Lymphocyte/monocyte to lactate dehydrogenase ratio prior to lymphodepletion impact the outcomes of patients with diffused large B cell lymphoma undergoing CAR-T cell therapy.

Factors associated with outcomes of chimeric antigen receptor (CAR)-T cell therapy in patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) have not been fully elucidated. We explored the impact of the prelymphodepletion (pre-LD) lymphocyte to monocyte ratio (LMR) and its ratio to lactate dehydrogenase (LDH) (LMR/LDH) on the efficacy and prognosis of 60 patients with R/R DLBCL undergoing CAR-T cell therapy. The optimal cutoff values for pre-LD LMR and LMR/LDH were 3.

Hospital admissions attributable to reduced air pollution due to clean-air policies in China.

The Air Pollution Prevention and Control Action Plan (APPCAP) is considered to be the most stringent air pollution control policy in China implemented since 2013. This policy is a milestone in China to mitigate serious air pollution. However, health benefits attributable to reduced fine-particulate air pollution after the implementation of the APPCAP have not been quantitatively estimated on a PM constituent-specific and morbidity cause-specific basis.

A highly stable lyophilized mRNA vaccine for Herpes Zoster provides potent cellular and humoral responses.

Herpes zoster (HZ) is a painful vesicular rash that occurs upon varicella-zoster virus (VZV) reactivation in older adults and immunocompromised individuals. Although there is currently an approved vaccine for the prevention of shingles, its administration is commonly associated with high reactogenicity. This highlights the need to develop new vaccine alternatives with long lasting immunity and improved tolerability upon administration.

Generation of dynamic oxygen vacancies in graphene quantum dots/NaNbO heterojunction for boosting photocatalytic hydrogen evolution.

The design and theoretical study of green, low-cost heterojunction photocatalysts with strong interfacial interactions are crucial for achieving efficient and stable photocatalytic hydrogen evolution (PHE). This study proposes a simple method to synthesizing graphene quantum dots (GQDs)/NaNbO heterojunction with dynamic oxygen vacancies. GQDs promote the formation of oxygen vacancies and increase the surface-active sites of NaNbO, significantly enhancing light absorption efficiency.

Modulating d-orbital electronic configuration of magnetic iron sulfide nanocrystals for maximized treatment efficiency of chromium-contaminated water.

Hexavalent chromium (Cr(VI)) is one of the most rigorously regulated contaminants frequently detected in surface and groundwater. Magnetic iron sulfides are naturally abundant, environmentally friendly materials ideal for the removal of Cr(VI) from contaminated water, but the high-spin states of Fe(III) ions limits their adsorption affinity. Herein, we develop a heteroatom-doping approach to boost the Cr(VI) removal efficacy of greigite.

Poverty alleviation resettlement in China reduces deforestation.

Deforestation frequently accompanies poverty, yet various antipoverty programs in many countries have exhibited mixed results in addressing deforestation. Poverty Alleviation Resettlement (PAR) stands out as one of the few government-led resettlement programs designed to alleviate poverty, offering comprehensive follow-up support for quality of life and employment after relocation. Our study uncovered empirical evidence of the PAR program's impact on forest quality.

Simultaneous Mental Fatigue and Mental Workload Assessment with Wearable High-Density Diffuse Optical Tomography.

Accurately assessing mental states-such as mental workload and fatigue- is crucial for ensuring the reliability and effectiveness of brain-computer interface (BCI)-based applications. Relying on signals from a limited brain region with low spatial resolution may fail to capture the full scope of relevant information. To address this, high-density diffuse optical tomography (HD-DOT), an emerging form of functional near-infrared spectroscopy (fNIRS) was employed in this study, which provides higher spatial resolution for hemodynamic measurements and enables the reconstruction of 3D brain images.

Hypoxia-Inducible Factor 1-Alpha Gene Polymorphisms Impact Risk of Severespectrum Hypertensive Disorders of Pregnancy: A Case-Control Study.

Hypoxia-inducible factor 1-alpha (HIF-1α) regulates cellular responses to hypoxia. Overexpression of HIF-1α is associated with abnormal placental trophoblast invasion and hypertensive disorders of pregnancy. We evaluated the putative association between polymorphisms and haplotypes in parental and child HIF-1α genes and the risk of severe-spectrum hypertensive disorders of pregnancy.

A Proposed Role for Lymphatic Supermicrosurgery in the Management of Alzheimer's Disease: A Primer for Reconstructive Microsurgeons.

The relatively recent discovery of a novel lymphatic system within the brain meninges has spurred interest in how waste products generated by neurons and glial cells-including proteins associated with Alzheimer's disease (AD) pathology such as amyloid beta (Aβ) and tau-are disposed of. Evidence is building that suggests disease progression in AD and other cognitive impairments could be explained by dysfunction in the brain's lymphatic system or obstruction of drainage. An interesting implication of this hypothesis is that, by relieving the obstruction of flow, lymphatic reconstruction along the drainage pathway could serve as a potential novel treatment.

ZKSCAN3 affects the autophagy‑lysosome pathway through TFEB in Parkinson's disease.

The present study aimed to explore the effects of zinc finger with KRAB and SCAN domains 3 (ZKSCAN3)/transcription factor EB (TFEB) on autophagy-lysosome pathway in Parkinson's disease (PD). SH-SY5Y cells were treated with 6-hydroxydopamine to establish a PD cell model. A ZKSCAN3 overexpression vector and short interfering (si)RNAs were also constructed.

Exploration of high-value pathways for lignin: From catalyst preparation to product development.

Considering the facts of fossil fuel depletion and environmental issues, the conversion of biomass into high value-added chemicals is of great importance. In this work, Ni and Co were encapsulated in lignin-derived phenolic resin spheres to obtain NiCo@LRS, which was then employed as a sacrificial template for the synthesis of the bimetallic catalyst NiCo@LC-RS. The Ni and Co act as the acid and dehydrogenation sites for the catalytic transfer hydrogenolysis of 2-phenoxy-1-phenylethanol (pp-ol) and corncob lignin, respectively, and exhibit a synergistic enhancement effect.

Diaphorina citri E3 ubiquitin ligase RNF115 inhibits CLas bacterial proliferation by targeting to the host histone H1.

The Asian citrus psyllid (ACP), Diaphorina citri, serves as the primary vector for Candidatus Liberibacter asiaticus (CLas), the pathogen responsible for citrus Huanglongbing (HLB). D. citri modulates the expression of its key proteins in response to CLas infection.

Artificial Intelligence Screening Tool for Obstructive Sleep Apnoea: A Study Based on Outpatients at a Sleep Medical Centre.

Purpose: Due to the lack of clear screening guidelines for different populations, identify strategies for obstructive sleep apnea (OSA) in the outpatient population are unclear, a large number of potential OSA outpatients have not been identified in time. The purpose of our study was to evaluate the applicability and accuracy of artificial intelligence sleep screening in outpatients and to provide a reference for OSA screening in different populations.

Methods: A type IV wearable artificial intelligence sleep monitoring (AISM) device was used to screen adults in the sleep clinic of the Sleep Medical Center for OSA screening, and the general demographic data of the patients were collected.

A premature termination codon mutation in the onion gene is associated with both glossy leaves and thrip resistance.

Plant epicuticular waxes (EW) play a critical role in defending against biotic and abiotic stresses. Notably, onions () present a distinctive case where the mutant with defect in leaf and stalk EW showed resistance to thrips compared with the wild type with integral EW. We identified a premature stop codon mutation in the gene, an ortholog of gene in that has been proved essential for the biosynthesis of very long-chain fatty acids (VLCFAs), in the onions with glossy leaf and stalks in our experiments.

β-Ionone Treatment Enhances the Antioxidant Capacity in Postharvest Broccoli ( L. var. ) by Maintaining the Levels of Bioactive Substances.

Broccoli is prone to nutrient loss during postharvest storage due to its high respiratory metabolism. In this study, we investigated the effects of 0.1 mm β-ionone on bioactive substances and antioxidant capacity during postharvest storage of broccoli.

Epidemiological and etiological investigation of a rare family cluster caused by severe fever with thrombocytopenia syndrome in Anhui Province in 2023.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease discovered in the 21st century. Human-to-human transmission of the disease has been documented, but the mechanisms of transmission require further investigation.

Methods: Epidemiological investigations and genetic analyses of the patients were conducted, and a retrospective cohort study was performed to analyze potential risk factors for person-to-person transmission.

Association of dietary quality indicators with gallstones in the US: NHANES 2017-2020.

Background: While dietary factors are known to influence gallstone development, the specific relationships between comprehensive dietary quality indicators and gallstone risk remain poorly understood. This study aimed to explore the association between dietary quality indicators and gallstones using data from the 2017 to 2020 US National Health and Nutrition Examination Survey (NHANES).

Methods: A total of 6,623 US adults were extracted from the 2017-2020 NHANES, of which 734 participants self-reported having gallstones.

Highly efficient ionic actuators enabled by sliding ring molecule actuation.

Ionic actuators with capability of electro-mechanical transduction are emerging as a useful platform for artificial intelligence and modern medical instruments. However, the insufficient ion transport inside material interfaces usually leads to limited energy transduction efficiency and energy density of actuators. Here, we report a polyrotaxane interface with adjustable ion transport based on sliding-ring effect for highly-efficient ionic actuators.

Green-Solvent Synthesis for In Situ Growth of Perovskite Phosphors without Ligand Assistance.

Cesium-lead halide perovskite nanomaterials have been considered new-generation emitters that can meet the requirements of high photoluminescence efficiency and the high color standard of Rec. 2020. However, their practical application is currently hindered by the challenge of achieving better stability and growth in green solvents.

Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China.

Background: As the population in China rapidly ages, the prevalence of mild cognitive impairment (MCI) is increasing considerably. However, the causes of MCI vary. The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of advancing to more severe cognitive diseases.

Clinical Outcomes of Hospitalized Immunocompromised Patients With COVID-19 and the Impact of Hyperinflammation: A Retrospective Cohort Study.

Purpose: Immunocompromised patients are at increased risk for severe outcomes from COVID-19 due to their altered immune responses, yet their inflammatory profiles and the interplay between immunosuppression remain poorly understood. We aimed to illustrate the inflammation profile and clinical outcomes of hospitalized immunocompromised patients with COVID-19.

Methods: We conducted a retrospective study using a multicenter database and included adult hospitalized patients with Corona virus disease 2019 (COVID-19) in China's late 2022 COVID-19 wave.

Socioeconomic and Demographic Modifiers of Depression's Impact on Emergency Department Utilization: A Stratified Analysis.

Background: The emergency department (ED) is often considered the last line of defense for urgent health crises, and people with depression may rely more heavily on ED services to address unexpected issues related to mental health or physical health due to the acute onset of symptoms or a lack of routine medical care.

Objective: This study aims to investigate the association between depressive symptoms and ED utilization and to systematically evaluate the moderating effects of socioeconomic status (SES), gender, and age on this relationship.

Methods: The study utilized data from the National Health and Nutrition Examination Survey (NHANES) covering the period from 2005 to 2018, with a final sample of 26,299 adult participants.

Multimodal integration of liquid biopsy and radiology for the noninvasive diagnosis of gallbladder cancer and benign disorders.

Gallbladder cancer (GBC) frequently mimics gallbladder benign lesions (GBBLs) in radiological images, leading to preoperative misdiagnoses. To address this challenge, we initiated a prospective, multicenter clinical trial (ChicCTR2100049249) and proposed a multimodal, non-invasive diagnostic model to distinguish GBC from GBBLs. A total of 301 patients diagnosed with gallbladder-occupying lesions (GBOLs) from 11 medical centers across 7 provinces in China were enrolled and divided into a discovery cohort and an independent external validation cohort.

A Novel NICU Sleep State Stratification: Multiperspective Features, Adaptive Feature Selection and Ensemble Model.

The examination of sleep patterns in newborns, particularly premature infants, is crucial for understanding neonatal development. This study presents an automated multi-sleep state classification approach for infants in neonatal intensive care units (NICU) using multiperspective feature extraction methodologies and machine learning to assess their neurological and physical development. The datasets for this study were collected from Children's Hospital Fudan University, Shanghai and consist of electroencephalography (EEG) recordings from two datasets, one comprising 64 neonates and the other 19 neonates.

Serum Enzymes and Pathologic Complete Response to the Addition of Targeted Therapy in Neoadjuvant Chemotherapy for HER2-Positive Breast Cancer Patients.

Background: This study investigated the association between circulating alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), lactate dehydrogenase (LDH), and gamma-glutamyltransferase (GGT) and the pathologic complete response (pCR) in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer receiving neoadjuvant chemotherapy with trastuzumab (H) and pertuzumab (P).

Methods: Data were collected from 290 patients with HER2-positive breast cancer at Sichuan Cancer Hospital between August 2019 and August 2023. Blood samples were collected to assess the serum enzyme levels, including ALT, AST, CK, LDH, and GGT.