Lysophosphatidylcholine promoting α-Synuclein aggregation in Parkinson's disease: disrupting GCase glycosylation and lysosomal α-Synuclein degradation.

In Parkinson's Disease (PD), elevated serum lysophosphatidylcholine (LPC) levels correlate with disease progression. However, the mechanisms by which abnormal LPC elevation contributes to PD-related neurotoxicity remain poorly understood. This study aims to investigate the pathogenic role of LPC in dopaminergic neuronal damage and elucidates its underlying mechanisms.

VM-UNet++ research on crack image segmentation based on improved VM-UNet.

Cracks are common defects in physical structures, and if not detected and addressed in a timely manner, they can pose a severe threat to the overall safety of the structure. In recent years, with advancements in deep learning, particularly the widespread use of Convolutional Neural Networks (CNNs) and Transformers, significant breakthroughs have been made in the field of crack detection. However, CNNs still face limitations in capturing global information due to their local receptive fields when processing images.

Synthesizing Conductive Metal-Organic Framework Nanosheets for High-Performing Chemiresistive Sensors.

Two-dimensional conjugated metal-organic frameworks (2D -MOFs) are emerging as unique electrode materials with great potential for electronic applications. However, traditional devices based on -MOFs often utilize them directly in the powder or nanoparticle form, leading to weak adhesion to the device substrate and resulting in low stability and high noise levels in the final device. In this study, we present a novel approach utilizing thin -MOFs synthesized via a general MOF nanosheet sacrifice approach, enhancing their aspect ratio and flexibility for high-performance electronic applications.

Effects of increasing n3:n6 ratio by replacing extruded soybeans with extruded flaxseed on dry matter intake, rumen fluid bacteria, and liver lipid metabolism in transition cows.

Background: The drop of dry matter intake (DMI) and rise of milk production in transitional dairy cows would mobilize reserved fat and disrupt lipid metabolism, eventually attributed to negative energy balance (NEB) and immune injury. The positive effect of n-3 polyunsaturated fatty acids (PUFA) on regulating energy metabolism and inflammation has been elucidated, however, the lack of regulatory mechanism of dairy cows deserves further investigation. In this study, 30 Holstein transition cows were divided into the control (CON) and HN3 groups based on the n-3: n-6 PUFA ratio in the diet.

Bacterial translocation and gut microbiome imbalance in an experimental infection model of legionellosis in guinea pigs.

Background: Recent studies have shown that in critically ill patients such as those with sepsis and shock, the lung and gut microbiomes undergo profound changes. Legionella pneumophila (Lp) can cause fatal infection, however, such changes have not been investigated in legionellosis. Here, we evaluated the microbiome of the lungs, blood, liver, and small intestine content in Lp-infected guinea pigs.

Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway.

Steroid-induced avascular necrosis of the femoral head (SANFH) is a progressive degenerative disease of the hip, primarily due to glucocorticoid (GC)-induced endothelial cell (EC) injury and compromised blood supply. Irisin is an EC-protective mytokine whose receptor is the integrin αVβ5. Caveolin-1 (CAV-1)， a major component of caveolae, causes endothelial dysfunction when phosphorylated.

Multiple omics-based machine learning reveals specific macrophage sub-clusters in renal ischemia-reperfusion injury and constructs predictive models for transplant outcomes.

Background: Ischemia-reperfusion injury (IRI) is closely associated with numerous severe postoperative complications, including acute rejection, delayed graft function (DGF) and graft failure. Macrophages are central to modulating the aseptic inflammatory response during the IRI process. The objective of this study is to conduct an analysis of the developmental and differentiation characteristics of macrophages in IRI, identify distinct molecules subtypes of IRI, and establish robust predictive strategies for DGF and graft survival.

Interlayer confinement toward short hydrogen bond network construction for fast hydroxide transport.

Driven by boosting demands for sustainable energy, highly conductive hydroxide exchange membranes (HEMs) are urgently required in electrochemical conversion devices. The hydrogen bonds shorter than 2.5 angstrom are expected to accelerate the ion transport.

Decrease in the internal quality control intermediate reproducibility imprecision of Cystatin C results in China in the years from 2014 to 2023.

Objectives: We evaluated the intermediate reproducibility imprecision of cystatin C results based on internal quality control (IQC) data.

Methods: Five performance specifications [1/3 total allowable error (TEa), 1/4TEa and three levels performance specifications based on biological variation] were used to calculate the proportion of laboratories with CVs less than or equal to the performance specifications, namely the pass rate. Based on the reference interval of Chinese adult serum cystatin C (0.

Combined transcriptomic and proteomic analyses reveal relevant myelin features in mice with ischemic stroke.

Ischemic stroke (IS), a leading cause of global disability and mortality, is characterized by white matter damage and demyelination. Despite advances, the molecular mechanisms driving post-IS myelin pathology remain poorly understood, limiting therapeutic development. This study investigates key myelin-related genes (MRGs) and their regulatory networks to identify novel therapeutic targets.

National prevalence and incidence of benign prostatic hyperplasia/lower urinary tract symptoms and validated risk factors pattern.

Background: To date, limited research has been conducted within China to elucidate the national prevalence and incidence rates of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS). Additionally, there is a scarcity of studies that have systematically investigated the reliable risk factor patterns associated with the development of BPH/LUTS among the Chinese population.

Methods: The study was in both cross-sectional and prospective cohort study design.

The TMBIM1-YBX1 axis orchestrates MDSC recruitment and immunosuppressive microenvironment in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) is notorious for its profoundly immunosuppressive nature. The complex crosstalk between diverse immune cell types and heterogeneous tumor cell populations shapes this challenging tumor immune microenvironment (TIME). In this study, the role of transmembrane BAX inhibitor motif-containing 1 (TMBIM1) in modulating the TIME and its potential as a therapeutic target in PDAC were investigated.

Erratum: Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling: Erratum.

[This corrects the article DOI: 10.7150/thno.60031.

IGF2BP3 promotes the proliferation and cisplatin resistance of bladder cancer by enhancing the mRNA stability of CDK6 in an m6A dependent manner.

Cisplatin-based chemotherapy is a primary treatment for bladder cancer, yet the development of chemoresistance poses a significant therapeutic challenge. Insulin-like growth factor II mRNA binding protein 3 (IGF2BP3) is an RNA-binding protein and a key m6A reader that regulates various cancers through m6A-dependent mechanisms. However, its role in chemotherapy resistance in bladder cancer remains unclear.

Effect of pulmonary rehabilitation for patients with long COVID-19: a systematic review and meta-analysis of randomized controlled trials.

Background: Pulmonary rehabilitation (PR) has demonstrated efficacy in managing long COVID-19, underscoring the need to refine and tailor PR strategies for optimal patient outcomes.

Objectives: To evaluate the impact of PR on patients with long COVID-19 and to compare the efficacy of different types and durations of PR interventions.

Design: Systematic review and meta-analysis.

The impact of thyroid function on surgical prognosis in patients undergoing cardiac and major vascular surgeries.

Objective: This study aims to elucidate the relationship between thyroid function and surgical prognosis in patients undergoing cardiac and major vascular surgeries.

Methods: A retrospective cohort study was conducted on patients undergoing cardiac or major vascular surgeries. Preoperative thyroid function tests, including TSH, free T3, and free T4 levels, as well as postoperative thyroid function tests, were assessed.

Factors influencing medical disputes among village doctors from seven provinces in China: a cross-sectional study.

Background: Medical disputes, with the progress of economic development and the improvement of people's awareness of rights protection, are becoming increasingly intense. This phenomenon may have a negative impact on doctors and the medical system, especially village doctors who are responsible for guarding the health of rural people. Therefore, it is urgent to explore the factors that affect the medical dispute experience of village doctors.

Metagenomic insight into the horizontal transfer mechanism of fluoroquinolone antibiotic resistance genes mediated by mobile genetic element in microalgae-bacteria consortia.

Antibiotics could accumulate in the environment with the discharge of wastewater from families, hospitals and livestock farms, which intensifies the spread of resistance genes around the world. Although microalgae-bacteria consortia (MBC) can efficiently remove antibiotics, the horizontal transfer mechanism of antibiotics resistance genes in MBC is still rarely reported. In this study, the removal efficiency of ofloxacin, norfloxacin and enrofloxacin by MBC under different antibiotic concentrations was investigated, while resistance genes in the MBC were identified and the mechanism of horizontal transfer was disclosed.

The historical connection of the Arctic and Qinghai-Tibet Plateau floras and their asynchronous diversification in response to Cenozoic climate cooling.

The Arctic and the Qinghai-Tibet Plateau (QTP) are two northern regions with the most extensive cold habitats on Earth and have undergone dramatic warming in recent decades. However, we know little about the historical connection of the Arctic and QTP biotas and their respective diversification processes. Here, we used Meconopsis and Oreomecon, an Arctic-QTP disjunct angiosperm genus pair with poor seed dispersal abilities, to shed light on the evolutionary connection of the Arctic and QTP floras and their respective diversification patterns.

High-Resolution Stretchable Soft Liquid Metal Circuits Based on Cu-Ga Alloying and Femtosecond Laser Ablation.

Flexible electronic circuits are critical in biomedical devices, human-machine interfaces, and wearable sensing systems, which further require flexible conductive materials with high conductivity, stretchability, and electrical stability. Liquid metal (LM) has attracted much attention due to its unique metallic conductivity and room-temperature fluidic properties. However, LM's high surface tension properties increase the difficulty of patterning processing.

Event-Related Brain Oscillations Changes in Major Depressive Disorder Patients During Emotional Face Recognition.

Major depressive disorder (MDD) is a disorder with multiple impairments, among which emotion disorder is the most main one. Nowadays, evoked activity (EA), such as event-related potential (ERP), has mostly been studied for MDD, but induced activity (IA) analysis is still lacking. In this paper, EA, IA and event-related spectral perturbation (ERSP) were studied and compared between MDD patients and healthy controls (HC).

MXene-induced construction of SnS2 nano-arrays with sulfur vacancies for high-efficiency photocatalytic CO2 reduction.

Solar-driven CO2 reduction has gained significant attention as a sustainable approach for CO2 utilization, enabling the selective production of fuels and chemicals. SnS2, a non-precious metal sulfide semiconductor, has great potential in photocatalytic CO2 reduction due to its unique physicochemical properties. However, low electrical conductivity and susceptibility to aggregation of pure SnS2 lead to a high charge recombination rate and hinder the photocatalytic efficiency.

Flexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration.

The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable of generating customizable patterned electric fields for in situ electrostimulation(electrical stimulation). Herein, this study reports a fuel cell patch (FCP) that can provide in situ electrostimulation and a hypoxic microenvironment to promote tissue repair synergistically.