Factors associated with oxidative stress in virologically suppressed people living with HIV on long-term antiretroviral therapy.

Background: Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favour of oxidants, that has been associated with an increased risk of morbidity and mortality in ART-treated people living with HIV (PLWH). We aimed to assess factors associated with OS in virologically suppressed PLWH on long-term modern ART.

Method: In this cross-sectional study we evaluated OS by measuring both the levels of derivatives-reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP).

Autism Spectrum Disorder Traits Predict Interoceptive Deficits and Eating Disorder Symptomatology in Children and Adolescents with Anorexia Nervosa-A Cross-Sectional Analysis: Italian Preliminary Data.

Background: Anorexia Nervosa (AN) is a severe Feeding and Eating Disorder (FED) that is more prevalent in females, often manifesting during adolescence. Recent research highlights an elevated presence of comorbid Autism Spectrum Disorder (ASD) traits among individuals with AN, with specific expressions in females accounting for sensorial and interoceptive experiences. This study retrospectively explores the association between ASD traits, eating symptomatology, and interoceptive deficits in Italian female adolescents with AN.

Gut-brain axis and neuroplasticity in health and disease: a systematic review.

The gut microbiota emerged as a potential modulator of brain connectivity in health and disease. This systematic review details current evidence on the gut-brain axis and its influence on brain connectivity. The initial set of studies included 532 papers, updated to January 2024.

Versatility of Diagon\Gel 4Two Implants in Aesthetic and Reconstructive Breast Surgery.

Background: Breast augmentation and breast reconstruction with implants are among the most performed surgery worldwide.

Objective: In the search for an ideal implant in terms of safety, shape and consistency, the authors report their experience with a subtype of breast implant, the Diagon\Gel 4Two implants, in both cosmetic and reconstructive cases by analyzing their experience on 116 consecutive patients.

Methods: One hundred and sixteen consecutive patients undergoing both aesthetic and reconstructive breast surgery using Diagon\Gel 4Two Implants between January 2021 and December 2022 were retrospectively reviewed.

Three-dimensional assessment of mandibular asymmetry in patients with unilateral cleft lip and palate at different growth stages: a cross-sectional study.

Introduction: The early diagnosis of mandibular asymmetry (MA) in patients with unilateral cleft lip and palate (UCLP) can contribute to its treatment.

Objective: The aim of this study was to evaluate the occurrence and the extent of MA in UCLP patients at different growth stages.

Methods: Cone-beam computed tomography (CBCT) of 47 UCLP patients were included, and divided into two groups (prepubertal stage and pubertal stage).

[Monoclonal Antibodies in Allergic Diseases: Development, Pharmacology, and Clinical Applications].

The understanding of immunological processes associated with allergic diseases and advancements in antibody bioengineering has driven the development of specific biological therapies. Monoclonal antibodies, selectively targeting cytokines involved in the pathogenesis of allergic processes or their receptors, have emerged as a promising tool in treating various conditions, including asthma, allergic rhinitis, urticaria, and severe atopic dermatitis. Since the approval of the first anti-CD3 mouse monoclonal antibody in 1986, remarkable progress has been achieved, marked by the development of chimeric, 'humanized,' and 'fully human' antibodies.

Diazoxide toxicity in congenital hyperinsulinism: A case report.

Background: Diazoxide is the sole approved drug for congenital hyperinsulinism; however, diuretic administration and vigilant monitoring are crucial to prevent and promptly identify potentially life-threatening adverse effects. This report aims to highlight a seldom-considered rare side effect of diazoxide. We believe that this brief report is of general interest to readership and increase the physicians' awareness of the guideline importance.

Screening fasting glucose before the OGTT: near-patient glucometer- or laboratory-based measurement?

Objectives: The measurement of fasting glucose is a common practice for lowering the risk of hyperglycemia before an oral glucose tolerance test (OGTT). In this study we analyze advantages and limitations of near-patient measurement of capillary fasting glucose with a portable glucometer or blood sampling and measurement of plasma glucose with laboratory instrumentation.

Methods: The final study population consisted of 241 subjects (mean age: 36 ± 8 years; 97.

Treatment of Genital Lymphedema With Lymphatic System Pedicled SCIP Transfer in Combination With Nanofibrillar Collagen Scaffolfds.

Genital lymphedema is a challenging condition often refractory to conservative treatments. This case report presents a novel surgical approach combining a lymphatic system transfer based on a pedicled superficial circumflex iliac perforator flap with nanofibrillar collagen scaffolds to address genital lymphedema secondary to hidradenitis suppurativa. A 47-year-old man with hidradenitis suppurativa-related genital lymphedema, unresponsive to conservative measures, underwent the procedure.

Outpatient Neurosurgery: ASCs and the Medicolegal Landscape.

The purpose of this work is to provide an understanding of the medicolegal landscape with regards to ambulatory surgery centers and physician owned hospitals, trends in our healthcare system, the benefits of facility ownership for both outpatient and inpatient spine surgery, and the effect of each on physicians and patients.

Intracellular Mg concentrations are differentially regulated in the sperm head and mid-piece in acrosome reaction inducing conditions.

The sperm ability to fertilize involves the regulation of ATP levels. Because inside cells, ATP is complexed with Mg ions, changes in ATP levels result in changes in intracellular Mg concentration ([Mg]), which can be followed using intracellular Mg sensors such as Mag-520. In this work, we tested conditions known to decrease sperm ATP such as starvation and capacitation.

Correlation between Periodontitis and Onset of Alzheimer's Disease: A Literature Review.

Background: Alzheimer's disease is a slowly progressing neurodegenerative illness and the most common form of dementia. This pathology leads to an increase in cognitive decline and is responsible, in patients, for several difficulties in performing various activities of daily living, such as oral hygiene. Several experimental studies have shown that oral health in patients with Alzheimer's disease worsens in direct proportion to the progression of the disease due to the appearance of gingivitis and periodontitis.

Ductus Venosus Agenesis in Monochorionic Twin Pregnancies Complicated by Fetal Growth Restriction: When to Deliver?

The prevalence of ductus venosus agenesis (ADV) in singleton pregnancies ranges from 0.04% to 0.15%, while its prevalence in twins remains largely unknown.

Association between Periodontal Disease and Oral Benign, Potentially Malignant, Malignant, and Chronic Immune-Mediated Disorders: A Clinical Study.

: Periodontal disease is an inflammatory, chronic, and multifactorial disease. The objective of this study is to analyze the association between periodontal disease and some disorders such as papillomas (benign lesions), lichen planus (a chronic immune-mediated disorder), leukoplakia (potentially malignant lesions), and oral cancer (malignant lesions). : For this study, 42 patients were recruited whose supragingival and subgingival plaque was qualitatively analyzed using a phase-contrast microscope, which allowed for the detection of compatible bacterial flora (immobile and composed mainly of cocci) indicative of periodontal health and incompatible bacterial flora (mobile and composed mainly of spirochetes) indicative of periodontal pathology.

Pain management in acute musculoskeletal injury: Effect of opioid nonopioid medications.

Background: The use of opioids for pain is linked to an increased risk of developing opioid use disorder, and has resulted in the emergence of the opioid crisis over the last few years.

Aim: The systematic review question is "How does the use of opioid medications in pain management, compared with non-opioid medications, affect pain intensity over the short, intermediate, and long-term in adults with acute traumatic pain?".

Methods: The protocol was prospectively registered on the International Prospective Register of Systematic Reviews: CRD42021279639.