Dithiocarbamate-based novel anti-histaminic agents: synthesis, characterization, crystal structure and thermal study.

A new -(4-fluorobenzyl) -(pyridin-2-ylmethyl) dithiocarbamate ligand () having structural similarity to clinically approved antihistaminic drugs (. pheniramine, chlorpheniramine, and brompheniramine) and its four metal complexes [Co(fbpm)] (1), [Ni(fbpm)] (2), [Cu(fbpm)] (3), and [Zn(fbpm)] (4) were successfully synthesized and characterized by various techniques elemental analysis, FT-IR spectroscopy, HR-MS, NMR spectroscopy, and absorption and emission spectroscopy. Furthermore, complexes 1 and 2 were characterized by single crystal X-ray diffraction.

Overexpression of the mitochondrial anti-viral signaling protein, MAVS, in cancers is associated with cell survival and inflammation.

Mitochondrial anti-viral signaling protein (MAVS) plays an important role in host defense against viral infection via coordinating the activation of NF-κB and interferon regulatory factors. The mitochondrial-bound form of MAVS is essential for its anti-viral innate immunity. Recently, tumor cells were proposed to mimic a viral infection by activating RNA-sensing pattern recognition receptors.

Prospects of Vitamin C as an Additive in Plasma of Stored Blood.

There is a dire necessity to improve blood storage and prolong shelf-life of blood. Very few studies have focused on oxidative stress (OS) in blood and its influence on plasma with storage. This study attempts to (i) elucidate the continuous changes occurring in plasma during storage through oxidant levels and antioxidant status and (ii) evaluate the influence of vitamin C (VC) as an additive during blood storage.

Curcumin as a modulator of oxidative stress during storage: a study on plasma.

Background: Plasma reflects the situations of oxidative stress in blood. Curcumin as an additive in storage solutions is not explored.

Materials And Methods: Blood was drawn from male Wistar rats (4 months old) and stored over a period of 20 days at 4 °C in CPDA-1.