-Hydroxybenzimidazole as a structurally modifiable platform for -oxyl radicals for direct C-H functionalization reactions.

Methods for direct functionalization of C-H bonds mediated by -oxyl radicals constitute a powerful tool in modern organic synthesis. While several -oxyl radicals have been developed to date, the lack of structural diversity for these species has hampered further progress in this field. Here we designed a novel class of -oxyl radicals based on -hydroxybenzimidazole, and applied them to the direct C-H functionalization reactions.

A Synthetic Route to Sodium α-Aminoalkanesulfinates and Their Application in the Generation of α-Aminoalkyl Radicals for Radical Addition Reactions.

The synthesis of sodium α-aminoalkanesulfinates and their synthetic utility as α-aminoalkyl radical precursors are reported. A variety of α-aminoalkanesulfinates were readily obtained from the reaction between the anions of N-Boc-protected alkylamines and 1,4-diazabicyclo[2.2.