships between depression, brain structure and function, and cortisol levels are unclear. The current study examined the whole-brain functional connectivity pattern of patients with MDD and evaluated the association between functional connectivity and serum cortisol levels in MDD.

Dynamic variations in platelet counts may reflect the severity and prognosis of stingray injuries in the early phase.

There is often a delay in offering quality and prompt treatment after a stingray sting. We present 3 cases of stings and discuss the Poisoning Severity Score (PSS) and a simple tool to assess the severity of such injuries. A 34-year-old man, who worked as an aquarium keeper, presented a wound on the left fifth digit caused by a stingray.

Inhibitory Effect of Propolis on Platelet Aggregation In Vitro.

Platelet hyperactivity plays an important role in arterial thrombosis and atherosclerosis. The present study was aimed to investigate the effects of different extracts of propolis and components of flavonoids on platelet aggregation. Platelet-rich plasma was prepared and incubated in vitro with different concentrations of the tested extracts and components of flavonoids.

Calycosin attenuates dextran sulfate sodium (DSS)-induced experimental colitis.

Objectives: Inflammatory bowel disease (IBD) results from dysregulation of intestinal mucosal immunity. It is an incurable disease that affects millions of people worldwide. Developing new strategies for the treatment of colitis has been a major challenge.

Semi-automated enhanced breast tumor segmentation for CT image.

Accurate detection of breast cancer region is essential for treatment. X-ray computed tomography (CT) is an effective diagnostic method of breast cancer besides MRI and ultrasound. In this paper, a semi-automated breast cancer segmentation method was proposed to CT images.

HEROD: a human ethnic and regional specific omics database.

Motivation: Genetic and gene expression variations within and between populations and across geographical regions have substantial effects on the biological phenotypes, diseases, and therapeutic response. The development of precision medicines can be facilitated by the OMICS studies of the patients of specific ethnicity and geographic region. However, there is an inadequate facility for broadly and conveniently accessing the ethnic and regional specific OMICS data.

Prediction of malignant and benign of lung tumor using a quantitative radiomic method.

Lung cancer is the leading cause of cancer mortality around the world, the early diagnosis of lung cancer plays a very important role in therapeutic regimen selection. However, lung cancers are spatially and temporally heterogeneous; this limits the use of invasive biopsy. But radiomics which refers to the comprehensive quantification of tumour phenotypes by applying a large number of quantitative image features has the ability to capture intra-tumoural heterogeneity in a non-invasive way.

Chemical composition, in vitro antioxidant activity and α-glucosidase inhibitory effects of the essential oil and methanolic extract of Elsholtzia densa Benth.

Elsholtzia densa Benth. is a traditional aromatic herb used in the pharmaceutical and flavouring industries. To analyse and compare the chemical composition, the oils and nonvolatile compounds in E.

IgG4-related spinal pachymeningitis.

The aim of this study is to study the clinical, laboratory, imaging pathology, and prognosis features of IgG4-related spinal pachymeningitis. We worked with a 55-year-old man suffering from IgG4-related spinal pachymeningitis who had the most widespread lesion in his dura mater. We also review previous related studies and discuss the clinical characteristics of this rare disease.

Downregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3.

Phosphoglycerate dehydrogenase (PHGDH) is the key enzyme of de novo serine biosynthesis. Previous reports have demonstrated that PHGDH plays an important role in some malignancies. However, the biological role of PHGDH in human cervical adenocarcinoma has not been explored.

A projection selection method to improve image quality in optical projection tomography.

Optical projection tomography (OPT) is a very important imaging tool for a mesoscopic-scale. It can provide three dimensional (3D) transmission and emission imaging. However, high-resolution OPT is limited in depth of field (DOF) due to a high numerical aperture, which causes a poor performance of OPT in imaging large samples.

[Cloning of tae-MIR156 precursor gene and sequence polymorphisms of tae-miR156 targeted TaSPL17].

Squamosa-promoter binding protein (SBP)-box genes, encoding plant-specific transcription factors, play an important role in plant development. Some members of the SBP-box gene family are regulated by miR156. In this study, we cloned the tae-MIR156 precursor gene, which could form a stem loop after its transcription.

Burkholderia and Cupriavidus spp. are the preferred symbionts of Mimosa spp. in southern China.

Rhizobia were isolated from invasive Mimosa spp. (M. diplotricha and M.