Publications by authors named "The National Birth Defects Prevention Study"
Conotruncal heart defects (CTDs) are heart malformations that affect the cardiac outflow tract and typically cause significant morbidity and mortality. Evidence from epidemiological studies suggests that maternal folate intake is associated with a reduced risk of heart defects, including CTD. However, it is unclear if folate-related gene variants and maternal folate intake have an interactive effect on the risk of CTDs.
View Article and Find Full Text PDFMaternal Exposure to Disinfection By-Products and Risk of Hypospadias in the National Birth Defects Prevention Study (2000-2005).
Ibrahim Zaganjor Thomas J Luben Tania A Desrosiers Alexander P Keil Lawrence S Engel The National Birth Defects Prevention Study
Int J Environ Res Public Health
December 2020
Article Synopsis
- The study aimed to analyze the link between maternal exposure to disinfection by-products (DBPs) and the occurrence of 2nd and 3rd degree hypospadias in newborns using data from a significant case-control study in the U.S.
- Researchers created three exposure metrics based on DBP concentration, estimated ingestion, and predicted internal dose from different activities like showering and bathing.
- The findings generally indicated no significant relationship between DBP exposure and hypospadias, with a slight risk observed only for certain bromodichloromethane levels, which disappeared when accounting for specific water-use behaviors.