Ab interno Schlemm's canal surgery: trabectome and i-stent.

In primary open-angle glaucoma, the site of greatest resistance to aqueous outflow is thought to be the trabecular meshwork. Augmentation of the conventional (trabecular) outflow pathway would facilitate physiologic outflow and subsequently lower intraocular pressure. Ab interno Schlemm's canal surgery including two novel surgical modalities, Trabectome (trabeculotomy internal approach) and Trabecular Micro-bypass Stent (iStent), is designed to reduce intraocular pressure by this approach.

Vision loss and recovery after trabeculectomy: risk and associated risk factors.

Objectives: To assess the risk of long-term vision loss after trabeculectomy and to determine the course of long-term vision loss vs transient loss and recovery.

Methods: The medical records of 301 eyes in 262 patients undergoing trabeculectomy between January 1999 and September 2003 were retrospectively reviewed. Postoperative vision loss was categorized as mild or moderate (decrease in Snellen visual acuity of 3-5 lines) vs severe (decrease of >5 lines).

Population and high-risk group screening for glaucoma: the Los Angeles Latino Eye Study.

Purpose: To evaluate the ability of various screening tests, both individually and in combination, to detect glaucoma in the general Latino population and high-risk subgroups.

Methods: The Los Angeles Latino Eye Study is a population-based study of eye disease in Latinos 40 years of age and older. Participants (n = 6082) underwent Humphrey visual field testing (HVF), frequency doubling technology (FDT) perimetry, measurement of intraocular pressure (IOP) and central corneal thickness (CCT), and independent assessment of optic nerve vertical cup disc (C/D) ratio.

Concentration of latanoprost ophthalmic solution after 4 to 6 weeks' use in an eye clinic setting.

Purpose: To determine the concentration of latanoprost in bottles of latanoprost ophthalmic solution 0.005% after 4 or 6 weeks of use in patients in an eye clinic setting.

Methods: Patients treated with latanoprost for open-angle glaucoma or ocular hypertension were randomly assigned to refill their prescriptions either at the Doheny Eye Institute clinic or a local pharmacy.

Intracameral tissue plasminogen activator after glaucoma surgery. Indications, effectiveness, and complications.

Purpose: To describe the authors' clinical experience with intracameral tissue plasminogen activator (tPA) after glaucoma surgery.

Methods: Retrospective review of medical records of all patients who received intracameral tPA after glaucoma surgery at the Doheny Eye Institute from November 4, 1992, to June 14, 1994. There were 20 tPA administrations (18 eyes of 17 patients) in doses ranging from 6 to 25 microgram.