Publications by authors named "Wen-Li"

Background: Early establishment of energy balance related behaviors (EBRBs) may be effective in combating unhealthy lifestyle in preschoolers. Parents are responsible for cultivating preschoolers' EBRBs directly through parenting practices. Although investigating the impact of various parenting practices on preschoolers' EBRBs is crucial to determine which practices should be recommended to parents to help reverse childhood unhealthy lifestyle, it is important to assess whether these effects of parenting practices on preschoolers' EBRBs would be similar across different groups of preschoolers, necessitating research into the moderating effects of demographic characteristics.

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Circularly polarized organic light-emitting diodes (CP-OLEDs) have significant promise for naked-eye 3D displays. However, most devices are fabricated using vacuum deposition technology, and development of efficient solution-processed CP-OLEDs, particularly those exhibiting low efficiency roll-off, remains a formidable challenge. This research successfully designed and synthesized two pairs of thermally activated delayed fluorescence (TADF) enantiomers through isomer engineering, namely (R/S)-N-5-TPA and (R/S)-N-4-TPA, which features fifth and fourth substitution sites of phthalimide (acceptor) by tri-phenylamine (donor), respectively.

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Ammonia oxidation plays a vital role in regulating soil nitrogen (N) cycle in agricultural soil, which is significantly influenced by different fertilizer regimes. However, there is still need to further investigate the effects of different fertilizer managements on rhizosphere soil ammonia-oxidizing archaea (AOA) and bacteria (AOB) community in the double-cropping rice field. Therefore, the effects of different long-term (37 years) fertilizer managements on rhizosphere soil potential nitrification activity (PNA), AOA and AOB community structure, and its relationship under the double-cropping rice system in southern of China were studied in the present paper.

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Given the increasing intensity of climate change, members of the public perceive its occurrence and participate in pro-environmental behaviours (PEBs) that are expected to alleviate severe climate situations. Related scholarship has paid much attention to how determining factors affect public actions and proven the gaps between pro-environmental behavioural intentions (PEBIs) and PEBs, but little research has focused on strategies to bridge the intention-behaviour gap. Hence, this study explores the influence of climate change perception (CCP) on PEBs and the role of climate literacy (CL) in addressing the gap.

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Background: Inhalation of hydrogen gas (H) as an antioxidant supplement may alleviate exercise-induced oxidative damage and protect post-exercise hydrogen peroxide signaling, which may help mediate beneficial exercise adaptation. The aims of this study were to determine the effects of H inhalation on plasma nitric oxide (NO) level and its synthesis precursor in professional athletes.

Methods: A randomized, placebo-controlled, double-blind, crossover trial was conducted with professional male rugby players for 3 weeks.

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Background: Pulmonary hypertension (PH) is a malignant vascular disease characterized by pulmonary arterial remodeling. Neural cell adhesion molecule 1 (NCAM1) is a cell surface glycoprotein that is involved in a variety of diseases, including cardiovascular disease. However, the role of NCAM1 in PH remains underexplored.

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Multimodal microrobots are of growing interest due to their capabilities to navigate diverse terrains, with promising applications in inspection, exploration, and biomedicine. Despite remarkable progress, it remains challenging to combine the attributes of excellent maneuverability, low power consumption, and high robustness in a single multimodal microrobot. We propose an architected design of a passively morphing wheel that can be stabilized at distinct geometric configurations, relying on asymmetric bending stiffness of bioinspired tentacle structures.

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  • The study aims to create a deep learning model to identify unstable intracranial aneurysms from CTA images, which is crucial for clinical assessments.
  • Researchers analyzed data from 1041 patients, classifying aneurysms as unstable or stable and developing multiple models to assess their effectiveness using various features.
  • The best-performing model, which combined clinical and deep learning features, showed superior accuracy in predicting aneurysm stability, suggesting its potential use in clinical decision-making.
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In recent years, there have been advancements in high-performance soft sensors with simultaneous moderate sensitivity and wide linearity. However, it remains challenging to combine high-efficiency production and high performance for soft sensors. The skin and hair structure provide an elegantly simple sensing model, where hair acts as signal receptors and basal skin acts as signal processors.

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Photochromic compounds have attracted much attention for their potential applications in photo-actuators, optoelectronic devices and optical recording techniques. This interest is driven by their key photochemical and photophysical properties, which can be reversibly modulated by light irradiation. Among them, diarylethene compounds have garnered extensive investigation due to their excellent thermal stability of both open- and closed-form isomers, robust fatigue resistance, high photocyclization quantum yield and good photochromic performance in both solution and solid phases.

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  • - This study investigates how traditional oral glucose tolerance test (OGTT) results may not effectively prevent negative outcomes in twin pregnancies, focusing on different glucose level patterns (high, medium, low).
  • - Analyzing 2,644 twin pregnancies, the researchers identified three glucose patterns, revealing that those with high glucose (HG) levels faced significantly higher risks for issues like stillbirth and neonatal complications compared to those with low glucose levels (LG).
  • - The findings suggest that pregnant women with the HG pattern should receive more careful monitoring and targeted interventions due to their increased risk of adverse outcomes for their newborns.
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  • Radiation-induced lung injury (RILI) causes cell death and fibrosis in lungs, but MSC-derived exosomes can help, although they lack targeting abilities and specific effects.
  • A study engineered these exosomes with the SARS-CoV-2 spike protein and the miRNA miR-486-5p to enhance their therapeutic effects.
  • The modified exosomes promoted lung cell growth and migration, reduced RILI and fibrosis, and inhibited ferroptosis by regulating fibrosis-related genes both in vitro and in vivo.
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The effects of dilute acid prehydrolysate from poplar were investigated and compared in the enzymatic hydrolysis, fermentation, and simultaneous saccharification fermentation (SSF) in this study. The improvement of enzymatic hydrolysis and fermentation with resin adsorption and surfactant addition has also been represented. A total of 16 phenolic alcohols, aldehydes, acids and 3 furan derivatives in the prehydrolysates were identified and quantified by gas chromatography/mass spectrometry (GC/MS).

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Purpose: To develop and validate a radiomic model for differentiating pulmonary invasive adenocarcinomas from benign lesions based on follow-up longitudinal CT images.

Methods: This is a retrospective study including 336 patients (161 with invasive adenocarcinomas and 175 with benign lesions) who underwent baseline (T0) and follow-up (T1) CT scans from January 2016 to June 2022. The patients were randomized in a 7:3 ratio into training and test sets.

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Background: Patients with unruptured intracranial aneurysms (UIAs) often experience emotional changes and cognitive impairments. However, the specific mechanisms underlying these impairments are still not fully understood.

Methods: In the present study, voxel-based morphometry (VBM) and surface-based morphometry (SBM) were employed to investigate structural alterations in 49 patients diagnosed with UIAs compared with 50 healthy controls.

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  • - This study explored how attending early childhood education and care (ECEC) impacts outdoor play, screen time, and sleep in children aged 2 and 3 years using data from Australian trials conducted between 2017 and 2020.
  • - Results showed that children who attended ECEC engaged in significantly more outdoor play and less screen time compared to those who didn't, although ECEC attendance didn't affect sleep duration.
  • - The study highlighted that children from higher socio-economic backgrounds were more likely to attend ECEC, indicating a need for future health programs to address those from lower socio-demographic backgrounds who may not access these services.
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  • This study explored the connection between immune traits and different types of pancreatitis using a method called Mendelian randomization.
  • Researchers collected data on 731 immune traits and linked that to findings on acute and chronic pancreatitis from large databases, confirming results through various analysis methods.
  • They found 36 immune traits associated with pancreatitis risk, highlighting specific immune cells that may serve as potential targets for future treatments and interventions.
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  • Castor plants are vital for industrial use, but drought causes oxidative stress that affects their growth and yields, prompting researchers to investigate the underlying mechanisms through various analyses.
  • The study found that drought stress impacted photosynthesis and activated different antioxidant enzymes over time, with significant changes in gene expression related to antioxidant activity and multiple metabolic pathways.
  • The research highlights important antioxidant genes and mechanisms, contributing to a better understanding of how castor plants cope with drought and offering insights for future breeding strategies.
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Nuclear speckles are nuclear membraneless organelles in higher eukaryotic cells playing a vital role in gene expression. Using an in situ reverse transcription-based sequencing method, we study nuclear speckle-associated human transcripts. Our data indicate the existence of three gene groups whose transcripts demonstrate different speckle localization properties: stably enriched in nuclear speckles, transiently enriched in speckles at the pre-messenger RNA stage, and not enriched.

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  • A biomimetic sucker design featuring a V-shaped notch was developed, demonstrating the ability to switch between high and low friction states while maintaining strong adhesion, enhancing performance by up to 94%.*
  • Two robots, the Adhesion Sliding Robot-1 (ASR-1) and Adhesion Sliding Robot-2 (ASR-2), were created to mimic these natural suckers, achieving successful movement on various surfaces and under challenging water conditions, indicating potential applications in environmental monitoring.*
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  • Vascular endothelial damage from ionizing radiation is a key cause of organ damage during nuclear accidents, and ferroptosis is a significant contributor to cell death in this context.
  • Luteolin has been shown to be resistant to ferroptosis and can significantly reduce radial vascular injury in vivo, while also demonstrating low toxicity and enhancing the antioxidant capacities of human umbilical vein endothelial cells (HUVECs).
  • The study identifies heat shock protein beta-1 (HSPB1) as a key target of luteolin, which inhibits ferroptosis by promoting the expression of HSPB1, SLC7A11, and GPX4, laying the foundation for potential therapeutic applications of luteolin in radiation-related injuries
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  • * A dataset of 566 diabetes cases was analyzed using various algorithms to develop predictive models, with results divided into low-risk and high-risk categories for DFU, employing a Monte Carlo cross-validation method for further analysis.
  • * Results showed that the ensemble learning method provided the best performance for predicting DFU risk, validated with an independent dataset to confirm the model's reliability across different populations.
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  • Post-myocardial infarction ventricular septal rupture (PIVSR) is a serious complication of acute myocardial infarction (AMI) with a high mortality rate of 71%, predominantly affecting older patients (average age 70.7 years).
  • A study involving 62 patients identified key risk factors for short-term mortality, including elevated white blood cell count, presence of cardiogenic shock, and lower left ventricular ejection fraction.
  • A predictive nomogram was created that effectively assesses the risk of early mortality in PIVSR patients, achieving a high accuracy rate with an AUC of 0.956.
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Objective: To observe the clinical efficacy of medical education combined with extended care in patients with bronchial asthma and its effect on adherence to inhaled glucocorticoids.

Methods: Ninety-eight patients with bronchial asthma were divided into the control group and the experimental group,  = 49, by utilizing the random number table method. The control group was given routine education and care as well as routine out-of-hospital instructions, and the experimental group was given medical education and extended care based on the control group.

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