Palm Oil Derived Tocotrienol-Rich Fraction Attenuates Vascular Dementia in Type 2 Diabetic Rats.

Vascular dementia (VaD) is a serious global health issue and type 2 diabetes mellitus (T2DM) patients are at higher risk. Palm oil tocotrienol-rich fraction (TRF) exhibits neuroprotective properties; however, its effect on VaD is not reported. Hence, we evaluated TRF effectiveness in T2DM-induced VaD rats.

The Attenuating Effect of Beta-Carotene on Streptozotocin Induced Diabetic Vascular Dementia Symptoms in Rats.

This study investigated the ameliorative effects of beta-carotene (BC) on diabetes-associated vascular dementia and its action against biomolecule oxidation. The diabetic vascular dementia (VaD) was induced by administration of nicotinamide (NA; 50 mg/kg; ) and streptozotocin (STZ; 50 mg/kg; ). The test compound, BC (50 and 100 mg/kg; ), and the reference compound, donepezil (DP) (1 mg/kg; ), were administered for 15 consecutive days.

A new species of Merothrips from the Dampa Tiger Reserve, Mizoram, India (Thysanoptera, Terebrantia).

Merothrips mizoramensis sp.n. is described from northeastern India based on a single macropterous female.

Redescription and lectotype designation of Gynaikothrips microchaetus Ananthakrishnan & Jagadish (Thysanoptera: Phlaeothripidae).

Gynaikothrips microchaetus Ananthakrishnan and Jagadish (1969) was described from Dharwar in Karnataka, and until now has been known only from southern India (Ananthakrishnan & Sen 1980). The original description was based on an unspecified number of syntypes, with no depositary indicated. However, one of the authors (R.

A Novel Internet of Things Framework Integrated with Real Time Monitoring for Intelligent Healthcare Environment.

During mammogram screening, there is a higher probability that detection of cancers is missed, and more than 16 percentage of breast cancer is not detected by radiologists. This problem can be solved by employing image processing algorithms which enhances the accuracy of the diagnostic through image segmentation which reduces the misclassified malignant cancers. By employing segmentation, the unnecessary regions in the breast close to the boundary between the breast tissue and segmented pectoral muscle can be removed, therefore enhancing the accuracy the calculation as well as feature estimation.

A Self Assistive Device for Deaf & Blind People Using IOT : Kathu-Kann Thaan Thunai Eyanthiram.

This paper presents Google speech API based aid for deaf and blind people. The live streaming speech on the microphone is sent to Google API server which converts the speech signal into text and displaying onto a LCD screen and amplifies the speech via speaker. The aid will use Request procedure protocol to send the encoded Mp3 audio to Google API server where the speech signal is converted into suitable text and sent back to the Raspberry pi using repeated request protocol.

Internet of Things with Maximal Overlap Discrete Wavelet Transform for Remote Health Monitoring of Abnormal ECG Signals.

In this paper, MODWT is used to decompose the Electrocardiography (ECG) signals and to identify the changes of R waves in the noisy input ECG signal. The MODWT is used to handle the arbitrary changes in the input signal. The R wave's detctected by the proposed framework is used by the doctors and careholders to take necessary action for the patients.

Relationships and revised status of (Thysanoptera: Phlaeothripinae).

The generic name Nagathrips was erected as a sub-genus of Mesothrips for the single species, crenulatus Varatharajan and Singh (2000). Subsequent studies revealed character states that were not included in the original description. These are: prosternal basantra absent; antennal segment III with one slender sense cone, segment IV with three similar sense cones; fore wings parallel-sided with no median constriction.

A new species of the genus (Thysanoptera: Thripidae) from the Western Ghats of India.

Thrips laurencei sp.n. is described from specimens collected on flowers of Hydrangea macrophylla in Western Ghats range of Tamil Nadu, India.

Effects of pre and post-treatments with dipyridamole in gentamicin-induced acute nephrotoxicity in the rat.

This study investigated the pretreatment and post-treatment effects of dipyridamole (20 mg/kg/day, p.o.) in gentamicin-induced acute nephrotoxicity in rats.

Nasal administration of leptin dose-dependently increases dopamine and serotonin outflow in the rat nucleus accumbens.

Leptin is an anorexigenic hormone that acts via its receptor (LepR) to regulate the hypothalamic arcuate nucleus circuitry to mediate energy homeostasis and feeding behavior. Moreover, leptin decreases the reward value of natural and artificial rewards, and low levels of circulating leptin have been implicated in several mood disorders linking leptin to the mesolimbic system. Therefore, the purpose of this study was to assess whether and to what extent an acute intranasal application of leptin is able to modulate monoamine neurotransmitters in the nucleus accumbens (NAc).

Effect of edaravone in diabetes mellitus-induced nephropathy in rats.

Edaravone, a synthetic-free radical scavenger, has been reported to reduce ischemia-reperfusion-induced renal injury by improving tubular cell function, and lowering serum creatinine and renal vascular resistance. The present study investigated the effect of edaravone in diabetes mellitus-induced nephropathy in rats. A single administration of streptozotocin (STZ, 55 mg/kg, i.

Electrical high frequency stimulation modulates GABAergic activity in the nucleus accumbens of freely moving rats.

Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is an effective treatment option for those affected by obsessive compulsive disorder, who do not respond to pharmacological treatment strategies. Yet, little is known about the mechanism by which DBS achieve its therapeutic effects. Previous studies have shown an increase in GABA levels due to high frequency stimulation (HFS) in the rat caudate putamen.

Fenofibrate and dipyridamole treatments in low-doses either alone or in combination blunted the development of nephropathy in diabetic rats.

Low-doses of fenofibrate and dipyridamole have pleiotropic renoprotective actions in diabetic rats. This study investigated their combined effect relative to their individual treatments and lisinopril in rats with diabetic nephropathy. Streptozotocin (55mg/kg, i.

Transmitter self-regulation by extracellular glutamate in fresh human cortical slices.

Glutamate is thought to be the most important excitatory neurotransmitter in the CNS, while glutamine predominantly serves as a precursor and metabolite in the glutamate-glutamine cycle. To verify the interaction between intrinsic extracellular glutamate, y-aminobutyric acid (GABA) levels and glial glutamine outflow in human tissue, fresh brain slices from human frontal cortex were incubated in superfusion chambers in vitro. Human neocortical tissue was obtained during surgical treatment of subcortical brain tumors.

Classical and pleiotropic actions of dipyridamole: Not enough light to illuminate the dark tunnel?

Dipyridamole is a platelet inhibitor indicated for the secondary prevention of transient ischemic attack. It inhibits the enzyme phosphodiesterase, elevates cAMP and cGMP levels and prevents platelet aggregation. Dipyridamole inhibits the cellular uptake of adenosine into red blood cells, platelets and endothelial cells that results in increased extracellular availability of adenosine, leading to modulation of cardiovascular function.

Antioxidant and pro-oxidant effects of oil palm (Elaeis guineensis) leaves extract in experimental diabetic nephropathy: a duration-dependent outcome.

Background: Catechins-rich oil palm (Elaeis guineensis) leaves extract (OPLE) is known to have antioxidant activity. Several polyphenolic compounds reported as antioxidants such as quercetin, catechins and gallic acid have been highlighted to have pro-oxidant activity at high doses. Therefore, the present study was conducted to investigate the antioxidant and pro-oxidant effects of chronically administering high dose of OPLE (1000 mg kg⁻¹) in an animal model of diabetic nephropathy (DN).

Analgesic and antipyretic effects of Sansevieria trifasciata leaves.

The ethanol and water extracts of Sansevieria trifasciata leaves showed dose-dependent and significant (P < 0.05) increase in pain threshold in tail-immersion test. Moreover, both the extracts (100 - 200 mg/kg) exhibited a dose-dependent inhibition of writhing and also showed a significant (P < 0.

Cross infectivity of baculovirus, Spilarctia obliqua nuclear polyhedrosis virus against mulberry pest, Porthesia xanthorrhoea Kollar.

Spilarctia obliqua nucleopolyhedrosis virus (SoNPV) has been found effective against S. obliqua (Walker) as well as Porthesia xanthorrhoea Kollar. LC50 concentration of S.