Comparing Cognitive Recovery of Remimazolam versus Propofol in Elderly Patients Undergoing Colonoscopy: A Randomized Controlled Trial.

Background: Remimazolam, a novel ultra-short-acting benzodiazepine, shows promise for procedural sedation. This study compared the cognitive recovery of remimazolam versus propofol in elderly patients undergoing colonoscopy.

Patients And Methods: In this prospective, randomized, double-blind, controlled trial, 228 patients aged ≥ 65 years undergoing outpatient colonoscopies were recruited.

One-for-all gene inactivation via PAM-independent base editing in bacteria.

Base editing is preferable for bacterial gene inactivation without generating double strand breaks, requiring homology recombination or highly efficient DNA delivery capability. However, the potential of base editing is limited by the adjoined dependence on the editing window and protospacer adjacent motif (PAM). Herein, we report an unconstrained base editing system to enable the inactivation of any genes of interest (GOIs) in bacteria.

Size-Coded Hydrogel Microbeads for Extraction-Free Serum Multi-miRNAs Quantifications with Machine-Learning-Aided Lung Cancer Subtypes Classification.

Classifying lung cancer subtypes, which are characterized by multi-microRNAs (miRNAs) upregulation, is important for therapy and prognosis evaluation. Liquid biopsy is a promising approach, but the pretreatment of RNA extraction is labor-intensive and impairs accuracy. Here we develop size-coded hydrogel microbeads for extraction-free quantification of miR-21, miR-205, and miR-375 directly from serum.

Non-Conjugated Gridized Nanopolymers as an Efficient Hole-Transport Material for Blue Perovskite Light-Emitting Diodes.

Despite the remarkable advancements in perovskite light-emitting diode (PeLED) technology, the development of blue PeLEDs has lagged. The primary bottleneck lies in the difficulty of finding hole transport materials (HTMs) that can both match the energy levels of blue perovskite materials and exhibit efficient hole transport performance. Herein, a novel non-conjugated polyethylene carbazole-based polymer (P-AGCz) is developed that has excellent solution processability and serves as an efficient dopant-free HTM for PeLEDs.

Neuroendocrine regulatory network underlying physiological shifts between reproduction and aestivation of sea cucumber Apostichopus japonicus: Insights from transcriptome analysis.

The sea cucumber Apostichopus japonicus is an economically significant marine species in China, with numerous studies focusing on its diverse physiological processes, including seasonal reproduction and aestivation. The neuroendocrine system plays a critical role in regulating these physiological transitions. In this study, we utilized transcriptomic techniques and bioinformatics tools to identify key functional genes in the nerve ring of A.

Light-induced charge transfer from a fullerene to a zeolitic imidazolate framework enhances alkaline electrocatalytic hydrogen production.

In the process of water electrolysis, the oxygen evolution reaction (OER) suffers from a high energy barrier, which has become a key factor restricting the large-scale commercial application of renewable energy technology. Therefore, it is necessary to develop a durable, efficient, low-cost and environmentally friendly OER electrocatalyst. In the present work, a photo-responsive fullerene (C) was encapsulated in the cavity of cobalt-containing flake-like zeolitic imidazolate framework-67 (C@F-ZIF-67).

Probing Single-Particle Electrocatalytic Stability: Electrogenerated Chemiluminescence Imaging of Nanoparticle Array.

Understanding the stability of single nanoparticles is crucial for optimizing their performance in various applications, including catalysis. In this study, we employed electrochemiluminescence (ECL) imaging to investigate the temporal stability of individual Au and Pt nanoparticles within precisely engineered arrays. Our results reveal significant differences in the stability of Au and Pt NPs.

Host metabolic inflammation fueled by bacterial DNA.

Metabolic diseases, characterized by chronic low-grade inflammation, exhibit a compromised gut barrier allowing the translocation of bacteria-derived products to bloodstream and distant metabolic organs. Bacterial DNA can be detected in metabolic tissues during the onset of these diseases, highlighting its role in the development of metabolic diseases. Extracellular vesicles (EVs) are involved in the delivery of bacterial DNA to the local tissues, and its sensing by the host triggers local and system inflammation.

Strengthened High-Concentration Quasi-Solid Electrolytes for Lithium Metal with Ultralong Stable Cyclability.

The lithium metal batteries coupled with nickel-rich LiNiCoMnO ( > 0.7) cathodes hold promise for surpassing the current energy density limit of lithium-ion batteries. However, conventional electrolytes containing free active solvents are highly susceptible to decomposition, particularly at the interfaces of lithium anode and high-voltage cathode.

Clinical outcomes of microwave ablation for solitary T1N0M0 papillary thyroid carcinoma: a more than 5-year follow-up study.

Objectives: This study aimed to evaluate the long-term efficacy and safety of microwave ablation (MWA) for solitary T1N0M0 papillary thyroid carcinoma (PTC) and compare them between T1a and T1b disease.

Materials And Methods: This retrospective study included 136 patients with solitary T1N0M0 PTC who were treated with MWA and followed up for more than 5 years. Outcomes were compared between patients with T1a and T1b disease.

Longitudinal history of mammographic breast density and breast cancer risk by familial risk, menopausal status, and initial mammographic density level in a high risk cohort: a nested case-control study.

Background: Elevated mammographic density is associated with increased breast cancer risk. However, the contribution of longitudinal changes in mammographic density to breast cancer risk beyond initial mammographic density levels, considering familial breast cancer risk and menopausal status, remains uncertain but holds important clinical implications.

Methods: In a nested case-control study within the Sister Study (323 cases, 899 controls; 12,095 mammograms), a cohort enriched for family history of breast cancer, we examined case-control status in relation to the largest annual change in percent density and dense area using mammograms available spanning 5.

An integrated physiological indicator and transcriptomic analysis reveals the response of soybean buds to high-temperature stress.

Background: Under global warming, high temperature (HT) has become a major meteorological factor affecting soybean production. To explore the candidate genes and regulatory mechanism of the soybean bud response to HT stress, previously identified as HT-tolerant ('Handou14'; HD14) and HT-sensitive ('Jiadou36'; JD36) were treated for 5 days in an artificial climate incubator either with HT (43 °C (day)/ 33 °C (night), 16 h light/8 h darkness) or the non-stress growth condition (25 °C, 16 h light/8 h darkness) as the control at the bud stage were used as experimental materials in this study. After HT treatment, changes in physiological indicators including hypocotyl length, enzyme activity and hormone content were detected; at the same time, the cotyledons, hypocotyls, and main roots were collected for transcriptome sequencing analysis.

High-Efficiency Enrichment of Metallic Particles in Lubricating Oil Based on Filter-Free Acoustic Manipulation Chip.

Enrichment of metal particles in lubricating oil is a crucial pretreatment for wear debris analyses in applications of condition-based machinery maintenance. Current techniques using physical filter cleaning and magnetic attachment to enrich metal particles have limitations in terms of efficiency and selectivity. This work presents an innovative acoustic manipulation chip for efficiently enriching metallic particles from lubricating oil.

Associations between Sensitivity to Thyroid Hormones and Visceral Adiposity in Euthyroid Adults.

Objectives: The study aimed to explore the association between thyroid hormone (TH) sensitivity and obesity assessed by body mass index (BMI) and visceral adiposity index (VAI) in euthyroid adults.

Methods: This cross-sectional study used the thyroid feedback quantile-based index (TFQI), thyroid stimulating hormone index (TSHI), and thyrotrophic T4 resistance index (TT4RI) to indicate central TH sensitivity, and VAI to assess visceral obesity. Participants were categorized according to tertiles.

Risk assessment of developmental and neurotoxicity by the flavoring agent perillaldehyde: NAC (N-acetylcysteine) mitigation of oxidative stress-mediated inhibition of the Nrf2 pathway.

Perillaldehyde (PAE), a prevalent flavoring agent, has raised safety concerns due to conflicting evidence regarding its toxicity. This study provides a comprehensive assessment of the developmental and neurotoxic effects of PAE in zebrafish, elucidating the underlying mechanisms of its toxicity. Results showed that PAE affected the viability and hatching rate of zebrafish at 96 h postfertilization with the 50 % lethal concentration (LC50) of 7.

Cortisol suppresses lipopolysaccharide-induced in vitro inflammatory response of large yellow croaker (Larimichthys crocea) via the glucocorticoid receptor and p38 mitogen-activated protein kinase pathways.

Glucocorticoids (GCs) are well-established anti-inflammatory agents, with cortisol, an endogenous GC, exerting pivotal regulatory effects on normal physiological processes. However, the immune regulatory role of cortisol in teleost fish, particularly in inflammation induced by pathogenic infection, remains largely unexplored. Here, we revealed that lipopolysaccharide (LPS) triggers a pro-inflammatory response in the large yellow croaker (Larimichthys crocea), as evidenced by increased expression of key pro-inflammatory cytokines and activation of the mitogen-activated protein kinase (MAPK) signaling pathway.

A systematic review of efficacy and safety of newer drugs approved from 2016 to 2023 for the treatment of complicated urinary tract infections.

: Complicated urinary tract infections are a significant cause of morbidity, hospitalization, and elevated hospital costs associated with kidney transplantations. The treatment of complicated urinary tract infections is very challenging, due to varying severities of infection and lower cure rates. The available drug options for treating these infections are limited, each with different mechanisms of action, efficacy, and safety profiles, making drug selection more difficult for healthcare professionals.

miRNA-148a-3p targets to regulate the lipid metabolism gene SOCS3 to reduce myocardial ischemia/reperfusion injury.

Background: Acute myocardial infarction (AMI) is a major cause of death in cardiovascular patients. SOCS3's protective role in cardiac I/R-I is being explored, and miRNAs, particularly miRNA-148a-3p, are suspected to target SOCS3. To elucidate the role of miRNA-148a-3p targeting lipid metabolism gene SOCS3 in cardiac ischemia-reperfusion injury (I/R-I) in rats.

Integrated untargeted/targeted metabolomics identifies a putative oxylipin signature in patients with atrial fibrillation and coronary heart disease.

Background And Objective: Atrial fibrillation (AF) and coronary heart disease (CHD) are closely related to metabolic dysregulation. However, the metabolic characteristics of AF patients with concomitant CHD remain unclear. The aims of this study were to elucidate the metabolic profiles of patients with AF and CHD to seek new therapeutic targets and related factors of AF combined with CHD.

Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1.

Brassinosteroids (BRs) are steroidal phytohormones indispensable for plant growth, development, and responses to environmental stresses. The export of bioactive BRs to the apoplast is essential for BR signaling initiation, which requires binding of a BR molecule to the extracellular domains of the plasma membrane-localized receptor complex. We have previously shown that the Arabidopsis thaliana ATP-binding cassette (ABC) transporter ABCB19 functions as a BR exporter and, together with its close homolog ABCB1, positively regulates BR signaling.

Association of glymphatic system dysfunction with cognitive impairment in temporal lobe epilepsy.

Objectives: To explore the relationship between glymphatic dysfunction and cognitive impairment in unilateral temporal lobe epilepsy (TLE).

Methods: This study retrospectively included 38 patients with unilateral TLE and 26 age- and gender-matched healthy controls (HCs). The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, choroid plexus volume (CPV), and cognitive assessment were obtained for each participant.