The Beneficial Effects of Combined Exercise and Polyphenols in Alzheimer's Disease.

Regular exercise enhances life quality, lowers the risk of cognitive damage, and slows the advancement of Alzheimer's disease (AD). Natural compounds rich in polyphenols have garnered attention as a non-pharmacological means of treating and preventing AD. The primary component of wine, grape seeds, and nuts is polyphenols.

Thermal Transfer Printed Flexible and Wearable Bionic Skin with Bilayer Nanofiber for Comfortable Multimodal Health Management.

The advent of bionic skin sensors represents a significant leap forward in the realm of wearable health monitoring technologies. Existing bionic skin technologies face several limitations, including complex and expensive manufacturing processes, low wearing comfort, and challenges in achieving comfortable real-time health monitoring. These shortcomings hinder the widespread adoption and practical utility of bionic skin in various applications.

Carboxymethyl Chitosan-Based Antioxidant Hydrogel Accelerates Diabetic Wound Healing.

Diabetic wound healing is hampered due to oxidative stress, exacerbated inflammation, and impaired angiogenesis in the wounds. A pH-sensitive antioxidant hydrogel based on carboxymethyl chitosan (CMCS), oligoprocyanidins (OPC), and oxide dextran (Oxd) is prepared to accelerate diabetic wound healing. The hydrogel network is formed via imine and hydrogen bonding interactions in the presence of hydroxyl, amino, and aldehyde groups, and deferoxamine (DFO) is incorporated into the hydrogel.

Glycogenin is dispensable for normal liver glycogen metabolism and body glucose homeostasis.

Glycogen is a glucose-storage polysaccharide molecule present in animals, fungi and bacteria. The enzyme glycogenin can self-glycosylate, forming an oligosaccharide chain that primes glycogen synthesis. This priming role of glycogenin was first believed to be essential for glycogen synthesis, but glycogen was then found in the skeletal muscle, heart, liver and brain of glycogenin-knockout mice (Gyg KO), thereby showing that glycogen can be synthesized without glycogenin.

Interaction of soy protein isolate with vitamin B during digestion: Focus on the binding mechanism, structure, and functional properties.

This study investigated the release mechanism and digestive characteristics of soy protein isolate (SPI)-loaded vitamin B during digestion. According to the molecular docking results, vitamin B interacted with the SPI through a hydrophobic pocket on the SPI surface. Spectroscopy revealed that the fluorescence intensity of the SPI and complex system increased with the digestion time.

Retinal thickness predicts the risk of cognitive decline over five years.

Background: Dementia poses a significant burden on healthcare systems. Early identification of individuals at risk for cognitive decline is crucial. The retina, an extension of the central nervous system, reflects neurodegenerative changes.

Accumulated BCAAs and BCKAs contribute to the HFD-induced deterioration of Alzheimer's disease via a dysfunctional TREM2-related reduction in microglial β-amyloid clearance.

A high-fat diet (HFD) induces obesity and insulin resistance, which may exacerbate amyloid-β peptide (Aβ) pathology during Alzheimer's disease (AD) progression. Branched-chain amino acids (BCAAs) accumulate in obese or insulin-resistant patients and animal models. However, roles of accumulated BCAAs and their metabolites, branched-chain keto acids (BCKAs), in the HFD-induced deterioration of AD and the underlying mechanisms remains largely unclear.

Non-traditional risk factors for atrial fibrillation: epidemiology, mechanisms, and strategies.

Atrial fibrillation (AF) has become the pre-dominant arrhythmia worldwide and is associated with high morbidity and mortality. Its pathogenesis is intricately linked to the deleterious impact of cardiovascular risk factors, emphasizing the pivotal imperative for early detection and mitigation strategies targeting these factors for the prevention of primary AF. While traditional risk factors are well recognized, an increasing number of novel risk factors have been identified in recent decades.

A mucus layer derived from porcine intestinal organoid air-liquid interface monolayer attenuates swine enteric coronavirus infection by antiviral activity of Muc2.

Background: The mucus layer provides the first defense that keeps the epithelium free from microorganisms. However, the effect of the small intestinal mucus layer on pathogen invasion is still poorly understood, especially for swine enteric coronavirus. To better understand virus‒mucus layer‒intestinal epithelium interactions, here, we developed a porcine intestinal organoid mucus‒monolayer model under air‒liquid interface (ALI) conditions.

Comparison of the effects of remimazolam and dexmedetomidine on the quality of recovery in functional endoscopic sinus surgery: a randomized clinical trial.

Background: Postoperative pain usually occur in patients who have undergone functional endoscopic sinus surgery (FESS). Remimazolam and dexmedetomidine could enhance the quality of recovery (QoR) after surgery. The aim of this study was to compare the effects of remimazolam and dexmedetomidine with respect to the QoR-40 score of patients who have undergone FESS.

Porous Organic Polymers for CO Capture and Catalytic Conversion.

Overuse of fossil fuels and anthropogenic activities have led to excessive emissions of carbon dioxide, leading to global warming, and measures to reduce atmospheric carbon dioxide concentrations are needed to overcome this global challenge. Therefore, exploring an environmentally friendly strategy for capturing airborne CO and converting it into high-value-added chemicals offers a promising pathway toward "carbon neutrality". In recent years, porous organic polymers have attracted much attention for carbon capture and the catalytic conversion of carbon dioxide because of their high specific surface area, high chemical stability, nanoscale porosity, and structural versatility, which make them easy to functionalize.

is implicated in central nervous system, orofacial and maxillofacial anomalies.

Background: Previous studies in mouse, and zebrafish embryos show strong expression in progenitor cells of neuronal and neural crest tissues suggesting its involvement in neural crest specification. However, the role of human transcription factor activator protein 2 ( in human embryonic central nervous system (CNS), orofacial and maxillofacial development is unknown.

Methods: Through a collaborative work, exome survey was performed in families with congenital CNS, orofacial and maxillofacial anomalies.

Identifying and counteracting fraudulent responses in online recruitment for health research: a scoping review.

Objectives: This study aimed to describe how health researchers identify and counteract fraudulent responses when recruiting participants online.

Design: Scoping review.

Eligibility Criteria: Peer-reviewed studies published in English; studies that report on the online recruitment of participants for health research; and studies that specifically describe methodologies or strategies to detect and address fraudulent responses during the online recruitment of research participants.

Degradable and Chain Extendable Segmented Hyperbranched Copolymers by Wavelength-Selective Photoiniferter Polymerization Using a Trithiocarbonate-Derived Dimethacrylate.

In this study, segmented hyperbranched copolymers with degradable and chain extendable cross-linker branch points were synthesized via green light-activated photoiniferter copolymerization of poly(ethylene glycol) methyl ether methacrylate (PEGMA) and a trithiocarbonate-derived dimethacrylate. A series of segmented hyperbranched copolymers with different degrees of branching were synthesized by changing the feed ratio of PEGMA to cross-linker to chain transfer agent. The segmented hyperbranched copolymers could be degraded into linear polymer chains by removing the trithocarbonate groups, which provides fundamental insights into the growth of primary chains during photoiniferter copolymerization.

A multivalent binding model infers antibody Fc species from systems serology.

Systems serology aims to broadly profile the antigen binding, Fc biophysical features, immune receptor engagement, and effector functions of antibodies. This experimental approach excels at identifying antibody functional features that are relevant to a particular disease. However, a crucial limitation of this approach is its incomplete description of what structural features of the antibodies are responsible for the observed immune receptor engagement and effector functions.

A cluster randomized trial assessing the effect of a digital health algorithm on quality of care in Tanzania (DYNAMIC study).

Digital clinical decision support tools have contributed to improved quality of care at primary care level health facilities. However, data from real-world randomized trials are lacking. We conducted a cluster randomized, open-label trial in Tanzania evaluating the use of a digital clinical decision support algorithm (CDSA), enhanced by point-of-care tests, training and mentorship, compared with usual care, among sick children 2 to 59 months old presenting to primary care facilities for an acute illness in Tanzania (ClinicalTrials.

Characteristics and Outcomes of mHealth Interventions in Psychosis: Systematic Mapping Review.

Background: Mobile health (mHealth) interventions have gained popularity in augmenting psychiatric care for adults with psychosis. Interest has grown in leveraging mHealth to empower individuals living with severe mental illness and extend continuity of care beyond the hospital to the community. However, reported outcomes have been mixed, likely attributed in part to the intervention and adopted outcomes, which affected between-study comparisons.

Manipulating π-π Interactions between Single Molecules by Using Antenna Electrodes as Optical Tweezers.

Via conductance measurements of thousands of single-molecule junctions, we report that the π-π coupling between neighboring aromatic molecules can be manipulated by laser illumination. We reveal that this optical manipulation originates from the optical plasmonic gradient force generated inside the nanogaps, in which the gapped antenna electrodes act as optical tweezers pushing the neighboring molecules closer together. These findings offer a nondestructive approach to regulate the interaction of the molecules, deepening the understanding of the mechanism of π-π interaction, and open an avenue to manipulate the relative position of extremely small objects down to the scale of single molecules.

Management of adult sepsis in resource-limited settings: global expert consensus statements using a Delphi method.

Purpose: To generate consensus and provide expert clinical practice statements for the management of adult sepsis in resource-limited settings.

Methods: An international multidisciplinary Steering Committee with expertise in sepsis management and including a Delphi methodologist was convened by the Asia Pacific Sepsis Alliance (APSA). The committee selected an international panel of clinicians and researchers with expertise in sepsis management.

Comprehensive assessment of pollution status, health risks and source apportionment of heavy metals in surface wetland soils of Yellow River Delta using Monte Carlo simulation and positive matrix factorization.

Excessive heavy metals (HMs) exposure in surface soils may cause non-negligible health risks to human beings; however, the potential health risk assessment of HMs in Yellow River Delta wetland (YRDW) soils has rarely been evaluated. In this study, we sampled surface wetland soils from ten typical functional areas in YRDW, assessed the HMs pollution status, evaluated their potential health risks, stimulated their probabilistic distributions of health risks and analyzed their potential source apportionment using Positive matrix factorization and Monte Carlo simulation. Enrichment factor (EF) and geo-accumulation index (I) indicated significant anthropogenic impacts, particularly in oil-contaminated sites, while Sediment Quality Guidelines (SQGs) comparison results suggested potential ecological risks, especially for As and Ni, which were occasionally above threshold effect levels.

Achieving High Solid-Liquid Ratio through Competitive Coordination towards Efficient Recovery of Metals from Spent Batteries.

The recycling of critical metals from spent lithium-ion batteries represents a significant step towards meeting the enhancing resource requirements in the new energy industry. Nevertheless, achieving effective leaching of metals from the stable metal-oxygen (MO6) structure of spent ternary cathodes and separation of metal products simultaneously still remained a huge challenge towards industrial applications. Herein, a competitive coordination strategy was proposed to design a novel deep eutectic solvent (DESs), which improved both leaching and selective metal recycling capacity even at high solid-liquid ratio (1:10).

Exploring the impact of Apelin and Reactive Oxygen Species on autophagy and cell senescence in pre-eclampsia.

This research investigates the interplay between Reactive Oxygen Species (ROS) and Apelin (APLN) in regulating autophagy, with implications for placental cell senescence and apoptosis in pre-eclampsia (PE). We manipulated APLN expression using sgRNA to study its effects on ROS levels and subsequent cellular responses. Our findings reveal that APLN overexpression elevates ROS production, accelerating cellular senescence and apoptosis.

Framework Nucleic Acid-Nanobody Fusion Probe-Based Pharmacokinetics Modulation and Analysis for Efficient Positron Emission Tomography Imaging.

Nanobodies are promising for immunoPET imaging due to their excellent antigen recognition and tumor targeting, yet rapid clearance limits their tumor accumulation. Although multimerization and albumin binding can extend their circulation time and improve tumor targeting, a simple and universal method for creating protein multimers is still needed. Here, we leveraged the facile synthesis, controllable size, and precise assembly of DNA nanotechnology to construct CD47-targeted framework nucleic acid-nanobody fusion probes with multiple valences and sizes.

Artificial Intelligence Recognition System of Pelvic Autonomic Nerve During Total Mesorectal Excision.

Background: The preservation of the pelvic autonomic nervous system in total mesorectal excision remains challenging to date. The application of laparoscopy has enabled visualization of fine anatomical structures; however, the rate of urogenital dysfunction remains high.

Objective: To establish an artificial intelligence neurorecognition system to perform neurorecognition during total mesorectal excision.