Screening and identification of potential target of 1'-acetoxychavicol acetate (ACA) in acquired lapatinib-resistant breast cancer.

1'-Acetoxychavicol acetate (ACA) eliminates breast cancer cells via the HER2/MAPK/ERK1/2 and PI3K/AKT pathways, and it also directly influences endocrine resistance by both enhancing pro-apoptotic signals and suppressing pro-survival molecules. This study utilized bioinformatics to assess ACA target genes for lapatinib-resistant breast cancer. We identified differentially expressed genes (DEGs) using GSE16179 microarray data.

Disaster preparedness: The role of spatial disaster learning using geospatial technology.

Unlabelled: Preparedness for natural disasters is crucial for people living in high-risk areas along the Ring of Fire, such as people in Indonesia. Although Spatial Disaster Learning using Geospatial Technology (SDL-GeoTech) has been developed, its effectiveness in enhancing students' preparedness remains unproven. This study examines the impact of SDL-GeoTech on junior high school students' readiness using a quasi-experimental, time-series, single-group pre-post-test design.

Exploring the determinants of exclusive breastfeeding practices among first-time mothers: A narrative review.

Exclusive breastfeeding (EBF) means giving only breast milk to babies 0-6 month without giving any drinks or food, except medicines and vitamins. Only 44% of babies received EBF worldwide in 2020. Meanwhile, in 2025, the target for achieving EBF is 50%.

Water pollution and sanitation in Indonesia: a review on water quality, health and environmental impacts, management, and future challenges.

As an archipelagic tropical developing country, Indonesia is characterized by vast expanses of rural and isolated areas. This review aims to discuss water pollution and sanitation's existing condition, health, and environmental impacts, alongside its management and challenges in Indonesia. The systematic review approach was utilized to ensure transparency and replicability, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria.

Prognostic role of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in critically ill COVID-19 patients: A retrospective study.

Introduction: Critical coronavirus disease (COVID-19) patients have a high mortality rate. To identify high-risk patients, first-level healthcare facilities can use the neutrophil-lymphocyte ratio (NLR) and the plateletlymphocyte ratio (PLR) as prognostic markers. We aimed to assess the NLR and the PLR profile in critically ill COVID-19 patients to predict disease severity.

Production and effects of nanomineral selenium (Nano-Se) feed additive on rumen fermentation, productivity, and reproductive performance of ruminants.

Nanotechnology (Nano) applications of feed additives can potentially improve feed-substrate efficiency to enhance livestock productivity. The utilization of Nano in feed in ruminants still tends to be under-explored and reviewed, particularly the application of Nano in trace minerals to enhance the reproductive performance and productivity of ruminants such as selenium. Trace minerals are essential for animal well-being and productivity, and the bioavailability of trace minerals is influenced by a complex matrix of interacting variables, including the chemical form of the minerals used and those found in the diet, the nature of the food ingested, the total composition of the diet, and the health and nutrition of the livestock.

Evaluation of the Usability and User Experience of the Jaminan Kesehatan Nasional Mobile Application in Indonesia.

Objectives: The National Health Insurance (Jaminan Kesehatan Nasional or JKN) mobile application represents an administrative transformation of health social insurance in Indonesia. The application's user base has quadrupled in the past 2 years. The study aimed to evaluate the usability and user experience of the JKN mobile application in Indonesia.

Effect of preventive chemotherapy for neglected tropical diseases in Indonesia from 1992 to 2022: A systematic review and meta-analysis.

Objectives: This study aimed to describe the prevalence of lymphatic filariasis (LF), soil-transmitted helminthiasis (STH) and schistosomiasis (SC) in Indonesia before and after PC implementation through a systematic review and meta-analysis.

Methods: Embase, MEDLINE, PubMed, Scopus, Web of Science and Google Scholar were searched for articles published between 1 January 1992 and 31 December 2022, reporting LF, STH and SC in Indonesia. Using the Ministry of Health lists of districts receiving PC programs, we identified whether data collection was conducted before or after PC implementation in that particular district.

Two amino acid pairs in the Gc glycoprotein of severe fever with thrombocytopenia syndrome virus responsible for the enhanced virulence.

Severe fever with thrombocytopenia syndrome (SFTS) is a significant public health concern, with a high fatality rate in humans and cats. In this study, we explored the genetic determinants that contribute to the different virulence of SFTS virus (SFTSV) based on Tk-F123 and Ng-F264 strains isolated from cats. Tk-F123 was 100% lethal in type I interferon receptor-knockout mice, whereas Ng-F264 exhibited no fatality.

Case Report: Smoking as the risk factor of persistent STEMI after primary percutaneous coronary intervention: how it could be happen?

Background: Acute coronary syndrome (ACS) remains one of the leading causes of death worldwide. Smoking may also increase the risk of developing ACS. The most advantageous therapy is percutaneous coronary intervention.

The Effect of Educational Videos Depicting The Impact of Smoking on Young Adults Smokers: A Qualitative Study.

Objective: The morbidity caused by smoking is increasing. Meanwhile, very few people access smoking cessation counseling in primary health care. Therefore, more massive and innovative efforts to increase motivation to quit smoking are needed.

Mapping the sources and strands of marine debris via particle modelling and In-situ sampling approaches in archipelagic countries.

Marine debris (MD) is a global issue that remains unresolved in Indonesia where the accumulation of this kind of pollution poses a significant threat to the marine ecosystem and health of the ocean. Understanding the sources and locations of stranded debris is crucial in identifying the required regulations and mitigation strategies. This study used the hypothetical sources to identify the stranded debris along the coastline of Selayar Island and its surrounding seas.

Expression of interferon-stimulated genes, but not polymorphisms in the interferon α/β receptor 2 gene, is associated with coronavirus disease 2019 mortality.

Excessive inflammatory response is a hallmark of severe COVID-19. This study investigated the associations between interferon-stimulated genes (ISGs) expression, genetic variation in the interferon α/β receptor 2 (IFNAR2) gene, and COVID-19 mortality. We investigated 67 patients with moderate-to-severe COVID-19.

A Systematic Review and Meta-analysis of the Impact of the COVID-19 Pandemic on Access to HIV Pre-exposure Prophylaxis: Lessons for Future Public Health Crises.

Background: The World Health Organization is committed to strengthening access to pre-exposure prophylaxis (PrEP) for HIV prevention and its integration into primary care services. Unfortunately, the COVID-19 pandemic has disrupted the delivery of primary care, including HIV-related services. To determine the extent of this disruption, we conducted a systematic review and meta-analysis of the changes in access to PrEP services during the pandemic and the reasons for these changes.

Factors Related to Hospital Inpatients among the Poor in Indonesia.

Background: The poor are vulnerable when they fall seriously ill and require hospitalization. The study aimed to analyze the factors related to hospital inpatients among the poor in Indonesia.

Methods: We analysed the 2018 Indonesian Basic Health Survey data.

Upcycling of Expanded Polystyrene Waste-Impregnated PVP Using Wet-Phase Inversion for Effective Microalgae Harvesting.

The aim of this study was to investigate the potential of upcycling Expanded Polystyrene (EPS) waste collected from food packaging into a membrane for microalgae harvesting, in which membrane filtration often challenges fouling and pore blocking. The target species is , with as a comparison agent. The membrane was fabricated from used Styrofoam, which typically ends up as single-use food packaging waste.

The impact of a multi-faceted intervention on non-prescription dispensing of antibiotics by urban community pharmacies in Indonesia: a mixed methods evaluation.

Introduction: Non-prescription antibiotic dispensing is prevalent among community pharmacies in several low- and middle-income countries. We evaluated the impact of a multi-faceted intervention to address this challenge in urban community pharmacies in Indonesia.

Methods: A pre-post quasi-experimental study was carried out in Semarang city from January to August 2022 to evaluate a 7-month long intervention comprising: (1) online educational sessions for pharmacists; (2) awareness campaign targeting customers; (3) peer visits; and (4) pharmacy branding and pharmacist certification.

Eleven-Year Report of High Number of Diphtheria Cases in Children in East Java Province, Indonesia.

A high incidence of diphtheria cases in children in East Java province, Indonesia, has been observed since the beginning of this century. Despite many efforts, the outbreaks continue. This study aims to explain the high incidence of diphtheria in children in East Java province since 2013.

Pathogen genomic surveillance status among lower resource settings in Asia.

Asia remains vulnerable to new and emerging infectious diseases. Understanding how to improve next generation sequencing (NGS) use in pathogen surveillance is an urgent priority for regional health security. Here we developed a pathogen genomic surveillance assessment framework to assess capacity in low-resource settings in South and Southeast Asia.

Comprehensive analysis of bulk and single-cell RNA sequencing data reveals Schlafen-5 (SLFN5) as a novel prognosis and immunity.

Recent advancements have elucidated the multifaceted roles of the Schlafen (SLFN) family, including SLFN5, SLFN11, SLFN12, SLFN13, and SLFN14, which are implicated in immunological responses. However, little is known about the roles of this gene family in relation to malignancy development. The current study aimed to explore the diagnostic and prognostic potential of Schlafen family genes in colorectal adenocarcinoma (COAD) through bioinformatics analysis.

Determination of appropriate policy targets to reduce the prevalence of stunting in children under five years of age in urban-poor communities in Indonesia: a secondary data analysis of the 2022 Indonesian national nutritional status survey.

Objective: Based on previous studies, urban-poor societies are very vulnerable to stunted children under five. The study aims to determine the appropriate policy targets to reduce the prevalence of stunted under-five children in urban-poor communities in Indonesia.

Design: A study was conducted using a secondary data analysis.

The incorporation of chitosan nanoparticles enhances the barrier properties and antifungal activity of chitosan-based nanocomposite coating films.

The potential alternative of exploring the development of nanocomposites through a single-molecule approach, such as combining chitosan nanoparticles (ChiNP) with chitosan (Chi), remains to be investigated. To maintain the insolubility of the ChiNP filler in the system, the protonation of weakly basic amino groups necessitates the pH of the coating solution above the pKa (6-6.5).