Late-life physical activity, midlife-to-late-life activity patterns, APOE ε4 genotype, and cognitive impairment among Chinese older adults: a population-based observational study.

Background: Although physical activity (PA) has been linked to cognitive health, the nuanced relationships between different dimensions of PA and cognitive impairment remain inconclusive. This study investigated associations between late-life PA levels, midlife-to-late-life activity patterns, and cognitive impairment in Chinese older adults, considering potential moderation by apolipoprotein E (APOE) ε4 genotype.

Methods: We analyzed baseline data from 6,899 participants (median age 68 years, 55.

Transferrin Modified Gold Nanoclusters-Based Biosensing Nanoplatform for High-Precision Multimodal Bioimaging of Tumor Cells.

Bioimaging technology has been broadly used in biomedicine, and the growth of multimodal imaging technology based on synergistic advantages can overcome the shortcomings of traditional single-modal bioimaging methods and attain high specificity and sensitivity in the fields of bioimaging and biosensing. The analysis of low-abundance microRNAs (miRNAs) in complex organisms is of high importance for early-stage diagnosis and clinical treatment of tumors. In our current study, a biosensing nanoplatform based on Tf-AuNCs and MnO nanosheets was developed for multimodal imaging of tumor cells.

Plug-In Design of the Microneedle Electrode Array for Multi-Parameter Biochemical Sensing in Gouty Arthritis.

Gouty arthritis is one of the most common forms of inflammatory arthritis and has brought a significant burden on patients and society. Current strategies for managing gout primarily focus on long-term urate-lowering therapy. With the rapid advancement of point-of-care testing (POCT) technology, continuous monitoring of gout-related biomarkers like uric acid (UA) or inflammatory cytokines can provide rapid and personalized diagnosis for gout management.

RNF7-Mediated ROS Targets Malignant Phenotype and Radiotherapy Sensitivity in Glioma With Different IDH1 Genotypes.

RNF7 (Ring Finger Protein 7) is a key component of CRLs (Cullin-RING-type E3 ubiquitin ligases) and has been found to possess intrinsic anti-ROS capabilities. Aberrant expression of RNF7 has been observed in various tumor types and is known to significantly influence tumor initiation and progression. However, the specific role of RNF7 in glioblastoma remains unclear.

Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats.

Background: Traumatic spinal cord injury (SCI) is an incurable condition that is the largest cause of disability. In previous studies, Isosteviol sodium (STVNa) has been shown to protect rats against acute focal cerebral ischemia; however, the effects of STVNa on SCI recovery in rats remain unknown.

Methods: STVNa was given intraperitoneally after SCI to see if it had any neuroprotective benefits.

The Space Radiobiological Exposure Facility on the China Space Station.

The Space Radiobiological Exposure Facility (SREF) is a general experimental facility at the China Space Station for scientific research in the fields of space radiation protection, space radiation biology, biotechnology, and the origin of life. The facility provides an environment with controllable temperatures for experiments with organic molecules and model organisms such as small animals, plant seeds, and microorganisms. The cultivation of small animals can be achieved in the facility with the use of microfluidic chips and images and videos of such experiments can be captured by microscopy.

SVMVGGNet-16: A Novel Machine and Deep Learning Based Approaches for Lung Cancer Detection Using Combined SVM and VGGNet-16.

Background And Objective: Lung cancer remains a leading cause of cancer-related mortality worldwide, necessitating early and accurate detection methods. Our study aims to enhance lung cancer detection by integrating VGGNet-16 form of Convolutional Neural Networks (CNNs) and Support Vector Machines (SVM) into a hybrid model (SVMVGGNet-16), leveraging the strengths of both models for high accuracy and reliability in classifying lung cancer types in different 4 classes such as adenocarcinoma (ADC), large cell carcinoma (LCC), Normal, and squamous cell carcinoma (SCC).

Methods: Using the LIDC-IDRI dataset, we pre-processed images with a median filter and histogram equalization, segmented lung tumors through thresholding and edge detection, and extracted geometric features such as area, perimeter, eccentricity, compactness, and circularity.

Anomaly Detection and Remaining Useful Life Prediction for Turbofan Engines with a Key Point-Based Approach to Secure Health Management.

Aero-engines, particularly turbofan engines, are highly complex systems that play a critical role in the aviation industry. As core components of modern aircraft, they provide the thrust necessary for flight and are essential for safe and efficient operations. However, the complexity and interconnected nature of these engines also make them vulnerable to failures and, in the context of intelligent systems, potential cyber-attacks.

Predicting Pharmacokinetics of Active Constituents in by Using Physiologically Based Pharmacokinetic Models.

Background/objectives: Spatholobi Caulis (SPC) is a medicinal plant that mainly grows in China and Southeast Asian countries and commonly used in clinics; the pharmacokinetic characteristics in humans need to be determined. This study was to establish the physiologically based pharmacokinetic (PBPK) models of multiple active constituents from SPC in rats, and predict the pharmacokinetic properties of rats with different dosages and extrapolated to humans.

Methods: The parameters were collected based on our previous study and by prediction using ADMET Predictor software predict.

Deformation Control of TC4 Titanium Alloy in Thin-Walled Hyperbolic Structures During Hot Forming Processes.

The thin-walled hyperbolic structures made from titanium alloy primarily encompass two typical forms: hyperbolic convex and hyperbolic concave (saddle). This paper addresses the technical challenges associated with the forming processes that frequently result in ripples or wrinkles in these configurations. Specifically, it investigates precision control techniques for the hot forming process of thin-walled hyperbolic skins from TC4 titanium alloy.

Nonlinear Thermomechanical Low-Velocity Impact Behaviors of Geometrically Imperfect GRC Beams.

This paper studies the thermomechanical low-velocity impact behaviors of geometrically imperfect nanoplatelet-reinforced composite (GRC) beams considering the von Kármán nonlinear geometric relationship. The graphene nanoplatelets (GPLs) are assumed to have a functionally graded (FG) distribution in the matrix beam along its thickness, following the X-pattern. The Halpin-Tsai model and the rule of mixture are employed to predict the effective Young modulus and other material properties.

Architecture-Aware Augmentation: A Hybrid Deep Learning and Machine Learning Approach for Enhanced Parkinson's Disease Detection.

Parkinson's Disease (PD) is a progressive neurodegenerative disorder affecting millions worldwide. Early detection is crucial for improving patient outcomes. Spiral drawing analysis has emerged as a non-invasive tool to detect early motor impairments associated with PD.

Effects of Oregano Essential Oil and/or Yeast Cultures on the Rumen Microbiota of Crossbred Simmental Calves.

This study hypothesized that combining oregano essential oil () and yeast cultures (s) would modulate rumen microbiota to promote gastrointestinal homeostasis and function. Twenty-four newborn, healthy, disease-free, crossbred Simmental male calves (birth weight ≥ 35 kg) were assigned to one of four treatments based on birth data. Treatments were as follows: (1) Control (), calves fed calf starter without additives; (2) , calves fed calf starter containing 60 mg/kg body weight () of OEO per day; (3) s, calves fed calf starter containing 45 mg/kg BW of YC per day; and (4) , calves fed calf starter with OEO (60 mg/kg, BW) and YC (45 mg/kg, BW) combination.

Development and Validation of a 5K Liquid Chip for Identifying Cashmere Goat Populations in Inner Mongolia Autonomous Region.

(1) Background: Cashmere goats, as one of the characteristic species, are rich in genetic resources. Protecting and rationally utilizing these genetic resources is of great significance for the genetic improvement of cashmere goats. (2) Methods: In this study, tissue samples were collected from , which included the Arbas type (); Erlangshan type (); Alashan type (), (), and ().

Synthesis of single-crystalline sp-carbon-linked covalent organic frameworks through imine-to-olefin transformation.

sp-carbon-linked covalent organic frameworks (spc-COFs) are crystalline porous polymers with repeat organic units linked by sp carbons, and have attracted increasing interest due to their robust skeleton and tunable semiconducting properties. Single-crystalline spc-COFs with well-defined structures can represent an ideal platform for investigating fundamental physics properties and device performance. However, the robust olefin bonds inhibit the reversible-reaction-based crystal self-correction, thus yielding polycrystalline or amorphous polymers.

An efficient fungi-biochar-based system for advancing sustainable management of combined pollution.

Heavy metal (HM) contamination poses significant global environmental threats, impacting ecosystems, public health, and sustainable development. Fungi, as eco-friendly alternatives to chemical treatments, have the potential to reduce HM bioavailability in contaminated soils while promoting plant growth. However, current fungal remediation methods face limitations in efficiency, long-term effectiveness, and the ability to address combined contamination, particularly with naturally occurring strains.

Are companies responding to minimum wage increases by reducing corporate social responsibility?

Corporate social responsibility (CSR) has been widely discussed. However, the existing literature does not delve into the theoretical mechanism to show how companies adjust their CSR in the face of minimum wage increases. This may be due to the lack of a theoretical framework that clarifies the relationship between minimum wage increases and CSR adjustments.

Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Infection.

Peritonitis caused by poses a severe threat to patients with end-stage renal failure. Treating multidrug-resistant infections requires the use of antibiotics with diverse mechanisms of action. Caseinolytic protease P (ClpP) is a promising antibacterial target; however, selective activation of (ClpP) over human ClpP (ClpP) remains challenging.

Novel carbon dots with dual Modulatory effects on the bone marrow and spleen as a potential therapeutic candidate for treating spinal cord injury.

Spinal cord injury triggers leukocyte mobilization from the peripheral circulation to the injury site, exacerbating spinal cord damage. Simultaneously, bone marrow hematopoietic stem cells (HSCs) and splenic leukocytes rapidly mobilize to replenish the depleted peripheral blood leukocyte pool. However, current treatments for spinal cord injuries overlook interventions targeting peripheral immune organs and tissues, highlighting the need to develop novel drugs capable of effectively regulating peripheral immunity and treating spinal cord injuries.

Magnetic Resonance Imaging Study on Older Patients with Cognitive Impairment and Depression.

Background: Understanding brain changes in older patients with depression and their relationship with cognitive abilities may aid in the diagnosis of depression in this population. This study aimed to explore the association between brain lesions and cognitive performance in older patients with depression.

Methods: We utilized magnetic resonance imaging data from a previous study, which included older adults with and without depression.

Ascorbic acid transporter MmSLC23A2 functions to inhibit apoptosis via ROS scavenging in hard clam (Mercenaria mercenaria) under acute hypo-salinity stress.

Solute carrier family 23 (SLC23) mediates cellular uptake of ascorbic acid, a crucial antioxidant protecting organisms against oxidative stress. Despite advances in understanding SLC23 in mammals, its physiological roles in bivalves remain poorly understood. Notably, euryhaline bivalves exhibit a significant expansion and positive selection of SLC23, highlighting the need for deeper investigation.

Interface-Engineered Manufacturing of Gradient Wood with Heterogeneous Structure for Lightweight and Sustainable Structural Materials.

Developing sustainable structural materials to replace traditional carbon-intensive structural materials fundamentally reshapes the concept of circular development. Herein, we propose an interface engineering strategy that utilizes water as a liquid medium to replace the residual air within natural wood. This approach minimizes the absorption of water-based softening agents by microcapillary channels of wood, enabling the controlled softening of the cell walls.

A high-performance g-CN/BiSiO heterojunction photocatalyst induced by constructing S-scheme electron-highways.

We have developed a novel S-scheme mechanism to expand the photoresponse range of BiSiO. This study reports the successful creation of a CN/BS heterojunction photocatalyst, which is composed of g-CN and BiSiO. The synthesis was achieved through a simple two-step procedure, involving hydrothermal treatment and subsequent calcination.

Effect of radiotherapy exposure on fruquintinib plus sintilimab treatment in refractory microsatellite stable metastatic colorectal cancer: a prospective observation study.

Background: Immune checkpoint inhibitors (ICIs) in combination with antiangiogenic drugs have shown promising outcomes in the third-line and subsequent treatments of patients with microsatellite stable metastatic colorectal cancer (MSS-mCRC). Radiotherapy (RT) may enhance the antitumor effect of immunotherapy. However, the effect of RT exposure on patients receiving ICIs and targeted therapy remains unclear.