Background: Stressful life events (SLEs) are associated with increased risk of depression or anxiety. Coping mechanisms may moderate this relationship but little is known on this topic in young people or in Latin America.
Aim: To investigate whether coping strategies predict odds of depression and/or anxiety and moderate the relationship between SLEs and depression and/or anxiety in young people in Peru, Lima and Bogotá.
Copolymer nanovesicles are used extensively in chemical processes and biomedical applications in which they are subjected to dynamic flow environments. Flow-induced vesicle deformation, fragmentation, and reorganization modify the energetic (e.g.
View Article and Find Full Text PDFObjective: Excess mortality in mentally ill is largely due to high rates of physical illnesses that lead to worse health outcomes. This study examines the intake of added sugar from sugar-sweetened beverages (SSBs) and factors associated with poor mental and physical health in people with severe mental illness.
Methods: Data were collected as part of the standard care of consumers attending the Collaborative Centre for Cardiometabolic Health in Psychosis clinics where a diet history is taken by a dietitian.
Proteins
December 2024
Staphylococcus aureus causes a wide range of infections, from mild skin conditions to severe, life-threatening diseases. Bacteriophage endolysins exhibit a selective capacity to degrade the peptidoglycan layer of Gram-positive bacteria, making promising biotherapeutic agents against antibiotic-resistant infections. PlyGRCS, a specific endolysin derived from S.
View Article and Find Full Text PDFIntrathoracic meningocele is a condition characterized by the protrusion of dura mater and cerebrospinal fluid within the thoracic cavity. This can be associated with neurofibromatosis type 1 (NF1) and other connective tissue disorders. Less commonly, it can occur in isolation.
View Article and Find Full Text PDFThis study presents a greener approach to the visible-light-induced micellar-catalyzed diastereoselective iodosulfonylation of cyclopropenes in a water medium. Remarkably, this process operates without a photocatalyst. Instead, it utilizes an electron-donor-acceptor complex formed between sulfonyl chloride and sodium iodide.
View Article and Find Full Text PDFEur Urol Focus
November 2024
Background And Objective: Focal therapy is increasingly being used as a treatment for localized prostate cancer (PC). Our aim was to evaluate oncological outcomes, recurrence patterns, and survival after high-intensity focused ultrasound (HIFU), to discuss the lessons learned from our experience, and to propose strategies to enhance patient selection for HIFU treatment.
Methods: Between 2016 and 2023, 113 patients underwent focal HIFU treatment for PC.
We have developed a tandem method essential for synthesizing sulfone-containing organic molecules, which has wide-ranging applications in agrochemicals, medicinal chemistry, and polymer science. This method involves a two-step process: an iodo-sulfonylated intermediate is formed initially, followed by elimination to regenerate the double bond, ultimately yielding sulfone-containing cyclopropenes. Control studies have confirmed the intermediacy of iodo-sulfonylated cyclopropane within the reaction sequence.
View Article and Find Full Text PDFAmines are essential due to their structural diversity and biological significance. Introducing the valuable bicyclopentane (BCP) moiety at the α-position of amines offers a promising strategy for developing novel bioactive compounds. This study outlines a divergent synthesis approach to generate α-amino-functionalized bicyclopentyl iodides and methylene cyclobutanols under mild and environmentally sustainable conditions.
View Article and Find Full Text PDFFront Psychol
November 2024
Background: Latin American youth have a high prevalence of mental health disorders and face major socioeconomic and public safety problems. This study assesses the association between stressful life events (SLEs) and depression, anxiety, and quality of life among adolescents and young adults from deprived neighbourhoods of Latin America.
Methods: The sample consisted of 2,402 participants, between adolescents (15-16 years) and young adults (20-24 years), from Bogotá (Colombia), Buenos Aires (Argentina), and Lima (Peru), assessed in 2021-2022 and recruited in education and community settings and social media.
Temperatures perceived early in the life cycle of mother plants can affect the germination of the offspring seeds. In Arabidopsis thaliana, vernalisation-insensitive mutants showed altered germination response to elevated maternal temperature, hence revealing a strong genetic determinism. However, the genetic control of this maternal effect and its prevalence across natural populations remain unclear.
View Article and Find Full Text PDFJ Child Adolesc Ment Health
November 2024
Reducing anxiety and depression in adolescents is a global health priority. Personal and social resources (e.g.
View Article and Find Full Text PDFWe use a 16-month-long, 20 Hz wind data from a mooring deployed in the Bay of Bengal (BoB) to study the characteristics of turbulent wind stress ( events in the marine atmospheric boundary layer (MABL). Quadrant analysis of the motion-corrected and suggests that sweep and ejections, representing downward stress transfer into the ocean, dominate the (~ 140%). In comparison, outward and inward interactions representing an upward stress transfer into the atmosphere provide the counter-contribution (~ 40%).
View Article and Find Full Text PDFWe developed a visible-light-induced vinyl amination of activated alkenes using TMSN and CsF through EDA complex formation under an oxygen atmosphere. Without light, the EDA complex forms between activated alkene, CsF, and oxygen. Upon exposure to light, oxygen in the complex gets excited, initiating the HAT process.
View Article and Find Full Text PDFIn this study, we have developed an effective and general strategy for synthesizing various 4-[(trifluoromethyl)thio]-2,3-dihydrofuran derivatives with high regioselectivity from easily prepared cyclopropyl ketone under mild reaction conditions. By the combination of photoredox, copper, and Lewis acid catalysis into a triple catalytic system, this methodology facilitates the selective cleavage of the carbon-carbon bonds and the formation of new carbon-oxygen and carbon-sulfur bonds. In addition, to enhance the synthetic feasibility of this protocol, we demonstrate its broad applicability across a wide range of substrates and its scalability for large-scale synthesis.
View Article and Find Full Text PDFEarly detection of breast cancer is essential for increasing survival rates, as it is one of the primary causes of death for women globally. Mammograms are extensively used by physicians for diagnosis, but selecting appropriate algorithms for image enhancement, segmentation, feature extraction, and classification remains a significant research challenge. This paper presents a computer-aided diagnosis (CAD)-based hybrid model combining convolutional neural networks (CNN) with a pruned ensembled extreme learning machine (HCPELM) to enhance breast cancer detection, segmentation, feature extraction, and classification.
View Article and Find Full Text PDFGlioblastoma (GBM) is the most common and lethal primary brain tumor in adults and is driven by self-renewing glioblastoma stem cells (GSC) that persist after therapy and seed treatment-refractory recurrent tumors. GBM tumors display a high degree of intra- and intertumoral heterogeneity that is a prominent barrier to targeted treatment strategies. This heterogeneity extends to GSCs that exist on a gradient between two transcriptional states or subtypes termed developmental and injury response.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
August 2024
Environmental pollution, being a major concern worldwide, needs a unique and ecofriendly solution. To answer this, researchers are aiming in utilizing plant extracts for the synthesis of nanoparticles. These NPs synthesized using plant extracts provide a potential, environmentally benign technique for biological and photocatalytic applications.
View Article and Find Full Text PDFA highly adaptable method has been developed for the alkenylation of a broad spectrum of inert alkanes, employing milder reaction conditions. Tetrabutylammonium decatungstate (TBADT) serves as a photocatalyst for hydrogen atom transfer (HAT), instigating the formation of transient alkyl radicals through C(sp)-H functionalization. These radicals exhibit regioselective addition to cyclopropenes, followed by the subsequent activation of C-C bonds, forming the corresponding vinylated derivatives.
View Article and Find Full Text PDFThe functionalization of α-C(sp)-H bonds in amines has become a focal point of contemporary research. Here, we report a new approach utilizing photocatalysis α-C(sp)-H bond functionalization in alicyclic and aliphatic secondary amines facilitated by intramolecular 1,5-hydrogen atom transfer (HAT). This finding unlocks a sustainable method for rapidly constructing complex heterocyclics cross-dehydrogenative C-C coupling of protected amines and nitrogen-containing heterocycles.
View Article and Find Full Text PDFJ Gastrointest Surg
October 2024
Background: Insulin resistance (IR) is one of the independent determinants influencing the length of hospital stay (LOHS) and postoperative complications in colorectal procedures. Preoperative oral carbohydrate loading (OCL) has emerged as a prospective countermeasure for IR. This study aimed to investigate the effects of preoperative carbohydrate loading on postoperative IR, inflammatory parameters, and clinical outcomes in patients undergoing elective colorectal surgery.
View Article and Find Full Text PDFEmerging and persistent contaminants (EPC) pose a significant challenge to water quality monitoring efforts. Effect-based monitoring (EBM) techniques provide an efficient and systematic approach in water quality monitoring, but they tend to be resource intensive. In this study, we investigated the EPC distribution for various land uses using target analysis (TA) and non-target screening (NTS) and in vitro bioassays, both individually and integrated, in the upper Ping River Catchment, northern Thailand.
View Article and Find Full Text PDFPatients with breast tumors that metastasize to the brain have limited treatment options and a very poor prognosis. More effective therapeutic strategies are desperately needed for this patient population. Recent evidence demonstrates that brain metastases arising from breast tumors display altered energy production that results in enhanced autophagy.
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