Publications by authors named "Widyawati"

Background: The incidence of diabetes mellitus (DM) and its complications is increasing in Indonesia. The patient's quality of life will decrease due to this condition. Diabetes self-management is a viable tactic for improving quality of life and reducing blood sugar levels.

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Background: Hyperglycemia in diabetes mellitus (DM) can lead to dyslipidemia, which is a risk factor for macrovascular complications such as heart disease and stroke. Aside from administering antidiabetic medications, DM treatment can also be achieved through the use of natural components, such as , commonly known as the ant nest plant (ANP).

Aim: This study aimed to investigate the impact of administering the ANP on the lipid profile of Wistar rats.

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Background: Key populations are defined as groups that are susceptible to HIV, including Men Sex with Men (MSM), Transgender (TG), Persons who Inject Drug (PID), and Female Sex Worker (FSW). These key populations groups are among the fastest-growing populations in Indonesia. These vulnerable groups are ostracized by society and health services, which makes it difficult to get treatment.

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Article Synopsis
  • Ovarian cancer often presents chemoresistance challenges due to the presence of cancer stem cells (CSCs) and specific protein expression patterns, which are linked to poor outcomes in patients.
  • A study involving 64 patients in Indonesia analyzed the expressions of CD44/CD24 (CSCs), RAD6, and DDB2 in ovarian cancer tissues to build a predictive scoring system for chemoresistance.
  • Results indicated a significant relationship between increased CSC and RAD6 expressions and decreased DDB2 expression with chemoresistance, leading to the development of the IHC-UNEDO scoring method as a potential predictive tool.
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Purpose: The purpose of this study is to explore adolescent pregnant women related to their pregnancy experience about mental health needs during pregnancy for the prevention of depression during pregnancy.

Methods: This research is a qualitative study design with a phenomenological approach. Data collection using interviews (in-depth interviews).

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Introduction: The marked increase in the number of individuals with diabetes mellitus (DM) worldwide each year has resulted in the importance of the spouse's contribution to the promotion and support of patient self-management programs.

Objectives: This study aimed to systematically explore the role or involvement of spouses in collaborative management and glycemic behavior change in DM.

Methods: Five databases including Scopus, PubMed, Cumulative Index of Nursing and Allied Health Literature, SAGE, and Web of Science were reviewed for relevant articles retrieved from 2017 to 2022.

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Objective: The objective of this study is to determine the validity and reliability of the red filter meibography by smartphone compared with infrared in assessing meibomian gland drop-out.

Methods And Analysis: An analytical cross-sectional study was done with a total of 35 subjects (68 eyes) with suspected MGD based on symptoms and lid morphological abnormalities. Meibomian glands were photographed using two smartphones (Samsung S9 and iPhone XR) on a slit-lamp with added red filter.

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Poor prognosis and higher mortality of chronic kidney disease are linked with cultural beliefs and practices. This study explored cultural beliefs and practices of Javanese people with end-stage renal disease undergoing hemodialysis for ≥5 years. A qualitative narrative inquiry was applied in this study.

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Objective: Various disease complications are a risk of overweight or obesity, so losing weight can reduce the risk of diseases caused by obesity. Binahong leaf ethanol extract () is a weight-loss herbal preparation.

Aim: This study aims to analyze whether extract is effective in losing weight by affecting the mechanism of adipogenesis in an animal obesity model.

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Objective: Dementia is a common aging-related neurodegenerative disease in the elderly worldwide. Alterations in neurogenesis and angiogenesis factors have been linked to cognitive impairment in neurological disorders. However, synthetic drugs to improve memory disorders have uncomfortable side effects.

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Background: Congestive heart failure (CHF) is a pathological state characterized by the incapability of the heart to properly perform its essential function of delivering blood to meet the metabolic demands of the body.

Case Description: The present case report concerns a 3-month-old male domestic kitten, displaying symptoms including an enlarged abdomen, emaciation, dehydration, dyspnea, rhinorrhea, and infestation with scabies. This animal, weighing 0.

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Background: Hyperglycemia conditions in diabetes mellitus (DM) can turn on pro-inflammatory cytokines like IL-6 and TNF-α. These cytokines play a role in insulin resistance and the development of DM complications. People in Indonesia have used to treat diabetes, but the leaf of this plant has not been studied to see if it can reduce inflammation.

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Background: leaves and (OE) fruit oil are natural sources that have been traditionally used for health and skin care purpose.

Objective: To assess the potential synergistic effect of combining ethanol extract of leaves (AHLE) and OE fruit oil in the formulation of clay masks, specifically in terms of their effect on facial skin.

Methods: AHLE was obtained by the maceration method, while OE was purchased commercially.

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Article Synopsis
  • This study investigates the factors influencing HBV DNA suppression in chronic hepatitis B patients receiving tenofovir disoproxil fumarate (TDF) over a 24-week period.
  • A case-control research was conducted involving 182 patients at two hospitals in Medan, Indonesia, where genetic and blood analyses were performed to evaluate various potential risk factors.
  • Findings revealed that specific CTLA-4 genetic polymorphisms, elevated CTLA-4 levels, high HBV DNA levels, and low ALT levels significantly increased the risk of not achieving HBV DNA suppression with TDF treatment, while no other demographic factors were found to impact the results.
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Background: Tenofovir disoproxil fumarate (TDF) is a first-line nucleotide analog (NA) drug for hepatitis B therapy. Long-term NA therapy increases peripheral T cell levels to enhance antiviral response, while CTLA-4 inhibits the activation.

Objective: This study analyzed the interaction between TDF and CTLA-4 through molecular docking.

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Backgroud: Immune impairment, marked by increased expression of cytotoxic T lymphocyte antigen (CTLA)-4, promotes the disease progression of chronic hepatitis B.

Objective: This study aimed to determine the association between serum CTLA-4 level and disease progression in patients with chronic hepatitis B.

Methods: A cross-sectional study was conducted at Haji Adam Malik General Hospital Medan, Indonesia between October 2021 to September 2022.

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Background: Cholestasis is a health problem, both in humans and animals, which in the disease's course involves oxidative stress, inflammation, and liver fibrosis. EA has been proven to have beneficial effects on various diseases.

Aim: This study was conducted to determine the effect of EA in protecting liver damage because of cholestasis.

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Squalene has been tested widely in pharmacological activity including anticancer, antiinflammatory, antioxidant, and antidiabetic properties. This study aims to examine antidiabetic activity of squalene in silico and in vivo models. In the in silico model, the PASS server was used to evaluate squalene antidiabetic properties.

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Objectives: To examine the potential positive and negative effects of spirituality and religion on life quality of patients with chronic kidney disease.

Method: The systematic review comprised studies published from 2010 to 2020 on how spiritual and religious coping mechanisms impact the life quality of chronic kidney disease patients. The search was conducted using Google Scholar, PubMed, Scopus, Ebsco, Clinical Key, Wiley and ProQuest databases.

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Objectives: To observe the relationship of perceived seriousness, perceived susceptibility, perceived benefits, perceived barriers and cues to action with adherence to coronavirus disease-2019 protocols among traders.

Method: The descriptive, quantitative, cross-sectional study was conducted from July to August 2021, in Jember Regency, East Java, Indonesia, and comprised traders in a traditional market. Data was collected using a demographic questionnaire, a questionnaire based on the Health Belief Model, and a coronovirus disease-2019 protocol adherence questionnaire after confirming the validity and reliability of the instruments.

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(1) Background: An earlier study on the hypoglycemic activity of S. polyanthum (Wight.) leaf methanol extract identified squalene as the major chemical compound.

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Background: The conventional standard treatment for ovarian cancer is not very effective, and the disease is fatal for women. Cancer Stem Cells (CSCs) that express CD44/CD24 can contribute to chemoresistance and a poor prognosis. We seek to investigate the expression of CSCs (CD44/CD24) in ovarian cancer and their predictive significance.

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Objective: This study aims to explore the perception of women and their husbands on the vulnerability of pregnant women to mental health disorders.

Method: Qualitative study using a phenomenological approach. The inclusion criteria were pregnant women of the second and third-trimester gestation (13-35 weeks).

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The study aims to determine the effect of the proportion of κ-carrageenan and the hot water extract of pluchea leaf tea on the quality and sensory properties of stink lily wet noodles. The research design is a randomized block design with two factors, i.e.

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Introduction: Coronavirus disease (COVID-19) must be controlled by involving all stakeholders, including the community. Community protocol compliance with COVID-19 health guidelines is essential. This study assessed the social determinants of health on community protocol compliance with COVID-19 health guidelines among adults in Yogyakarta, Indonesia.

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