Publications by authors named "Valizadeh Arshad"
Epigenetics refers to nucleotide sequence-independent events, and heritable changes, including DNA methylation and histone modification (as the two main processes), contributing to the phenotypic features of the cell. Both genetics and epigenetics contribute to determining the outcome of regulatory gene expression systems. Indeed, the flexibility of epigenetic effects and stability of genetic coding lead to gene regulation complexity in response signals.
View Article and Find Full Text PDFRNA interference (RNAi) is an important phenomenon that has diverse genetic regulatory functions at the pre- and posttranscriptional levels. The major trigger for the RNAi pathway is double-stranded RNA (dsRNA). dsRNA is processed to generate various types of major small noncoding RNAs (ncRNAs) that include microRNAs (miRNAs), small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs) in Drosophila melanogaster (D.
View Article and Find Full Text PDFArticle Synopsis
- The research aims to improve the efficiency of generating functional motor neurons from human embryonic stem cells (hESCs) using a cocktail of small molecules instead of traditional morphogen factors.
- Five different stages of the differentiation process were analyzed, showing that the hESC-derived neural ectoderm expressed essential neural markers and demonstrated characteristics of motor neurons through various testing methods.
- Although the differentiated motor neurons expressed key markers, the electrical activity measured indicated that the voltage-gated ion channels were insufficient for generating action potentials, suggesting further refinement is needed in the differentiation protocol.