Designing Ultra-Narrow-Band Red Phosphor via Oxygen Vacancy Engineering for Transparent Display Application.

Narrow-band red phosphors have been crucial in enabling energy-efficient and wide color gamut display technologies. Developing novel red phosphors with narrower FWHM and suitable positions is still an urgent demand. Herein, a nanorod-shaped NbO:Pr phosphor, featuring a single ultra-narrow-band red emission at 612 nm with FWHM of only 19 nm, is reported.

Progress in the Management of Retinal Detachment Associated With Morning Glory Syndrome.

Morning glory syndrome (MGS) is a rare congenital optic disc malformation characterized by a distinctive funnel-shaped optic disc resembling a blooming morning glory flower, typically diagnosed in childhood or adolescence and primarily presenting unilaterally, although bilateral cases have been reported. The anomaly features an enlarged optic disc, radiating blood vessels, and surrounding excavation, leading to visual impairment that can range from mild to profound. The etiology of MGS is not fully understood but has been associated with genetic factors, particularly mutations in the PAX6 and PAX2 genes, which play critical roles in eye development.

Crab bioturbation alters the community assemblies of abundant and rare bacteria on an intertidal wetland in the Yellow River estuary.

Introduction: Revealing assembly patterns of abundant and rare bacteria is pivotal for comprehending the responses of soil bacterial community to environmental changes. Crabs exert significant impacts on soil environments through their frequent burrowing activities in intertidal wetlands. However, there remains a paucity of knowledge regarding the influencing mechanism of crab bioturbation on community assemblies of abundant and rare bacteria.

Enabling real-time reconstruction for large field-of-view single-molecule localization microscopy using discrete field-dependent point-spread function.

Single-molecule localization microscopy (SMLM) is a powerful super-resolution imaging technique that offers resolution far beyond the optical diffraction limit. The commonly used high numerical-aperture (NA) objective lenses in SMLM can only provide a nearly ideal point-spread function (PSF) at the center of the field-of-view (FOV), whereas the off-axis PSF is often distorted due to optical aberrations. Since precision and accuracy of three-dimensional (3D) spatial localization of single molecules heavily depend on the system's PSF, the FOV of 3D SMLM is often restricted to about 50 µm × 50 µm limiting its applications in visualizing intra-/intercellular interactions and high-throughput single-molecule analysis.

Minimizing the Use of Per- and Polyfluoroalkyl Substances for Textured Wetting-Resistant Surfaces.

Per- and polyfluoroalkyl substances (PFAS) have been used as synthetic chemicals to create textured wetting-resistant surfaces, which have a broad range of applications including omniphobic membranes, self-cleaning textiles, and anticorrosion coatings. However, the high persistence, toxicity, and bioaccumulation potential of PFAS have led to rising public concerns and stringent regulations, especially after the U.S.

Comparison of sterile normal saline and 1% povidone-iodine for vaginal preparation in vesicovaginal fistula: a randomised trial.

Background: Vaginal preparation before transvaginal gynecological surgeries improves the success rate. However, there is no consensus on which agent is superior for transvaginal repair of vesicovaginal fistula (VVF). We aimed to compare irritation symptoms and antimicrobial function between sterile normal saline (SS) and 1% povidone-iodine (PI) for vaginal preparation in surgical repair of VVF.

Associations of Inflammatory Markers With Neurological Dysfunction and Prognosis in Patients With Progressive Stroke.

Objective: This study aimed to explore the associations between inflammatory markers and the severity of early neurological dysfunction and prognosis in patients with progressive stroke (PS) and evaluated the predictive value of inflammatory markers for PS.

Methods: Among 711 acute ischemic stroke (AIS) patients, 210 patients with PS and 501 patients without PS were included. Six inflammatory markers, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and pan-immune-inflammation value (PIV), were measured and compared between two groups.

Recyclable magnetic composites prepared by a novel reverse encapsulation reaction to increase benzene rings reactive sites for enhanced removal of 3,4-diaminotoluene: Theoretical prediction with experimental statistics.

The widespread distribution of organic amine reagent in the aquatic environment has severely constrained ecological health, and mitigating its potential environmental hazards is imperative. Herein, the recyclable magnetic composite (FeO-3-Amino-Tereph-acid) with abundant homogenous reaction sites and excellent removal efficacy (34.72 mg/g) towards 3,4-diaminotoluene (UENE) contaminant was fabricated via the reverse direction layer-by-layer reaction.

Integration of network pharmacology, bioinformatics and experimental verification strategy to discover the pharmacological mechanisms of mogroside acts against pharyngitis.

Ethnopharmacological Relevance: Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu & Zhang, a popular herb in traditional Chinese materials, has been broadly employed in food and medicine homology. According to TCM, S.

Cubebin alleviates chronic stress-induced depression-like behavior in mice by regulating the gut microbiome.

The gut-brain axis is dysregulated as a consequence of alterations in the gut microbiota. These alterations increase toxic microbial metabolites, endotoxemia, and the release of immune mediators and contribute to the development of depression. Cubebin is a dibenzyl butyrolactone lignan, and its stem is also known as Agaru in Tibetan areas, it is commonly used as a sedative and tranquilizing medicine.

Integration of Electrohydrodynamic Printing and Hydroprinting for the Cost-Effective Fabrication of Microscale Conformal Transparent Electrodes on Diverse Curved Surfaces.

Hydroprinting has emerged as a cost-effective solution to transfer planar flexible electronics onto diverse curved surfaces for the fabrication of conformal transparent electrodes (CTEs) in the fields of microelectronics and healthcare monitoring. However, current hydroprinting strategies commonly rely on intricate multiple-step microfabrication processes or inkjet/direct/screen printing, largely limiting accessibility or resolution for microscale CTEs. Here, an integration strategy is proposed by combining electrohydrodynamic printing and hydroprinting, simplifying the fabrication of microscale CTEs with remarkable electrical/thermal/sensing capabilities and robust mechanical stability.

Effects of dual intake channels on energy efficiency and emissions of the uniflow scavenging opposed-piston engine.

Uniflow scavenging opposed-piston two-stroke diesel engine has high power density and thermal efficiency. However, the uniflow scavenging performance control is inflexible and inefficient. In this study, the dual intake channels are proposed.

Microglia-derived sEV: Friend or foe in the pathogenesis of cognitive impairment.

As immune cells, microglia serve a dual role in cognition. Microglia-derived sEV actively contribute to the development of cognitive impairment by selectively targeting specific cells through various substances such as proteins, RNA, DNA, lipids, and metabolic waste. In recent years, there has been an increasing focus on understanding the pathogenesis and therapeutic potential of sEV.

Intravesical chemotherapy in BCG waiting period may prolong time to recurrence for high-risk NMIBC patients.

Purpose: This study aimed to determine whether administering intravesical chemotherapy (IVC) during the Bacillus Calmette - Guérin (BCG) waiting period after the second TURBT improves the recurrence-free survival (RFS) of patients with non - muscle - invasive bladder cancer (NMIBC).

Methods: A retrospective analysis was performed on patients who had undergone a second TURBT and subsequent intravesical BCG immunotherapy (IBI) at the Affiliated Hospital of Xuzhou Medical University between January 2012 and December 2023. The patients were divided into two groups (A and B) based on whether they continued IVC during the BCG waiting period, and RFS was compared between the two groups.

Pure data correction enhancing remote sensing image classification with a lightweight ensemble model.

The classification of remote sensing images is inherently challenging due to the complexity, diversity, and sparsity of the data across different image samples. Existing advanced methods often require substantial modifications to model architectures to achieve optimal performance, resulting in complex frameworks that are difficult to adapt. To overcome these limitations, we propose a lightweight ensemble method, enhanced by pure data correction, called the Exceptionally Straightforward Ensemble.

LC-MS/MS-based metabolomics and multivariate statistical analysis reveal the mechanism of yeast extracellular proteases on myofibrillar protein degradation, metabolite development and sensory characteristics improvement.

Yeast extracellular proteases play a key role in developing the taste of dry-cured ham, whereas the mechanism of yeast proteases on taste formation of dry-cured ham is not fully studied. The proteases characteristics of yeast isolated form Jinhua ham, hydrolysis capacities for myofibrillar proteins (MP), free amino acid contents, metabolite compositions, taste parameters and the relationship between metabolites and taste parameters were investigated to reveal the mechanism of Rhodotorula mucilaginosa AUMC 9298 (RM) and Candida parapsilosis d70a (CP) proteases on MP hydrolysis and taste development of dry-cured ham. The proteases of RM and CP showed high hydrolysis activities at the conditions of pH 5.

KRAS4B oncogenic mutants promote non-small cell lung cancer progression via the interaction of deubiquitinase USP25 with RNF31.

Kirsten rat sarcoma viral oncogene homolog (KRAS) oncogenic mutations are genetic drivers in various cancers, including non-small cell lung cancer (NSCLC). However, the regulatory mechanisms underlying the progression of NSCLC driven by oncogenic KRAS mutants are incompletely understood. Here, we show that ubiquitin specific peptidase 25 (USP25) impedes ring finger protein 31 (RNF31)-mediated linear ubiquitination of KRAS oncogenic mutants (KRAS) independently of its deubiquitinase activity, which facilitates the plasma membrane (PM) localization and the downstream oncogenic signaling of KRAS.

Functional MRI-based machine learning strategy for prediction of postoperative delirium in cardiac surgery patients: A secondary analysis of a prospective observational study.

Study Objective: Delirium is a common complication after cardiac surgery and is associated with poor prognosis. An effective delirium prediction model could identify high-risk patients who might benefit from targeted prevention strategies. We introduce machine learning models that employ resting-state functional MRI datasets obtained before surgery to predict postoperative delirium.

Exploring New Physics with PandaX-4T Low Energy Electronic Recoil Data.

New particles beyond the standard model of particle physics, such as axions, can be effectively searched through their interactions with electrons. We use the large liquid xenon detector PandaX-4T to search for novel electronic recoil signals induced by solar axions, neutrinos with anomalous magnetic moment, axionlike particles, dark photons, and light fermionic dark matter. A detailed background model is established using the latest datasets with 1.

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation.

Purpose: To investigate the effect of matrix stiffness on the morphology and stem characters of maintenance and differentiation of limbal niche cells (LNCs) and the mechanisms involved.

Methods: Human LNCs were isolated, cultured, and identified based on published literature, and LNCs from passages 4 to 6 (P4-P6) were used in this study. They were coated with hydrogels of different concentrations to prepare matrices with different stiffnesses, and non-coated plate were used for the control group.

A deep-learning model for predicting tyrosine kinase inhibitor response from histology in gastrointestinal stromal tumor.

Over 90% of gastrointestinal stromal tumors (GISTs) harbor mutations in KIT or PDGFRA that can predict response to tyrosine kinase inhibitor (TKI) therapies, as recommended by NCCN (National Comprehensive Cancer Network) guidelines. However, gene sequencing for mutation testing is expensive and time-consuming and is susceptible to a variety of preanalytical factors. To overcome the challenges associated with genetic screening by sequencing, in the current study we developed an artificial intelligence-based deep-learning （DL） model that uses convolutional neural networks (CNN) to analyze digitized hematoxylin and eosin staining in tumor histological sections to predict potential response to imatinib or avapritinib treatment in GIST patients.

Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.

Objective: People with Hashimoto's thyroiditis (HT) often have low vitamin D3 concentrations. Some research has suggested that vitamin D3 supplementation reduces thyroid inflammation, but this remains controversial.

Methods: EAT was induced in female NOD/ShiLtJ mice by giving them water containing 0.

Case report: A case report and literature review on the efficacy of high-dose aumolertinib combined intrathecal pemetrexed by Ommaya reservoir for EGFR-mutated NSCLC with leptomeningeal metastasis as the initial symptoms.

Leptomeningeal metastasis (LM) is a significant complication of advanced non-small cell lung cancer (NSCLC), occurring in only 3-5% of patients and exceedingly rare in newly diagnosed NSCLC patients. This also indicates that the tumor is highly malignant and aggressive, which brings great challenges to treatment. Here we present a case report of an EGFR-mutated NSCLC patient who presented with LM as the primary clinical manifestation, and review the latest advances in existing studies on LM-related treatment.

Female adnexal tumor of probable Wolffian origin (FATWO): a case report and literature review.

Female adnexal tumor of probable Wolffian origin (FATWO) is a rare gynecologic tumor. We describe a case of 53-year-old female patient in whom an adnexal mass was found. Microscopic examination revealed that the tumor arose in the adnexal soft tissue, composed of bland cells with an admixture of solid and sieve-like patterning, while presenting a high mitotic activity.