The IGF2BP2-circ-DAPK1 axis promotes high-glucose-induced ferroptosis of HUVECs by decreasing NQO1 expression.

Circular RNAs (circRNAs) are non-coding RNAs with covalently closed loop structures that participate in various biological processes. However, the functions of many circRNAs remain unclear. Endothelial cell dysfunction, which involves abnormal ferroptosis, a unique form of regulated cell death, is a characteristic of various diseases.

Similar Molecular Features in Two Cases of CARD14-Associated Papulosquamous Eruption.

Subjects carrying variants in the caspase recruitment domain family member 14 (CARD14) gene can exhibit characteristics of psoriasis and pityriasis rubra pilaris (PRP). The term 'CARD14-associated papulosquamous eruption (CAPE)' is used to describe individuals presenting with symptoms of both conditions. This study aimed to diagnose two cases of CAPE and explore the pathogenic mechanisms, including inflammatory trends and differential features.

Membrane-intercalating conjugated oligoelectrolytes for lipid membrane imaging.

Membrane-intercalating conjugated oligoelectrolytes (MICOEs), a class of phospholipid bilayer mimics, demonstrate an exceptional ability to spontaneously integrate into biological membranes through a combination of electrostatic and hydrophobic interactions. This unique property makes them promising candidates for membrane imaging applications. Over the past decade, MICOEs have been successfully applied to imaging and tracking a wide range of biological membranes, including microbial membranes, mammalian plasma membranes, intracellular membranes, extracellular vesicles, and artificial liposomes.

Association of cardiometabolic index and new-onset stroke in middle-aged and elderly Chinese: a national prospective cohort study.

Background And Aims: The Cardiometabolic Index (CMI), a novel metabolic marker, has been associated with various metabolic diseases in previous studies. However, its relationship with stroke risk remains underexplored. This study investigates the potential correlation between CMI and stroke risk among Chinese adults aged 45 and older.

An outbreak of rhinovirus infection in a primary school in Shenyang City, China, in 2022.

Rhinovirus (RV) is a common pathogen that causes respiratory tract infection and can cause outbreaks in hospitals and welfare institutions. A cluster of respiratory diseases occurred in a primary school in Shenyang City, Liaoning Province, China, in 2022. In this outbreak, a total of 31 students had symptoms similar to those of upper respiratory tract infection, mainly cough and sore throat.

A cohort study of prolactin and non-puerperal mastitis using real world data.

Non-puerperal mastitis (NPM) is an umbrella term for non-specific inflammatory mastitis that occurs during the non-puerperal period and has an unclear aetiology. The current study aims to characterize NPM patients and examine the determinants associated with NPM severity. This study analyzed the NPM inpatients admitted to the Department of Breast Surgery, Longhua Hospital Affiliated with the Shanghai University of Traditional Chinese Medicine from 2016 to 2020.

Preparation of capecitabine-poly(p-dioxanone) electrospraying nanoparticles and influence of particle size on their colorectal cancer inhibitive efficiency.

Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. Capecitabine is a chemotherapeutic agent commonly used for the treatment of colon cancer. To realize local sustained release, promote efficient local intracellular transport, and mitigate the systemic toxic effects of capecitabine, a capecitabine prodrug, capecitabine-poly (p-dioxanone) (Cap-PPDO), was successfully synthesized.

Compression-Durable Soft Electronic Circuits Enabled by Embedding Self-Healing Biphasic Liquid-Solid Metal Into Microstructured Elastomeric Channels.

Compression strongly degrades the electrical conductivity of the liquid-metal-based circuits because the liquid state is prone to be squashed. Here, a new compressible and stretchable biphasic liquid-solid self-healing circuit is proposed by filling GalnSn-BilnSn biphasic metal into micropillar-embedded channels. The underlying BilnSn solid alloy layer serves as a compression resistance layer, while the upper GalnSn liquid metal layer enables the real-time filling of the cracks in the solid layer under large deformations, resulting in autonomous self-healing and maintenance of conductivity under both stretching and compression.

Revisiting the Treatment Algorithm for Atlantoaxial Dislocation after 10 Years: A Multi-center Study with Mid-to-long-term Follow-up.

Study Design: A multi-center retrospective cohort study.

Objective: To overcome the limitations of former single-center strategy studies, an updated classification guiding surgical management of Atlantoaxial dislocation (AAD) is proposed in this study based on a large multi-center retrospective cohort study with mid-to-long-term follow-up.

Summary Of Background Data: AAD is the most prevalent disorder affecting the cranio-vertebral junction, often leading to myelopathy and impairment of cranial nerve function, which can result in significant morbidity or even mortality.

Total Synthesis of (-)- and (+)-Talaroenamine B and Diphenylene Derivatives.

The first total synthesis of (±)-talaroenamine B was achieved through a concise four-step procedure. The key feature of this synthetic strategy lies in a one-pot reaction involving I (III)-mediated oxidative dearomatization to construct a racemic cyclohexanedione unit, followed by imination using a chiral auxiliary to afford a separable mixture of diastereoisomers. A further acid-catalyzed substitution reaction of aniline with the diastereoisomers led to the natural product (-)-talaroenamine B and its enantiomer (+)-talaroenamine B.

Effect of Statin on Clinical Outcomes in Critically Ill Patients with Non-traumatic Subarachnoid Hemorrhage: A Retrospective Analysis Based on MIMIC Database.

Background: Non-traumatic subarachnoid hemorrhage (NSAH) is a type of hemorrhagic stroke with high mortality and low recovery rates. Although statins are commonly used in cardiovascular diseases, their impact on SAH prognosis remains unclear. This study aimed to explore the relationship between statin use and short- and long-term all-cause mortality in critically ill patients with NSAH.

Stimuli-responsive polymer-dasatinib prodrug to reprogram cancer-associated fibroblasts for boosted immunotherapy.

The barriers from cancer-associated fibroblasts (CAFs) have diminished the clinical efficacy of immunotherapy for triple-negative breast cancer (TNBC). The obstacles from CAFs often result in poor drug penetration, constrained cytotoxic T lymphocyte infiltration, and an immunosuppressive microenvironment. Herein, chondroitin sulfate (CS) was engineered to conjugate dasatinib (DAS), a tyrosine kinase inhibitor, via the cathepsin B (CTSB)-responsive GFLG linker to produce CS-GFLG-DAS (CGD), which could be employed to reverse the CAF phenotype and regulate the biosynthesis of extracellular matrix (ECM), thus enhancing the efficacy of immune checkpoint blockade (ICB) therapy.

Nuclear MicroRNA-124-3p Promotes Neurite Outgrowth After Spinal Cord Injury by Enhancing Cttn Transcription.

The outgrowth of motor neurons needs to be enhanced for the efficient recovery of sensory and movement abilities after nerve injury. The microRNA miR-124-3p can repair spinal cord injury (SCI) and promote neurite outgrowth. In this study, we aimed to investigate the effect of miR-124-3p on neurite outgrowth and the mechanism underlying its effect on SCI.

The impact of HBsAg reduction via siRNA treatment on natural and vaccine (BRII-179)-induced HBV-specific humoral and cellular immune responses.

Background And Aims: The impact of HBsAg reduction from small interfering RNA (siRNA) treatments on HBV-specific immunity of CHB participants has not been adequately analyzed in human. We conducted a phase 2a study treating CHB participants with 9 4-weekly doses of HBV-targeted siRNA elebsiran (BRII-835), either alone (n=10) or in combination with a VLP-based therapeutic vaccine (BRII-179) containing Pre-S1, Pre-S2, and S antigens, co-administered with (n=39) or without (n=41) IFNα.

Methods: We analyzed longitudinally for 72 weeks virological, clinical, and immunological parameters including HBsAg, ALT, anti-HBs, the neutralizing activity of representative sera, and frequency and cytokine secretion ability of T cells specific for Pre-S1, Pre-S2, and S both directly ex vivo and after in vitro expansion.

Comparative immobilization of 30 PFAS mixtures onto biochar, clay, nanoparticle, and polymer derived engineered adsorbents: Machine learning insights into carbon chain length and removal mechanism.

Per- and polyfluoroalkyl substances (PFAS) are a group of fluorinated chemicals that cause potential risk in PFAS-impacted soil and water. The adsorption efficiency of 30 PFAS mixtures using different adsorbents in environmentally relevant concentrations was investigated. Different meso/microporous designed adsorbents (n = 7) were used for PFAS adsorption and their interfacial interactions.

Tailoring nanovectors for optimal neoantigen vaccine efficacy.

The primary objective of neoantigen vaccines is to elicit a robust anti-tumor immune response by generating neoantigen-specific T cells that can eradicate tumor cells. Despite substantial advancements in personalized neoantigen prediction using next-generation sequencing, machine learning, and mass spectrometry, challenges remain in efficiently expanding neoantigen-specific T cell populations . This challenge impedes the widespread clinical application of neoantigen vaccines.

Systematic investigation into matrix effect compensation in the GC-MS analysis of flavor components using analyte protectants.

Accurate quantitative analysis of flavor components is critical to eusuring product quality and safety. Matrix effects (MEs) in gas chromatography (GC) analysis frequently leads to a low sensitivity and inaccurate quantitation. This study first analyzed the MEs of 32 representative flavor components that cover the volatility range of GC-amenable analytes.

Effect of bamboo biochar preparation conditions on immobilization of laccase and its application.

In this paper, bamboo biochar was prepared and used for laccase immobilization. Biochar was prepared under different conditions (pyrolysis temperature, heating rate and dwell time) to understand biochar characteristics impacts on enzyme activity. The results showed that the preparation conditions had an important effect on the content of carboxyl groups on biochar.

Illuminating green fluorescent protein: Characterizing tri-peptide fluorescent chromophore, probing reactivity of cysteines, and unveiling site-directed modifications through mass spectrometry.

Bioconjugation technologies enable covalent attachment of diagnostic or therapeutic effectuators onto biological targets, allowing for the precise delivery of desired drugs to the intended targets with enhanced potency, selectivity, specificity, and prolonged duration of action. As the number of bioconjugation techniques has grown enormously, identification and in-depth characterization of in-process products play a critical role in the development of covalent drug conjugates. This is especially significant in light of the increased complexity of novel biotherapeutics derived from biological matrices.

PointCG: Self-Supervised Point Cloud Learning Via Joint Completion and Generation.

The core of self-supervised point cloud learning lies in setting up appropriate pretext tasks, to construct a pre-training framework that enables the encoder to perceive 3D objects effectively. In this paper, we integrate two prevalent methods, masked point modeling (MPM) and 3D-to-2D generation, as pretext tasks within a pre-training framework. We leverage the spatial awareness and precise supervision offered by these two methods to address their respective limitations: ambiguous supervision signals and insensitivity to geometric information.

Synthesis and modification of novel magnetic cellulose composite microspheres for laccase immobilization.

In this paper, an effective strategy to improve the stability and recovery convenience of immobilized laccase by preparing magnetic particles from cheap filter paper fibers was studied, that is, MC@Fe3O4 microparticles were prepared by simple cellulose regeneration and carboxyl group functionalization, and then immobilized laccase under mild conditions. The Box-Behnken design (BBD) was used to optimize the enzyme concentration, pH value and contact time affecting the immobilization yield. The results showed that the concentration of laccase and pH value had important effects on the immobilization yield.

Decreased endogenous nitric oxide production in acute decompensated heart failure with a reduced ejection fraction.

Aims: Heart failure represents a substantial burden to both patients and healthcare systems worldwide. Nitric oxide (NO) dysregulation may play a key role in patients transitioning from chronic to acute heart failure with a reduced ejection fraction (HFrEF). Plasma nitrite (NO ) is highly reflective of local nitric oxide production and has not been studied in acute HFrEF.

Efficacy of triamcinolone acetonide combined with recombinant bovine basic fibroblast growth factor in preventing scar formation after adult circumcision using a stapler device: A randomized controlled trial.

Background: This randomized controlled trial aimed to investigate the potential benefits of local application of triamcinolone acetonide combined with topical recombinant bovine basic fibroblast growth factor in promoting wound healing and reducing scar formation after circumcision using a stapler device.

Methods: A total of 192 patients with phimosis or redundant prepuce were randomly assigned to either the observation group (n = 96) or the control group (n = 96). Both groups underwent circumcision using a stapler device.